Direct quantitative bioanalysis of drugs in dried blood spot samples using a thin-layer chromatography mass spectrometer interface

Analytical Chemistry

Volumn 81, Issue 24, 2009, Pages 10275-10284

  Abu Rabie, Paul ^a   Spooner, Neil ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTES; BIOANALYSIS; BIOANALYTICAL; CHEMICAL SPACE; CHROMATOGRAPHIC PERFORMANCE; COST SAVING; DIRECT ANALYSIS; DRIED BLOOD SPOTS; EFFECTIVE TOOL; EXTRACTION TIME; HPLC SEPARATION; HPLC-MS ANALYSIS; MS- INTERFACE; PRELIMINARY ASSESSMENT;

BLOOD; CHROMATOGRAPHIC ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETERS; MASS SPECTROMETRY; THIN LAYER CHROMATOGRAPHY;

EXTRACTION;

4 NITROPHTHALIC ACID; 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL] 6 TRIFLUOROMETHYLINDOLINE; BENZETHONIUM CHLORIDE; IBUPROFEN; PARACETAMOL; PARACETAMOL DERIVATIVE; PHTHALIC ACID DERIVATIVE; PROGUANIL; SIMVASTATIN; SITAMAQUINE; UNCLASSIFIED DRUG;

ACCURACY; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; COST CONTROL; DRUG DETERMINATION; ELUTION; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; MASS SPECTROMETER; MASS SPECTROMETRY; NONHUMAN; QUANTITATIVE ANALYSIS; SPECTRAL SENSITIVITY; THIN LAYER CHROMATOGRAPHY; THIN LAYER CHROMATOGRAPHY MASS SPECTROMETER; VALIDATION PROCESS;

ACETAMINOPHEN; AMINOQUINOLINES; BENZETHONIUM; BLOOD CHEMICAL ANALYSIS; CHLOROGUANIDE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HUMANS; IBUPROFEN; MASS SPECTROMETRY; PHTHALIC ACIDS; SENSITIVITY AND SPECIFICITY; SIMVASTATIN;

EID: 72449175156     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac901985e     Document Type: Article

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