Development and validation of a fully automated online human dried blood spot analysis of bosentan and its metabolites using the Sample Card And Prep DBS System

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 885-886, Issue , 2012, Pages 50-60

  Ganz, Norbert ^a   Singrasa, Maharajah ^a   Nicolas, Laurent ^b   Gutierrez, Marcelo ^b   Dingemanse, Jasper ^b   Döbelin, Werner ^c   Glinski, Mirko ^a  

^a Inovalab AG   (Switzerland)

^b ACTELION PHARMACEUTICALS LTD   (Switzerland)

^c Prolab Instruments GmbH   (Switzerland)

Author keywords

Bosentan; Dried blood spot; Fully automated; Online extraction; Pulmonary arterial hypertension; SCAP DBS

Indexed keywords

BOSENTAN; DRIED BLOOD SPOTS; FULLY AUTOMATED; ONLINE EXTRACTION; PULMONARY ARTERIAL HYPERTENSION; SCAP DBS;

ACETIC ACID; BLOOD; ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; PH;

AUTOMATION;

2 PROPANOL; ACETIC ACID; BOSENTAN; METHANOL; RO 478634; RO 485033; RO 641056; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CHEMICAL REACTION; CHROMATOGRAPHY; CONTROLLED STUDY; DRIED BLOOD SPOT TESTING; DRUG DETERMINATION; DRUG ISOLATION; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; TEMPERATURE; VALIDATION STUDY;

AUTOMATION, LABORATORY; CHROMATOGRAPHY, LIQUID; DRIED BLOOD SPOT TESTING; DRUG STABILITY; HEMATOCRIT; HUMANS; LINEAR MODELS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SULFONAMIDES; TANDEM MASS SPECTROMETRY;

EID: 84856641203     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2011.12.012     Document Type: Article

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