GABA A receptors involved in sleep and anaesthesia: β1- versus β3-containing assemblies

Pflugers Archiv European Journal of Physiology

Volumn 463, Issue 1, 2012, Pages 187-199

  Yanovsky, Yevgenij ^a   Schubring, Stephan ^a   Fleischer, Wiebke ^a   Gisselmann, Günter ^b   Zhu, Xin Ran ^b   Lübbert, Hermann ^b   Hatt, Hanns ^b   Rudolph, Uwe ^c   Haas, Helmut L ^a   Sergeeva, Olga A ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c MCLEAN HOSPITAL   (United States)

Author keywords

GABA; Histamine; Hypothalamus; Patch clamp; Sleep

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BETA1; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; DIOXANE DERIVATIVE; PI 24513; PROPOFOL; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; GABRB1 PROTEIN, MOUSE; GABRB1 PROTEIN, RAT; GABRB3 PROTEIN, MOUSE; GABRB3 PROTEIN, RAT; HISTAMINE;

ANESTHESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; EVOKED RESPONSE; GABAERGIC TRANSMISSION; MALE; MOUSE; NONHUMAN; POSTERIOR HYPOTHALAMUS; PREOPTIC NUCLEUS; PRIORITY JOURNAL; RAT; SEDATION; SLEEP; TUBEROMAMILLARY NUCLEUS; WILD TYPE; ACTION POTENTIAL; ANIMAL; C57BL MOUSE; CHANNEL GATING; CYTOLOGY; DRUG EFFECT; ELECTROPHYSIOLOGY; GENE EXPRESSION; GENETICS; INHIBITORY POSTSYNAPTIC POTENTIAL; LATERAL HYPOTHALAMUS; LOCOMOTION; METABOLISM; MOUSE MUTANT; NERVE CELL; PHYSIOLOGY; POINT MUTATION; PROTEIN SUBUNIT; WISTAR RAT;

ACTION POTENTIALS; ANESTHESIA; ANIMALS; ELECTROPHYSIOLOGICAL PHENOMENA; GABA-A RECEPTOR AGONISTS; GAMMA-AMINOBUTYRIC ACID; GENE EXPRESSION; HISTAMINE; HYPOTHALAMIC AREA, LATERAL; INHIBITORY POSTSYNAPTIC POTENTIALS; ION CHANNEL GATING; LOCOMOTION; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; NEURONS; POINT MUTATION; PROPOFOL; PROTEIN SUBUNITS; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SLEEP;

EID: 84856697479     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-0988-4     Document Type: Article

References (42)

1. RP Bonin BA Orser 2008 GABA(A) receptor subtypes underlying general anesthesia Pharmacol Biochem Behav 90 105 112 18201756 1:CAS:528: DC%2BD1cXmvFSjs7c%3D
2. VY Cheng LJ Martin EM Elliott JH Kim HT Mount FA Taverna JC Roder JF MacDonald A Bhambri N Collinson KA Wafford BA Orser 2006 Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate J Neurosci 26 3713 3720 16597725 1:CAS:528:DC%2BD28Xjs1yks7c%3D
3. TM DeLorey A Handforth SG Anagnostaras GE Homanics BA Minassian A Asatourian MS Fanselow A Delgado-Escueta GD Ellison RW Olsen 1998 Mice lacking the beta3 subunit of the GABAA receptor have the epilepsy phenotype and many of the behavioral characteristics of Angelman syndrome J Neurosci 18 8505 8514 9763493 1:CAS:528:DyaK1cXms1ehu7k%3D (Pubitemid 28465025)
4. NP Franks 2008 General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal Nat Rev Neurosci 9 370 386 18425091 1:CAS:528:DC%2BD1cXkvVensb8%3D (Pubitemid 351556044)
5. P Friederich BW Urban 1999 Interaction of intravenous anesthetics with human neuronal potassium currents in relation to clinical concentrations Anesthesiology 91 1853 1860 10598630 1:CAS:528:DC%2BD3cXivFKmsg%3D%3D
6. T Gallopin P Fort E Eggermann B Cauli PH Luppi J Rossier E Audinat M Muhlethaler M Serafin 2000 Identification of sleep-promoting neurons in vitro Nature 404 992 995 10801127 1:CAS:528:DC%2BD3cXjtFynsbc%3D (Pubitemid 30243592)
7. J Glykys I Mody 2006 Hippocampal network hyperactivity after selective reduction of tonic inhibition in GABA A receptor alpha5 subunit-deficient mice J Neurophysiol 95 2796 2807 16452257 1:CAS:528:DC%2BD28Xkslyju7o%3D
8. H Haas P Panula 2003 The role of histamine and the tuberomamillary nucleus in the nervous system Nat Rev Neurosci 4 121 130 12563283 1:CAS:528:DC%2BD3sXot12iuw%3D%3D (Pubitemid 37271382)
9. HL Haas OA Sergeeva O Selbach 2008 Histamine in the nervous system Physiol Rev 88 1183 1241 18626069 1:CAS:528:DC%2BD1cXpslKgsLc%3D
10. H Higuchi M Funahashi T Miyawaki Y Mitoh A Kohjitani M Shimada R Matsuo 2003 Suppression of the hyperpolarization-activated inward current contributes to the inhibitory actions of propofol on rat CA1 and CA3 pyramidal neurons Neurosci Res 45 459 472 12657459 1:CAS:528:DC%2BD3sXitlajsro%3D (Pubitemid 36349103)
11. C Hill-Venning D Belelli JA Peters JJ Lambert 1997 Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor Br J Pharmacol 120 749 756 9138677 1:CAS:528: DyaK2sXhvFSjtLo%3D
12. PJ Jones Y Wang MD Smith NJ Hargus HS Eidam HS White J Kapur ML Brown MK Patel 2007 Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity J Pharmacol Exp Ther 320 828 836 17090703 1:CAS:528:DC%2BD2sXhs1Wrs78%3D (Pubitemid 46147965)
13. YH Ju A Guzzo MW Chiu P Taylor MF Moran JW Gurd JF MacDonald BA Orser 2009 Distinct properties of murine alpha 5 gamma-aminobutyric acid type a receptors revealed by biochemical fractionation and mass spectroscopy J Neurosci Res 87 1737 1747 19156871 1:CAS:528:DC%2BD1MXlsVWntb8%3D
14. R Jurd M Arras S Lambert B Drexler R Siegwart F Crestani M Zaugg KE Vogt B Ledermann B Antkowiak U Rudolph 2003 General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit FASEB J 17 250 252 12475885 1:CAS:528:DC%2BD3sXhtVOjsbg%3D
15. MD Krasowski SM O'Shea CE Rick PJ Whiting KL Hadingham C Czajkowski NL Harrison 1997 Alpha subunit isoform influences GABA(A) receptor modulation by propofol Neuropharmacology 36 941 949 9257938 1:CAS:528:DyaK2sXkvFCltr0%3D (Pubitemid 27300124)
16. DW Lam JN Reynolds 1998 Modulatory and direct effects of propofol on recombinant GABAA receptors expressed in xenopus oocytes: influence of alpha- and gamma2-subunits Brain Res 784 179 187 9518600 1:CAS:528:DyaK1cXlsFWrtg%3D%3D (Pubitemid 28137861)
17. Lin JS, Anaclet C, Sergeeva OA, Haas HL (2011) The waking brain: an update. Cell Mol Life Sci [Epub ahead of print]
18. JS Lin K Sakai G Vanni-Mercier M Jouvet 1989 A critical role of the posterior hypothalamus in the mechanisms of wakefulness determined by microinjection of muscimol in freely moving cats Brain Res 479 225 240 2924157 1:CAS:528:DyaL1MXhtVyrt74%3D (Pubitemid 19035906)
19. R Lingamaneni HC Hemmings Jr 2003 Differential interaction of anaesthetics and antiepileptic drugs with neuronal Na+ channels, Ca2+ channels, and GABA(A) receptors Br J Anaesth 90 199 211 12538378 1:CAS:528: DC%2BD3sXit1GqsL4%3D (Pubitemid 36181966)
20. D McGinty H Gong N Suntsova MN Alam M Methippara R Guzman-Marin R Szymusiak 2004 Sleep-promoting functions of the hypothalamic median preoptic nucleus: inhibition of arousal systems Arch Ital Biol 142 501 509 15493551 1:STN:280:DC%2BD2critlSrug%3D%3D (Pubitemid 39297605)
21. LE Nelson TZ Guo J Lu CB Saper NP Franks M Maze 2002 The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathway Nat Neurosci 5 979 984 12195434 1:CAS:528:DC%2BD38XnsVGku7w%3D
22. HT Nguyen KY Li RL daGraca E Delphin M Xiong JH Ye 2009 Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors Anesthesiology 110 326 332 19194159 1:CAS:528:DC%2BD1MXpt1egsA%3D%3D
23. D Nitz JM Siegel 1996 GABA release in posterior hypothalamus across sleep-wake cycle Am J Physiol 271 R1707 R1712 8997373 1:CAS:528: DyaK2sXmt1Kisg%3D%3D
24. R Parmentier S Kolbaev BP Klyuch D Vandael JS Lin O Selbach HL Haas OA Sergeeva 2009 Excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone J Neurosci 29 4471 4483 19357273 1:CAS:528:DC%2BD1MXkvVymsrc%3D
25. B Rehberg DS Duch 1999 Suppression of central nervous system sodium channels by propofol Anesthesiology 91 512 520 10443615 1:CAS:528: DyaK1MXlsFyltLY%3D (Pubitemid 29365035)
26. DS Reynolds TW Rosahl J Cirone GF O'Meara A Haythornthwaite RJ Newman J Myers C Sur O Howell AR Rutter J Atack AJ Macaulay KL Hadingham PH Hutson D Belelli JJ Lambert GR Dawson R McKernan PJ Whiting KA Wafford 2003 Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms J Neurosci 23 8608 8617 13679430 1:CAS:528:DC%2BD3sXns1Srsbw%3D (Pubitemid 37158760)
27. U Rudolph B Antkowiak 2004 Molecular and neuronal substrates for general anaesthetics Nat Rev Neurosci 5 709 720 15322529 1:CAS:528:DC%2BD2cXmvVaqsrw%3D (Pubitemid 39150142)
28. U Rudolph F Crestani D Benke I Brunig JA Benson JM Fritschy JR Martin H Bluethmann H Mohler 1999 Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes Nature 401 796 800 10548105 1:CAS:528:DyaK1MXntFaru70%3D
29. OA Sergeeva N Andreeva M Garret A Scherer HL Haas 2005 Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit J Neurosci 25 88 95 15634770 1:CAS:528:DC%2BD2MXhtVWku70%3D (Pubitemid 40110769)
30. OA Sergeeva KS Eriksson IN Sharonova VS Vorobjev HL Haas 2002 GABA(A) receptor heterogeneity in histaminergic neurons Eur J Neurosci 16 1472 1482 12405960 (Pubitemid 35334984)
31. OA Sergeeva O Kletke A Kragler A Poppek W Fleischer SR Schubring B Gorg HL Haas XR Zhu H Lubbert G Gisselmann H Hatt 2010 Fragrant dioxane derivatives identify {beta}1-subunit-containing GABAA receptors J Biol Chem 285 23985 23993 20511229 1:CAS:528:DC%2BC3cXptFOqtL8%3D
32. JE Sherin JK Elmquist F Torrealba CB Saper 1998 Innervation of histaminergic tuberomammillary neurons by GABAergic and galaninergic neurons in the ventrolateral preoptic nucleus of the rat J Neurosci 18 4705 4721 9614245 1:CAS:528:DyaK1cXjslGjtrc%3D (Pubitemid 28280179)
33. R Siegwart R Jurd U Rudolph 2002 Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors J Neurochem 80 140 148 11796752 1:CAS:528: DC%2BD38Xjt1ajug%3D%3D (Pubitemid 34614586)
34. TL Steininger MN Alam H Gong R Szymusiak D McGinty 1999 Sleep-waking discharge of neurons in the posterior lateral hypothalamus of the albino rat Brain Res 840 138 147 10517961 1:CAS:528:DyaK1MXmtlGqtrg%3D (Pubitemid 29434833)
35. TL Steininger H Gong D McGinty R Szymusiak 2001 Subregional organization of preoptic area/anterior hypothalamic projections to arousal-related monoaminergic cell groups J Comp Neurol 429 638 653 11135241 1:CAS:528:DC%2BD3MXitlejsw%3D%3D (Pubitemid 32011859)
36. I Sukhotinsky V Zalkind J Lu DA Hopkins CB Saper M Devor 2007 Neural pathways associated with loss of consciousness caused by intracerebral microinjection of GABA A-active anesthetics Eur J Neurosci 25 1417 1436 17425568 1:STN:280:DC%2BD2s3kt1Kluw%3D%3D (Pubitemid 46568766)
37. R Szymusiak D McGinty 2008 Hypothalamic regulation of sleep and arousal Ann N Y Acad Sci 1129 275 286 18591488 1:CAS:528:DC%2BD1cXnvVansbw%3D (Pubitemid 351994150)
38. K Takahashi JS Lin K Sakai 2006 Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse J Neurosci 26 10292 10298 17021184 1:CAS:528:DC%2BD28XhtVymu77N (Pubitemid 44527422)
39. G Vanni-Mercier S Gigout G Debilly JS Lin 2003 Waking selective neurons in the posterior hypothalamus and their response to histamine H3-receptor ligands: an electrophysiological study in freely moving cats Behav Brain Res 144 227 241 12946612 1:CAS:528:DC%2BD3sXms1ykuro%3D (Pubitemid 37011182)
40. VS Vorobjev 1991 Vibrodissociation of sliced mammalian nervous tissue J Neurosci Methods 38 145 150 1784118 1:STN:280:DyaK387kvFSqsw%3D%3D
41. Y Yanovsky S Li BP Klyuch Q Yao P Blandina MB Passani JS Lin H Haas OA Sergeeva 2011 L-Dopa activates histaminergic neurons J Physiol 589 1349 66 21242252 1:CAS:528:DC%2BC3MXksFOrs7c%3D
42. AY Zecharia LE Nelson TC Gent M Schumacher R Jurd U Rudolph SG Brickley M Maze NP Franks 2009 The involvement of hypothalamic sleep pathways in general anesthesia: testing the hypothesis using the GABAA receptor beta3N265M knock-in mouse J Neurosci 29 2177 2187 19228970 1:CAS:528:DC%2BD1MXisV2hu70%3D