iPS cells: A more critical review

Stem Cells and Development

Volumn 17, Issue 3, 2008, Pages 391-397

  Liu, Shi V ^a  

^a Eagle Institute of Molecular Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT STEM CELL; CELL CLONE; CELL DIFFERENTIATION; CELL NUCLEUS TRANSPLANTATION; CELL TRANSFER; CELL TRANSFORMATION; CHROMATIN IMMUNOPRECIPITATION; DNA METHYLATION; EMBRYONIC STEM CELL; FIBROBLAST; GENE EXPRESSION; HUMAN; NONHUMAN; ONCOGENE C MYC; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REGENERATIVE MEDICINE; REVIEW; SOMATIC CELL; STEM CELL; STEM CELL TRANSPLANTATION;

ANIMALS; CELL DIFFERENTIATION; EMBRYONIC STEM CELLS; HUMANS; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELLS;

IPS;

EID: 46749120232     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2008.0062     Document Type: Review

References (67)

1. Takahashi K and S Yamanaka. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
2. Liu SV. (2008). The iPS spinning in top journals. Top Watch 3:19-21.
3. Rao M and ML Condic. (2008). Alternative sources of pluripotent stem cells: scientific solutions to an ethical dilemma. Stem Cells Dev 17:1-10.
4. Kennedy D. (2007). Breakthrough of the Year. Science 318:1833.
5. Anonymous. (2007). Breakthrough of the year: the runnersup. Science 318:1844.
6. Anonymous. (2007). Stem cell success. Nature 450:1130.
7. Pera MF. (2008). Stem cells. A new year and a new era. Nature 451:135-136.
8. Holden C and G Vogel. (2008). Cell biology. A seismic shift for stem cell research. Science 319:560-563.
9. Rodolfa KT and K Eggan. (2006). A transcriptional logic for nuclear reprogramming. Cell 126:652-655.
10. Okita K, T Ichisaka and S Yamanaka. (2007). Generation of germline-competent induced pluripotent stem cells. Nature 448:313-317.
11. Wernig M, A Meissner, R Foreman et al. (2007). In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448:318-324.
12. Maherali N, R Sridharan, W Xie, J Utikal, S Eminli, K Arnold, M Statfeld, R Yachechko, J Tchieu and R Jaenisch. (2007). Directly reprogrammed fibroblasts show global epigenetic remodeling and widespread tissue contribution. Cell Stem Cell 1:55-70.
13. Liu SV. (2007). iPS cells: stem cells induced from terminally differentiated cells or just pre-existing stem cells being detected? Logical Biology 7:63-65.
14. Yu J, MA Vodyanik, K Smuga-Otto, J Antosiewicz-Bourget, JL Frane, S Tian, J Nie, GA Jonsdottir, V Ruotti, R Stewart, II Slukvin and JA Thompson. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
15. Takahashi K, K Tanabe, M Ohnuki, T Ichisaka, K Tomoda and S Yamanaka. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872.
16. Hanna J, M Wernig, S Markoulaki, C-W Sun, A Meissner, JP Cassady, C Beard, T Brambrink, L-C Wu, TM Townes and R Jaenisch. (2007). Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science 318:1920-1923.
17. Park IH, R Zhao, JA West, A Yabuuchi, H Huo, TA Ince, PH Lerou, MW Lensch and GQ Daley. (2007). Reprogramming of human somatic cells to pluripotency with defined factors. Nature 451:141-146.
18. Liu SV. (2008). Are iPS cells really induced from differentiated cells? Logical Biology 8:1-7.
19. Liu SV. (2008). One factor dropped from the 'inducing' soup, one piece of evidence added against the 'induction' claim. Logical Biology 8:39-41.
20. Nakagawa M, M Yoyanagi, K Tanabe, T Takahashi, T Ichisaka, T Aoi, K Okita, Y Mochiduki, N Takizawa and S Yamanata. (2008). Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nature Biotechnol 26:101-106.
21. Pera MF and K Hasegawa. (2008). Simpler and safer cell reprogramming. Nature Biotechnol 26:59-60.
22. Masaki H, T Ishikawa, S Takahashi et al. (2008). Heterogeneity of Pluripotent marker gene expression in Colonies generated in human iPS cell induction culture. Stem Cell Res 2:105-115.
23. Aoi T, K Yae, M Nakagawa et al. (2007). Generation of pluripotent stem cells from adult mouse liver and stomach cells. Science AOP February 14, 2008:DOI 10.1126/science.1154884.
24. Liu SV. (2008). The final blow-up of the induction and reprogramming claim for iPS cells. Logical Biology. 8:57-61.
25. Gurdon J. (2007). Primate therapeutic cloninng in practice. Nature Biotechnol 26:64-65.
26. Liu SV. (2007). Are iPS cells really indistinguishable from ES cells? Logical Biology 7:66-68.
27. Liu SV. (2007). Rebuttal against an authoritative but ungrounded peer review. Logical Biology 7:73-75.
28. Rodolfa K, FP Di Giorgio and S Sullivan. (2007). Defined reprogramming: a vehicle for changing the differentiated state. Differentiation 75:577-579.
29. Rossant J. (2007). Stem cells: the magic brew. Nature 448:260-262.
30. Yamanaka S. (2007). Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 1:39-49.
31. Yamanaka S. (2007). Induction of pluripotent stem cells from mouse fibroblasts by four transcription factors. Cell Prolif 41:51-56.
32. Tai MH, CC Chang, M Kiupel, JD Webster, LK Olson and JE Trosko. (2005). Oct4 expression in adult human stem cells: evidence in support of the stem cell theory of carcinogenesis. Carcinogenesis 26:495-502.
33. Lengner C, FD Camargo, K Hochedlinger, G Elstead, S Zaidi, S Gokhale, H Scholer, A Tomilin and R Jaenisch. (2007). Oct4 expression is not required for mouse somatic stem cell self-renewal. Cell Stem Cell 1:403-415.
34. Zangrossi S, M Marabese, M Broggini, R Giordano, M D'Erasmo, E Montelatici, D Initini, A Neri, P Rebulla and L Lazzari. (2007). Oct-4 expression in adult human differentiated cells challenges its role as a pure stem cell marker. Stem Cells 25:1675-1680.
35. Liu SV. (2007). What is a stem cell? Logical Biology 7:12-17.
36. Brambrink T, R Foreman, GG Welstead, CJ Lengner, M Wernig, H Suh and R Jaenisch. (2008). Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2:151-159.
37. Stadtfeld M, N Maherali, D Breault and K Hochedlinger. (2008). Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell 2:1-11.
38. Liu SV. (2008). Sequential reprogramming into iPS cells or sequential differentiation of isolated pre-existing stem cells. Logical Biology 8:27-29.
39. Trosko JE. (2006). From adult stem cells to cancer stem cells: Oct-4 Gene, cell-cell communication, and hormones during tumor promotion. Ann NY Acad Sci 1089:36-58.
40. Atlasi Y, SJ Mowla, SA Ziaee and AR Bahrami. (2007). OCT-4, an embryonic stem cell marker, is highly expressed in bladder cancer. Int J Cancer 120:1598-1602.
41. Hochedlinger K, Y Yamada, C Beard and R Jaenisch. 2005. Ectopic expression of Oct-4 blocks progenitor-cell differentiation and causes dysplasia in epithelial tissues. Cell 121:465-477.
42. Li XL, Y Eishi, YQ Bai, H Sakai, Y Akiyama, M Tani, T Takizawa, M Koike and Y Yuasa. (2004). Expression of the SRY-related HMG box protein SOX2 in human gastric carcinoma. Int J Oncol 24:257-263.
43. Tsukamoto T, T Mizoshita, M Mihara, H Tanaka, Y Takenaka, Y Yamamura, S Nakamura, T Ushijima and M Takematsu. (2005). Sox2 expression in human stomach adenocarcinomas with gastric and gastric-and-intestinal-mixed phenotypes. Histopathology 46:649-658.
44. Sanada Y, K Yoshida, M Ohara, M Oeda, K Konishi and Y Tsutani. (2006). Histopathologic evaluation of stepwise progression of pancreatic carcinoma with immunohistochemical analysis of gastric epithelial transcription factor SOX2: comparison of expression patterns between invasive components and cancerous or nonneoplastic intraductal components. Pancreas 32:164-170.
45. Sanada Y, K Yoshida, K Konishi, M Oeda, M Ohara and Y Tsutani. (2006). Expression of gastric mucin MUC5AC and gastric transcription factor SOX2 in ampulla of vater adenocarcinoma: comparison between expression patterns and histologic subtypes. Oncol Rep 15:1157-1161.
46. Schmitz M, A Temme, V Senner, R Ebner, S Schwind, S Stevanovic, R Wehner, G Schackert, HK Schackert, M Fussel, M Bachmann, EP Rieber and B Weigle. (2007). Identification of SOX2 as a novel glioma-associated antigen and potential target for T cell-based immunotherapy. Br J Cancer 96:1293-1301.
47. Rodriguez-Pinilla SM, D Sarrio, G Moreno-Bueno, Y Rodruguez-Gil, MA Martinez, L Hernandez, D Hardisson, JS Reis-Filho and J Palacios. (2007). Sox2: a possible driver of the basal-like phenotype in sporadic breast cancer. Mod Pathol 20:474-481.
48. Phi JH, SH Park, SK Kim, SH Paek, JH Kim, YJ LEe, BK Cho, C-K Park, D-H Lee and K-C Wang. (2008). Sox2 expression in brain tumors: a reflection of the neuroglial differentiation pathway. Am J Surg Pathol 32:103-112.
49. Rowland BD and DS Peeper. (2006). KLF4, p21 and context-dependent opposing forces in cancer. Nature Rev Cancer 6:11-23.
50. Foster KW, S Ren, ID Louro, SM Lobo-Ruppert, P McKie-Bell, W Grizzle, MR Hayes, TR Broker, LT Chow and JM Ruppert. (1999). Oncogene expression cloning by retroviral transduction of adenovirus E1A-immortalized rat kidney RK3E cells: transformation of a host with epithelial features by c-MYC and the zinc finger protein GKLF. Cell Growth Differ 10:423-434.
51. Foster KW, Z Liu, CD Nail, X Lie, TJ Fitzgerald, SK Bailey, AR Frost, ID Louro, TM Townes, AJ Paterson, JE Kudlow, SM Lobo-Ruppert and JM Ruppert. (2005). Induction of KLF4 in basal keratinocytes blocks the proliferation- differentiation switch and initiates squamous epithelial dysplasia. Oncogene 24:1491-1500.
52. Foster KW, AR Frost, P McKie-Bell, CY Lin, JA Engler, WE Grizzle and JM Ruppert. (2000). Increase of GKLF messenger RNA and protein expression during progression of breast cancer. Cancer Res 60:6488-6495.
53. Pandya AY, LI Talley, AR Frost, TJ Fitzgerlad, V Trivedi, M Chakravarthy, DC Chhieng, WE Grizzle, JA Engler, H Kronotiras, KI Bland, AF LoBuglio, SM Lobo-Ruppert and JM Ruppert. (2004). Nuclear localization of KLF4 is associated with an aggressive phenotype in early-stage breast cancer. Clin Cancer Res 10:2709-2719.
54. Tanaka Y, T Era, S Nishikawa and S Kawamata. (2007). Forced expression of Nanog in hematopoietic stem cells results in a gammadeltaT-cell disorder. Blood 110:107-115.
55. Liu SV. (2008). IPS cells are man-made cancer cells. Logical Biology 8:16-18.
56. Liu SV. (2007). Can the iPS airplane really fly high in the therapeutic sky? Logical Biology 7:84-96.
57. Xu R-X. (2004). Burns Regenerative Medicine and Therapy. Karger, Basel.
58. Xu R-X. (2004). Method and composition for repairing and promoting regeneration of mucosal tissue in the gastrointestinal tract. US Patent 6685971 B2.
59. Xu R-X. (2006). Physiological tissue repair and functional organ regeneration by cultivation of regenerative stem cells in vivo and in situ. US Patent 6991813 B2.
60. Blelloch R, M Venere, J Yen and M Ramalho-Santo. (2007). Generation of induced pluripotent stem cells in the absence of drug selection. Cell Stem Cell 1:245-247.
61. Liu SV. (2007). Invalidating the induction claim and adopting an activation mechanism for stem cells useful for regenerative medicine. Logical Biology 7:96-99.
62. Anonymous. (2007). Stem cell breakthroughs. Time [http://www.time.com/ time/specials/2007/top10/article/0,30583,1686204_1686252_1690920, 00.html?cnn=yes].
63. Wilmut I, AE Schnieke, J McWhir, AJ Kind and KH Campbell. (1997). Viable offspring derived from fetal and adult mammalian cells. Nature 385:810-813.
64. Boyle A. (2007). Skin cells made to mimic stem cells. MSNBC [http://www.msnbc.msn.com/id/21886974/:(Nov. 20, 2007)].
65. Zaehres H and HR Scholer. (2007). Induction of pluripotency: From mouse to human. Cell 131:834-835.
66. Anonymous. (2008). A reprogramming rush. Nature 452:388.
67. Cyranoski D. (2008). Stem cells: 5 things to know before jumping on the iPS bandwagon. Nature 452:406-408.