Biphasic, triphasic and multiphasic calcium orthophosphates

Acta Biomaterialia

Volumn 8, Issue 3, 2012, Pages 963-977

  Dorozhkin, Sergey V ^a  

^a NONE   (Russian Federation)

Author keywords

Biphasic; Calcium orthophosphates; Hydroxyapatite; Phase; Triphasic

Indexed keywords

BIOCERAMICS; BIOCOMPATIBILITY; BONE; CELL ENGINEERING; CONTROLLED DRUG DELIVERY; MEDICAL APPLICATIONS; SCAFFOLDS (BIOLOGY); TARGETED DRUG DELIVERY;

BIPHASIC; BONE DEFECT; CALCIUM ORTHOPHOSPHATE; DENTAL APPLICATIONS; IN-VITRO; MAXILLOFACIAL APPLICATIONS; ORTHOPAEDIC APPLICATIONS; PHASE; POLYPHASIC; TRI-PHASIC;

HYDROXYAPATITE;

AMORPHOUS CALCIUM PHOSPHATE; ANHYDROUS DICALCIUM PHOSPHATE; ANHYDROUS MONOCALCIUM PHOSPHATE; BIOCERAMICS; CALCIUM DEFICIENT HYDROXYAPATITE; CALCIUM PHOSPHATE; CALCIUM PHOSPHATE DIBASIC; CALCIUM PHOSPHATE MONOBASIC; FLUORAPATITE; HYDROXYAPATITE; MOLECULAR SCAFFOLD; TETRACALCIUM PHOSPHATE; UNCLASSIFIED DRUG;

ARTHRODESIS; AUTOGRAFT; BIOCHEMICAL COMPOSITION; BONE CONDUCTION; BONE MATRIX; BONE REMODELING; COMBUSTION; CRYSTAL STRUCTURE; DECOMPOSITION; HIGH TEMPERATURE; MOLECULAR STABILITY; OSSIFICATION; OSTEOLYSIS; OSTEOTOMY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; PROSTHESIS; REVIEW; SCANNING ELECTRON MICROSCOPY; THERMOSTABILITY; TISSUE ENGINEERING; X RAY DIFFRACTION; ZETA POTENTIAL;

EID: 84856538691     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2011.09.003     Document Type: Review

References (348)

1. H.A. Lowenstam, and S. Weiner On biomineralization 1989 Oxford University Press New York p. 324
2. S. Mann Biomimetic materials chemistry 1996 VCH Weinheim, Germany p. 400
3. S.V. Dorozhkin Calcium orthophosphates as bioceramics: state of the art J Funct Biomater 1 2010 22 107
4. S.V. Dorozhkin Medical application of calcium orthophosphate bioceramics Bio 1 2011 1 51
5. 2O J Cryst Growth 104 1990 820 832
6. L.C. Chow Development of self-setting calcium phosphate cements J Ceram Soc Jpn 99 1991 954 964
7. S.V. Dorozhkin Calcium orthophosphates J Mater Sci 42 2007 1061 1095
8. S.V. Dorozhkin Calcium orthophosphates in nature biology and medicine Materials 2 2009 399 498
9. D.A. Anuta, and D. Richardson Biphasic hydroxyapatite/beta-tricalcium phosphate granules bound in polymerized methyl methacrylate: bone substitute studies Transactions of the Annual Meeting of the Society for Biomaterials in Conjunction with the Interna 8 1985 62 (Pubitemid 18542254)
10. D.C. Moore, M.W. Chapman, and D.J. Manske Evaluation of a new biphasic calcium phosphate ceramic for use in grafting long bone diaphyseal defects Transactions of the Annual Meeting of the Society for Biomaterials in Conjunction with the Interna 8 1985 160 (Pubitemid 18542348)
11. E.I. Dorozhkina, and S.V. Dorozhkin Mechanism of the solid-state transformation of a calcium-deficient hydroxyapatite (CDHA) into biphasic calcium phosphate (BCP) at elevated temperatures Chem Mater 14 2002 4267 4272
12. S.V. Dorozhkin Mechanism of solid-state conversion of non-stoichiometric hydroxyapatite to diphase calcium phosphate Russ Chem Bull Int Ed 52 2003 2369 2375 (Pubitemid 39023728)
13. G. Daculsi, F. Jegoux, and P. Layrolle The micro macroporous biphasic calcium phosphate concept for bone reconstruction and tissue engineering B. Basu, D.S. Katti, A. Kumar, Advance biomaterials: fundamentals processing and applications 2009 Wiley-American Ceramic Society New York 101 142
14. G. Daculsi, S. Baroth, and R.Z. LeGeros 20 years of biphasic calcium phosphate bioceramics development and applications R. Narayan, P. Colombo, D. Singh, J. Salem, Advance in bioceramics and porous ceramics II 2010 Wiley-American Ceramic Society Newyork 45 58
15. G. Daculsi Biphasic calcium phosphate concept applied to artificial bone, implant coating and injectable bone substitute Biomaterials 19 1998 1473 1478 (Pubitemid 28470675)
16. S.E. Lobo, and L.T. Arinzeh Biphasic calcium phosphate ceramics for bone regeneration and tissue engineering applications Materials 3 2010 815 826
17. G. Daculsi, R.Z. LeGeros, E. Nery, K. Lynch, and B. Kerebel Transformation of biphasic calcium phosphate ceramics in vivo: ultrastructural and physicochemical characterization J Biomed Mater Res 23 1989 883 894 (Pubitemid 19192255)
18. A. Soueidan, O.I. Gan, J.M. Bouler, F. Gouin, and G. Daculsi Biodegradation of synthetic biphasic calcium phosphate and biological calcified substratum by cells of hemopoietic origin Cells Mater 5 1995 31 44
19. M. Benahmed, J.M. Bouler, D. Heymann, O. Gan, and G. Daculsi Biodegradation of synthetic biphasic calcium phosphate by human monocytes in vitro: a morphological study Biomaterials 17 1996 2173 2178 (Pubitemid 26364771)
20. N. Kivrak, and A.C. Ta Synthesis of calcium hydroxyapatite-tricalcium phosphate (HA-TCP) composite bioceramic powders and their sintering behavior J Am Ceram Soc 81 1998 2245 2252 (Pubitemid 128594865)
21. H.Y. Yasuda, S. Mahara, T. Nishiyama, and Y. Umakoshi Preparation of hydroxyapatite/α-tricalcium phosphate composites by colloidal process Sci Tech Adv Mater 3 2002 29 33 (Pubitemid 34141155)
22. S.H. Kwon, Y.K. Jun, S.H. Hong, and H.E. Kim Synthesis and dissolution behavior of β-TCP and HA/β-TCP composite powders J Eur Ceram Soc 23 2003 1039 1045
23. H.R.R. Ramay, and M. Zhang Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering Biomaterials 25 2004 5171 5180 (Pubitemid 38510403)
24. S. Kannan, and J.M.F. Ferreira Synthesis and thermal stability HAP and β-TCP composites with co-substituted sodium magnesium and fluorine Chem Mater 18 2006 198 203 (Pubitemid 43112890)
25. 2 composites Sci Sintering 38 2006 245 253
26. Y. Li, D. Li, and W. Weng In vitro dissolution behavior of biphasic tricalcium phosphate composite powders composed of α-tricalcium phosphate and β-tricalcium phosphate Key Eng Mater 368-372 2008 1206 1208 (Pubitemid 351414086)
27. A.K. Guha, S. Singh, R. Kumaresan, S. Nayar, and A. Sinha Mesenchymal cell response to nanosized biphasic calcium phosphate composites Coll Surf B Biointerfaces 73 2009 146 151
28. Y. Huang, W. Huang, L. Sun, Q. Wang, A. He, and C.C. Han Phase transition from α-TCP into β-TCP in TCP/HA composites Int J Appl Ceram Technol 7 2010 184 188
29. B. Viswanath, and N. Ravishankar Biphasic composite of tricalcium phosphate reinforced with hydroxyapatite whiskers Mater Res Soc Symp Proc 898 2005 80 85 (Pubitemid 46884533)
30. T. Liu, D.A. Yang, and L. Di Preparation of β-TCP/HAP composite bioceramics Key Eng Mater 336-338 2007 1642 1645
31. K. Cheng, S. Zhang, and W.J. Weng Sol-gel prepared β-TCP/FHA biphasic coatings Thin Solid Films 515 2006 135 140 (Pubitemid 44572080)
32. K. Cheng, S. Zhang, W. Weng, K.A. Khor, S. Miao, and Y. Wang The adhesion strength and residual stress of colloidal-sol gel derived β-tricalcium- phosphate/fluoridated-hydroxyapatite biphasic coatings Thin Solid Films 516 2008 3251 3255
33. G. Daculsi, D. Chappard, E. Aguado, G. Legeay, P. Layrolle, and P. Weiss Multiphasic biomaterials: a concept for bone substitutes developed in the "Pays de la Loire" Key Eng Mater 361-363 2008 17
34. G. Daculsi, A.P. Uzel, P. Weiss, E. Goyenvalle, and E. Aguado Developments in injectable multiphasic biomaterials. The performance of microporous biphasic calcium phosphate granules and hydrogels J Mater Sci: Mater Med 21 2010 855 861
35. J. Bernstein Polymorphism in molecular crystals 2002 Oxford University Press New York p. 424
36. J. Bernstein Polymorphism - a perspective Cryst Growth Des 11 2011 632 650
37. R.F. Ellinger, E.B. Nery, and K.L. Lynch Histological assessment of periodontal osseous defects following implantation of hydroxyapatite and biphasic calcium phosphate ceramics: a case report Int J Periodont Restor Dent 3 1986 22 33
38. E.B. Nery, K.L. Lynch, W.M. Hirthe, and K.H. Mueller Bioceramic implants in surgically produced infrabony defects J Periodontol 46 1975 328 347
39. R.Z. LeGeros Calcium phosphate materials in restorative dentistry: a review Adv Dent Res 2 1988 164 183
40. I.R. Gibson, I. Rehman, S.M. Best, and W. Bonfield Characterization of the transformation from calcium-deficient apatite to β-tricalcium phosphate J Mater Sci Mater Med 11 2000 799 804 (Pubitemid 32014534)
41. X. Yang, X. Lu, Q. Zhang, X. Zhang, Z. Gu, and J. Chen BCP coatings on pure titanium plates by CD method Mater Sci Eng C 27 2007 781 786 (Pubitemid 46617251)
42. E.S. Molloy, M.P. Morgan, B. McDonnell, J. O'Byrne, and G.M. McCarthy BCP crystals increase prostacyclin production and upregulate the prostacyclin receptor in OA synovial fibroblasts: potential effects on mPGES1 and MMP-13 Osteoarthritis Cartilage 15 2007 414 420 (Pubitemid 46394284)
43. A. Lecomte, H. Gautier, J.M. Bouler, A. Gouyette, Y. Pegon, and G. Daculsi Biphasic calcium phosphate: a comparative study of interconnected porosity in two ceramics J Biomed Mater Res B Appl Biomater 84B 2008 1 6
44. F. Tancret, J.M. Bouler, J. Chamousset, and L.M. Minois Modelling the mechanical properties of microporous and macroporous biphasic calcium phosphate bioceramics J Eur Ceram Soc 26 2006 3647 3656 (Pubitemid 44418015)
45. J.M. Bouler, M. Trecant, J. Delecrin, J. Royer, N. Passuti, and G. Daculsi Macroporous biphasic calcium phosphate ceramics: influence of five synthesis parameters on compressive strength J Biomed Mater Res 32 1996 603 609 (Pubitemid 26403525)
46. G. Daculsi, P. Weiss, J.M. Bouler, O. Gauthier, F. Millot, and E. Aguado Biphasic calcium phosphate/hydrosoluble polymer composites: a new concept for bone and dental substitution biomaterials Bone 25 Suppl. 2 1999 59S 61S (Pubitemid 29333181)
47. O. Gauthier, E. Goyenvalle, J.M. Bouler, J. Guicheux, P. Pilet, and P. Weiss At al. Macroporous biphasic calcium phosphate ceramics versus injectable bone substitute: a comparative study 3 and 8 weeks after implantation in rabbit bone J Mater Sci: Mater Med 12 2001 385 390 (Pubitemid 32488113)
48. R.Z. LeGeros, S. Lin, R. Rohanizadeh, D. Mijares, and J.P. LeGeros Biphasic calcium phosphate bioceramics: preparation, properties and applications J Mater Sci Mater Med 14 2003 201 209 (Pubitemid 36408019)
49. G. Daculsi, O. Laboux, O. Malard, and P. Weiss Current state of the art of biphasic calcium phosphate bioceramics J Mater Sci Mater Med 14 2003 195 200 (Pubitemid 36408018)
50. I. Alam, I. Asahina, K. Ohmamiuda, and S. Enomoto Comparative study of biphasic calcium phosphate ceramics impregnated with rhBMP-2 as bone substitutes J Biomed Mater Res 54 2001 129 138
51. G. Daculsi Biphasic calcium phosphate granules concept for injectable and mouldable bone substitute Adv Sci Technol 49 2006 9 13
52. S.E. Lobo, and T.L. Arinzeh Biphasic calcium phosphate ceramics for bone regeneration and tissue engineering applications Materials 3 2010 815 826
53. R.Z. LeGeros Variability of HAP/β-TCP ratios in sintered apatites J Dent Res 65 1986 292
54. S.D. Langstaff, M. Sayer, T.J.N. Smith, S.M. Pugh, S.A.M. Hesp, and W.T. Thompson Resorbable bioceramics based on stabilized calcium phosphates. Part I: Rational design, sample preparation and material characterization Biomaterials 20 1999 1727 1741 (Pubitemid 29393128)
55. S.D. Langstaff, M. Sayer, T.J.N. Smith, and S.M. Pugh Resorbable bioceramics based on stabilized calcium phosphates. Part II: Evaluation of biological response Biomaterials 22 2001 135 150
56. J.W. Reid, A.M. Pietak, M. Sayer, D. Dunfield, and T.J.N. Smith Phase formation and evolution in the silicon substituted tricalcium phosphate/apatite system Biomaterials 26 2005 2887 2897 (Pubitemid 39650940)
57. L. Pan, Y. Li, W. Weng, K. Cheng, C. Song, and P. Du Preparation of submicron biphasic α-TCP/HA powders Key Eng Mater 309-311 2006 219 222
58. C. Kui Slip casting derived α-TCP/HA biphasic ceramics Key Eng Mater 330-332 2007 51 54 (Pubitemid 46121056)
59. S. Sanchez-Sálcedo, D. Arcos, and M. Vallet-Regí Upgrading calcium phosphate scaffolds for tissue engineering applications Key Eng Mater 377 2008 19 42 (Pubitemid 351702015)
60. Y. Li, F. Kong, and W. Weng Preparation and characterization of novel biphasic calcium phosphate powders (α-TCP/HA) derived from carbonated amorphous calcium phosphates J Biomed Mater Res B Appl Biomater 89B 2009 508 517
61. M. Oishi, C. Ohtsuki, M. Kitamura, M. Kamitakahara, S. Ogata, and T. Miyazaki Fabrication and chemical durability of porous bodies consisting of biphasic tricalcium phosphates Phosphorus Res Bull 17 2004 95 100
62. M. Kamitakahara, C. Ohtsuki, M. Oishi, S. Ogata, T. Miyazaki, and M. Tanihara Preparation of porous biphasic tricalcium phosphate and its in vivo behavior Key Eng Mater 284-286 2005 281 284 (Pubitemid 46780359)
63. R. Wang, W. Weng, X. Deng, K. Cheng, X. Liu, and P. Du Dissolution behavior of submicron biphasic tricalcium phosphate powders Key Eng Mater 309-311 2006 223 226
64. Y. Li, W. Weng, and K.C. Tam Novel highly biodegradable biphasic tricalcium phosphates composed of α-tricalcium phosphate and β-tricalcium phosphate Acta Biomater 3 2007 251 254 (Pubitemid 46223891)
65. C. Zou, K. Cheng, W. Weng, C. Song, P. Du, and G. Shen Characterization and dissolution-reprecipitation behavior of biphasic tricalcium phosphate powders J Alloys Compounds 509 2011 6852 6858
66. J.S.V. Albuquerque, R.E.F.Q. Nogueira, T.D. Pinheiro da Silva, D.O. Lima, and M.H. Prado da Silva Porous triphasic calcium phosphate bioceramics Key Eng Mater 254-256 2004 1021 1024
67. J.W. Reid, and J.A. Hendry Rapid, accurate phase quantification of multiphase calcium phosphate materials using Rietveld refinement J Appl Crystallogr 39 2006 536 543 (Pubitemid 44125584)
68. F. Mendona, L.H.L. Louro, J.B. de Campos, and M.H.P. da Silva Porous biphasic and triphasic bioceramics scaffolds produced by gelcasting Key Eng Mater 361-363 2008 27 30
69. R. Vani, E.K. Girija, K. Elayaraja, P.S. Prakash, R. Kesavamoorthy, and K.S. Narayana Hydrothermal synthesis of porous triphasic hydroxyapatite/(α and β) tricalcium phosphate J Mater Sci Mater Med 20 2009 S43 S48
70. B.T. Lee, M.H. Youn, R.K. Paul, K.H. Lee, and H.Y. Song In situ synthesis of spherical BCP nanopowders by microwave assisted process Mater Chem Phys 104 2007 249 253 (Pubitemid 47069619)
71. O. Brown, M. McAfee, S. Clarke, and F. Buchanan Sintering of biphasic calcium phosphates J Mater Sci Mater Med 21 2010 2271 2279
72. E. Caroline Victoria, and F.D. Gnanam Synthesis and characterisation of biphasic calcium phosphate Trends Biomater Artif Organs 16 2002 12 14
73. S. Lin, R.Z. LeGeros, R. Rohanizadeh, D. Mijares, and J.P. LeGeros Biphasic calcium phosphate (BCP) bioceramics: preparation and properties Key Eng Mater 240-242 2004 473 476
74. O.E. Petrov, E. Dyulgerova, L. Petrov, and R. Popova Characterization of calcium phosphate phases obtained during the preparation of sintered biphase Ca-P ceramics Mater Lett 48 2001 162 167 (Pubitemid 32279469)
75. M. Maciejewski, T.J. Brunner, S.F. Loher, W.J. Stark, and A. Baiker Phase transitions in amorphous calcium phosphates with different Ca/P ratios Thermochim Acta 468 2008 75 80
76. Z.Z. Zyman, M.V. Tkachenko, and D.V. Polevodin Preparation and characterization of biphasic calcium phosphate ceramics of desired composition J Mater Sci Mater Med 19 2008 2819 2825
77. M. Lukić, Z. Stojanović, S.D. Škapin, M. Maček-Kržmanc, M. Mitrić, and S. Marković Dense fine-grained biphasic calcium phosphate (BCP) bioceramics designed by two-step sintering J Eur Ceram Soc 31 2011 19 27
78. I. Manjubala, and M. Sivakimar In situ synthesis of biphasic calcium phosphate ceramics using microwave irradiation Mater Chem Phys 71 2001 272 278 (Pubitemid 32716076)
79. J. Ji, J. Ran, L. Gou, F. Wang, and L. Sun Microwave plasma sintering and in vitro study of porous HA/β-TCP biphasic bioceramics Key Eng Mater 280-283 2005 1519 1524 (Pubitemid 46840870)
80. I. Manjubala, T.P. Sastry, and R.V. Kumar Bone in-growth induced by biphasic calcium phosphate ceramic in femoral defect of dogs J Biomater Appl 19 2005 341 360 (Pubitemid 40573244)
81. S. Jalota, S.B. Bhaduri, and A.C. Tas In vitro testing of calcium phosphate (HA TCP and biphasic HA-TCP) whiskers J Biomed Mater Res A 78A 2006 481 490 (Pubitemid 44255497)
82. S.P. Victor, and T.S. Sampath Kumar BCP ceramic microspheres as drug delivery carriers: synthesis, characterisation and doxycycline release J Mater Sci Mater Med 19 2008 283 290
83. N. Rameshbabu, and K. Prasad Rao Microwave synthesis, characterization and in-vitro evaluation of nanostructured biphasic calcium phosphates Cur Appl Phys 9 2009 S29 S31
84. A. Farzadi, M. Solati-Hashjin, Z. Tahmasebi-Birgani, and A. Aminian Microwave-assisted synthesis and characterization of biphasic calcium phosphate nanopowders Ceram Trans 218 2010 59 65
85. D. Veljović, E. Palcevskis, A. Dindune, S. Putić, I. Balać, and R. Petrović Microwave sintering improves the mechanical properties of biphasic calcium phosphates from hydroxyapatite microspheres produced from hydrothermal processing J Mater Sci 45 2010 3175 3183
86. D. Veljović, I. Zalite, E. Palcevskis, I. Smiciklas, R. Petrović, and D. Janaćković Microwave sintering of fine grained HAP and HAP/TCP bioceramics Ceram Int 36 2010 595 603
87. J. Marchi, P. Greil, J.C. Bressiani, A. Bressiani, and F. Müller Influence of synthesis conditions on the characteristics of biphasic calcium phosphate powders Int J Appl Ceram Technol 6 2009 60 71
88. X. Yang, and Z. Wang Synthesis of biphasic ceramics of hydroxyapatite and β-tricalcium phosphate with controlled phase content and porosity J Mater Chem 8 1998 2233 2237 (Pubitemid 128703210)
89. T.R. Tadjiev, C. Sungsu, and K. Sukyoung Mechano-chemical synthesis of biphasic calcium phosphates with the various ratio of HA and β-TCP Key Eng Mater 330-332 2007 7 10 (Pubitemid 46121045)
90. R.R. Rao, H.N. Roopa, and T.S. Kannan Solid state synthesis and thermal stability of HAP and HAP-β-TCP composite ceramic powders J Mater Sci Mater Med 8 1997 511 518 (Pubitemid 27359044)
91. 3 Mater Chem Phys 80 2003 409 420
92. 3 J Therm Anal Calorim 83 2006 145 149 (Pubitemid 43383227)
93. J.S. Cho, Y.N. Ko, H.Y. Koo, and Y.C. Kang Synthesis of nano-sized biphasic calcium phosphate ceramics with spherical shape by flame spray pyrolysis J Mater Sci Mater Med 21 2010 1143 1149
94. J. Peña, and M. Vallet-Regí Hydroxyapatite, tricalcium phosphate and biphasic materials prepared by a liquid mix technique J Eur Ceram Soc 23 2003 1687 1696 (Pubitemid 36568157)
95. J. Chen, Y. Wang, X. Chen, R. Li, L. Chen, and H. Wen A simple sol-gel technique for synthesis of nanostructured hydroxyapatite, tricalcium phosphate and biphasic powders Mater Lett 65 2011 1923 1926
96. I. Sopyan, and A.N. Natasha Preparation of nanostructured manganese-doped biphasic calcium phosphate powders via sol-gel method Ionics 15 2009 735 741
97. C. Schopper, F. Ziya-Ghazvini, W. Goriwoda, D. Moser, F. Wanschitz, and E. Spassova HA/TCP compounding of a porous CaP biomaterial improves bone formation and scaffold degradation-a long-term histological study J Biomed Mater Res B Appl Biomater 74B 2005 458 467 (Pubitemid 40917716)
98. M. Castillo, R.A. Ayers, X. Zhang, F. Schowengerdt, and J.J. Moore Combustion synthesis of porous glasses and ceramics for bone repair Biomed Sci Instrum 37 2001 469 474 (Pubitemid 32381481)
99. R. Ayers, S. Nielsen-Preiss, V. Ferguson, G. Guglielmo, J.J. Moore, and H.J. Kleebe Osteoblast-like cell mineralization induced by multiphasic calcium phosphate ceramic Mater Sci Eng C 26 2006 1333 1337 (Pubitemid 44164661)
100. R. Ayers, N. Hannigan, N. Vollmer, and C. Unuvar Combustion synthesis of heterogeneous calcium phosphate bioceramics from calcium oxide and phosphate precursors Int J Self-Propag High-Temp Synth 20 2011 6 14
101. 2O addition Biomaterials 20 1999 475 484
102. 4 J Biomed Mater Res 51 2000 157 163
103. F. Tavangarian, R. Emadi, and S.I. Roohani Esfahani A novel method to synthesis of β-TCP/HA biphasic nanocrystalline powder by using bovine bone Int J Modern Physics B 24 2010 3365 3372
104. R. Emadi, S.I. Roohani Esfahani, and F. Tavangarian A novel, low temperature method for the preparation of β-TCP/HAP biphasic nanostructured ceramic scaffold from natural cancellous bone Mater Lett 64 2010 993 996
105. H.B. Jin, C.B. Guo, K.Y. Mao, S. Dorozhkin, and S. Agathopoulos Preparation of porous biphasic β-TCP/HA bioceramics with a natural trabecular structure from calcined cancellous bovine bone J Ceram Soc Jpn 118 2010 52 56
106. P. Sarin, S.J. Lee, Z.D. Apostolov, and W.M. Kriven Porous biphasic calcium phosphate scaffolds from cuttlefish bone J Am Ceram Soc 94 2011 2362 2370
107. N.R. Babu, K.P. Rao, and T.S.S. Kumar Effect of coralline derived biphasic calcium phosphate shot blasting on titanium surfaces Trans Indian Inst Met 57 2004 85 89 (Pubitemid 39289190)
108. T. Nakano, K. Kaibara, Y. Umakoshi, S. Imazato, K. Ogata, and A. Ehara Change in microstructure and solubility improvement of HAp ceramics by heat-treatment in a vacuum Mater Trans 43 2002 3105 3111
109. W. Kiba, S. Imazato, Y. Takahashi, S. Yoshioka, S. Ebisu, and T. Nakano Efficacy of polyphasic calcium phosphates as a direct pulp capping material J Dent 38 2010 828 837
110. J. Weng, X. Liu, X. Zhang, Z. Ma, X. Ji, and Z.Z. Zyman Further studies on the plasma-sprayed amorphous phase in hydroxyapatite coatings and its deamorphization Biomaterials 14 1993 578 582 (Pubitemid 23219801)
111. K.A. Gross, C.C. Berndt, and H. Herman Amorphous phase formation in plasma-sprayed hydroxyapatite coatings J Biomed Mater Res 39 1998 407 414 (Pubitemid 28063456)
112. 9 Inorg Chem 6 1967 884 891
113. M.T. Carayon, and J.L. Lacout Study of the Ca/P atomic ratio of the amorphous phase in plasma-sprayed hydroxyapatite coatings J Solid State Chem 172 2003 339 350
114. D.J. Yang, T.R. Tadjiev, J.W. Kim, C.K. You, S.K. Choi, and K.B. Park Comparative study of the degradation behavior of mechanically mixed and chemically precipitated biphasic calcium phosphates Key Eng Mater 309-311 2006 227 230
115. Y. Zhang, Y. Yokogawa, and T. Kameyama Bimodal porous bi-phasic calcium phosphate ceramics and its dissolution in SBF solution Key Eng Mater 330-332 2007 91 94 (Pubitemid 46121066)
116. Y. Zhang, Y. Yokogawa, and T. Kameyama Preparation of biphasic calcium phosphate porous ceramics prepared from fine powders with different particle size and its dissolution behavior in simulated body fluid Key Eng Mater 336-338 2007 1688 1691 (Pubitemid 46424957)
117. R.W.N. Nilen, and P.W. Richter The thermal stability of hydroxyapatite in biphasic calcium phosphate ceramics J Mater Sci: Mater Med 19 2008 1693 1702 (Pubitemid 351409326)
118. Y.M. Kong, H.E. Kim, and H.W. Kim Phase conversion of tricalcium phosphate into Ca-deficient apatite during sintering of hydroxyapatite- tricalcium phosphate biphasic ceramics J Biomed Mater Res B Appl Biomater 84B 2008 334 339
119. Y. Tanimoto, Y. Shibata, A. Murakami, T. Miyazaki, and N. Nishiyama Effect of varying HAP/TCP ratios in tape-cast biphasic calcium phosphate ceramics on response in vitro J Hard Tissue Biol 18 2009 71 76
120. P. Wongwitwichot, J. Kaewsrichan, K.H. Chua, and B.H.I. Ruszymah Comparison of TCP and TCP/HA hybrid scaffolds for osteoconductive activity Open Biomed Eng J 4 2010 279 285
121. C.L. Hung, J.C. Yang, W.J. Chang, C.Y. Hu, Y.H. Lin, and C.H. Huang In vivo graft performance of an improved bone substitute composed of poor crystalline hydroxyapatite based biphasic calcium phosphate Dent Mater J 30 2011 21 28
122. Y.K. Jun, S.H. Hong, and Y.M. Kong Effect of co-precipitation on the low-temperature sintering of biphasic calcium phosphate J Am Ceram Soc 89 2006 2295 2297
123. Y. Sogo, T. Sakurai, K. Onuma, and A. Ito The most appropriate (Ca+Zn)/P molar ratio to minimize the zinc content of ZnTCP/HAP ceramic used in the promotion of bone formation J Biomed Mater Res 62 2002 457 463 (Pubitemid 35332210)
124. A.M. Costa, G.A. Soares, R. Calixto, and A.M. Rossi Preparation and properties of zinc containing biphasic calcium phosphate bioceramics Key Eng Mater 254-256 2004 119 122
125. I. Manjubala, and T.S.S. Kumar Preparation of biphasic calcium phosphate doped with magnesium fluoride for osteoporotic applications J Mater Sci Lett 20 2001 1225 1227 (Pubitemid 32829658)
126. H.S. Ryu, K.S. Hong, J.K. Lee, D.J. Kim, J.H. Lee, and B.S. Chang Magnesia-doped HA/β-TCP ceramics and evaluation of their biocompatibility Biomaterials 25 2004 393 401 (Pubitemid 37329690)
127. S. Kannan, I.A.F. Lemos, J.H.G. Rocha, and J.M.F. Ferreira Synthesis and characterization of magnesium substituted biphasic mixtures of controlled hydroxyapatite/β-tricalcium phosphate ratios J Solid State Chem 178 2005 3190 3196 (Pubitemid 41376005)
128. H.S. Ryu, K.S. Hong, J.K. Lee, and D.J. Kim Variations of structure and composition in magnesium incorporated hydroxyapatite/β-calcium phosphate J Mater Res 21 2006 428 436 (Pubitemid 43292860)
129. S. Kannan, F. Goetz-Neunhoeffer, J. Neubauer, A.H.S. Rebelo, P. Valério, and J.M.F. Ferreira Rietveld structure and in vitro analysis on the influence of magnesium in biphasic (hydroxyapatite and β-tricalcium phosphate) mixtures J Biomed Mater Res B Appl Biomater 90B 2009 404 411
130. S. Gomes, G. Renaudin, E. Jallot, and J.M. Nedelec Structural characterization and biological fluid interaction of sol-gel-derived Mg-substituted biphasic calcium phosphate ceramics ACS Appl Mater Interfaces 1 2009 505 513
131. M. Tamai, K. Isama, R. Nakaoka, and T. Tsuchiya Synthesis of a novel β-tricalcium phosphate/hydroxyapatite biphasic calcium phosphate containing niobium ions and evaluation of its osteogenic properties J Artif Organs 10 2007 22 28 (Pubitemid 46475002)
132. S. Kannan, J.M. Ventura, and J.M.F. Ferreira In situ formation and characterization of fluorine-substituted biphasic calcium phosphate ceramics of varied F-HAP/β-TCP ratios Chem Mater 17 2005 3065 3068 (Pubitemid 40857999)
133. S. Kannan, J.H.G. Rocha, and J.M.F. Ferreira Synthesis of hydroxy-chloroapatites solid solutions Mater Lett 60 2006 864 868
134. S. Kannan, J.M.G. Ventura, A.F. Lemos, A. Barba, and J.M.F. Ferreira Effect of sodium addition on the preparation of hydroxyapatites and biphasic ceramics Ceram Int 34 2008 7 13 (Pubitemid 47633738)
135. S. Kannan, J.M.G. Ventura, and J.M.F. Ferreira Synthesis and thermal stability of potassium substituted hydroxyapatites and hydroxyapatite/β- tricalciumphosphate mixtures Ceram Int 33 2007 1489 1494 (Pubitemid 47445944)
136. S. Kannan, A. Rebelo, A.F. Lemos, A. Barba, and J.M.F. Ferreira Synthesis and mechanical behaviour of chlorapatite and chlorapatite/β-TCP composites J Eur Ceram Soc 27 2007 2287 2294 (Pubitemid 44933046)
137. I. Mayer, F.J.G. Cuisinier, I. Popov, Y. Schleich, S. Gdalya, and O. Burghaus Phase relation between β-tricalcium phosphate and hydroxyapatite with manganese (II): structural and spectroscopic properties Eur J Inorg Chem 7 2006 1460 1465
138. I. Sopyan, N.A. Nawawi, and Q.H. Shah Dense manganese doped biphasic calcium phosphate for load bearing bone implants Adv Mater Res 93-94 2010 393 396
139. Sopyan I, Ramesh S, Nawawi NA, Tampieri A, Sprio S. Effects of manganese doping on properties of sol-gel derived biphasic calcium phosphate ceramics. Ceram Int 2011; submitted for publication.
140. S. Kannan, F. Goetz-Neunhoeffer, J. Neubauer, and J.M.F. Ferreira Ionic substitution in biphasic hydroxyapatite and β-tricalcium phosphate mixtures: structural analysis by Rietveld refinement J Am Ceram Soc 91 2008 1 12
141. B. Li, X. Chen, B. Guo, X. Wang, H. Fan, and X. Zhang Fabrication and cellular biocompatibility of porous carbonated biphasic calcium phosphate ceramics with a nanostructure Acta Biomater 5 2009 134 143
142. 3+-doped bi-phase calcium phosphate under visible light J Mater Sci 45 2010 1237 1241
143. S. Gomes, G. Renaudin, A. Mesbah, E. Jallot, C. Bonhomme, and F. Babonneau Thorough analysis of silicon substitution in biphasic calcium phosphate bioceramics: a multi-technique study Acta Biomater 6 2010 3264 3274
144. P. Kanchana, and C. Sekar Influence of strontium on the synthesis and surface properties of biphasic calcium phosphate (BCP) bioceramics J Appl Biomater Biomech 8 2010 153 158
145. S. Kannan, S.I. Vieira, S.M. Olhero, P.M.C. Torres, S. Pina, and O.A.B. da Cruz e Silva Synthesis, mechanical and biological characterization of ionic doped carbonated hydroxyapatite/β-tricalcium phosphate mixtures Acta Biomater 7 2011 1835 1843
146. H.W. Kim, Y.H. Koh, Y.M. Kong, J.G. Kang, and H.E. Kim Strontium substituted calcium phosphate biphasic ceramics obtained by a powder precipitation method J Mater Sci Mater Med 15 2004 1129 1134
147. D. Guo, K. Xu, and Y. Liu Physicochemical properties and cytotoxicities of Sr-containing biphasic calcium phosphate bone scaffolds J Mater Sci Mater Med 21 2010 1927 1936
148. K. Takahashi, J.J.J.P. van den Beucken, J.G.C. Wolke, T. Hayakawa, N. Nishiyama, and J.A. Jansen Characterization and in vitro evaluation of biphasic calcium pyrophosphate-tricalciumphosphate radio frequency magnetron sputter coatings J Biomed Mater Res A 84A 2008 682 690 (Pubitemid 351237785)
149. G. Chen, W. Li, B. Zhao, and K. Sun A novel biphasic bone scaffold: β-calcium phosphate and amorphous calcium polyphosphate J Am Ceram Soc 92 2009 945 948
150. Y.W. Yang, T.Q. Mao, Z. Gao, R. Hou, X.D. Su, and X.G. Hu Biocompatibility of ostrich multiphasic calcium phosphate ceramic scaffold Chin J Clin Rehabil 8 2004 2626 2627 (Pubitemid 39029814)
151. S.V. Dorozhkin Calcium orthophosphate cements for biomedical application J Mater Sci 43 2008 3028 3057
152. S.V. Dorozhkin Calcium orthophosphate cements and concretes Materials 2 2009 221 291
153. M. Kohri, K. Miki, D.E. Waite, H. Nakajima, and T. Okabe In vitro stability of biphasic calcium phosphate ceramics Biomaterials 14 1993 299 304 (Pubitemid 23106676)
154. D. Guo, K. Xu, and Y. Han The in situ synthesis of biphasic calcium phosphate scaffolds with controllable compositions, structures, and adjustable properties J Biomed Mater Res A 88A 2009 43 52
155. P. Jian, T. Jiemo, D. Limin, W. Chen, and Z. Qingfeng Self-setting biphase porous calcium phosphate cement Key Eng Mater 336-338 2007 1615 1617 (Pubitemid 46424938)
156. K.A. Gross, and K.A. Bhadang Sintered hydroxyfluorapatites. Part III: Sintering and resultant mechanical properties of sintered blends of hydroxyapatite and fluorapatite Biomaterials 25 2004 1395 1405 (Pubitemid 37479318)
157. K.A. Bhadang, and K.A. Gross Influence of fluorapatite on the properties of thermally sprayed hydroxyapatite coatings Biomaterials 25 2004 4935 4945 (Pubitemid 38520824)
158. S.M. Barinov, L.I. Shvorneva, D. Ferro, I.V. Fadeeva, and S.V. Tumanov Solid solution formation at the sintering of hydroxyapatite-fluorapatite ceramics Sci Technol Adv Mater 5 2004 537 541
159. K.A. Bhadang, and K.A. Gross Mechanical property development in isothermally sintered mechanical blends of hydroxyapatite and fluorapatite J Australas Ceram Soc 41 2005 56 67
160. H.B. van Rees, M. Mengeot, and E. Kostiner Monoclinic-hexagonal transition in hydroxyapatite and deuterohydroxyapatite single crystals Mater Res Bull 8 1973 1307 1309
161. 3/m) reversible phase transition in hydroxyapatite Thermochim Acta 371 2001 53 56 (Pubitemid 32299115)
162. O. Hochrein, R. Kniep, and D. Zahn Atomistic simulation study of the order/disorder (monoclinic to hexagonal) phase transition of hydroxyapatite Chem Mater 17 2005 1978 1981 (Pubitemid 40567206)
163. V.J. Mulley, and C.D. Cavendish A thermogravimetric method for the analysis of mixtures of brushite and monetite Analyst 95 1970 304 307
164. 4 and the formation of an amorphous phase Am Mineral 96 2011 368 373
165. A.M. Kaushal, V.R. Vangala, and R. Suryanarayanan Unusual effect of water vapor pressure on dehydration of dibasic calcium phosphate dehydrate J Pharm Sci 100 2011 1456 1466
166. 2O and their reactions with KCl, examined with simultaneous TG, DTG, DTA and EGA J Therm Anal 17 1979 479 488
167. 2O Russ J Phys Chem 72 1998 1391 1393
168. 2O system under thermal treatment Thermochim Acta 168 1990 103 113
169. 2O Thermochim Acta 173 1990 101 115
170. H. Kim, R.P. Camata, Y.K. Vohra, and W.R. Lacefield Control of phase composition in hydroxyapatite/tetracalcium phosphate biphasic thin coatings for biomedical applications J Mater Sci Mater Med 16 2005 961 966 (Pubitemid 41356689)
171. L. Perez, L.J. Shyu, and G.H. Nancollas The phase transformation of calcium phosphate dihydrate into octacalcium phosphate in aqueous suspensions Colloid Surf 38 1989 295 304
172. J. Zhang, A. Ebrahimpour, and G.H. Nancollas Dual constant composition studies of phase transformation of dicalcium phosphate dihydrate into octacalcium phosphate J Colloid Interface Sci 152 1992 132 140
173. 2O) transformation in DMEM solutions at 36.5 C Mater Sci Eng C 30 2010 245 254
174. N. Temizel, G. Girisken, and A.C. Tas Accelerated transformation of brushite to octacalcium phosphate in new biomineralization media between 36.5°C and 80°C Mater Sci Eng C 31 2011 1136 1143
175. L. Morejón-Alonso, R.G. Carrodeguas, J.A.D. García-Menocal, J.A.A. Pérez, and S.M. Manent Effect of sterilization on the properties of CDHA-OCP-β-TCP biomaterial Mater Res 10 2007 15 20 (Pubitemid 46813357)
176. L. Morejón-Alonso, R.G. Carrodeguas, and J.A.D. García-Menocal Transformations in CDHA/OCP/β-TCP scaffold during ageing in simulated body fluid at 36.5°C J Biomed Mater Res B Appl Biomater 84B 2008 386 393
177. S. Yamada, D. Heymann, J.M. Bouler, and G. Daculsi Osteoclastic resorption of biphasic calcium phosphate ceramic in vitro J Biomed Mater Res 37 1997 346 352 (Pubitemid 27481449)
178. S. Yamada, D. Heymann, J.M. Bouler, and G. Daculsi Osteoclastic resorption of calcium phosphate ceramics with different hydroxyapatite/β- tricalcium phosphate ratios Biomaterials 18 1997 1037 1041 (Pubitemid 27322607)
179. M. Schumacher, U. Deisinger, G. Ziegler, and R. Detsch Indirect rapid prototyping of biphasic calcium phosphate scaffolds as bone substitutes: influence of phase composition macroporosity and pore geometry on mechanical properties J Mater Sci Mater Med 21 2010 3119 3127
180. M. Schumacher, F. Uhl, R. Detsch, U. Deisinger, and G. Ziegler Static and dynamic cultivation of bone marrow stromal cells on biphasic calcium phosphate scaffolds derived from an indirect rapid prototyping technique J Mater Sci Mater Med 21 2010 3039 3048
181. D.V. Tuyen, and B.T. Lee Formation and characterization of porous spherical biphasic calcium phosphate (BCP) granules using PCL Ceram Int 37 2011 2043 2049
182. J.M. Bouler, and G. Daculsi In vitro carbonated apatite precipitation on biphasic calcium phosphate pellets presenting various HA/β-TCP ratios Key Eng Mater 192-195 2001 119 122 (Pubitemid 32073882)
183. Y. Leng, J. Chen, and S. Qu TEM study of calcium phosphate precipitation on HA/TCP ceramics Biomaterials 24 2003 2125 2131 (Pubitemid 36434031)
184. Y.R. Duan, Z.R. Zhang, C.Y. Wang, J.Y. Chen, and X.D. Zhang Dynamic study of calcium phosphate formation on porous HA/TCP ceramics J Mater Sci Mater Med 15 2004 1205 1211
185. C. Deng, Y. Wang, Y. Wu, X. Wang, X. Chen, and H. Zheng Apatite formation on porous HA/TCP in animals' serums in vitro Key Eng Mater 330-332 2007 955 958 (Pubitemid 46120930)
186. C. Deng, Y. Wang, J. Chen, H. Zheng, H. Chen, and D. Zhang Growth of apatite in bovine serums on porous HA/TCP ceramics Key Eng Mater 368-372 2008 1184 1186 (Pubitemid 351414079)
187. J. Toquet, R. Rohanizadeh, J. Guicheux, S. Couillaud, N. Passuti, and G. Daculsi Osteogenic potential in vitro of human bone marrow cells cultured on macroporous biphasic calcium phosphate ceramic J Biomed Mater Res 44 1999 98 108
188. S.N. Silva, M.M. Pereira, A.M. Goes, and M.F. Leite Effect of biphasic calcium phosphate on human macrophage functions in vitro J Biomed Mater Res A 65A 2003 475 481 (Pubitemid 38075878)
189. N. Rochet, A. Loubat, J.P. Laugier, P. Hofman, J.M. Bouler, and G. Daculsi Modification of gene expression induced in human osteogenic and osteosarcoma cells by culture on a biphasic calcium phosphate bone substitute Bone 32 2003 602 610 (Pubitemid 37297384)
190. I.J. de Kok, S.J. Peter, M. Archambault, C. van den Bos, S. Kadiyala, and I. Aukhil Investigation of allogeneic mesenchymal stem cell-based alveolar bone formation: preliminary findings Clin Oral Implants Res 14 2003 481 489 (Pubitemid 37485604)
191. H.L. Holtorf, T.L. Sheffield, C.G. Ambrose, J.A. Jansen, and A.G. Mikos Flow perfusion culture of marrow stromal cells seeded on porous biphasic calcium phosphate ceramics Ann Biomed Eng 33 2005 1238 1248 (Pubitemid 41240017)
192. M.B. Eslaminejad, M. Jafarian, A. Khojasteh, F.M. Abbas, M.M. Dehghan, and R. Hassanizadeh In vivo bone formation by canine mesenchymal stem cells loaded onto HA/TCP scaffolds: qualitative and quantitative analysis Yakhteh Med J 10 2008 205 212
193. S. Oda, A. Kinoshita, T. Higuchi, T. Shizuya, and I. Ishikawa Ectopic bone formation by biphasic calcium phosphate (BCP) combined with recombinant human bone morphogenetic protein-2 (rhBMP-2) J Med Dent Sci 44 1997 53 62 (Pubitemid 127705659)
194. X. Zhu, H. Fan, D. Li, Y. Xiao, and X. Zhang Protein adsorption and zeta potentials of a biphasic calcium phosphate ceramic under various conditions J Biomed Mater Res B Appl Biomater 82B 2007 65 73 (Pubitemid 47015354)
195. J.I. Kim, J.H. Yun, G.J. Chae, S.W. Jung, C.S. Kim, and K.S. Cho RhBMP-2 using biphasic calcium phosphate block as a carrier induces new bone formation in a rat subcutaneous tissue J Korean Acad Periodontol 38 2008 355 362
196. X.D. Zhu, H.S. Fan, Y.M. Xiao, D.X. Li, H.J. Zhang, and T. Luxbacher Effect of surface structure on protein adsorption to biphasic calcium-phosphate ceramics in vitro and in vivo Acta Biomater 5 2009 1311 1318
197. S.S. Banerjee, A. Bandyopadhyay, and S. Bose Biphasic resorbable calcium phosphate ceramic for bone implants and local alendronate delivery Adv Eng Mater 12 2010 B148 B155
198. G. Daculsi, and P. Layrolle Osteoinductive properties of micro macroporous biphasic calcium phosphate bioceramics Key Eng Mater 254-256 2004 1005 1008
199. H.I. Shin, K.H. Kim, I.K. Kang, and K.S. Oh Successful osteoinduction by cell-macroporous biphasic HA-TCP ceramic matrix Key Eng Mater 288-289 2005 245 248 (Pubitemid 46840559)
200. D. le Nihouannen, G. Daculsi, A. Saffarzadeh, O. Gauthier, S. Delplace, and P. Pilet Ectopic bone formation by microporous calcium phosphate ceramic particles in sheep muscles Bone 36 2005 1086 1093 (Pubitemid 40803450)
201. F. Ye, X. Lu, and J. Wang A long-term evaluation of osteoinductive HA/β-TCP ceramics in vivo: 45 years study in pigs J Mater Sci Mater Med 18 2007 2173 2178 (Pubitemid 350167384)
202. B.H. Fellah, O. Gauthier, P. Weiss, D. Chappard, and P. Layrolle Comparison of osteoinduction by autologous bone and biphasic calcium phosphate ceramic in goats Key Eng Mater 330-332 2007 1063 1066 (Pubitemid 46120955)
203. F. Schwarz, M. Herten, D. Ferrari, M. Wieland, L. Schmitz, and E. Engelhardt Guided bone regeneration at dehiscence-type defects using biphasic hydroxyapatite + beta tricalcium phosphate (Bone Ceramic®) or a collagen-coated natural bone mineral (BioOss Collagen®): an immunohisto-chemical study in dogs Int J Oral Maxillofac Surg 36 2007 1198 1206 (Pubitemid 350138396)
204. U. Ripamonti, P.W. Richter, R.W.N. Nilen, and L. Renton The induction of bone formation by smart biphasic hydroxyapatite tricalcium phosphate biomimetic matrices in the non-human primate Papio ursinus J Cell Mol Med 12 2008 2609 2621
205. L. Sun, L. Wu, C. Bao, C. Fu, X. Wang, and J. Yao Gene expressions of Collagen type I ALP and BMP-4 in osteo-inductive BCP implants show similar pattern to that of natural healing bones Mater Sci Eng C 29 2009 1829 1834
206. J.C. Roldán, R. Detsch, S. Schaefer, E. Chang, M. Kelantan, and W. Waiss Bone formation and degradation of a highly porous biphasic calcium phosphate ceramic in presence of BMP-7 VEGF and mesenchymal stem cells in an ectopic mouse model J Craniomaxillofac Surg 38 2010 423 430
207. D. Barbieri, H. Yuan, F. de Groot, W.R. Walsh, and J.D. de Bruijn Influence of different polymeric gels on the ectopic bone forming ability of an osteoinductive biphasic calcium phosphate ceramic Acta Biomater 7 2011 2007 2014
208. M. Hashimoto-Uoshima, I. Ishikawa, A. Kinoshita, H.T. Weng, and S. Oda Clinical and histologic observation of replacement of biphasic calcium phosphate by bone tissue in monkeys Int J Periodontics Restorative Dent 15 1995 205 213
209. A.B. Diggs, J.W. Halloran, and S.J. Hollister Cathodoluminescence as a method of microstructure characterization of biphasic ceramics composed of hydroxyapatite and β-tricalcium phosphate Key Eng Mater 284-286 2005 333 336 (Pubitemid 46780372)
210. R.Z. LeGeros Calcium phosphate-based osteoinductive materials Chem Rev 108 2008 4742 4753
211. R.E. Grundel, M.W. Chapman, T. Yee, and D.C. Moore Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna Clin Orthop 266 1991 244 258
212. N. Passuti, J. Delécrin, and G. Daculsi Experimental data regarding macroporous biphasic calcium phosphate ceramics Eur J Orthop Surg Traumatol 7 1997 79 84
213. O. Gauthier, J.M. Bouler, E. Aguado, P. Pilet, and G. Daculsi Macroporous biphasic calcium phosphate ceramics: influence of macropore diameter and macroporosity percentage on bone ingrowth Biomaterials 19 1998 133 139 (Pubitemid 28239476)
214. O. Gauthier, J.M. Bouler, E. Aguado, R.Z. LeGeros, P. Pilet, and G. Daculsi Elaboration conditions influence physicochemical properties and in vivo bioactivity of macroporous biphasic calcium phosphate ceramics J Mater Sci: Mater Med 10 1999 199 204 (Pubitemid 29216639)
215. S. Li, J.R. de Wijn, J. Li, P. Layrolle, and K. de Groot Macroporous biphasic calcium phosphate scaffold with high permeability/porosity ratio Tissue Eng 9 2003 535 548 (Pubitemid 36740496)
216. C.C. Teixeira, Y. Nemelivsky, C. Karkia, and R.Z. LeGeros Biphasic calcium phosphate: a scaffold for growth plate chondrocyte maturation Tissue Eng 12 2006 2283 2289 (Pubitemid 44734986)
217. R.J. Chung, M.F. Hsieh, K.C. Huang, F.I. Chou, and L.H. Perng Preparation of porous HA/beta-TCP biphasic bioceramic using a molten salt process Key Eng Mater 309-311 2006 1075 1078
218. S.M. Rabiee, S.M.J. Mortazavi, F. Moztarzadeh, D. Sharifi, S. Sharifi, and M. Solati-Hashjin Mechanical behavior of a new biphasic calcium phosphate bone graft Biotechnol Bioprocess Eng 13 2008 204 209 (Pubitemid 351689332)
219. A. Macchetta, I.G. Turner, and C.R. Bowen Fabrication of HA/TCP scaffolds with a graded and porous structure using a camphene-based freeze-casting method Acta Biomater 5 2009 1319 1327
220. S. Sánchez-Salcedo, F. Balas, I. Izquierdo-Barba, and M. Vallet-Regí In vitro structural changes in porous HA/β-TCP scaffolds in simulated body fluid Acta Biomater 5 2009 2738 2751
221. S.K. lan Levengood, S.J. Polak, M.J. Poellmann, D.J. Hoelzle, A.J. Maki, and S.G. Clark The effect of BMP-2 on micro- and macroscale osteointegration of biphasic calcium phosphate scaffolds with multiscale porosity Acta Biomater 6 2010 3283 3291
222. A.M. le Ray, H. Gautier, J.M. Bouler, P. Weiss, and C. Merle A new technological procedure using sucrose as porogen compound to manufacture porous biphasic calcium phosphate ceramics of appropriate micro- and macrostructure Ceram Int 36 2010 93 101
223. F. Pecqueux, F. Tancret, N. Payraudeau, and J.M. Bouler Influence of microporosity and macroporosity on the mechanical properties of biphasic calcium phosphate bioceramics: modelling and experiment J Eur Ceram Soc 30 2010 819 829
224. M. Peroglio, L. Gremillard, C. Gauthier, L. Chazeau, S. Verrier, and M. Alini Mechanical properties and cytocompatibility of poly(-caprolactone)- infiltrated biphasic calcium phosphate scaffolds with bimodal pore distribution Acta Biomater 6 2010 4369 4379
225. S.I. Roohani-Esfahani, S. Nouri-Khorasani, Z. Lu, R. Appleyard, and H. Zreiqat The influence of hydroxyapatite nanoparticle shape and size on the properties of biphasic calcium phosphate scaffolds coated with hydroxyapatite-PCL composites Biomaterials 31 2010 5498 5509
226. Calvo-Guirado JL, Delgado-Ruíz RA, Ramírez-Fernández MP, Maté-Sánchez JE, Ortiz-Ruiz A, Marcus A. Histomorphometric and mineral degradation study of Ossceram®: a novel biphasic β-tricalcium phosphate in critical size defects in rabbits. Clin Oral Implants Res 2011; submitted for publication.
227. S. Baroth, X. Bourges, E. Goyenvalle, E. Aguado, and G. Daculsi Injectable biphasic calcium phosphate bioceramic: the HYDROS® concept Bio-Med Mater Eng 19 2009 71 76
228. L. le Guehennec, E. Goyenvalle, E. Aguado, P. Pilet, M.B. d'Arc, and M. Bilban MBCP® biphasic calcium phosphate granules and tissucol® fibrin sealant in rabbit femoral defects: the effect of fibrin on bone ingrowth J Mater Sci Mater Med 16 2005 29 35 (Pubitemid 40476214)
229. F. Jegoux, E. Goyenvalle, M.B. d'Arc, E. Aguado, and G. Daculsi In vivo biological performance of composites combining micro-macroporous biphasic calcium phosphate granules and fibrin sealant Arch Orthop Trauma Surg 125 2005 153 159 (Pubitemid 41166839)
230. G. Bluteau, P. Pilet, X. Bourges, M. Bilban, R. Spaethe, and G. Daculsi The modulation of gene expression in osteoblasts by thrombin coated on biphasic calcium phosphate ceramic Biomaterials 27 2006 2934 2943 (Pubitemid 43208918)
231. D. le Nihouannen, A. Saffarzadeh, O. Gauthier, F. Moreau, P. Pilet, and R. Spaethe Bone tissue formation in sheep muscles induced by a biphasic calcium phosphate ceramic and fibrin glue composite J Mater Sci: Mater Med 19 2008 667 675 (Pubitemid 351244034)
232. E. Goyenvalle, E. Aguado, P. Pilet, and G. Daculsi Biofunctionality of MBCP ceramic granules (TricOs™) plus fibrin sealant (Tisseel®) versus MBCP ceramic granules as a filler of large periprosthetic bone defects: an investigative ovine study J Mater Sci: Mater Med 21 2010 1949 1958
233. Reppenhagen S, Reichert JC, Rackwitz L, Rudert M, Raab P, Daculsi G, Nöth U. Biphasic bone substitute and fibrin sealant for treatment of benign bone tumours and tumour-like lesions. Int Orthopaedics 2011; submitted for publication.
234. G. Daculsi, I. Khairoun, R.Z. LeGeros, F. Moreau, P. Pilet, and X. Bourges Bone ingrowth at the expense of a novel macroporous calcium phosphate cement Key Eng Mater 330-332 2007 811 814 (Pubitemid 46120895)
235. A. Dupraz, T.P. Nguyen, M. Richard, G. Daculsi, and N. Passuti Influence of a cellulosic ether carrier on the structure of biphasic calcium phosphate ceramic particles in an injectable composite material Biomaterials 20 1999 663 673 (Pubitemid 29126737)
236. P. Iooss, A.M. le Ray, G. Grimandi, G. Daculsi, and C. Merle A new injectable bone substitute combining poly(-caprolactone) microparticles with biphasic calcium phosphate granules Biomaterials 22 2001 2785 2794 (Pubitemid 32727995)
237. C. Trojani, F. Boukhechba, J.C. Scimeca, F. Vandenbos, J.F. Michiels, and G. Daculsi Ectopic bone formation using an injectable biphasic calcium phosphate/Si-HPMC hydrogel composite loaded with undifferentiated bone marrow stromal cells Biomaterials 27 2006 3256 3264 (Pubitemid 43348526)
238. A.J. Zhou, S.A. Peel, and C.M. Clokie An evaluation of hydroxyapatite and biphasic calcium phosphate in combination with Pluronic F127 and BMP on bone repair J Craniofac Surg 18 2007 1264 1275 [correction 2008;19:871] (Pubitemid 350098580)
239. T.Q. Bao, R.A. Franco, and B.T. Lee Preparation and characterization of novel poly(-caprolactone)/biphasic calcium phosphate hybrid composite microspheres J Biomed Mater Res B Appl Biomater 98B 2011 272 279
240. N.C. Bleach, S.N. Nazhat, K.E. Tanner, M. Kellomäki, and P. Törmälä Effect of filler content on mechanical and dynamic mechanical properties of particulate biphasic calcium phosphate-polylactide composites Biomaterials 23 2002 1579 1585 (Pubitemid 34158580)
241. J.S. Sun, F.H. Lin, Y.J. Wang, Y.C. Huang, S.C. Chueh, and F.Y. Hsu Collagen-hydroxyapatite/tricalcium phosphate microspheres as a delivery system for recombinant human transforming growth factor-β1 Artif Organs 27 2003 605 612
242. C.R. Yang, Y.J. Wang, X.F. Chen, and N.R. Zhao Biomimetic fabrication of BCP/COL/HCA scaffolds for bone tissue engineering Mater Lett 59 2005 3635 3640 (Pubitemid 41491802)
243. M. Radić, N. Ignjatović, Z. Nedić, M. Mitrić, D. Miličević, and D. Uskoković Synthesis and characterization of biphasic calcium phosphate/poly-(dl-lactide-co-glycolide) biocomposite Mater Sci Forum 494 2005 537 542 (Pubitemid 47566779)
244. N. Ignjatović, P. Ninkov, Z. Ajduković, V. Konstantinović, and D. Uskoković Biphasic calcium phosphate/poly-(dl-lactide-co-glycolide) biocomposite as filler and blocks for reparation of bone tissue Mater Sci Forum 494 2005 519 524 (Pubitemid 47566776)
245. J. Li, P. Habibovic, H. Yuan, M. van den Doel, C.E. Wilson, and J.R. de Wijn Biological performance in goats of a porous titanium alloy-biphasic calcium phosphate composite Biomaterials 28 2007 4209 4218 (Pubitemid 47212399)
246. N. Ignjatovic, P. Ninkov, Z. Ajdukovic, D. Vasiljevic-Radovic, and D. Uskokovic Biphasic calcium phosphate coated with poly-dl-lactide-co-glycolide biomaterial as a bone substitute J Eur Ceram Soc 27 2007 1589 1594 (Pubitemid 44743192)
247. H. Oudadesse, A.C. Derrien, M. Mami, S. Martin, G. Cathelineau, and L. Yahia Aluminosilicates and biphasic HA-TCP composites: studies of properties for bony filling Biomed Mater 2 2007 S59 S64
248. A. Sendemir-Urkmez, and R.D. Jamison The addition of biphasic calcium phosphate to porous chitosan scaffolds enhances bone tissue development in vitro J Biomed Mater Res A 81A 2007 624 633 (Pubitemid 46786893)
249. A.S. Urkmez, S.G. Clark, M.B. Wheeler, M.S. Goldwasser, and R.D. Jamison Evaluation of chitosan/biphasic calcium phosphate scaffolds for maxillofacial bone tissue engineering Macromol Symp 269 2008 100 105
250. B.T. Lee, D.V. Quang, M.H. Youn, and H.Y. Song Fabrication of biphasic calcium phosphates/polycaprolactone composites by melt infiltration process J Mater Sci Mater Med 19 2008 2223 2229
251. T.X. Wu, W.Z. Yang, Y.D. Li, H.J. Zhang, L.H. Chen, and D.L. Zhou Biocompatibility of biphasic calcium phosphate/poly l-lactic acid composite material J Clin Rehabil Tissue Eng Res 13 2009 4025 4028
252. J. Shen, Y. Li, Y. Zuo, Q. Zou, L. Cheng, and L. Zhang Characterization and cytocompatibility of biphasic calcium phosphate/polyamide 6 scaffolds for bone regeneration J Biomed Mater Res B Appl Biomater 95B 2010 330 338
253. L. Bakhtiari, H.R. Rezaie, S.M. Hosseinalipour, and M.A. Shokrgozar Investigation of biphasic calcium phosphate/gelatin nanocomposite scaffolds as a bone tissue engineering Ceram Int 36 2010 2421 2426
254. L. Bakhtiari, H.R. Rezai, S.M. Hosseinalipour, and M.A. Shokrgozar Preparation of porous biphasic calcium phosphate-gelatin nanocomposite for bone tissue engineering J Nano Res 11 2010 67 72
255. W. Yang, G. Yin, D. Zhou, J. Gu, and Y. Li In vitro characteristics of surface-modified biphasic calcium phosphate/poly(l-lactide) biocomposite Adv Eng Mater 12 2010 B128 B132
256. M.Y. Zhang, C. Ye, U.J. Erasquin, T. Huynh, C. Cai, and G.J. Cheng Laser engineered multilayer coating of biphasic calcium phosphate/titanium nanocomposite on metal substrates ACS Appl Mater Interfaces 3 2011 339 350
257. J.A. Puértolas, J.L. Vadillo, S. Sánchez-Salcedo, A. Nieto, E. Gómez-Barrena, and M. Vallet-Regí Compression behaviour of biphasic calcium phosphate and biphasic calcium phosphate-agarose scaffolds for bone regeneration Acta Biomater 7 2011 841 847
258. J.H. Lee, Y.B. Lee, N.G. Rim, S.Y. Jo, Y.M. Lim, and H. Shin Development and characterization of nanofibrous poly(lactic-co-glycolic acid)/biphasic calcium phosphate composite scaffolds for enhanced osteogenic differentiation Macromol Res 19 2011 172 179
259. 2 and BCP nanopowders J Eur Ceram Soc 31 2011 1541 1548
260. H. He, J. Yu, J.E.L. Cao, D. Wang, H. Zhang, and H. Liu Biocompatibility and osteogenic capacity of periodontal ligament stem cells on nHAC/PLA and HA/TCP scaffolds J Biomater Sci Polym Ed 22 2011 179 194
261. T.M. Lee, B.C. Wang, Y.C. Yang, E. Chang, and C.Y. Yang Comparison of plasma-sprayed hydroxyapatite coatings and hydroxyapatite/tricalcium phosphate composite coatings: in vivo study J Biomed Mater Res 5 2001 360 367 (Pubitemid 32240172)
262. M. Stewart, J.F. Welter, and V.M. Goldberg Effect of hydroxyapatite/ tricalcium-phosphate coating on osseointegration of plasma-sprayed titanium alloy implants J Biomed Mater Res A 69A 2004 1 10 (Pubitemid 38364954)
263. B.D. Hahn, D.S. Park, J.J. Choi, J. Ryu, W.H. Yoon, and B.K. Lee Effect of the HA/β-TCP ratio on the biological performance of calcium phosphate ceramic coatings fabricated by a room-temperature powder spray in vacuum J Am Ceram Soc 92 2009 793 799
264. H. Benhayoune, R. Drevet, J. Fauré, S. Potiron, T. Gloriant, and H. Oudadesse Elaboration of monophasic and biphasic calcium phosphate coatings on Ti6Al4V substrate by pulsed electrodeposition current Adv Eng Mater 12 2010 B192 B199
265. G. Daculsi, R. LeGeros, M. Durand, P. Borget, S. Baroth, and E. Goyenvalle Injectable apatitic calcium phosphate cements and microporous biphasic calcium phosphate granules complex for bone repair J Aust Ceram Soc 46 2010 1 5
266. Khairoun I, LeGeros RZ, Daculsi G, Bouler JM, Guicheux J, Gauthier O. Macroporous resorbable and injectable calcium phosphate-based cements (MCPC) for bone repair augmentation regeneration and osteoporosis treatment. European Patent 1 761 472 B1, 2011.
267. W.Z. Yang, D.L. Zhou, G.F. Yin, and G.D. Li Surface modification of biphasic calcium phosphate bioceramic powders Appl Surf Sci 255 2008 477 479
268. Z.L. Zhu, H.Y. Yu, Q. Zeng, and H.W. He Characterization and biocompatibility of fluoridated biphasic calcium phosphate ceramics Appl Surf Sci 255 2008 552 554
269. A. Piattelli, A. Scarano, and C. Mangano Clinical and histologic aspects of biphasic calcium phosphate ceramic (BCP) used in connection with implant placement Biomaterials 17 1996 1767 1770 (Pubitemid 26355419)
270. T.L. Arinzeh, T. Tran, J. Mcalary, and G. Daculsi A comparative study of biphasic calcium phosphate ceramics for human mesenchymal stem-cell-induced bone formation Biomaterials 26 2005 3631 3638 (Pubitemid 40038157)
271. H. Yuan, C.A. van Blitterswijk, K. de Groot, and J.D. de Bruijn A comparison of bone formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) implanted in muscle and bone of dogs at different time periods J Biomed Mater Res A 78A 2006 139 147 (Pubitemid 44032536)
272. H. Yuan, C.A. van Blitterswijk, K. de Groot, and J.D. de Bruijn Cross-species comparison of ectopic bone formation in biphasic calcium phosphate (BCP) and hydroxyapatite (HA) scaffolds Tissue Eng 12 2006 1607 1615 (Pubitemid 44174794)
273. C. Balik, T. Tokdemir, A. Senköylü, N. Ko, M. Timuin, and S. Akin Early weight bearing of porous HA/TCP (60/40) ceramics in vivo: a longitudinal study in a segmental bone defect model of rabbit Acta Biomater 3 2007 985 996 (Pubitemid 47382666)
274. K. Kurashina, H. Kurita, Q. Wu, A. Ohtsuka, and H. Kobayashi Ectopic osteogenesis with biphasic ceramics of hydroxyapatite and tricalcium phosphate in rabbits Biomaterials 23 2002 407 412 (Pubitemid 33051030)
275. L. Zhang, N. Hanagata, M. Maeda, T. Minowa, T. Ikoma, and H. Fan Porous hydroxyapatite and biphasic calcium phosphate ceramics promote ectopic osteoblast differentiation from mesenchymal stem cells Sci Technol Adv Mater 10 2009 025003
276. M. Jafarian, M.B. Eslaminejad, A. Khojasteh, F.M. Abbas, M.M. Dehghan, and R. Hassanizadeh Marrow-derived mesenchymal stem cells-directed bone regeneration in the dog mandible: a comparison between biphasic calcium phosphate and natural bone mineral Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105 2008 e14 e24
277. S.S. Jensen, M.M. Bornstein, M. Dard, D.D. Bosshardt, and D. Buser Comparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects: a long-term histomorphometric study in minipigs J Biomed Mater Res B Appl Biomater 90B 2009 171 181
278. B.H. Fellah, O. Gauthier, P. Weiss, D. Chappard, and P. Layrolle Osteogenicity of biphasic calcium phosphate ceramics and bone autograft in a goat model Biomaterials 29 2008 1177 1188
279. G. Grandi, C. Heitz, L.A. dos Santos, M.L. Silva, M.S. Filho, and R.M. Pagnocelli Comparative histomorphometric analysis between α-Tcp cement and β-Tcp/Ha granules in the bone repair of rat calvaria Mater Res 14 2011 11 16
280. S.J. Froum, S.S. Wallace, S.C. Cho, N. Elian, and D.P. Tarnow Histomorphometric comparison of a biphasic bone ceramic to anorganic bovine bone for sinus augmentation: 6- to 8-month postsurgical assessment of vital bone formation. A pilot study Int J Periodontics Restorative Dent 28 2008 273 281
281. N. Pandit, R. Gupta, and S. Gupta A comparative evaluation of biphasic calcium phosphate material and bioglass in the treatment of periodontal osseous defects: a clinical and radiological study J Contemp Dent Pract 11 2010 025 32
282. S.S. Jensen, A. Yeo, M. Dard, E. Hunziker, R. Schenk, and D. Buser Evaluation of a novel biphasic calcium phosphate in standardized bone defects: a histologic and histomorphometric study in the mandibles of minipigs Clin Oral Implants Res 18 2007 752 760
283. E.B. Nery, R.Z. LeGeros, K.L. Lynch, and K. Lee Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/β-TCP in periodontal osseous defects J Periodontol 63 1992 729 735
284. Cho JS, Chung CP, Rhee SH. Bioactivity and osteoconductivity of biphasic calcium phosphates. Bioceramics Dev Appl 2011;1:article ID D101129.
285. T. Suzuki, M. Hukkanen, R. Ohashi, Y. Yokogawa, K. Nishizawa, and F. Nagata Growth and adhesion of osteoblast-like cells derived from neonatal rat calvaria on calcium phosphate ceramics J Biosci Bioeng 89 2000 18 26 (Pubitemid 30099945)
286. S. Tarafder, S. Bodhak, A. Bandyopadhyay, and S. Bose Effect of electrical polarization and composition of biphasic calcium phosphates on early stage osteoblast interactions J Biomed Mater Res B Appl Biomater 97B 2011 306 314
287. O. Malard, J.M. Bouler, J. Guicheux, D. Heymann, P. Pilet, and C. Coquard Influence of biphasic calcium phosphate granulometry on bone ingrowth, ceramic resorption and inflammatory reactions: preliminary in vitro and in vivo study J Biomed Mater Res 46 1999 103 111 (Pubitemid 29233186)
288. J.M. Curran, J.A. Gallagher, and J.A. Hunt The inflammatory potential of biphasic calcium phosphate granules in osteoblast/macrophage co-culture Biomaterials 26 2005 5313 5320 (Pubitemid 40462346)
289. B.H. Fellah, N. Josselin, D. Chappard, P. Weiss, and P. Layrolle Inflammatory reaction in rats muscle after implantation of biphasic calcium phosphate micro particles J Mater Sci Mater Med 18 2007 287 294 (Pubitemid 46332850)
290. B.H. Fellah, B. Delorme, J. Sohier, D. Magne, P. Hardouin, and P. Layrolle Macrophage and osteoblast responses to biphasic calcium phosphate microparticles J Biomed Mater Res A 93A 2010 1588 1595
291. G. Daculsi, N. Passuti, S. Martin, C. Deudon, R.Z. LeGeros, and S. Raher Macroporous biphasic calcium phosphate ceramic for long bone surgery in human and dogs: clinical and histological study J Biomed Mater Res 24 1990 379 396 (Pubitemid 20132807)
292. C. Schwartz, P. Liss, B. Jacquemaire, P. Lecestre, and P. Frayssinet Biphasic synthetic bone substitute use in orthopaedic and trauma surgery: clinical radiological and histological results J Mater Sci Mater Med 10 1999 821 825 (Pubitemid 30064208)
293. E.W.H. Bodde, J.G.C. Wolke, R.S.Z. Kowalski, and J.A. Jansen Bone regeneration of porous β-tricalcium phosphate (Conduit™ TCP) and of biphasic calcium phosphate ceramic (Biosel®) in trabecular defects in sheep J Biomed Mater Res A 82A 2007 711 722 (Pubitemid 47258585)
294. M. Ozalay, O. Sahin, S. Akpinar, G. Ozkoc, M. Cinar, and N. Cesur Remodeling potentials of biphasic calcium phosphate granules in open wedge high tibial osteotomy Arch Orthop Trauma Surg 129 2009 747 752
295. S.E. Lobo, F.H. Wykrota, A.C. Oliveira, I. Kerkis, G.B. Mahecha, and H.J. Alves Quantification of bone mass gain in response to the application of biphasic bioceramics and platelet concentrate in critical-size bone defects J Mater Sci Mater Med 20 2009 1137 1147
296. C.A. Garrido, S.E. Lobo, F.M. Turíbio, and R.Z. LeGeros Biphasic calcium phosphate bioceramics for orthopaedic reconstructions: clinical outcomes Int J Biomater 2011 129727
297. C. Suneelkumar, K. Datta, M.R. Srinivasan, and S.T. Kumar Biphasic calcium phosphate in periapical surgery J Conserv Dent 11 2008 92 96
298. D.C. Moore, M.W. Chapman, and D. Manske The evaluation of a biphasic calcium phosphate ceramic for use in grafting long-bone diaphyseal defects J Orthop Res 5 1987 356 365 (Pubitemid 17652989)
299. J.W. Park, E.S. Kim, J.H. Jang, J.Y. Suh, K.B. Park, and T. Hanawa Healing of rabbit calvarial bone defects using biphasic calcium phosphate ceramics made of submicron-sized grains with a hierarchical pore structure Clin Oral Implants Res 21 2010 268 276
300. L. de Gabory, R. Bareille, D. Stoll, L. Bordenave, and J.C. Fricain Biphasic calcium phosphate to repair nasal septum: the first in vitro and in vivo study Acta Biomater 6 2010 909 919
301. L. de Gabory, S. Delmond, C. Deminiere, D. Stoll, L. Bordenave, and J.C. Fricain Assessment of biphasic calcium phosphate to repair nasal septum defects in sheep Plast Reconstr Surg 127 2011 107 116
302. J. Wang, W. Chen, Y. Li, S. Fan, J. Weng, and X. Zhang Biological evaluation of biphasic calcium phosphate ceramic vertebral laminae Biomaterials 19 1998 1387 1392 (Pubitemid 28425458)
303. S.B. Bolder, N. Verdonschot, B.W. Schreurs, and P. Buma Acetabular defect reconstruction with impacted morsellized bone grafts or TCP/HA particles. A study on the mechanical stability of cemented cups in an artificial acetabulum
304. C. Nich, P. Bizot, R. Nizard, and L. Sedel Femoral reconstruction with macroporous biphasic calcium phosphate ceramic in revision hip replacement Key Eng Mater 240-242 2003 853 856
305. N. Zwetyenga, S. Catros, A. Emparanza, C. Deminiere, F. Siberchicot, and J.C. Fricain Mandibular reconstruction using induced membranes with autologous cancellous bone graft and HA-βTCP: animal model study and preliminary results in patients Int J Oral Maxillofac Surg 38 2009 1289 1297
306. M.S. Huang, H.D. Wu, N.C. Teng, B.Y. Peng, J.Y. Wu, and W.J. Chang In vivo evaluation of poorly crystalline hydroxyapatite-based biphasic calcium phosphate bone substitutes for treating dental bony defects J Dent Sci 5 2010 100 108
307. P. Sunil, S.C. Goel, A. Rastogi, and N.C. Aryya Incorporation and biodegradation of hydroxyapatite-tricalcium phosphate implanted in large metaphyseal defects-an animal study Indian J Exp Biol 46 2008 836 841
308. J.L. Rouvillain, F. Lavallé, H. Pascal-Mousselard, Y. Catonné, and G. Daculsi Clinical radiological and histological evaluation of biphasic calcium phosphate bioceramic wedges filling medial high tibial valgisation osteotomies Knee 16 2009 392 397
309. D.Y. Cho, W.Y. Lee, P.C. Sheu, and C.C. Chen Cage containing a biphasic calcium phosphate ceramic (Triosite) for the treatment of cervical spondylosis Surg Neurol 63 2005 497 503 [discussion 503]
310. Z. Artzi, M. Weinreb, G. Carmeli, R. Lev-Dor, M. Dard, and C.E. Nemcovsky Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autogenous and hydroxyapatite/biphasic tricalcium phosphate graft materials: at 6 and 9 months in humans Clin Oral Implants Res 19 2008 686 692
311. J.H. Lee, U.W. Jung, C.S. Kim, S.H. Choi, and K.S. Cho Histologic and clinical evaluation for maxillary sinus augmentation using macroporous biphasic calcium phosphate in human Clin Oral Implants Res 19 2008 767 771
312. A. Friedmann, M. Dard, B.M. Kleber, J.P. Bernimoulin, and D.D. Bosshardt Ridge augmentation and maxillary sinus grafting with a biphasic calcium phosphate: histologic and histomorphometric observations Clin Oral Implants Res 20 2009 708 714
313. C. Lindgren, M. Hallman, L. Sennerby, and R. Sammons Back-scattered electron imaging and elemental analysis of retrieved bone tissue following sinus augmentation with deproteinized bovine bone or biphasic calcium phosphate Clin Oral Implants Res 21 2010 924 930
314. E.B. Nery, K.K. Lee, S. Czajkowski, J.J. Dooner, M. Duggan, and R.F. Ellinger A Veterans Administration Cooperative Study of biphasic calcium phosphate ceramic in periodontal osseous defects J Periodontol 61 1990 737 744
315. G. Daculsi, P. Corlieu, M.B. d'Arc, and M. Gersdorff Macroporous biphasic calcium phosphate efficiency in mastoid cavity obliteration: experimental and clinical findings Ann Otol Rhinol Laryngol 101 1992 669 674
316. J.M. Toth, H.S. An, T.H. Lim, Y. Ran, N.G. Weiss, and W.R. Lundberg Evaluation of porous biphasic calcium phosphate ceramics for anterior cervical interbody fusion in a caprine model Spine 20 1995 2203 2210
317. H. Shi, J. Ma, N. Zhao, Y. Chen, and Y. Liao Periodontal regeneration in experimentally-induced alveolar bone dehiscence by an improved porous biphasic calcium phosphate ceramic in beagle dogs J Mater Sci Mater Med 19 2008 3515 3524
318. Y. Wang, M. Ni, P.F. Tang, and G. Li Novel application of HA-TCP biomaterials in distraction osteogenesis shortened the lengthening time and promoted bone consolidation J Orthop Res 27 2009 477 482
319. Wang L, Shi H, Chen Y, Xue J, Chen Y, Liao Y. Healing of acute alveolar bone dehiscence following treatment with porous biphasic calcium phosphate in beagle dogs. Clin Oral Invest 2011; submitted for publication.
320. S. Tarafder, S. Banerjee, A. Bandyopadhyay, and S. Bose Electrically polarized biphasic calcium phosphates: adsorption and release of bovine serum albumin Langmuir 26 2010 16625 16629
321. F.B. de Carvalho, G.T.S. Aciole, J.M.S. Aciolea, L. Silveira Jr, J.N. dos Santos, and A.L.B. Pinheiro Assessment of bone healing on tibial fractures treated with wire osteosynthesis associated or not with infrared laser light and biphasic ceramic bone graft (HATCP) and guided bone regeneration (GBR): Raman spectroscopy study Proc SPIE 7887 2011 78870T
322. B. Su, J. Su, J. Ran, and B. Su Biological performance of dental biphasic calcium phosphate ceramics modified by cold plasma Key Eng Mater 368-372 2008 1264 1267 (Pubitemid 351414102)
323. J.S. Grimes, T.J. Bocklage, and J.D. Pitcher Collagen and biphasic calcium phosphate bone graft in large osseous defects Orthopedics 29 2006 145 148 (Pubitemid 43263404)
324. A. Zorica, I. Nenad, P. Dragan, and U. Dragan Substitution of osteoporotic alveolar bone by biphasic calcium phosphate/poly-dl-lactide-co- glycolide biomaterials J Biomater Appl 21 2007 317 328 (Pubitemid 46090492)
325. G.I. Im, J.H. Ahn, S.Y. Kim, B.S. Choi, and S.W. Lee A hyaluronate-atelocollagen/β-tricalcium phosphate-hydroxyapatite biphasic scaffold for the repair of osteochondral defects: a porcine study Tissue Eng A 16 2010 1189 1200
326. X. Struillou, H. Boutigny, Z. Badran, B.H. Fellah, O. Gauthier, and S. Sourice Treatment of periodontal defects in dogs using an injectable composite hydrogel/biphasic calcium phosphate J Mater Sci Mater Med 22 2011 1707 1717
327. H. Gautier, C. Merle, J.L. Auget, and G. Daculsi Isostatic compression a new process for incorporating vancomycin into biphasic calcium phosphate: comparison with a classical method Biomaterials 21 2000 243 249
328. M. Sunder, N.R. Babu, S.P. Victor, K.R. Kumar, and T.S.S. Kumar Biphasic calcium phosphates for antibiotic release Trends Biomater Artif Organs 18 2005 213 218
329. F. Laurent, A. Bignon, J. Goldnadel, J. Chevalier, G. Fantozzi, and E. Viguier A new concept of gentamicin loaded HAP/TCP bone substitute for prophylactic action: in vitro release validation J Mater Sci Mater Med 19 2008 947 951 (Pubitemid 351236751)
330. E. Viguier, A. Bignon, F. Laurent, D. Goehrig, G. Boivin, and J. Chevalier A new concept of gentamicin loaded HAP/TCP bone substitute for prophylactic action: in vivo pharmacokinetic study J Mater Sci Mater Med 22 2011 879 886
331. C. Schopper, D. Moser, E. Spassova, W. Goriwoda, G. Lagogiannis, and B. Hoering Bone regeneration using a naturally grown HA/TCP carrier loaded with rhBMP-2 is independent of barrier-membrane effects J Biomed Mater Res A 85A 2008 954 963 (Pubitemid 351717964)
332. J.W. Kim, K.H. Choi, J.H. Yun, J. Ui-Won, C.S. Kim, and S.H. Choi Bone formation of block and particulated biphasic calcium phosphate lyophilized with Escherichia coli-derived recombinant human bone morphogenetic protein 2 in rat calvarial defects Oral Surg Oral Med Oral Pathol Oral Radiol Endod 112 2011 298 306
333. Jang JW, Yun JH, Lee KI, Jang JW, Jung UW, Kim CS, et al. Osteoinductive activity of biphasic calcium phosphate with different rhBMP-2 doses in rats. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2011; submitted for publication.
334. Park JC, So SS, Jung IH, Yun JH, Choi SH, Cho KS, Kim CS. Induction of bone formation by Escherichia coli-expressed recombinant human bone morphogenetic protein-2 using block-type macroporous biphasic calcium phosphate in orthotopic and ectopic rat models. J Periodontal Res 2011; submitted for publication.
335. F. Schwarz, M. Sager, D. Ferrari, I. Mihatovic, and J. Becker Influence of recombinant human platelet-derived growth factor on lateral ridge augmentation using biphasic calcium phosphate and guided bone regeneration: a histomorphometric study in dogs J Periodontol 80 2009 1315 1323
336. T. Balaguer, F. Boukhechba, A. Clavé, S. Bouvet-Gerbettaz, C. Trojani, and J.F. Michiels Biphasic calcium phosphate microparticles for bone formation: benefits of combination with blood clot Tissue Eng A 16 2010 3495 3505
337. C.C. Mouline, D. Quincey, J.P. Laugier, G.F. Carle, J.M. Bouler, and N. Rochet Osteoclastic differentiation of mouse and human monocytes in a plasma clot/biphasic calcium phosphate microparticles composite Eur Cell Mater 20 2010 379 392
338. R.E. Grundel, M.W. Chapman, T. Yee, and D.C. Moore Autogeneic bone marrow and porous biphasic calcium phosphate ceramic for segmental bone defects in the canine ulna Clin Orthop Rel Res 266 1991 244 258
339. C. Castellani, G. Zanoni, S. Tangl, M. van Griensven, and H. Redl Biphasic calcium phosphate ceramics in small bone defects: potential influence of carrier substances and bone marrow on bone regeneration Clin Oral Implants Res 20 2009 1367 1374
340. N. Ignjatovic, Z. Ajdukovic, and D. Uskokovic New biocomposite [biphasic calcium phosphate/poly-dl-lactide-co-glycolide/biostimulative agent] filler for reconstruction of bone tissue changed by osteoporosis J Mater Sci Mater Med 16 2005 621 626 (Pubitemid 40905071)
341. A. Sculean, P. Windisch, D. Szendröi-Kiss, A. Horváth, P. Rosta, and J. Becker Clinical and histologic evaluation of an enamel matrix derivative combined with a biphasic calcium phosphate for the treatment of human intrabony periodontal defects J Periodontol 79 2008 1991 1999
342. T.L. Livingston, S. Gordon, M. Archambault, S. Kadiyala, K. Mcintosh, and A. Smith Mesenchymal stem cells combined with biphasic calcium phosphate ceramics promote bone regeneration J Mater Sci Mater Med 14 2003 211 218 (Pubitemid 36408020)
343. J. Wang, Y. Qiu, C.L. Xia, X.B. Tang, and Y. Hu Enriched bone marrow mesenchymal stem cells combined with HA/TCP for spine fusion J Clin Rehabil Tissue Eng Res 11 2007 5536 5539 (Pubitemid 47433433)
344. A.M.H. Ng, K.K. Tan, M.Y. Phang, O. Aziyati, G.H. Tan, and M.R. Isa Differential osteogenic activity of osteoprogenitor cells on HA and TCP/HA scaffold of tissue engineered bone J Biomed Mater Res A 85A 2008 301 312 (Pubitemid 351535311)
345. W. Zhang, X.F. Walboomers, G.J.V.M. van Osch, J. van den Dolder, and J.A. Jansen Hard tissue formation in a porous HA/TCP ceramic scaffold loaded with stromal cells derived from dental pulp and bone marrow Tissue Eng A 14 2008 285 294
346. T. Wang, W.D. Tian, S.W. Li, and Y.M. Liao Biphasic calcium phosphate nanocomposite loaded with bone marrow stromal cells for repair of critical cranial defect in rats J Clin Rehabil Tissue Eng Res 12 2008 2606 2610 (Pubitemid 351864016)
347. A. Jan, G.K. Sándor, B.B. Brkovic, S. Peel, Y.D. Kim, and W.Z. Xiao Effect of hyperbaric oxygen on demineralized bone matrix and biphasic calcium phosphate bone substitutes Oral Surg Oral Med Oral Pathol Oral Radiol Endod 109 2010 59 66
348. R. Rohanizadeh, M. Padrines, J.M. Bouler, D. Couchourel, Y. Fortun, and G. Daculsi Apatite precipitation after incubation of biphasic calcium-phosphate ceramic in various solutions: influence of seed species and proteins J Biomed Mater Res 42 1998 530 539 (Pubitemid 28503757)