Apaf-1 deficiency confers resistance to ultraviolet-induced apoptosis in mouse embryonic fibroblasts by disrupting reactive oxygen species amplification production and mitochondrial pathway

Free Radical Biology and Medicine

Volumn 52, Issue 5, 2012, Pages 889-897

  Feng, Rentian ^a,b   Han, Jie ^a   Ziegler, Judith ^a   Yang, Minying ^c   Castranova, Vincent ^b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

^c UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Apaf 1; Apoptosis; Free radicals; Mitochondria; Mouse embryo fibroblast; Reactive oxygen species amplification loop; UVC radiation

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 9; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN BCL XL; PROTEIN P47; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; FEEDBACK SYSTEM; FIBROBLAST; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; ULTRAVIOLET RADIATION; UPREGULATION;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASE 8; CELL CYCLE PROTEINS; CELL DIVISION; CELL NUCLEUS SHAPE; CELLS, CULTURED; ENZYME ACTIVATION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FIBROBLASTS; MAP KINASE SIGNALING SYSTEM; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; ULTRAVIOLET RAYS;

EID: 84856690047     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.11.028     Document Type: Article

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