Extra-embryonic human Wharton's jelly stem cells do not induce tumorigenesis, unlike human embryonic stem cells

Reproductive BioMedicine Online

Volumn 24, Issue 2, 2012, Pages 235-246

  Gauthaman, Kalamegam ^a   Fong, Chui Yee ^a   Suganya, Cheyyatraivendran Arularasu ^a   Subramanian, Arjunan ^a   Biswas, Arijit ^a   Choolani, Mahesh ^a   Bongso, Ariff ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

cytokines; human embryonic stem cells; human Wharton's jelly stem cells; matrigel; SCID mice; teratoma

Indexed keywords

CYTOKINE; GAMMA INTERFERON; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 3; INTERLEUKIN 4; INTERLEUKIN 6; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; RED FLUORESCENT PROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CELL THERAPY; CONTROLLED STUDY; ECTODERM; EMBRYO; EMBRYONIC STEM CELL; ENDODERM; FEMALE; HUMAN; HUMAN CELL; IMMUNOGENICITY; INFLAMMATION; MESODERM; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PLURIPOTENT STEM CELL; STEM CELL; STEM CELL TRANSPLANTATION; TERATOMA; WHARTON JELLY;

ANIMALS; CELL LINE; CELL TRANSFORMATION, NEOPLASTIC; CYTOKINES; EMBRYONIC STEM CELLS; FEMALE; HUMANS; INJECTIONS, INTRAMUSCULAR; INJECTIONS, INTRAPERITONEAL; INJECTIONS, SUBCUTANEOUS; INTERLEUKINS; MICE; MICE, SCID; MULTIPOTENT STEM CELLS; WHARTON JELLY;

EID: 84856672801     PISSN: 14726483     EISSN: 14726491     Source Type: Journal    
DOI: 10.1016/j.rbmo.2011.10.007     Document Type: Article

References (50)

1. B. Blum, and N. Benvenisty The tumorigenecity of human embryonic stem cells Adv. Cancer Res. 100 2008 133 158 (Pubitemid 351932182)
2. A. Brederlau, A.S. Correia, S.V. Anisimov, M. Elmi, G. Paul, L. Roybon, A. Morizane, F. Bergquist, I. Riebe, U. Nannmark, M. Carta, E. Hanse, J. Takahashi, Y. Sasai, K. Funa, P. Brundin, P.S. Eriksson, and J.Y. Li Transplantation of human embryonic stem cell-derived cells to a rat model of Parkinson's disease: effect of in-vitro differentiation on graft survival and teratoma formation Stem Cells 24 2006 1433 1440 (Pubitemid 44464659)
3. A. Can, and S. Karahuseyinoglu Concise review: human umbilical cord stroma with regard to the source of fetus-derived stem cells Stem Cells 25 2007 2886 2895 (Pubitemid 350127873)
4. F. Cao, S. Lin, X. Xie, P. Ray, M. Patel, X. Zhang, M. Drukker, S.J. Dylla, A.J. Connolly, X. Chen, I.L. Weissman, S.S. Gambhir, and J.C. Wu In vivo visualization of embryonic stem cell survival, proliferation and migration after cardiac delivery Circulation 113 2006 1005 1014 (Pubitemid 43879476)
5. M.K. Carpenter, J. Frey-Vasconcells, and M.S. Rao Developing safe therapies from human pluripotent stem cells Nat. Biotechnol. 27 2009 606 613
6. K.C. Chao, K.F. Chao, Y.S. Fu, and S.H. Liu Islet-like clusters derived from mesenchymal stem cells in Wharton's jelly of the human umbilical cord for transplantation to control type 1 diabetes PLoS ONE e1451 2008 1 9
7. M.T. Conconi, P. Burra, L.R. Di, C. Calore, M. Turetta, S. Bellini, P. Bo, G.G. Nussdorfer, and P.P. Parnigotto CD105 (+) cells from Wharton's jelly show in vitro and in vivo myogenic differentiative potential Int. J. Mol. Med. 18 2006 1089 1096
8. M.J. Cooke, M. Stojkovic, and S.A. Przyborski Growth of teratomas derived from human pluripotent stem cells is influenced by the graft site Stem Cells Dev. 15 2006 254 259 (Pubitemid 43726503)
9. A.L. Cornish, I.K. Campbell, B.S. McKenzie, S. Chatfield, and I.P. Wicks G-CSF and GM-CSF as therapeutic targets in rheumatoid arthritis Nat. Rev. Rheumatol. 5 2009 554 559
10. L.M. Coussens, and Z. Werb Inflammation and cancer Nature 420 2002 860 867 (Pubitemid 36019639)
11. P. De Coppi, G. Bartsch Jr., M.M. Siddiqui, T. Xu, C.C. Santos, L. Perin, G. Mostoslavsky, A.C. Serre, E.Y. Snyder, J.J. Yoo, M.E. Furth, S. Soker, and A. Atala Isolation of amniotic stem cell lines with potential for therapy Nat. Biotechnol. 25 2007 100 106 (Pubitemid 46087908)
12. H. Emonard, J.A. Grimaud, B. Nusgens, C.M. Lapire, and J.M. Foidart Reconstituted basement-membrane matrix modulates fibroblast activities in vitro J. Cell. Physiol. 133 1987 95 102 (Pubitemid 18022451)
13. C.G. Fan, Q.J. Zhang, and J.R. Zhou Therapeutic potentials of mesenchymal stem cells derived from human umbilical cord Stem Cell Rev. Rep. 7 2011 195 207
14. J. Ferbas, J.V. Giorgi, S. Amini, K. Grovit-Ferbas, D.J. Wiley, R. Detels, and S. Plaeger Antigen-specific production of RANTES, macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta in vitro is a correlate of reduced human immunodeficiency virus burden in vivo J. Infect. Dis. 182 2000 1247 1250
15. C.Y. Fong, M. Richards, N. Manasi, A. Biswas, and A. Bongso Comparative growth behaviour and characterization of stem cells from human Wharton's jelly Reprod. BioMed. Online 15 2007 708 718 (Pubitemid 350285987)
16. C.Y. Fong, L.L. Chak, A. Subramanian, J.H. Tan, A. Biswas, K. Gauthaman, M. Choolani, W.K. Chan, and A. Bongso A three dimensional anchorage independent in-vitro system for the prolonged growth of embryoid bodies to study cancer behaviour and anticancer agents Stem Cell Rev. Rep. 5 2009 410 419
17. C.Y. Fong, K. Gauthaman, and A. Bongso Teratomas from pluripotent stem cells: a clinical hurdle J. Cell. Biochem. 111 2010 764 781
18. C.Y. Fong, A. Subramanian, A. Biswas, K. Gauthaman, P. Srikanth, M.P. Hande, and A. Bongso Derivation efficiency, cell proliferation, frozen-thaw survival, 'stemness' properties, and differentiation of human Wharton's jelly stem cells Reprod. BioMed. Online 21 2010 391 401
19. C.Y. Fong, L.L. Chak, A. Biswas, J.H. Tan, K. Gauthaman, W.K. Chan, and A. Bongso Human Wharton's jelly stem cells have unique transcriptome profiles compared to human embryonic stem cells and other mesenchymal stem cells Stem Cell Rev. Rep. 7 2011 1 16
20. C.Y. Fong, A. Subramanian, K. Gauthaman, J. Venugopal, A. Biswas, S. Ramakrishna, and A. Bongso Human Umbilical Cord Wharton's Jelly Stem Cells Undergo Chondrogenic Differentiation when Grown on Nanofibrous Scaffolds and in a Sequential Two-stage Culture Medium Environment Stem Cell Rev. Rep. 2011 10.1007/s12015-011-9289-8
21. T. Fujikawa, S.H. Oh, L. Pi, H.M. Hatch, T. Shupe, and B.E. Petersen Teratoma formation leads to failure of treatment for type 1 diabetes using embryonic stem cell-derived insulin-producing cells Am. J. Pathol. 166 2005 1781 1791 (Pubitemid 40734401)
22. K. Gauthaman, J.R. Venugopal, F.C. Yee, A. Biswas, S. Ramakrishna, and A. Bongso Osteogenic Differentiation of Human Wharton's Jelly Stem Cells on Nanofibrous Substrates In Vitro Tissue Eng. Part A 17 2010 71 81
23. N. Golestaneh, and B. Mishra TGF-beta, neuronal stem cells and glioblastoma Oncogene 24 2005 5722 5730 (Pubitemid 43086132)
24. I. Gutierrez-Aranda, V. Ramos-Mejia, and C. Bueno Human induced pluripotent stem cells develop teratoma more efficiently and faster than human embryonic stem cells regardless the site of injection Stem Cells 28 2010 1568 1570
25. H. Hentze, P.L. Soong, S.T. Wang, B.W. Phillips, T.C. Putti, and N.R. Dunn Teratoma formation by human embryonic stem cells: evaluation of essential parameters for future safety studies Stem Cell Res. 2 2009 198 210
26. T.R. Hercus, D. Thomas, M.A. Guthridge, P.G. Ekert, J.K. Scott, M.W. Parker, and A.F. Lopez The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease Blood 114 2009 1289 1298
27. S. Illancheran, Y. Moodley, and U. Manuelpillai Human fetal membranes: a source of stem cells for tissue regeneration and repair? Placenta 3 2009 2 10
28. K. Kita, G.G. Gauglitz, T.T. Phan, D.N. Herndon, and M.G. Jeschke Isolation and characterization of mesenchymal stem cells from the sub-amniotic human umbilical cord lining membrane Stem Cells Dev. 19 2010 491 502
29. P.A. Klimiuk, J.J. Goronzy, and C.M. Weyand IL-16 as an anti-inflammatory cytokine in rheumatoid synovitis J. Immunol. 162 1999 4293 4299 (Pubitemid 29314821)
30. M.A. Laflamme, K.Y. Chen, and A.V. Naumova Cardiomyocytes derived from human embryonic stem cells in pro-survival factors enhance function of infarcted rat hearts Nat. Biotechnol. 25 2007 1015 1024 (Pubitemid 47517637)
31. L.C. Laurent, I. Ulitsky, I. Slavin, H. Tran, A. Schork, R. Morey, C. Lynch, J.V. Harness, S. Lee, M.J. Barrero, S. Ku, M. Marina Martynova, R. Semechkin, V. Galat, J. Gottesfeld, J.C.I. Belmonte, C. Murry, H.S. Keirstead, H.S. Park, U. Schmidt, A.L. Laslett, F.J. Muller, C.M. Nievergelt, R. Shamir, and J.F. Loring Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESC and iPSCs during reprogramming and time in culture Cell Stem Cell 8 2011 106 118
32. B. Lawrenz, H. Schiller, E. Willbold, M. Ruediger, A. Muhs, and S. Esser Highly sensitive biosafety model for stem-cell-derived grafts Cytotherapy 6 2004 212 222 (Pubitemid 38868094)
33. A.S. Lee, C. Tang, F. Cao, X. Xie, K. Bogt, A. Hwang, A.J. Connolly, R.C. Robbins, and J.C. Wu Effects of cell number on teratoma formation by human embryonic stem cells Cell Cycle 8 2009 2608 2612
34. Q. Lian, Y. Zhang, J. Zhang, H.K. Zhang, X. Wu, Y. Zhang, F.F.Y. Lam, S. Kang, J.C. Xia, W.H. Lai, K.W. Au, Y.Y. Chow, C.W. Siu, C.N. Lee, and H.F. Tse Functional mesenchymal stem cells derived from human induced pluripotent stem cells attenuate limb ischemia in mice Circulation 121 2010 1113 1123
35. H. Lin, T.R. Mosmann, L. Guilbert, S. Tuntipopipat, and T.G. Wegmann Synthesis of T helper 2-type cytokines at the maternal-fetal interface J. Immunol. 151 1993 4562 4573 (Pubitemid 23318510)
36. L. Ling, Y. Ni, Q. Wang, H. Wang, S. Hao, Y. Hu, W. Jiang, and Y. Hou Transdifferentiation of mesenchymal stem cells derived from human fetal lung to hepatocyte-like cells Cell Biol. Int. 32 2008 1091 1098
37. S.V. Liu IPS cells: a more critical review Stem Cells Dev. 17 2008 391 397 (Pubitemid 351948206)
38. H.F. Lodish, B. Zhou, G. Liu, and C.Z. Chen Micromanagement of the immune system by microRNAs Nat. Rev. Immunol. 8 2008 120 130 (Pubitemid 351161305)
39. R.D. Lund, S. Wang, B. Lu, S. Girman, T. Holmes, Y. Sauvé, D.J. Messina, I.R. Harris, A.J. Kihm, A.M. Harmon, F.Y. Chin, A. Gosiewska, and S.K. Mistry Cells isolated from umbilical cord tissue rescue photoreceptors and visual functions in a rodent model of retinal disease Stem Cells 25 2007 602 611 (Pubitemid 46354218)
40. Y. Moodley, D. Atienza, U. Manuelpillai, C.S. Samuel, J. Tchongue, S. Ilancheran, R. Boyd, and A. Trounson Human umbilical cord mesenchymal stem cells reduce fibrosis of bleomycin-induced lung injury Am. J. Pathol. 175 2009 303 313
41. D. Philip, S.S. Chen, W. Fitzgerald, J. Orenstein, L. Margolis, and H.K. Kleinman Complex extracellular matrices promote tissue-specific stem cell differentiation Stem Cells 23 2005 288 296 (Pubitemid 40239523)
42. T.A. Prokhorova, L.M. Harkness, U. Frandsen, N. Ditzel, H.D. Schrøder, J.S. Burns, and M. Kassem Teratoma formation by human embryonic stem cells is site dependent and enhanced by the presence of matrigel Stem Cells Dev. 18 2009 47 54
43. S. Ramalingam, R. Kannangai, O.C. Abraham, S. Subramanian, P. Rupali, S.A. Pulimood, M.V. Jesudason, and G. Sridharan Investigation of apoptotic markers among human immunodeficiency virus (HIV-1) infected individuals Indian J. Med. Res. 128 2008 728 733
44. M. Schuldiner, R. Eiges, A. Eden, O. Yanuka, J. Itskovitz-Eldorb, Ronald S. Goldstein, and N. Benvenisty Induced neuronal differentiation of human embryonic stem cells Brain Res. 913 2001 201 205 (Pubitemid 32817068)
45. C.C. Shih, S.J. Forman, P. Chu, and M. Slovak Human embryonic stem cells are prone to generate primitive, undifferentiated tumors in engrafted human fetal tissues in severe combined immunodeficient mice Stem Cells Dev. 16 2007 893 902
46. M. Tone, M.J. Powell, Y. Tone, S.A. Thompson, and H. Waldmann IL-10 gene expression is controlled by the transcription factors Sp1 and Sp3 J. Immunol. 165 2000 286 291 (Pubitemid 30429518)
47. L. Wang, and M.S. Detamore Insulin-like growth factor-1 improves chondrogenesis of predifferentiated human umbilical cord mesenchymal stromal cells J Orthop. Res 27 2009 1109 1115
48. M.L. Weiss, C. Anderson, S. Medicetty, K.B. Seshareddy, R.J. Weiss, I. Vanderwerff, D. Troyer, and K.R. McIntosh Immune properties of human umbilical cord Wharton's jelly-derived cells Stem Cells 26 2008 2865 2874
49. Z. Wen, S. Zheng, C. Zhou, J. Wang, and T. Wang Repair mechanisms of bone marrow mesenchymal stem cells in myocardial infarction J. Cell. Mol. Med. 15 2011 1032 1043
50. Y.N. Wu, Z. Yang, J.H.P. Hui, H.W. Ouyang, and E.H. Lee Cartilaginous ECM component-modification of the micro-bead culture system for chondrogenic differentiation of mesenchymal stem cells Biomaterials 28 2007 4056 4067 (Pubitemid 47053933)