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Volumn 26, Issue 2-3, 2012, Pages 71-80

Foxp3 is critical for human natural CD4+CD25+ regulatory T cells to suppress alloimmune response

Author keywords

Alloimmune response; Foxp3; Phenotype; SiRNA; Suppressive function

Indexed keywords

SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXP3;

EID: 84856548581     PISSN: 09663274     EISSN: 18785492     Source Type: Journal    
DOI: 10.1016/j.trim.2011.10.005     Document Type: Article
Times cited : (17)

References (43)
  • 1
    • 0034716925 scopus 로고    scopus 로고
    • Regulatory T cells: key controllers of immunologic self-tolerance
    • Sakaguchi S. Regulatory T cells: key controllers of immunologic self-tolerance. Cell 2000, 101:455-458.
    • (2000) Cell , vol.101 , pp. 455-458
    • Sakaguchi, S.1
  • 2
    • 16844365788 scopus 로고    scopus 로고
    • Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self
    • Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol 2005, 6:345-352.
    • (2005) Nat Immunol , vol.6 , pp. 345-352
    • Sakaguchi, S.1
  • 6
    • 49649113444 scopus 로고    scopus 로고
    • Acquisition of suppressive function by activated human CD4+CD25- T cells is associated with the expression of CTLA-4 not Foxp3
    • Zheng Y., Manzotti C.N., Burke F., Hong S., Youn J. Acquisition of suppressive function by activated human CD4+CD25- T cells is associated with the expression of CTLA-4 not Foxp3. J Immunol 2008, 181:1683-1691.
    • (2008) J Immunol , vol.181 , pp. 1683-1691
    • Zheng, Y.1    Manzotti, C.N.2    Burke, F.3    Hong, S.4    Youn, J.5
  • 7
    • 40449092356 scopus 로고    scopus 로고
    • Naïve precursors of human regulatory T cells require Foxp3 for suppression and are susceptible to HIV infection
    • Antons A.K., Wang R., Oswald-Richter K., Tseng M., Arendt C.W., Kalams S.A., et al. Naïve precursors of human regulatory T cells require Foxp3 for suppression and are susceptible to HIV infection. J Immunol 2008, 74:764-773.
    • (2008) J Immunol , vol.74 , pp. 764-773
    • Antons, A.K.1    Wang, R.2    Oswald-Richter, K.3    Tseng, M.4    Arendt, C.W.5    Kalams, S.A.6
  • 8
    • 0037385330 scopus 로고    scopus 로고
    • Foxp3 programs the development and function of CD4+CD25+ regulatory T cells
    • Fontenot J.D., Gavin M.A., Rudensky A.Y. Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. Nat Immunol 2003, 4:330-336.
    • (2003) Nat Immunol , vol.4 , pp. 330-336
    • Fontenot, J.D.1    Gavin, M.A.2    Rudensky, A.Y.3
  • 9
    • 0037385314 scopus 로고    scopus 로고
    • An essential role for scurfin in CD4+CD25+ T regulatory cells
    • Khattri R., Cox T., Yasayko S.A., Ramsdell F. An essential role for scurfin in CD4+CD25+ T regulatory cells. Nat Immunol 2003, 4:337-342.
    • (2003) Nat Immunol , vol.4 , pp. 337-342
    • Khattri, R.1    Cox, T.2    Yasayko, S.A.3    Ramsdell, F.4
  • 11
    • 0035162560 scopus 로고    scopus 로고
    • Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse
    • Brunkow M.E., Jeffery E.W., Hjerrild K.A., Paeper B., Clark L.B., Yasayko S.A., et al. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet 2001, 27:68-73.
    • (2001) Nat Genet , vol.27 , pp. 68-73
    • Brunkow, M.E.1    Jeffery, E.W.2    Hjerrild, K.A.3    Paeper, B.4    Clark, L.B.5    Yasayko, S.A.6
  • 12
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bebett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, x-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat Genet 2001, 27:20-21.
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bebett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 13
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin R.S., Ramsdell F., Peake J., Faravelli F., Casanova J.L., Buist N., et al. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat Genet 2001, 27:18-20.
    • (2001) Nat Genet , vol.27 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3    Faravelli, F.4    Casanova, J.L.5    Buist, N.6
  • 14
    • 35448930435 scopus 로고    scopus 로고
    • - T cells by T-cell receptor stimulation is transforming growth factor-ß-dependent but does not confer a regulatory phenotype
    • - T cells by T-cell receptor stimulation is transforming growth factor-ß-dependent but does not confer a regulatory phenotype. Blood 2007, 15:2983-2990.
    • (2007) Blood , vol.15 , pp. 2983-2990
    • Tran, D.Q.1    Ramsey, H.2    Shevach, E.M.3
  • 16
    • 20844432429 scopus 로고    scopus 로고
    • Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level
    • Roncador G., Brown P.J., Maestre L., Hue S., Martínez-Torrecuadrada J.L., Ling K.L., et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005, 35:1681-1691.
    • (2005) Eur J Immunol , vol.35 , pp. 1681-1691
    • Roncador, G.1    Brown, P.J.2    Maestre, L.3    Hue, S.4    Martínez-Torrecuadrada, J.L.5    Ling, K.L.6
  • 18
    • 58149476779 scopus 로고    scopus 로고
    • Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells
    • Xia G., Shah M., Luo X. Prevention of allograft rejection by amplification of Foxp3(+)CD4(+)CD25(+) regulatory T cells. Transl Res 2009, 153:60-70.
    • (2009) Transl Res , vol.153 , pp. 60-70
    • Xia, G.1    Shah, M.2    Luo, X.3
  • 19
    • 33645148088 scopus 로고    scopus 로고
    • The silent treatment: siRNAs as small molecule drugs
    • Dykxhoorn D.M., Pallister D., Lieberman J. The silent treatment: siRNAs as small molecule drugs. Gene Ther 2006, 13:541-552.
    • (2006) Gene Ther , vol.13 , pp. 541-552
    • Dykxhoorn, D.M.1    Pallister, D.2    Lieberman, J.3
  • 20
    • 26044469804 scopus 로고    scopus 로고
    • Silence of the transcripts: RNA interference in medicine
    • Barik S. Silence of the transcripts: RNA interference in medicine. J Mol Med 2005, 83:764-773.
    • (2005) J Mol Med , vol.83 , pp. 764-773
    • Barik, S.1
  • 22
    • 34247255870 scopus 로고    scopus 로고
    • Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1
    • Peer D., Zhu P., Carman C.V., Lieberman J., Shimaoka M. Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci U S A 2007, 104:4095-4100.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 4095-4100
    • Peer, D.1    Zhu, P.2    Carman, C.V.3    Lieberman, J.4    Shimaoka, M.5
  • 24
    • 33847415066 scopus 로고    scopus 로고
    • Natural regulatory T cells: mechanisms of suppression
    • Miyara M., Sakaguchi S. Natural regulatory T cells: mechanisms of suppression. Trends Mol Med 2007, 13:108-116.
    • (2007) Trends Mol Med , vol.13 , pp. 108-116
    • Miyara, M.1    Sakaguchi, S.2
  • 25
    • 34147131338 scopus 로고    scopus 로고
    • Involvement of the programmed death-1/programmed death-1 ligand pathway in CD4+CD25+ regulatory T-cell responses
    • Kitazawa Y., Fujino M., Wang Q., Kimura H., Azuma M., Kubo M., et al. Involvement of the programmed death-1/programmed death-1 ligand pathway in CD4+CD25+ regulatory T-cell responses. Transplantation 2007, 83:774-782.
    • (2007) Transplantation , vol.83 , pp. 774-782
    • Kitazawa, Y.1    Fujino, M.2    Wang, Q.3    Kimura, H.4    Azuma, M.5    Kubo, M.6
  • 27
    • 33645778289 scopus 로고    scopus 로고
    • MHC class II expression identifies functionally distinct regulatory T cells
    • Baecher-Allan C., Wolf E., Hafler D.A. MHC class II expression identifies functionally distinct regulatory T cells. J Immunol 2006, 176:4622-4631.
    • (2006) J Immunol , vol.176 , pp. 4622-4631
    • Baecher-Allan, C.1    Wolf, E.2    Hafler, D.A.3
  • 28
    • 36248976097 scopus 로고    scopus 로고
    • CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells
    • Pandiyan P., Zheng L., Ishihara S., Reed J., Lenardo M.J. CD4+CD25+Foxp3+ regulatory T cells induce cytokine deprivation-mediated apoptosis of effector CD4+ T cells. Nat Immunol 2007, 8:1353-1362.
    • (2007) Nat Immunol , vol.8 , pp. 1353-1362
    • Pandiyan, P.1    Zheng, L.2    Ishihara, S.3    Reed, J.4    Lenardo, M.J.5
  • 29
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of Foxp3
    • Bennett C.L., Christie J., Ramsdell F., Brunkow M.E., Ferguson P.J., Whitesell L., et al. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of Foxp3. Nat Genet 2001, 27:20-21.
    • (2001) Nat Genet , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5    Whitesell, L.6
  • 30
    • 33745194618 scopus 로고    scopus 로고
    • IPEX and the role of Foxp3 in the development and function of human Tregs
    • Le Bras S., Geha R.S. IPEX and the role of Foxp3 in the development and function of human Tregs. J Clin Invest 2006, 116:1473-1475.
    • (2006) J Clin Invest , vol.116 , pp. 1473-1475
    • Le Bras, S.1    Geha, R.S.2
  • 31
    • 34948875308 scopus 로고    scopus 로고
    • Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells
    • Torgerson T.R., Ochs H.D. Immune dysregulation, polyendocrinopathy, enteropathy, X-linked: forkhead box protein 3 mutations and lack of regulatory T cells. J Allergy Clin Immunol 2007, 120:744-750.
    • (2007) J Allergy Clin Immunol , vol.120 , pp. 744-750
    • Torgerson, T.R.1    Ochs, H.D.2
  • 32
    • 33947121146 scopus 로고    scopus 로고
    • Transient regulatory T-cells: a state attained by all activated human T-cells
    • Pillai V., Ortega S.B., Wang C.K., Karandikar N.J. Transient regulatory T-cells: a state attained by all activated human T-cells. Clin Immunol 2007, 123:18-29.
    • (2007) Clin Immunol , vol.123 , pp. 18-29
    • Pillai, V.1    Ortega, S.B.2    Wang, C.K.3    Karandikar, N.J.4
  • 34
    • 27644449311 scopus 로고    scopus 로고
    • The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs
    • [PubMed: 16211090]
    • Allan Sarah E., Laura Passerini, Rosa Bacchetta, Crellin N., Dai M., Orban P.C., et al. The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs. J Clin Invest 2005, 115:3276-3284. [PubMed: 16211090].
    • (2005) J Clin Invest , vol.115 , pp. 3276-3284
    • Allan, S.E.1    Laura, P.2    Rosa, B.3    Crellin, N.4    Dai, M.5    Orban, P.C.6
  • 35
    • 33746228122 scopus 로고    scopus 로고
    • Foxp3 controls regulatory T cell function through cooperation with NFAT
    • Wu Y., Borde M., Heissmeyer V., Feuerer M., Lapan A.D., Stroud J.C., et al. Foxp3 controls regulatory T cell function through cooperation with NFAT. Cell 2006, 126:375-387.
    • (2006) Cell , vol.126 , pp. 375-387
    • Wu, Y.1    Borde, M.2    Heissmeyer, V.3    Feuerer, M.4    Lapan, A.D.5    Stroud, J.C.6
  • 36
    • 17044393922 scopus 로고    scopus 로고
    • Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells
    • Bettelli E., Dastrange M., Oukka M. Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells. Proc Natl Acad Sci U S A 2005, 102:5138-5143.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 5138-5143
    • Bettelli, E.1    Dastrange, M.2    Oukka, M.3
  • 37
    • 34247215187 scopus 로고    scopus 로고
    • Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1
    • Ono M., Yaguchi H., Ohkura N., Kitabayashi I., Nagamura Y., Nomura T., et al. Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1. Nature 2007, 446:685-689.
    • (2007) Nature , vol.446 , pp. 685-689
    • Ono, M.1    Yaguchi, H.2    Ohkura, N.3    Kitabayashi, I.4    Nagamura, Y.5    Nomura, T.6
  • 38
    • 33846340789 scopus 로고    scopus 로고
    • FOXP3: not just for regulatory T cells anymore
    • Ziegler S.F. FOXP3: not just for regulatory T cells anymore. Eur J Immunol 2007, 37:21-23.
    • (2007) Eur J Immunol , vol.37 , pp. 21-23
    • Ziegler, S.F.1
  • 39
    • 59849093427 scopus 로고    scopus 로고
    • Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation
    • Chauhan S.K., Saban D.R., Lee H.K., Dana R. Levels of Foxp3 in regulatory T cells reflect their functional status in transplantation. J Immunol 2009, 182:148-153.
    • (2009) J Immunol , vol.182 , pp. 148-153
    • Chauhan, S.K.1    Saban, D.R.2    Lee, H.K.3    Dana, R.4
  • 40
    • 80955181118 scopus 로고    scopus 로고
    • Moving to tolerance: clinical application of T regulatory cells
    • [Epub ahead of print] [PubMed: 21620722]
    • McMurchy A.N., Bushell A., Levings M., Wood K.J. Moving to tolerance: clinical application of T regulatory cells. Semin Immunol May 28, 2011, [Epub ahead of print] [PubMed: 21620722].
    • (2011) Semin Immunol
    • McMurchy, A.N.1    Bushell, A.2    Levings, M.3    Wood, K.J.4
  • 41
    • 79954558470 scopus 로고    scopus 로고
    • Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells
    • Wood K.J., Bushell A., Jones N.D. Immunologic unresponsiveness to alloantigen in vivo: a role for regulatory T cells. Immunol Rev 2011, 241:119-132.
    • (2011) Immunol Rev , vol.241 , pp. 119-132
    • Wood, K.J.1    Bushell, A.2    Jones, N.D.3
  • 43
    • 65549145814 scopus 로고    scopus 로고
    • Control of regulatory T cell lineage commitment and maintenance
    • Josefowicz S.Z., Rudensky A. Control of regulatory T cell lineage commitment and maintenance. Immunity 2009, 30:616-625.
    • (2009) Immunity , vol.30 , pp. 616-625
    • Josefowicz, S.Z.1    Rudensky, A.2


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