5-fluorouracil-loaded poly(ε-caprolactone) nanoparticles combined with phage E gene therapy as a new strategy against colon cancer

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 95-107

  Ortiz, Raúl ^a,b   Prados, José ^a   Melguizo, Consolación ^a   Arias, José L ^a   Adolfina Ruiz, M ^a   Álvarez, Pablo J ^a   Caba, Octavio ^a,b   Luque, Raquel ^c   Segura, Ana ^d   Aránega, Antonia ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF JAÉN   (Spain)

^c HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^d CSIC   (Spain)

Author keywords

5 fuorouracil; Colon cancer; Combined therapy; E gene; Gene therapy; Poly ( caprolactone)

Indexed keywords

CASPASE 3; CASPASE 9; FLUOROURACIL; NANOCARRIER; NANOPARTICLE; POLYCAPROLACTONE; ANTINEOPLASTIC AGENT; PHAGE E; UNCLASSIFIED DRUG;

ADVANCED CANCER; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BACTERIOPHAGE; CANCER CELL; CELL PROLIFERATION; COLON ADENOCARCINOMA; COLON CANCER; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRION; NANOMEDICINE; PROTEIN EXPRESSION; RECURRENT CANCER; SUICIDE GENE; SUICIDE GENE THERAPY; CANCER CELL CULTURE; CANCER CELL DESTRUCTION; CANCER RESISTANCE; CELL DAMAGE; CHEMOSENSITIZATION; DRUG CYTOTOXICITY; DRUG RELEASE; GENE ACTIVITY; GENE DELIVERY SYSTEM; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN LOCALIZATION; SURFACE CHARGE;

ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; COLONIC NEOPLASMS; DRUG CARRIERS; FLUOROURACIL; GENE THERAPY; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NANOPARTICLES; POLYESTERS; VIRAL PROTEINS;

PHAGE E;

EID: 84856689029     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55:74-108.
2. Berrino F, De Angelis R, Sant M, et al. Survival for eight major cancers and all cancers combined for European adults diagnosed in 1995-1999: results of the EUROCARE-4 study. Lancet Oncol. 2007;8: 773-783.
3. Zhang N, Yin Y, Xu SJ, Chen WS. 5-Fluorouracil: mechanisms of resistance and reversal strategies. Molecules. 2008;13:1551-1569.
4. Bertolini A, Fiumano M, Muffatti A, et al. Acute cardiotoxicity from 5-fuorouracil: an underestimated toxicity. Minerva Cardioangiol. 1999; 47:269-273.
5. Cooke JWB, Bright R, Coleman MJ, Jenkins KP. Process research and development of a dihydropyrimidine dehydrogenase inactivator: Large-scale preparation of eniluracil using a Sonogashira coupling. Org Process Res Dev. 2001;5:383-336.
6. Couvreur P, Vauthier C. Nanotechnology: intelligent design to treat complex disease. Pharm Res. 2006;23:1417-1450.
7. Arias JL, Reddy LH, Couvreur P. Polymeric nanoparticulate system augmented the anticancer therapeutic effcacy of gemcitabine. J Drug Target. 2009;17:586-598.
8. Arias JL, Reddy LH, Couvreur P. Superior preclinical efficacy of gemcitabine developed as chitosan nanoparticulate system. Biomacromolecules. 2011;12:97-104.
9. Zhang L, Yang M, Wang Q, et al. 10-Hydroxycamptothecin loaded nanoparticles: preparation and antitumor activity in mice. J Control Release. 2007;119:153-162.
10. Devalapally H, Duan Z, Seiden M V, Amiji MM. Modulation of drug resistance in ovarian adenocarcinoma by enhancing intracel-lular ceramide using tamoxifen-loaded biodegradable polymeric nanoparticles. Clin Cancer Res. 2008;14:3193-3203.
11. Arias JL, Lopez-Viota M, Saez-Fernandez E, Ruiz MA. Formulation and physicochemical characterization of poly(epsilon-caprolactone) nanoparticles loaded with ftorafur and diclofenac sodium. Colloids Surf B Biointerfaces. 2010;75:204-208.
12. Durai R, Yang SY, Seifalian AM, Winslet MC. Principles and applications of gene therapy in colon cancer. J Gastrointestin Liver Dis. 2008;17:59-67.
13. Millan A, Huerta S. Apoptosis-inducing factor and colon cancer. J Surg Res. 2009;151:163-170.
14. Prabhudesai SG, Rekhraj S, Roberts G, Darzi AW, Ziprin P. Apoptosis and chemo-resistance in colorectal cancer. J Surg Oncol. 2007;96: 77-88.
15. Showalter SL, Huang YH, Witkiewicz A, et al. Nanoparticulate delivery of diphtheria toxin DNA effectively kills Mesothelin expressing pancreatic cancer cells. Cancer Biol Ther. 2008;7:1584-1590.
16. Geden SE, Gardner RA, Fabbrini MS, Ohashi M, Phanstiel Iv O, Teter K. Lipopolyamine treatment increases the effcacy of intoxication with saporin and an anticancer saporin conjugate. FEBS J. 2007; 274: 4825-4836.
17. Zhao JM, Wen YJ, Li Q, et al. A promising cancer gene therapy agent based on the matrix protein of vesicular stomatitis virus. FASEB J. 2008;22:4272-4280.
18. Ortiz R, Prados J, Melguizo C, et al. The cytotoxic activity of the phage E protein suppress the growth of murine B16 melanomas in vitro and in vivo. J Mol Med. 2009;87:899-911.
19. Witte A, Wanner G, Lubitz W, Holtje J V. Effect of phi X174 protein E-mediated lysis on murein composition of Escherichia coli. FEMS Microbiol Lett. 1998;164:149-157.
20. Sinha VR, Bansal K, Kaushik R, Kumria R, Trehan A. Poly-epsilon-caprolactone microspheres and nanospheres: an overview. Int J Pharm. 2004;278:1-23.
21. Food and Drug Administration, HHS. International Conference on Harmonisation; Stability Data Package for Registration Applications in Climatic Zones III and IV; Stability Testing of New Drug Substances and Products; availability. Notice. Fed Regist. 2003;68:65717-65718.
22. O'Brien RW, White LR. Electrophoretic mobility of a spherical colloidal particle. J Chem Soc Faraday Trans. 1978;2:1607-1626.
23. Zhang Y, Yuan J, Zhang H Y, et al. Natural resistance to apoptosis correlates with resistance to chemotherapy in colorectal cancer cells. Clin Exp Med. 2011. DOI: 10.1007/s10238-011-0146-0145.
24. Prados J, Melguizo C, Ortiz R, et al. Regression of established subcutaneous B16-F10 murine melanoma tumors after gef gene therapy associated with the mitochondrial apoptotic pathway. Exp Dermatol. 2010;19:363-371.
25. Decuzzi P, Pasqualini R, Arap W, Ferrari M. Intravascular delivery of particulate systems: does geometry really matter? Pharm Res. 2009;26: 235-243.
26. Arias JL, Ruiz MA, Lopez-Viota M, Delgado AV. Poly(alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery: a comparative study. Colloids Surf B Biointerfaces. 2008;62:64-70.
27. Soppimath KS, Aminabhavi TM, Kulkarni AR, Rudzinski WE. Biodegradable polymeric nanoparticles as drug delivery devices. J Control Release. 2001;70:1-20.
28. Wang ZX, Bian HB, Yang JS, De W, Ji XH. Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer. Cancer Biol Ther. 2009;8:1480-1488.
29. Karasawa H, Miura K, Fujibuchi W, et al. Down-regulation of cIAP2 enhances 5-FU sensitivity through the apoptotic pathway in human colon cancer cells. Cancer Sci. 2009;100:903-913.
30. Li BH, Yang XZ, Li PD, et al. IL-4/Stat6 activities correlate with apoptosis and metastasis in colon cancer cells. Biochem Biophys Res Commun. 2008;369:554-560.
31. Kanyama H, Tomita N, Yamano T, et al. Enhancement of the anti-tumor effect of 5′-deoxy-5-fuorouridine by transfection of thymidine phosphorylase gene into human colon cancer cells. Jpn J Cancer Res. 1999;90:454-459.
32. Kerr DJ, Seymour LW, Maruta F. Gene therapy for colorectal cancer. Expert Opin Biol Ther. 2003;3:779-788.
33. Fillat C, Carrio M, Cascante A, Sangro B. Suicide gene therapy mediated by the herpes simplex virus thymidine kinase gene/ganciclovir system: ffteen years of application. Curr Gene Ther. 2003;3:13-26.
34. Zhang G, Liu T, Chen YH, et al. Tissue specifc cytotoxicity of colon cancer cells mediated by nanoparticle-delivered suicide gene in vitro and in vivo. Clin Cancer Res. 2009;15:201-207.
35. Teimoori-Toolabi L, Azadmanesh K, Amanzadeh A, Zeinali S. Selective suicide gene therapy of colon cancer exploiting the urokinase plasmi-nogen activator receptor promoter. BioDrugs. 2010;24:131-146.
36. Lee S W, Lee YL, Lee YJ, et al. Enhanced antitumor effects by combination gene therapy using MDR1 gene shRNA and HSV1-tk in a xenograft mouse model. Cancer Lett. 2010;291:83-89.
37. Portsmouth D, Hlavaty J, Renner M. Suicide genes for cancer therapy. Mol Aspects Med. 2007;28:4-41.
38. Chen LS, Wang M, Ou WC, et al. Effcient gene transfer using the human JC virus-like particle that inhibits human colon adenocarcinoma growth in a nude mouse model. Gene Ther. 2010;17:1033-1041.
39. Ya o Q, Cao S, Li C, et al. Turn a diarrhoea toxin into a receptor-mediated therapy for a plethora of CLDN-4-overexpressing cancers. Biochem Biophys Res Commun. 2010;398:413-419.
40. Boulaiz H, Prados J, Melguizo C, et al. Inhibition of growth and induction of apoptosis in human breast cancer by transfection of gef gene. Br J Cancer. 2003;89:192-198.
41. Boulaiz H, Prados J, Melguizo C, et al. Tumour malignancy loss and cell differentiation are associated with induction of gef gene in human melanoma cells. Br J Dermatol. 2008;159:370-378.
42. Agu CA, Klein R, Schwab S, et al. The cytotoxic activity of the bacteriophage lambda-holin protein reduces tumour growth rates in mammary cancer cell xenograft models. J Gene Med. 2006;8: 229-241.
43. Rama AR, Prados J, Melguizo C, et al. E phage gene transfection enhances sensitivity of lung and colon cancer cells to chemotherapeutic agents. Int J Oncol. 2010;37:1503-1514.
44. Melet A, Song K, Bucur O, Jagani Z, Grassian AR, Khosravi-Far R. Apoptotic pathways in tumor progression and therapy. Adv Exp Med Biol. 2008;615:47-79.
45. Watanabe T, Komuro Y, Kiyomatsu T, et al. Prediction of sensitivity of rectal cancer cells in response to preoperative radiotherapy by DNA microarray analysis of gene expression profles. Cancer Res. 2006;66: 3370-3374.
46. Prados J, Melguizo C, Rama A, et al. Combined therapy using suicide gef gene and paclitaxel enhances growth inhibition of multicellular tumour spheroids of A-549 human lung cancer cells. Int J Oncol. 2008; 33:121-127.
47. Shieh GS, Shiau AL, Yo YT, et al. Low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model. Cancer Res. 2006;66: 9957-9966.
48. Deharvengt S, Rejiba S, Wack S, Aprahamian M, Hajri A. Effcient electrogene therapy for pancreatic adenocarcinoma treatment using the bacterial purine nucleoside phosphorylase suicide gene with fudarabine. Int J Oncol. 2007;30:1397-1406.
49. Hagiwara S, Kudo M, Nakatani T, et al. Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumour cell growth in nude mice by apoptosis of p53. Br J Cancer. 2007;97:1532-1537.
50. Abaza MS, Al-Saffar A, Al-Sawan S, Al-Attiyah R. c-myc anti-sense oligonucleotides sensitize human colorectal cancer cells to chemotherapeutic drugs. Tumour Biol. 2008;29:287-303.