The effect of aging on bone formation in porous hydroxyapatite: Biochemical and histological analysis

Journal of Bone and Mineral Research

Volumn 12, Issue 6, 1997, Pages 989-994

  Inoue, Keisuke ^a,b   Ohgushi, H ^a   Yoshikawa, T ^a   Okumura, M ^a   Sempuku, T ^a   Tamai, S ^a   Dohi, Y ^a  

^a NARA MEDICAL UNIVERSITY   (Japan)

^b NONE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; HYDROXYAPATITE; OSTEOCALCIN;

ADOLESCENT; AGED; AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; IMPLANT; MALE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOBLAST; RAT; STROMA CELL;

AGING; ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; CELL DIFFERENTIATION; DURAPATITE; MALE; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; PROSTHESES AND IMPLANTS; RATS; RATS, INBRED F344; TRANSPLANTATION, ISOGENEIC;

EID: 0031010503     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.1997.12.6.989     Document Type: Article

References (30)

1. Tonna EA, Cronkite EP 1962 Changes in the skeletal cell proliferative response to trauma concomitant with aging. J Bone Joint Surg 44-A:1557-1568.
2. Trueta J, Cavadias AX 1955 Vascular changes caused by the Kuntscher type of nailing: An experimental study in the rabbit. J Bone Joint Surg 37-B:492-505.
3. Huang WC 1988 How dose the age factor influence the hypertrophy of vascularized bone grafts? An experimental study. J Nara Med Assoc 39:756-772.
4. Ohgushi H, Goldberg VM, Caplan AI 1989 Heterotopic osteogenesis in porous ceramics induced by marrow cells. J Orthop Res 7:568-578.
5. Ohgushi H, Okumura M, Tamai S, Shors EC, Caplan AI 1990 Marrow cell induced osteogenesis in porous hydroxyapatite and tricalcium phosphate: A comparative histomorphometric study of ectopic bone formation. J Biomed Mater Res 24:1563-1570.
6. Okumura M, Ohgushi H, Tamai S 1991 Bonding osteogenesis in coralline hydroxyapatite combined with bone marrow cells. Biomaterials 12:411-416.
7. Okumura M, Ohgushi H, Tamai S, Shors EC 1991 Primary bone formation in porous hydroxyapatite ceramic: A light and scanning electron microscopic study. Cells Mater 1:29-34.
8. Ohgushi H, Okumura M, Yoshikawa T, Inoue K, Sempuku T, Tamai S, Shors EC 1992 Bone formation process in porous calcium carbonate and hydroxyapatite. J Biomed Mater Res 26:885-895.
9. Ohgushi H, Okumura M 1990 Osteogenic capacity of rat and human marrow cells in porous ceramics. Acta Orthop Scand 61:431-434.
10. Alphons JT, Romanini L, Rossi P, Borroni M, Greco F, Garcia-Araujo C, Garcia-Dihinx L, Murcia-Mazon A, Hein W, Anderson J 1995 Hydroxyapatite-coated hip prostheses. Clin Orthop 312:211-225.
11. Ohgushi H, Okumura M, Yoshikawa T, Sempuku T, Inoue K, Tamai S, Shors EC 1991 Osteogenic capacity of hydroxyapatite coated porous calcium carbonate implants. Bioceramics 4:213-219.
12. Shors EC, White EW, Kopchok G 1989 Biocompatibility, osteoconduction and biodegradation of porous hydroxyapatite, tricalcium phosphate, sintered hydroxyapatite and calcium carbonate in rabbit bone defects. Mat Res Soc Symp Proc 110:211-218.
13. Yoshikawa T, Ohgushi H, Okumura M, Tamai S, Dohi Y, Moriyama T 1992 Biochemical and histological sequences of membranous ossification in ectopic site. Calcif Tissue Int 50:184-188.
14. Lian J, Stewwart C, Puchacz E, Mackowiak S, Shalhoub V, Collart D, Zambetti G, Stein G 1989 Structure of the rat osteocalcin gene and regulation of vitamin D-dependent expression. Biochemistry 86:1143-1147.
15. Alper G, Bernick S, Yazdi M, Nimni ME 1989 Osteogenesis in bone defects in rats: The effects of hydroxyapatite and demineralized bone matrix. Am J Med Sci 298:371-376.
16. Tsuji T, Hughes FJ, McCulloch CAG, Melcher AH 1990 Effects of donor age on osteogenic cells of rat bone marrow in vitro. Mech Aging Dev 51:121-132.
17. Tabuchi C, Simmons DJ, Fausto A, Russell JE, Binderman I, Avioli LV 1986 Bone deficit in ovariectomized rats: Functional contribution of the marrow stromal cell population and the effect of oral dihydrotachysterol treatment. J Clin Invest 78:637-642.
18. Chavassieux PM, Chenu C, Valentin-Opran A, Merle B, Delmas PD, Hartmann DJ, Saez S, Meunier PJ 1990 Influence of experimental conditions on osteoblast activity in human primary bone cell cultures. J Bone Miner Res 5:337-343.
19. Goshima J, Goldberg VM, Caplan AI 1991 The origin of bone formed in composite grafts of porous calcium phosphate ceramic loaded with marrow cells. Clin Orthop 269:274-283.
20. Strates BS, Stock AJ, Connolly JF 1988 Skeletal repair in the aged: A preliminary study in rabbits. Am J Med Sci 296:266-269.
21. Zhang RW, Simmons DJ, Crowther RS, Mohan S, Baylink DJ 1991 Contribution of marrow stromal cells to the regulation of osteoblast proliferation in rats: Evidence for the involvement of insulin-like growth factors. Bone Miner 13:201-215.
22. Zhang RW, Supowit SC, Klein GL, Lu Z, Christensen MD, Lozano R, Simmons DJ 1995 Rat tail suspension reduces messenger RNA level for growth factors and osteopontin and decreases the osteoblastic differentiation of bone marrow stromal cells. J Bone Miner Res 10:415-423.
23. Nishimoto SK, Chang CH, Gendler E, Stryker WF, Nimni ME 1985 The effect of aging on bone formation in rats: Biochemical and histological evidence for decreased bone formation capacity. Calcif Tissue Int 37:617-624.
24. Owen M 1985 Lineage of osteogenic cells and their relationship to the stromal system. In: Peck WA (ed.) Bone and Mineral Research, Vol 3, Chapter 1. Elsevier Science Publisher, New York, NY, U.S.A., pp. 1-25.
25. Simmons DJ 1996 The in vivo role of bone marrow fibroblast-like stromal cells. Calcif Tissue Int 58:129-132.
26. Simmons DJ, Kidder L, Thomas M 1990 Effect of cortisone on cells at the bone-marrow interface. Calcif Tissue Int 46:327-332.
27. Tabuchi C, Simmons DJ, Fausto A, Binderman I, Avioli LV 1989 Effect of dihydrotachysterol on bone induction in ovariectomized rats. Bone Miner 5:359-370.
28. Herbertson A, Aubin JE 1995 Dexamethasone alters the sub-population make-up of rat bone marrow stromal cell cultures. J Bone Miner Res 10:285-294.
29. Dohi Y, Ohgushi H, Tabata S, Yoshikawa T, Dohi K, Moriyama T 1992 Osteogenesis associated with bone Gla protein gene expression in diffusion chambers by bone marrow cells with demineralized bone matrix. J Bone Miner Res 7:1173-1180.
30. Dohi Y manuscript in preparation.