Lipopolyamine treatment increases the efficacy of intoxication with saporin and an anticancer saporin conjugate

FEBS Journal

Volumn 274, Issue 18, 2007, Pages 4825-4836

  Geden, Sandra E ^b   Gardner, Richard A ^b   Fabbrini, M Serena ^c   Ohashi, Masato ^d   Phanstiel IV, Otto ^b   Teter, Ken ^a,b  

^a Biomolecular Research Annex   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

^c CNR Consiglio Nazionale delle Ricerche   (Italy)

^d OKAZAKI INSTITUTE FOR INTEGRATIVE BIOSCIENCE   (Japan)

Author keywords

Anticancer therapy; Endosome; Intracellular trafficking; Plant ribosome inactivating protein; Polyamine

Indexed keywords

AMINE; ANTINEOPLASTIC AGENT; DIMETHYL SULFOXIDE; DIPHTHERIA TOXIN; LIPOPOLYAMINE; RICIN; SAPORIN; SAPORIN UROKINASE PLASMINOGEN ACTIVATOR CONJUGATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL MUTANT; CONTROLLED STUDY; CYTOSOL; DRUG EFFICACY; DRUG MECHANISM; ENDOSOME; GENE THERAPY; INTOXICATION; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CHO CELLS; COLD; CRICETINAE; CRICETULUS; DIMETHYL SULFOXIDE; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENDOSOMES; LYSOSOMES; POLYAMINES; RIBOSOME INACTIVATING PROTEINS, TYPE 1; RICIN; URINARY PLASMINOGEN ACTIVATOR;

EID: 34548444675     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2007.06008.x     Document Type: Article

References (38)

1. Stirpe F (2004) Ribosome-inactivating proteins. Toxicon 44, 371 383.
2. Cavallaro U, del Vecchio A, Lappi DA Soria MR (1993) A conjugate between human urokinase and saporin, a type-1 ribosome-inactivating protein, is selectively cytotoxic to urokinase receptor-expressing cells. J Biol Chem 268, 23186 23190.
3. Crowley CW, Cohen RL, Lucas BK, Liu G, Shuman MA Levinson AD (1993) Prevention of metastasis by inhibition of the urokinase receptor. Proc Natl Acad Sci USA 90, 5021 5025.
4. Christensen L, Wiborg Simonsen AC, Heegaard CW, Moestrup SK, Andersen JA Andreasen PA (1996) Immunohistochemical localization of urokinase-type plasminogen activator, type-1 plasminogen-activator inhibitor, urokinase receptor and alpha(2)-macroglobulin receptor in human breast carcinomas. Int J Cancer 66, 441 452.
5. Verspaget HW, Sier CF, Ganesh S, Griffioen G Lamers CB (1995) Prognostic value of plasminogen activators and their inhibitors in colorectal cancer. Eur J Cancer 31A, 1105 1109.
6. Flavell DJ (1998) Saporin immunotoxins. Curr Top Microbiol Immunol 234, 57 61.
7. Fabbrini MS, Carpani D, Bello-Rivero I Soria MR (1997) The amino-terminal fragment of human urokinase directs a recombinant chimeric toxin to target cells: internalization is toxin mediated. FASEB J 11, 1169 1176.
8. Ippoliti R, Lendaro E, Benedetti PA, Torrisi MR, Belleudi F, Carpani D, Soria MR Fabbrini MS (2000) Endocytosis of a chimera between human pro-urokinase and the plant toxin saporin: an unusual internalization mechanism. FASEB J 14, 1335 1344.
9. Vago R, Marsden CJ, Lord JM, Ippoliti R, Flavell DJ, Flavell SU, Ceriotti A Fabbrini MS (2005) Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells. FEBS J 272, 4983 4995.
10. Ippoliti R, Ginobbi P, Lendaro E, D'Agostino I, Ombres D, Benedetti PA, Brunori M Citro G (1998) The effect of monensin and chloroquine on the endocytosis and toxicity of chimeric toxins. Cell Mol Life Sci 54, 866 875.
11. Cavallaro U Soria MR (1995) Targeting plant toxins to the urokinase and alpha 2-macroglobulin receptors. Semin Cancer Biol 6, 269 278.
12. Sandvig K van Deurs B (2002) Membrane traffic exploited by protein toxins. Annu Rev Cell Dev Biol 18, 1 24.
13. Kawai S Nishizawa M (1984) New procedure for DNA transfection with polycation and dimethyl sulfoxide. Mol Cell Biol 4, 1172 1174.
14. Lechardeur D Lukacs GL (2002) Intracellular barriers to non-viral gene transfer. Curr Gene Ther 2, 183 194.
15. Eliyahu H, Barenholz Y Domb AJ (2005) Polymers for DNA delivery. Molecules 10, 34 64.
16. Gardner RA, Belting M, Svensson K Phanstiel O (2007) Synthesis and transfection efficiencies of new lipophilic polyamines. J Med Chem 50, 308 318.
17. Fabbrini MS, Carpani D, Soria MR Ceriotti A (2000) Cytosolic immunization allows the expression of preATF-saporin chimeric toxin in eukaryotic cells. FASEB J 14, 391 398.
18. Roy CR (2002) Exploitation of the endoplasmic reticulum by bacterial pathogens. Trends Microbiol 10, 418 424.
19. Lord JM, Roberts LM Lencer WI (2005) Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane: co-opting basic mechanisms of endoplasmic reticulum-associated degradation. Curr Top Microbiol Immunol 300, 149 168.
20. Savino C, Federici L, Ippoliti R, Lendaro E Tsernoglou D (2000) The crystal structure of saporin SO6 from Saponaria officinalis and its interaction with the ribosome. FEBS Lett 470, 239 243.
21. Teter K Holmes RK (2002) Inhibition of endoplasmic reticulum-associated degradation in CHO cells resistant to cholera toxin, Pseudomonas aeruginosa exotoxin A, and ricin. Infect Immun 70, 6172 6179.
22. Teter K, Jobling MG Holmes RK (2003) A class of mutant CHO cells resistant to cholera toxin rapidly degrades the catalytic polypeptide of cholera toxin and exhibits increased endoplasmic reticulum-associated degradation. Traffic 4, 232 242.
23. Ogris M Wagner E (2002) Tumor-targeted gene transfer with DNA polyplexes. Somat Cell Mol Genet 27, 85 95.
24. Santanche S, Bellelli A Brunori M (1997) The unusual stability of saporin, a candidate for the synthesis of immunotoxins. Biochem Biophys Res Commun 234, 129 132.
25. Sussman DJ Milman G (1984) Short-term, high-efficiency expression of transfected DNA. Mol Cell Biol 4, 1641 1643.
26. Ohashi M, Miwako I, Nakamura K, Yamamoto A, Murata M, Ohnishi S Nagayama K (1999) An arrested late endosome-lysosome intermediate aggregate observed in a Chinese hamster ovary cell mutant isolated by novel three-step screening. J Cell Sci 112, 1125 1138.
27. Ohashi M, Miwako I, Yamamoto A Nagayama K (2000) Arrested maturing multivesicular endosomes observed in a Chinese hamster ovary cell mutant, LEX2, isolated by repeated flow-cytometric cell sorting. J Cell Sci 113, 2187 2205.
28. Sandvig K, Madshus IH Olsnes S (1984) Dimethyl sulphoxide protects cells against polypeptide toxins and poliovirus. Biochem J 219, 935 940.
29. Simpson JC, Roberts LM Lord JM (1996) Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol. Exp Cell Res 229, 447 451.
30. Day PJ, Pinheiro TJ, Roberts LM Lord JM (2002) Binding of ricin A-chain to negatively charged phospholipid vesicles leads to protein structural changes and destabilizes the lipid bilayer. Biochemistry 41, 2836 2843.
31. Sun J, Pohl EE, Krylova OO, Krause E, Agapov II, Tonevitsky AG Pohl P (2004) Membrane destabilization by ricin. Eur Biophys J 33, 572 579.
32. Roldan AL, Cubellis MV, Masucci MT, Behrendt N, Lund LR, Dano K, Appella E Blasi F (1990) Cloning and expression of the receptor for human urokinase plasminogen activator, a central molecule in cell surface, plasmin dependent proteolysis. EMBO J 9, 467 474.
33. Selbo PK, Sandvig K, Kirveliene V Berg K (2000) Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization. Biochim Biophys Acta 1475, 307 313.
34. Yip WL, Weyergang A, Berg K, Tonnesen HH Selbo PK (2007) Targeted delivery and enhanced cytotoxicity of cetuximab-saporin by photochemical internalization in EGFR-positive cancer cells. Mol Pharm 4, 241 251.
35. Bachran C, Sutherland M, Heisler I, Hebestreit P, Melzig MF Fuchs H (2006) The saponin-mediated enhanced uptake of targeted saporin-based drugs is strongly dependent on the saponin structure. Exp Biol Med 231, 412 420.
36. Hebestreit P, Weng A, Bachran C, Fuchs H Melzig MF (2006) Enhancement of cytotoxicity of lectins by Saponinum album. Toxicon 47, 330 335.
37. van den Akker F, Sarfaty S, Twiddy EM, Connell TD, Holmes RK Hol WG (1996) Crystal structure of a new heat-labile enterotoxin, LT-IIb. Structure 4, 665 678.
38. Chang PP, Moss J, Twiddy EM Holmes RK (1987) Type II heat-labile enterotoxin of Escherichia coli activates adenylate cyclase in human fibroblasts by ADP ribosylation. Infect Immun 55, 1854 1858.