Preparation and characterization of novel poly(ε-caprolactone)/ biphasic calcium phosphate hybrid composite microspheres

Journal of Biomedical Materials Research - Part B Applied Biomaterials

Volumn 98 B, Issue 2, 2011, Pages 272-279

  Bao, Trinh Quang ^a   Franco, Rose Ann ^a   Lee, Byong Taek ^a  

^a Soonchunhyang University   (South Korea)

Author keywords

BCP; in vitro; NH 4HCO 3; PCL; PCL BCP MPs

Indexed keywords

BCP; IN VITRO; NH 4HCO 3; PCL; PCL/BCP MPS;

ADHESION; AMMONIUM COMPOUNDS; BIODEGRADATION; BONE; CELL ADHESION; CELL CULTURE; DEGRADATION; EMULSIFICATION; GEOMETRICAL OPTICS; MICROSPHERES; PHOSPHATES; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION; X RAY DIFFRACTION ANALYSIS;

CALCIUM PHOSPHATE;

AMMONIA; BICARBONATE; CALCIUM PHOSPHATE; MICROSPHERE; POLYCAPROLACTONE;

ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CELL ADHESION; CELL CULTURE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; COMPOSITE MATERIAL; CYTOTOXICITY; MORPHOLOGY; OSTEOBLAST; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION;

ANIMALS; BICARBONATES; BONE SUBSTITUTES; CALCIUM PHOSPHATES; CELL ADHESION; CELL CULTURE TECHNIQUES; CELL PROLIFERATION; HUMANS; METHODS; MICROSPHERES; OSTEOBLASTS; PARTICLE SIZE; POLYESTERS; POROSITY;

EID: 79960086770     PISSN: 15524973     EISSN: 15524981     Source Type: Journal    
DOI: 10.1002/jbm.b.31849     Document Type: Article

References (25)

1. Fujihara K, Kotaki M, Ramakrishna S,. Guided bone regeneration membrane made of polycaprolactone/calcium carbonate composite nano-fibers. Biomaterials 2005; 26: 4139-4147. (Pubitemid 40138660)
2. Chen QZ, Boccaccini AR,. Poly(D,L -lactic acid) coated 45S5 Bioglass-based scaffolds: Processing and characterization. J Biomed Mater Res A 2006; 77: 445-457. (Pubitemid 47240771)
3. Moriah N, Lonnie DS,. Drug-releasing scaffolds fabricated from drug-loaded microspheres. J Biomed Mater Res 2001; 59: 349-356.
4. Torquato S, Truskett TM, Debenedetti PG,. Is random close packing of spheres well defined? Phys Rev Lett 2000; 84: 2064-2067.
5. Ruhe PQ, Hedberg EL, Padron NT, Spauwen PHM, Jansen JA, Mikos AG,. Biocompatibility and degradation of poly(DL -lactic-coglycolic acid)/calcium phosphate cement composites. J Biomed Mater Res A 2005; 74: 533-544. (Pubitemid 41216255)
6. Ray AML, Chiffoleau S, Iooss P, Grimandi G, Gouyette A, Daculsi G, Merle C,. Vancomycin encapsulation in biodegradable poly(ε-caprolactone) microparticles for bone implantation. Influence of the formulation process on size, drug loading, in vitro release and cytocompatibility. Biomaterials 2003; 24: 443-449. (Pubitemid 35287516)
7. Hong S, Xixue H, Yang F, Bei J, Wang S,. An injectable scaffold: rhBMP-2-loaded poly(lactide-co-glycolide)/hydroxyapatite composite microspheres. Acta Biomater 2010; 6: 455-465.
8. Yang F, Cui W, Xiong Z, Liu L, Bei JZ, Wang SG,. Poly(L -lactide-co-glycolide)/tricalcium phosphate composite scaffold and its various changes during degradation in vitro. Polym Degrad Stabil 2006; 91: 3065-3073. (Pubitemid 44913968)
9. Elizabeth RB, Kadriye T, Alexandra PM, Helena SA, Rui LR,. A novel enzymatically-mediated drug delivery carrier for bone tissue engineering applications: Combining biodegradable starch-based microparticles and differentiation agents. J Mater Sci Mater Med 2008; 19: 1617-1623.
10. Iooss P, Ray AML, Grimandi G, Daculsi G, Merle C,. A new injectable bone substitute combining poly(ε-caprolactone) microparticles with biphasic calcium phosphate granules. Biomaterials 2001; 22: 2785-2794. (Pubitemid 32727995)
11. Kersch N, Heidi R, Kim E, Sean M, Avashnee C, Wim R, Roger N,. An emulsion preparation for novel micro-porous polymeric hemi-shells. Mater Lett 2008; 62: 252-254.
12. Victor SP, Kumar TSS,. BCP ceramic microspheres as drug delivery carriers: Synthesis, characterisation and doxycycline release. J Mater Sci Mater Med 2008; 19: 283-290.
13. Daculsi G, Passuti N, Martin S, Deudon C, LeGeros RZ, Raher S,. Macroporous calcium phosphate ceramic for long bone surgery in humans and dogs. Clinical and histological study. J Biomed Mater Res 1990; 24: 379-396. (Pubitemid 20132807)
14. Saltzman M W, Baldwin S,. Materials for protein delivery in tissue engineering. Adv Drug Deliv Rev 1998; 33: 71-86. (Pubitemid 28403537)
15. Shelton RM, Liu Y, Cooper PR, Gbureck U, German MJ, Barralet JE,. Bone marrow cell gene expression and tissue construct assembly using octacalcium phosphate microscaffolds. Biomaterials 2006; 27: 2874-2881. (Pubitemid 43165756)
16. Lin S, Shaobing Z, Weijia W, Xiaohong L, Jianxin W, Jie W,. Preparation and characterization of porous biodegradable microspheres used for controlled protein delivery. Colloids Surf A Physicochem Eng Aspects 2009; 345: 173-181.
17. Kim TK, Yoon JJ, Lee DS, Park TG,. Gas foamed open porous biodegradable polymeric microspheres. Biomaterials 2006; 27: 152-159. (Pubitemid 41278516)
18. Yuanyuan W, Li L, Shengrong G,. Characterization of biodegradable and cytocompatible nano-hydroxyapatite/polycaprolactone porous scaffolds in degradation in vitro. Polym Degrad Stab 2010; 95: 207-213.
19. Zhao J, Guo LY, Yang XB, Weng J,. Preparation of bioactive porous HA/PCL composite scaffolds. Appl Surf Sci 2008; 255: 2942-2946.
20. Lebourg M, Antõn JS, Ribelles JLG,. Hybrid structure in PCL-HAp scaffold resulting from biomimetic apatite growth. J Mater Sci Mater Med 2010; 21: 33-44.
21. Qiu X, Han Y, Zhuang X, Chen X, Li Y, Jing X,. Preparation of nanohydroxyapatite/poly(L -lactide) biocomposite microspheres. J Nanopart Res 2007; 9: 901-908. (Pubitemid 46988311)
22. Shi X, Wang Y, Ren L, Gong Y, Wang DA,. Enhancing alendronate release from a novel PLGA/hydroxyapatite microspheric system for bone repairing applications. Pharm Res 2009; 26: 422-430.
23. Chung YW, Hui FL, Dey CS,. Enhancement of recombinant human macrophage colony-stimulating factor production using culture systems with porous polymeric microspheres. J Taiwan Inst Chem Eng 2010; 41: 203-208.
24. Lee BT, Youn MH, Paul RK, Lee KH, Song HY,. In situ synthesis of spherical BCP nanopowders by microwave assisted process. Mater Chem Phys 2007; 104: 249-253. (Pubitemid 47069619)
25. Hiep NT, Lee BT,. Electro-spinning of PLGA/PCL blends for tissue engineering and their biocompatibility. J Mater Sci Mater Med 2010; 21: 1969-1978.