A mutation in the β 3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of α IIbβ 3 to an active state

Journal of Thrombosis and Haemostasis

Volumn 10, Issue 2, 2012, Pages 289-297

  Hauschner, H ^a   Mor Cohen, R ^a   Seligsohn, U ^a   Rosenberg, N ^a  

^a The Amalia Biron Research Institute of Thrombosis and Hemostasis   (Israel)

Author keywords

IIb; 3; Glanzmann thrombasthenia; Integrins; Variant Glanzmann thrombasthenia

Indexed keywords

ALPHA2B BETA3 INTEGRIN; BETA3 INTEGRIN; CYSTEINE; FIBRINOGEN; INTEGRIN; SERINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL MEMBRANE; CELL SPREADING; CELL STRAIN BHK; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; CYTOPLASMIC TAIL; GENE MUTATION; GLANZMANN DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; WILD TYPE;

ANIMALS; CELL LINE; CRICETINAE; FIBRINOGEN; FLOW CYTOMETRY; INTEGRIN BETA3; LIGANDS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBASTHENIA; TRANSFECTION;

EID: 84856558611     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2011.04577.x     Document Type: Article

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