Clinical and histologic evaluation of an enamel matrix derivative combined with a biphasic calcium phosphate for the treatment of human intrabony periodontal defects

Journal of Periodontology

Volumn 79, Issue 10, 2008, Pages 1991-1999

  Sculean, Anton ^a   Windisch, Péter ^b   Szendröi Kiss, Dóra ^b   Horváth, Attila ^b   Rosta, Péter ^b   Becker, Jürgen ^c   Gera, István ^b   Schwarz, Frank ^c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Calcium phosphate; Case series; Histology

Indexed keywords

CALCIUM PHOSPHATE; COLLAGEN; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN;

ADULT; ARTICLE; BONE DEVELOPMENT; BONE PROSTHESIS; CASE CONTROL STUDY; CEMENTUM; CHRONIC PERIODONTITIS; COMPARATIVE STUDY; CONNECTIVE TISSUE; DENTIN; FEMALE; FOLLOW UP; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; OSTEOLYSIS; PATHOLOGY; PERIODONTAL DISEASE; PERIODONTICS; PERIODONTITIS; PERIODONTIUM; PHYSIOLOGY; PROSPECTIVE STUDY; TOOTH DEVELOPMENT; TOOTH EXTRACTION; TOOTH ROOT; TREATMENT OUTCOME;

ADULT; ALVEOLAR BONE LOSS; BONE SUBSTITUTES; CALCIUM PHOSPHATES; CASE-CONTROL STUDIES; CEMENTOGENESIS; CHRONIC PERIODONTITIS; COLLAGEN; CONNECTIVE TISSUE; DENTAL CEMENTUM; DENTAL ENAMEL PROTEINS; DENTIN; EPITHELIAL ATTACHMENT; FEMALE; FOLLOW-UP STUDIES; GUIDED TISSUE REGENERATION, PERIODONTAL; HUMANS; MALE; MIDDLE AGED; OSTEOGENESIS; PERIODONTAL ATTACHMENT LOSS; PERIODONTAL POCKET; PROSPECTIVE STUDIES; TOOTH EXTRACTION; TOOTH ROOT; TREATMENT OUTCOME;

EID: 53549126970     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2008.080009     Document Type: Article

References (46)

1. Heijl L. Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol 1997;24:693-696.
2. Mellonig JT. Enamel matrix derivative for periodontal reconstructive surgery: Technique and clinical and histologic case report. Int J Periodontics Restorative Dent 1999;19:8-19.
3. Sculean A, Donos N, Windisch P, et al. Healing of human intrabony defects following treatment with enamel matrix proteins or guided tissue regeneration. J Periodontal Res 1999;34:310-322.
4. Yukna RA, Mellonig J. Histologic evaluation of periodontal healing in humans following regenerative therapy with enamel matrix derivative. A 10-case series. J Periodontol 2000;71:752-759.
5. Sculean A, Chiantella GC, Windisch P, Donos N. Clinical and histologic evaluation of treatment of intrabony defects with an enamel matrix protein derivative (Emdogain). Int J Periodontics Restorative Dent 2000;20:374-381.
6. Bosshardt DD, Sculean A, Windisch P, Pjetursson BE, Lang NP. Effects of enamel matrix proteins on tissue formation along the roots of human teeth. J Periodontal Res 2005;40:158-167.
7. Majzoub Z, Bobbo M, Atiyeh F, Cordioli G. Two patterns of histologic healing in an intrabony defect following treatment with an enamel matrix derivative: A human case report. Int J Periodontics Restorative Dent 2005;25:283-294.
8. Bosshardt DD, Sculean A, Donos N, Lang NP. Pattern of mineralization after periodontal tissue engineering with enamel matrix proteins. Eur J Oral Sci 2006;114(Suppl. 1):225-231.
9. Van der Pauw MT, Van den Bos T, Everts V, Beertsen W. Enamel matrix-derived protein stimulates attachment of periodontal ligament fibroblasts and enhances alkaline phosphatase activity and transforming growth factor β1 release of periodontal ligament and gingival fibroblasts. J Periodontol 2000;71:31-43.
10. Lyngstadaas SP, Lundberg E, Ekdahl H, Andersson C, Gestrelius S. Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Periodontol 2001;28:181-188.
11. Haase HR, Bartold PM. Enamel matrix derivative induces matrix synthesis by cultured human periodontal ligament cells. J Periodontol 2001;72:341-348.
12. Okubo K, Kobayashi M, Takiguchi T, et al. Participation of endogenous IGF-I and TGF-β1 with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells. J Periodontal Res 2003;38:1-9.
13. Cattaneo V, Rota C, Silvestri M, et al. Effect of enamel matrix derivative on human periodontal fibroblasts: Proliferation, morphology and root surface colonization. An in vitro study. J Periodontal Res 2003;38:568-574.
14. Palioto DB, Coletta RD, Granner E, Graner E, Joly JC, de Lima AF. The influence of enamel matrix derivative associated with insulin-like growth factor-I on periodontal ligament fibroblasts. J Periodontol 2004;75:498-504.
15. Schwartz Z, Carnes DL, Pulliam R, et al. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. J Periodontol 2000;71:1287-1296.
16. Kawase T, Okuda K, Yoshie H, Burns DM. Cytostatic action of enamel matrix derivative (EMDOGAIN) on human oral squamous cell carcinoma-derived SCC25 epithelial cells. J Periodontal Res 2000;35:291-300.
17. Sculean A, Auschill TM, Donos N, Brecx M, Arweiler N. Effect of an enamel matrix derivative (Emdogain) on ex vivo dental plaque vitality. J Clin Periodontol 2001;28:1074-1078.
18. Arweiler NB, Auschill TM, Donos N, Sculean A. Antibacterial effect of an enamel matrix protein derivative on in vivo dental plaque vitality. Clin Oral Investig 2002;6:205-209.
19. Heijl L, Heden G, Svardström G, Östgren A. Enamel matrix derivative (Emdogain) in the treatment of intrabony periodontal defects. J Clin Periodontol 1997;24:705-714.
20. Pontoriero R, Wennström J, Lindhe J. The use of barrier membranes and enamel matrix proteins in the treatment of angular bone defects. A prospective controlled clinical study. J Clin Periodontol 1999;26:833-840.
21. Okuda K, Momose M, Miyazaki A, et al. Enamel matrix derivative in the treatment of human intrabony osseous defects. J Periodontol 2000;71:1821-1828.
22. Silvestri M, Ricci G, Rasperini G, Sartori S, Cattaneo V. Comparison of treatments of intrabony defects with enamel matrix derivative, guided tissue regeneration with a nonresorbable membrane and Widman modified flap. A pilot study. J Clin Periodontol 2000;27:603-610.
23. Froum SJ, Weinberg MA, Rosenberg E, Tarnow D. A comparative study utilizing open flap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects: A 12-month re-entry study. J Periodontol 2001;72:25-34.
24. Sculean A, Windisch P, Chiantella GC, Donos N, Brecx M, Reich E. Treatment of intrabony defects with enamel matrix proteins and guided tissue regeneration. A prospective controlled clinical study. J Clin Periodontol 2001;28:397-403.
25. Tonetti MS, Lang NP, Cortellini P, et al. Enamel matrix proteins in the regenerative therapy of deep intrabony defects. A multicenter randomized controlled clinical trial. J Clin Periodontol 2002;29:317-325.
26. Wachtel H, Schenk G, Bohm S, Weng D, Zuhr O, Hurzeler MB. Microsurgical access flap and enamel matrix derivative for the treatment of periodontal intrabony defects: A controlled clinical study. J Clin Periodontol 2003;30:496-504.
27. Wikesjö UME, Selvig KA. Periodontal wound healing and regeneration. Periodontol 2000 1999;19:21-39.
28. Guida L, Annunziata M, Belardo S, Farina R, Scabbia A, Trombelli L. Effect of autogenous cortical bone particulate in conjunction with enamel matrix derivative in the treatment of periodontal intraosseous defects. J Periodontol 2007;78:231-238.
29. Gurinsky BS, Mills MP, Mellonig JT. Clinical evaluation of demineralized freeze-dried bone allograft and enamel matrix derivative versus enamel matrix derivative alone for the treatment of periodontal osseous defects in humans. J Periodontol 2004;75:1309-1318.
30. Lekovic V, Camargo PM, Weinlaender M, Nedic M, Aleksic Z, Kenney EB. A comparison between enamel matrix proteins used alone or in combination with bovine porous bone mineral in the treatment of intrabony periodontal defects in humans. J Periodontol 2000;71:1110-1116.
31. Velasquez-Plata D, Scheyer ET, Mellonig JT. Clinical comparison of an enamel matrix derivative used alone or in combination with a bovine-derived xenograft for the treatment of periodontal osseous defects in humans. J Periodontol 2002;73:433-440.
32. Zucchelli G, Amore C, Montebugnoli L, De Sanctis M. Enamel matrix proteins and bovine porous bone mineral in the treatment of intrabony defects: A comparative controlled clinical trial. J Periodontol 2003;74:1725-1735.
33. Sculean A, Windisch P, Keglevich T, Chiantella GC, Gera I, Donos N. Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative combined with a bovine-derived xenograft. Int J Periodontics Restorative Dent 2003;23:47-55.
34. Sculean A, Windisch P, Keglevich T, Gera I. Clinical and histological evaluation of an enamel matrix protein derivative combined with a bioactive glass for the treatment of intrabony periodontal defects in humans. Int J Periodontics Restorative Dent 2005;25:139-147.
35. Döri F, Arweiler N, Gera I, Sculean A. Clinical evaluation of an enamel matrix protein derivative combined with either a natural bone mineral or beta-tricalcium phosphate. J Periodontol 2005;76:2236-2243.
36. Bokan I, Bill JS, Schlagenhauf U. Primary flap closure combined with Emdogain alone or Emdogain and Cerasorb in the treatment of intra-bony defects. J Clin Periodontol 2006;33:885-893.
37. Nery EB, LeGeros RZ, Lynch KL, Lee K. Tissue response to biphasic calcium phosphate ceramic with different ratios of HA/βTCP in periodontal osseous defects. J Periodontol 1992;63:729-735.
38. Zafiropoulos GGK, Hoffmann O, Kasaj A, Willershausen B, Weiss O, Van Dyke TE. Treatment of intrabony defects using guided tissue regeneration and autogenous spongiosa alone or combined with hydroxyapatite/β-tricalcium phosphate bone substitute or bovine derived xenograft. J Periodontol 2007;78:2216-2225.
39. Piattelli A, Scarano A, Mangano C. Clinical and histologic aspects of biphasic calcium phosphate ceramic (BCP) used in connection with implant placement. Biomaterials 1996;17:1767-1770.
40. Schwarz F, Herten M, Ferrari D, et al. Guided bone regeneration at dehiscence-type defects: using biphasic hydroxyapatite + beta tricalcium phosphate (Bone Ceramic) or a collagen-coated natural bone mineral (BioOss Collagen): An immunohistochemical study in dogs. Int J Oral Maxillofac Surg 2007;36:1198-1206.
41. Jensen SS, Yeo A, Dard M, Hunziker E, Schenk R, Buser D. Evaluation of a novel biphasic calcium phosphate in standardized bone defects: A histologic and histomorphometric study in the mandibles of minipigs. Clin Oral Implants Res 2007;18:752-760.
42. Karring T, Lindhe J, Cortellini P. Regenerative periodontal therapy. In: Lindhe J, Karring T, Lang NP, eds. Clinical Periodontology and Implant Dentistry. Copenhagen: Blackwell Munksgaard; 2003:650-704.
43. Armitage GC. Development of a classification system for periodontal diseases and conditions. Ann Periodontol 1999;4:1-6.
44. Löe H. The Gingival Index, the Plaque Index and the Retention Index system. J Periodontol 1967;38:610-616.
45. Blomlöf JPS, Blomlöf LB, Lindskog SF. Smear removal and collagen exposure after non-surgical root planing followed by etching with EDTA gel preparation. J Periodontol 1996;67:841-845.
46. Sculean A, Stavropoulos A, Berakdar M, Windisch P, Karring T, Brecx M. Formation of human cementum following different modalities of regenerative therapy. Clin Oral Investig 2005;9:58-64.