Dried blood spots as a sample collection technique for the determination of pharmacokinetics in clinical studies: Considerations for the validation of a quantitative bioanalytical method

Analytical Chemistry

Volumn 81, Issue 4, 2009, Pages 1557-1563

  Spooner, Neil ^a   Lad, Rakesh ^a   Barfield, Matt ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANALYTE; BIOANALYTICAL METHODS; BLOOD VOLUMES; CLINICAL STUDIES; DRIED BLOOD SPOTS; DRUG CONCENTRATIONS; HPLC-MS/MS; HUMAN BLOODS; MASS SPECTROMETRIC DETECTIONS; ORAL DOSE; PLASMA SAMPLES; QUANTITATIVE DATUM; QUANTITATIVE DETERMINATIONS; REVERSED-PHASE HPLC; SAMPLE COLLECTIONS; SELECTED REACTION MONITORING;

DRUG PRODUCTS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHASE SEPARATION; PLASMAS; SOLVENT EXTRACTION; SOLVENTS; STABILITY CRITERIA; THERMAL EFFECTS;

BLOOD;

PARACETAMOL; DRUG; GLUCURONAMIDE; GLUCURONIC ACID;

ACCURACY; ARTICLE; BLOOD SAMPLING; BLOOD VOLUME; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG STRUCTURE; HUMAN; MASS SPECTROMETRY; QUANTITATIVE ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; SOLVENT EXTRACTION; TEMPERATURE SENSITIVITY; BLOOD; BLOOD ANALYSIS; CHEMISTRY; CIRCULATION; CLINICAL TRIAL; DRUG TOXICITY; INTERNATIONAL COOPERATION; METABOLISM; METHODOLOGY; PHARMACOKINETICS; SENSITIVITY AND SPECIFICITY; STATISTICAL MODEL; TEMPERATURE; VALIDATION STUDY;

ACETAMINOPHEN; BLOOD CHEMICAL ANALYSIS; BLOOD CIRCULATION; BLOOD SPECIMEN COLLECTION; CLINICAL TRIALS AS TOPIC; DRUG TOXICITY; GLUCURONATES; HUMANS; INTERNATIONALITY; LINEAR MODELS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SENSITIVITY AND SPECIFICITY; TEMPERATURE;

EID: 63649092684     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac8022839     Document Type: Article

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