β-Amyloid protein (Aβ) and human amylin regulation of apoptotic genes occurs through the amylin receptor

Apoptosis

Volumn 17, Issue 1, 2012, Pages 37-47

  Jhamandas, Jack H ^a   MacTavish, David ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Caspases; Cell culture; Neuroprotection; Programmed cell death; RNA; RT PCR arrays

Indexed keywords

AMYLIN; AMYLIN RECEPTOR; AMYLOID BETA PROTEIN[1-42]; CASPASE 6; CASPASE 8; RNA;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FETUS; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; NERVE CELL CULTURE; NEUROPROTECTION; PRIORITY JOURNAL; RECEPTOR BLOCKING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELLS, CULTURED; GENE EXPRESSION REGULATION; HUMANS; ISLET AMYLOID POLYPEPTIDE; NEURONS; PEPTIDE FRAGMENTS; RATS; RECEPTORS, ISLET AMYLOID POLYPEPTIDE;

RATTUS;

EID: 84856718443     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-011-0656-3     Document Type: Article

References (30)

1. Sun MK, Alkon DL (2006) Links between Alzheimer's disease and diabetes. Drugs Today (Barcelona) 42:481-489 (Pubitemid 44221017)
2. Craft S (2007) Insulin resistance and Alzheimer's disease pathogenesis: potential mechanisms and implications for treatment. Curr Alzheimer Res 4:147-152 (Pubitemid 46557503)
3. Lin L, Holscher C (2007) Common pathological processes in Alzheimer disease and type 2 diabetes: a review. Brain Res Rev 56:384-402 (Pubitemid 350166529)
4. Götz J, Ittner LM, Lim YA (2009) Common features between diabetes mellitus and Alzheimer's disease. Cell Mol Life Sci 66:1321-1325
5. Farris W, Mansourian S, Chang YL, Lindsley L, Eckman EA, Frosch MP, Eckman CB, Tanzi RE, Selkoe DJ, Guenette S (2003) Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein and the beta-amyloid precursor protein intracellular domain in vivo. Proc Natl Acad Sci USA 100:4162-4167 (Pubitemid 36418174)
6. Gasparini L, Xu H (2003) Potential roles of insulin and IGF-1 in Alzheimer's disease. Trends Neurosci 26:404-406 (Pubitemid 37288973)
7. Munch G, Schinzel R, Loske C, Wong A, Durany N, Li JJ, Vlassara H, Smith MA, Perry G, Riederer P (1998) Alzheimer's disease- synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. J Neural Transm 105:439-461 (Pubitemid 28365028)
8. Yamagishi S, Takeuchi M, Inagaki Y, Nakamura K, Imaizumi T (2003) Role of advanced glycation end products (AGEs) and their receptor (RAGE) in the pathogenesis of diabetic microangiopathy. Int J Clin Pharmacol Res 23:129-134 (Pubitemid 38821763)
9. Ledesma MD, Bonay P, Colaco C, Avila J (1994) Analysis of microtubule-associated protein tau glycation in paired helicalfilaments. J Biol Chem 269:21614-21619 (Pubitemid 24274797)
10. Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, Reid KB (1987) Purification and characterization of a peptide from amyloid- rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 84:8628-8632 (Pubitemid 18033465)
11. Lorenzo A, Razzaboni B, Weir GC, Yankner BA (1994) Pancreatic islet cell toxicity of amylin associated with type-2 diabetes mellitus. Nature 368:756-760 (Pubitemid 24153418)
12. Lim YA, Ittner LM, Lim YL, Götz J (2008) Human but not rat amylin shares neurotoxic properties with Abeta42 in long-term hippocampal and cortical cultures. FEBS Lett 582:2188-2194
13. Yankner BA, Lu T (2009) Amyloid beta-protein toxicity and the pathogenesis of Alzheimer disease. J Biol Chem 284:4755-4759
14. Arispe N, Pollard HB, Rojas E (1993) Giant multilevel cation channels formed by Alzheimer disease amyloid b-protein [AbP- (1-40)] in bilayer membrane. Proc Natl Acad Sci USA 90: 10573-10577 (Pubitemid 23347084)
15. Kawahara M (2010) Neurotoxicity of b-amyloid protein: oligomerization, channel formation, and calcium dyshomeostasis. Curr Pharm Des 16:2779-2789
16. Jhamandas JH, Cho C, Jassar B, Harris K, MacTavish D, Easaw J (2001) Cellular mechanisms for amyloid-b protein activation of rat cholinergic basal forebrain neurons. J Neurophysiol 86: 1312-1320 (Pubitemid 32847777)
17. Jhamandas JH, Harris KH, Cho C, Fu W, MacTavish D (2003) Human amylin actions on rat cholinergic basal forebrain neurons: antagonism of beta-amyloid effects. J Neurophysiol 90: 3130-3136
18. Jhamandas JH, MacTavish D (2004) Antagonist of the amylin receptor blocks b-amyloid toxicity in rat cholinergic basal forebrain neurons. J Neurosci 24:5579-5584 (Pubitemid 38812640)
19. Lim YA, Rhein V, Baysang G, Meier F, Poljak A, Raftery MJ, Guilhaus M, Ittner LM, Eckert A, Gotz J (2010) Ab and human amylin share a common toxicity pathway via mitochondrial dysfunction. Proteomics 10:1621-1633
20. Yuan J, Yankner BA (2000) Apoptosis in the nervous system. Nature 407:802-809
21. Bredesen DE, Rao RV, Mehlen P (2006) Cell death in the nervous system. Nature 443:796-802 (Pubitemid 44622684)
22. Stine WB Jr, Dahlgren KN, Krafft GA, LaDu MJ (2003) In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis. J Biol Chem 278:11612-11622 (Pubitemid 36792723)
23. White JA, Manelli AM, Holmberg KH, Van Eldik LJ, Ladu MJ (2005) Differential effects of oligomeric and fibrillar amyloidbeta 1-42 on astrocyte-mediated inflammation. Neurobiol Dis 18:459-465 (Pubitemid 40332705)
24. Jhamandas JH, Li Z, Westaway D, Yang J, Jassar S, MacTavish D (2011) Actions of b-amyloid (Ab) on human neurons are expressed through the amylin receptor. Am J Pathol 178:140-149
25. Afkhami-Goli A, Noorbakhsh F, Keller AJ, Vergnolle N, Westaway D, Jhamandas JH, Andrade-Gordon P, Hollenberg MD, Arab H, Dyck RH, Power C (2007) Proteinase-activated receptor- 2 exerts protective and pathogenic cell type-specific effects in Alzheimer's disease. J Immunol 179:5493-5503
26. Mattson MP, Cheng B, Davis D, Bryant K, Lieberburg I, Rydel RE (1992) b-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity. J Neurosci 12:376-389
27. Ryan SD, Whitehead SN, Swayne LA, Moffat TC, Hou W, Ethier M, Bourgeois AJ, Rashidian J, Blanchard AP, Fraser PE, Park DS, Figeys D, Bennett SA (2009) Amyloid-{beta}42 signals tau hyperphosphorylation and compromises neuronal viability by disrupting alkylacylglycerophosphocholine metabolism. Proc Natl Acad Sci USA 106:20936-20941
28. Hay DL, Christopoulos G, Christopoulos A, Sexton PM (2004) Amylin receptors: molecular composition and pharmacology. Biochem Soc Trans 32:865-867 (Pubitemid 39524399)
29. Morfis M, Tilakaratne N, Furness SG, Christopoulos G, Werry TD, Christopoulos A, Sexton PM (2008) Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology 149:5423-5431
30. Cantarella G, Uberti D, Carsana T, Lombardo G, Bernardini R, Memo M (2003) Neutralization of TRAIL death pathway protects human neuronal cell line from beta-amyloid toxicity. Cell Death Differ 10:134-141 (Pubitemid 36511839)