Study of dried blood spots technique for the determination of dextromethorphan and its metabolite dextrorphan in human whole blood by LC-MS/MS

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 877, Issue 8-9, 2009, Pages 799-806

  Liang, Xiaorong ^a   Li, Yinghe ^a   Barfield, Matthew ^b   Ji, Qin C ^a  

^a 206 Carnegie Center   (United States)

^b GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Dextromethorphan; Dextrorphan; Dried blood spot (DBS); LC MS MS

Indexed keywords

ACETONITRILE; ASSAYS; BIOMOLECULES; CHROMATOGRAPHIC ANALYSIS; CURING; ETHERS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; PLASMAS;

ANALYTES; BIOANALYTICAL ASSAYS; BLOOD MATRIXES; BLOOD SAMPLES; BLOOD SAMPLINGS; CONCENTRATION LEVELS; CONCENTRATION RANGES; DEXTROMETHORPHAN; DEXTRORPHAN; DRIED BLOOD SPOT (DBS); LC-MS/MS; LOWER LIMIT OF QUANTITATIONS; METHYL-TERT-BUTYL ETHERS; PUNCH OUTS; SAMPLE VOLUMES; TANDEM MASS SPECTROMETRIES; TEST SITES; WHOLE BLOODS;

BLOOD;

ACETONITRILE; DEXTROMETHORPHAN; DEXTRORPHAN; DRUG METABOLITE; DRUG RESIDUE; TERT BUTYL METHYL ETHER;

ACCURACY; ANALYTIC METHOD; ARTICLE; BLOOD; BLOOD SAMPLING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DETERMINATION; EVAPORATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SUPERNATANT; TANDEM MASS SPECTROMETRY;

BLOOD SPECIMEN COLLECTION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DEXTROMETHORPHAN; DEXTRORPHAN; HUMANS; TANDEM MASS SPECTROMETRY;

EID: 61349169172     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2009.02.015     Document Type: Article

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