Roles of endogenous glutathione levels on 6-hydroxydopamine-induced apoptotic neuronal cell death in human neuroblastoma SK-N-SH cells

Neuropharmacology

Volumn 43, Issue 3, 2002, Pages 434-443

  Shimizu, Eiji ^a   Hashimoto, Kenji ^a,b   Komatsu, Naoya ^a   Iyo, Masaomi ^a  

^a CHIBA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Welfide Corporation   (Japan)

Author keywords

6 Hydroxydopamine; Apoptosis; Glutathione; N Acetylcysteine; Oxidative stress

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; ACETYLCYSTEINE; BUTHIONINE SULFOXIMINE; DNA FRAGMENT; DYE; GLUTATHIONE; OXIDOPAMINE;

APOPTOSIS; ARTICLE; CELL LEVEL; CELL PROTECTION; CELL STRAIN; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME IMMUNOASSAY; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; INCUBATION TIME; NERVE CELL NECROSIS; NEUROBLASTOMA; NEUROPROTECTION; OXIDATION; PRIORITY JOURNAL; PROTEIN INDUCTION; STAINING;

ACETYLCYSTEINE; APOPTOSIS; BENZIMIDAZOLES; BRAIN NEOPLASMS; BUTHIONINE SULFOXIMINE; CYSTINE; DNA FRAGMENTATION; FLUORESCENT DYES; FREE RADICAL SCAVENGERS; GLUTATHIONE; HUMANS; NEUROBLASTOMA; NEURONS; OXIDOPAMINE; SYMPATHOLYTICS; TUMOR CELLS, CULTURED;

EID: 0036710977     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00108-9     Document Type: Article

References (68)

1. Ahlemeyer B., Krieglstein J. Inhibition of glutathione depletion by retinoic acid and tocopherol protects cultured neurons from staurosporine-induced oxidative stress and apoptosis. Neurochemistry International. 36:2000;1-5.
2. Anderson M.E. Determination of glutathione and glutathione disulfide in biological samples. Methods in Enzymology. 113:1985;548-555.
3. Aruoma O.I., Halliwell B., Hoey B.M., Butler J. The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid. Free Radical Biology and Medicine. 6:1989;593-597.
4. Baker M.A., Cerniglia G.J., Zaman A. Microtiter plate assay for the measurement of glutathione and glutathione disulfide in large numbers of biological samples. Analytical Biochemistry. 190:1990;360-365.
5. Berman S.B., Hastings T.G. Dopamine oxidation alters mitochondrial respiration and induces permeability transition in brain mitochondria. Implications for Parkinson's disease. Journal of Neurochemistry. 73:1999;1127-1137.
6. Bursztajn S., Feng J.J., Berman S.A., Nanda A. Poly (ADP-ribose) polymerase induction is an early signal of apoptosis in human neuroblastoma. Brain Research Molecular Brain Research. 76:2000;363-376.
7. Canals S., Casarejos M.J., Rodriguez-Martin E., de Bernardo S., Mena M.A. Neurotrophic and neurotoxic effects of nitric oxide on fetal midbrain cultures. Journal of Neurochemistry. 76:2001;56-68.
8. Carroll J.E., Howard E.F., Hess D.C., Wakade C.G., Chen Q., Cheng C. Nuclear factor-kappa B activation during cerebral reperfusion: Effect of attenuation with N-acetylcysteine treatment. Brain Research Molecular Brain Research. 56:1998;186-191.
9. Cohen G., Heikkila R.E. The generation of hydrogen peroxide, superoxide radical, and hydroxyl radical by 6-hydroxydopamine, dialuric acid, and related cytotoxic agents. Journal of Biological Chemistry. 249:1974;2447-2452.
10. Colton C.A., Pagan F., Snell J., Colton J.S., Cummins A., Gilbert D.L. Protection from oxidation enhances the survival of cultured mesencephalic neurons. Experimental Neurology. 132:1995;54-61.
11. Cotgreave I.A. N-acetylcysteine: Pharmacological considerations and experimental and clinical applications. Advances in Pharmacology. 38:1997;205-227.
12. De Vries N., De Flora S. N-acetyl-l-cysteine. Journal of Cellular Biochemistry. 17F:(Supplement):1993;270-277.
13. Deneke S.M., Susanto I., Vogel K.A., Williams C.E., Lawrence R.A. Mechanisms of use of extracellular glutathione by lung epithelial cells and pulmonary artery endothelial cells. American Journal of Respiratory Cell and Molecular Biology. 12:1995;662-668.
14. Deneke S.M. Thiol-based antioxidants. Current Topics in Cellular Regulation. 36:2000;151-180.
15. Dodel R.C., Du Y., Bales K.R., Ling Z., Carvey P.M., Paul S.M. Caspase-3-like proteases and 6-hydroxydopamine induced neuronal cell death. Brain Research Molecular Brain Research. 64:1999;141-148.
16. Dringen R. Metabolism and functions of glutathione in brain. Progress in Neurobiology. 62:2000;649-671.
17. Dringen R., Gutterer J.M., Hirrlinger J. Glutathione metabolism in brain. Metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. European Journal of Biochemistry. 267:2000;4912-4916.
18. Efferth T., Fabry U., Osieka R. Anti-Fas/Apo-1 monoclonal antibody CH-11 depletes glutathione and kills multidrug-resistant human leukemic cells. Blood Cells, Molecules and Diseases. 22:1996;2-9.
19. Ferrari G., Yan C.Y., Greene L.A. N-acetylcysteine (D- and L-stereoisomers) prevents apoptotic death of neuronal cells. Journal of Neuroscience. 15:1995;2857-2866.
20. Froissard P., Monrocq H., Duval D. Role of glutathione metabolism in the glutamate-induced programmed cell death of neuronal-like PC12 cells. European Journal of Pharmacology. 326:1997;93-99.
21. Fujisawa K., Aono H., Hasunuma T., Yamamoto K., Mita S., Nishioka K. Activation of transcription factor NF-kappa B in human synovial cells in response to tumor necrosis factor alpha. Arthritis and Rheumatism. 39:1996;197-203.
22. Gabby M., Tauber M., Porat S., Simantov R. Selective role of glutathione in protecting human neuronal cells from dopamine-induced apoptosis. Neuropharmacology. 35:1996;571-578.
23. Gilgun-Sherki Y., Melamed E., Offen D. Oxidative stress induced-neurodegenerative diseases: The need for antioxidants that penetrate the blood-brain barrier. Neuropharmacology. 40:2001;959-975.
24. Glinka Y., Gassen M., Youdim M.B. Mechanism of 6-hydroxydopamine neurotoxicity. Journal of Neural Transmission. 50:(Supplemental):1997;55-66.
25. Glinka Y.Y., Youdim M.B. Inhibition of mitochondrial complexes I and IV by 6-hydroxydopamine. European Journal of Pharmacology. 292:1995;329-332.
26. Griffith O.W. Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Analytical Biochemistry. 106:1980;207-212.
27. Gschwind M., Huber G. Apoptotic cell death induced by beta-amyloid 1-42 peptide is cell type dependent. Journal of Neurochemistry. 65:1995;292-300.
28. Graham D.G., Tiffany S.M., Bell W.R. Jr., Gutknecht W.F. Autoxidation versus covalent binding of quinones as the mechanism of toxicity of dopamine, 6-hydroxydopamine, and related compounds toward C1300 neuroblastoma cells in vitro. Molecular Pharmacology. 14:1978;644-653.
29. Han S.K., Mytilineou C., Cohen G. L-DOPA up-regulates glutathione and protects mesencephalic cultures against oxidative stress. Journal of Neurochemistry. 66:1996;501-510.
30. Iwata S., Hori T., Sato N., Hirota K., Sasada T., Mitsui A., Hirakawa T., Yodoi J. Adult T cell leukemia (ATL)-derived factor/human thioredoxin prevents apoptosis of lymphoid cells induced by L-cystine and glutathione depletion: Possible involvement of thiol-mediated redox regulation in apoptosis caused by pro-oxidant state. Journal of Immunology. 158:1997;3108-3117.
31. Jenner P. Altered mitochondrial function, iron metabolism and glutathione levels in Parkinson's disease. Acta Neurologica Scandinavica. 87:1993;6-13.
32. Jonsson G. Chemical neurotoxins as denervation tools in neurobiology. Annual Review of Neuroscience. 3:1980;169-187.
33. Keogh B., Allen R.G., Tresini M., Furth J.J., Cristofalo V.J. Antioxidants stimulate transcriptional activation of the c-fos gene by multiple pathways in human fetal lung fibroblasts (WI-38). Journal of Cellular Physiology. 176:1998;624-633.
34. Kosower N.S., Kosower E.M. The glutathione status of cells. International Review of Cytology. 54:1978;109-160.
35. Koyama Y., Kimura Y., Hashimoto H., Matsuda T., Baba A. L-lactate inhibits L-cystine/L-glutamate exchange transport and decreases glutathione content in rat cultured astrocytes. Journal of Neuroscience Research. 59:2000;685-691.
36. LaVoie M.J., Hastings T.G. Dopamine quinone formation and protein modification associated with the striatal neurotoxicity of methamphetamine. Evidence against a role for extracellular dopamine. Journal of Neuroscience. 19:1999;1484-1491.
37. Lee J.S., Kypreos K.E., Sonenshein G.E. Synchronization of cultured vascular smooth muscle cells following reversal of quiescence induced by treatment with the antioxidant N-acetylcysteine. Experimental Cell Research. 239:1998;447-453.
38. Liang Y.O., Plotsky P.M., Adams R.N. Isolation and identificaton of an in vivo reaction product of 6-hydroxydopamine. Journal of Medicinal Chemistry. 20:1977;581-583.
39. Liu M., Wikonkal N.M., Brash D.E. Induction of cyclin-dependent kinase inhibitors and G(1) prolongation by the chemopreventive agent N-acetylcysteine. Carcinogenesis. 20:1999;1869-1872.
40. Margolis R.L., Chuang D.M., Post R.M. Programmed cell death: Implications for neuropsychiatric disorders. Biological Psychiatry. 35:1994;946-956.
41. Martinez M., Martinez N., Hernandez A.I., Ferrandiz M.L. Can N-acetylcysteine be beneficial in Parkinson's disease? Life Science. 64:1999;1253-1257.
42. Mayer M., Noble M. N-acetyl-L-cysteine is a pluripotent protector against cell death and enhancer of trophic factor-mediated cell survival in vitro. Proceedings of the National Academy of Sciences of the USA. 91:1994;7496-7500.
43. Mazor D., Golan E., Philip V., Katz M., Jafe A., Ben-Zvi Z., Meyerstein N. Red blood cell permeability to thiol compounds following oxidative stress. European Journal of Haematology. 57:1996;241-246.
44. Meister A. Glutathione metabolism. Methods in Enzymology. 251:1995;3-7.
45. Mendez-Alvarez E., Soto-Otero R., Hermida-Ameijeiras A., Lopez-Martin M.E., Labandeira-Garcia J.L. Effect of iron and manganese on hydroxyl radical production by 6-hydroxydopamine: Mediation of antioxidants. Free Radical Biology and Medicine. 31:2001;986-998.
46. Miller A.C., Henderson B.W. Effect of DL-buthionine-S, R-sulfoximine on the growth of EMT6 and RIF mouse tumors. Journal of the National Cancer Institute. 77:1986;505-510.
47. Morshead C.M., van der Kooy D. A cell-survival factor (N-acetyl-L-cysteine) alters the in vivo fate of constitutively proliferating subependymal cells in the adult forebrain. Journal of Neurobiology. 42:2000;338-346.
48. Nappi A.J., Vass E. The effects of glutathione and ascorbic acid on the oxidations of 6-hydroxydopa and 6-hydroxydopamine. Biochimica et Biophysica Acta. 1201:1994;498-504.
49. Pileblad E., Magnusson T., Fornstedt B. Reduction of brain glutathione by L-buthionine sulfoximine potentiates the dopamine-depleting action of 6-hydroxydopamine in rat striatum. Journal of Neurochemistry. 52:1989;978-980.
50. Pileblad E., Magnusson T. Increase in rat brain glutathione following intracerebroventricular administration of gamma-glutamylcysteine. Biochemical Pharmacology. 44:1992;895-903.
51. Rabenstein, D.L., Millis, K.K., 1995. Nuclear magnetic resonance study of the thioltransferase-catalyzed glutathione/glutathione disulfide interchange reaction. Biochimica et Biophysica Acta 1249, 29-36.
52. Ratan R.R., Baraban J.M. Apoptotic death in an in vitro model of neuronal oxidative stress. Clinical and Experimental Pharmacology and Physiology. 22:1995;309-310.
53. Reed D.J. Review of the current status of calcium and thiols in cellular injury. Chemical Research in Toxicology. 3:1990;495-502.
54. Reiter R.J. Oxidative processes and antioxidative defense mechanisms in the aging brain. The FASEB Journal. 9:1995;526-533.
55. Riederer P., Sofic E., Raush W.D., Shmidt B., Reynolds G.P., Jellinger K., Youdim M.B. Transition metals, ferritin, glutathione, and ascorbic acid in Parkinsonian brain. Journal of Neurochemistry. 52:1989;515-520.
56. Rodriguez-Pallares J., Rey P., Soto-Otero R., Labandeira-Garcia J.L. N-acetylcysteine enhances production of dopaminergic neurons from mesencephalic-derived precursor cells. Neuroreport. 12:2001;3935-3938.
57. Schulz J.B., Lindenau J., Seyfried J., Dichgans J. Glutathione, oxidative stress and neurodegeneration. European Journal of Biochemistry. 267:2000;4904-4911.
58. Sechi G., Deledda M.G., Bua G., Satta W.M., Deiana G.A., Pes G.M., Rosati G. Reduced intravenous glutathione in the treatment of early Parkinson's disease. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 20:1996;1159-1170.
59. Si F., Ross G.M., Shin S.H. Glutathione protects PC12 cells from ascorbate- and dopamine-induced apoptosis. Experimental Brain Research. 123:1998;263-268.
60. Sian J., Dexter D.T., Lees A.J., Daniel S., Agid Y., Javoy-Agid F., Jenner P., Marsden C.D. Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia. Annals of Neurology. 36:1994;348-355.
61. Soto-Otero R., Mendez-Alvarez E., Hermida-Ameijeiras A., Munoz-Patino A.M., Labandeira-Garcia J.L. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: Potential implication in relation to the pathogenesis of Parkinson's disease. Journal of Neurochemistry. 74:2000;1605-1612.
62. Talley A.K., Dewhurst S., Perry S.W., Dollard S.C., Gummuluru S., Fine S.M., New D., Epstein L.G., Gendelman H.E., Gelbard H.A. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: Protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Molecular and Cellular Biology. 15:1995;2359-2366.
63. Thomas E.L., Learn D.B., Jefferson M.M., Weatherred W. Superoxide-dependent oxidation of extracellular reducing agents by isolated neutrophils. Journal of Biological Chemistry. 263:1988;2178-2186.
64. Ungerstedt U. 6-hydroxydopamine-induced degeneration of the nigrostriatal dopamine pathway: The turning syndrome. Pharmacology and Therapeutics. 2:1976;37-40.
65. van Zandwijk N. N-acetylcysteine (NAC) and glutathione (GSH): Antioxidant and chemopreventive properties, with special reference to lung cancer. Journal of Cellular Biochemistry. 22:(Supplement):1995;24-32.
66. Vandeputte C., Guizon I., Genestie-Denis I., Vannier B., Lorenzon G. A microtiter plate assay for total glutathione and glutathione disulfide contents in cultured/isolated cells: Performance study of a new miniaturized protocol. Cell Biology and Toxicology. 10:1994;415-421.
67. Wilson J.X. Antioxidant defense of the brain: A role for astrocytes. Canadian Journal of Physiology and Pharmacology. 75:1997;1149-1163.
68. Yan C.Y., Greene L.A. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. Journal of Neuroscience. 18:1998;4042-4049.