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Volumn 145, Issue 1-2, 2012, Pages 66-73

A potential test system for detecting contaminations by bacterial lipoproteins

Author keywords

Bacterial lipoproteins; Bovine; HEK293 TLR2; IL 8; PAMP; Toll like receptor 2

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM LIPOPROTEIN; HUMAN SERUM ALBUMIN; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; LIPOPROTEIN; OVALBUMIN; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

EID: 84856531380     PISSN: 01652427     EISSN: 18732534     Source Type: Journal    
DOI: 10.1016/j.vetimm.2011.10.009     Document Type: Article
Times cited : (3)

References (58)
  • 1
    • 0022410044 scopus 로고    scopus 로고
    • Synthetic lipopeptide analogs of bacterial lipoprotein are potent polyclonal activators for murine B lymphocytes
    • Bessler W.G., Cox M., Lex A., Suhr B., Wiesmüller K.H., Jung G. Synthetic lipopeptide analogs of bacterial lipoprotein are potent polyclonal activators for murine B lymphocytes. J. Immunol. 2009, 135:1900-1905.
    • (2009) J. Immunol. , vol.135 , pp. 1900-1905
    • Bessler, W.G.1    Cox, M.2    Lex, A.3    Suhr, B.4    Wiesmüller, K.H.5    Jung, G.6
  • 2
    • 0026634780 scopus 로고
    • Synthetic lipopeptides as novel adjuvants
    • Bessler W.G., Jung G. Synthetic lipopeptides as novel adjuvants. Res. Immunol. 1992, 143:548-553.
    • (1992) Res. Immunol. , vol.143 , pp. 548-553
    • Bessler, W.G.1    Jung, G.2
  • 4
    • 0346731246 scopus 로고    scopus 로고
    • How we detect microbes and respond to them: the Toll-like receptors and their transducers
    • Beutler B., Hoebe K., Du X., Ulevitch R.J. How we detect microbes and respond to them: the Toll-like receptors and their transducers. J. Leukoc. Biol. 2003, 74:479-485.
    • (2003) J. Leukoc. Biol. , vol.74 , pp. 479-485
    • Beutler, B.1    Hoebe, K.2    Du, X.3    Ulevitch, R.J.4
  • 5
    • 18644372395 scopus 로고    scopus 로고
    • The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells
    • Borsutzky S., Kretschmer K., Becker P.D., Mühlradt P.F., Kirschning C.J., Weiss S., Guzman C.A. The mucosal adjuvant macrophage-activating lipopeptide-2 directly stimulates B lymphocytes via the TLR2 without the need of accessory cells. J. Immunol. 2005, 174:6308-6313.
    • (2005) J. Immunol. , vol.174 , pp. 6308-6313
    • Borsutzky, S.1    Kretschmer, K.2    Becker, P.D.3    Mühlradt, P.F.4    Kirschning, C.J.5    Weiss, S.6    Guzman, C.A.7
  • 8
    • 68749115366 scopus 로고    scopus 로고
    • Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins
    • Carpenter S., O'Neill L.A. Recent insights into the structure of Toll-like receptors and post-translational modifications of their associated signalling proteins. Biochem. J. 2009, 422:1-10.
    • (2009) Biochem. J. , vol.422 , pp. 1-10
    • Carpenter, S.1    O'Neill, L.A.2
  • 9
    • 0030669230 scopus 로고    scopus 로고
    • Human monocytoid cell lines as indicators of endotoxin. Comparison with rabbit pyrogen and Limulus amoebocyte lysate assay
    • Eperon S., De Groote D., Werner Felmayer G., Jungi T.W. Human monocytoid cell lines as indicators of endotoxin. Comparison with rabbit pyrogen and Limulus amoebocyte lysate assay. J. Immunol. Methods 1997, 207:135-145.
    • (1997) J. Immunol. Methods , vol.207 , pp. 135-145
    • Eperon, S.1    De Groote, D.2    Werner Felmayer, G.3    Jungi, T.W.4
  • 10
    • 84864794408 scopus 로고    scopus 로고
    • Identification of full length TLR1 and functional characterization of lipopeptide recognition by bovine TLR2/1 heterodimer
    • Farhat K., Riekenberger S., Jung G., Wiesmueller K.-H., Jungi T.W., Ulmer A.J. Identification of full length TLR1 and functional characterization of lipopeptide recognition by bovine TLR2/1 heterodimer. Vet. Res. 2010, 41:34-45.
    • (2010) Vet. Res. , vol.41 , pp. 34-45
    • Farhat, K.1    Riekenberger, S.2    Jung, G.3    Wiesmueller, K.-H.4    Jungi, T.W.5    Ulmer, A.J.6
  • 11
    • 51549101589 scopus 로고    scopus 로고
    • The response of HEK293 cells transfected with bovine TLR2 to established pathogen-associated molecular patterns and to bacteria causing mastitis in cattle
    • Farhat K., Sauter K.S., Brcic M., Ulmer A.J., Frey J., Jungi T.W. The response of HEK293 cells transfected with bovine TLR2 to established pathogen-associated molecular patterns and to bacteria causing mastitis in cattle. Vet. Immunol. Immunopathol. 2008, 125:326-336.
    • (2008) Vet. Immunol. Immunopathol. , vol.125 , pp. 326-336
    • Farhat, K.1    Sauter, K.S.2    Brcic, M.3    Ulmer, A.J.4    Frey, J.5    Jungi, T.W.6
  • 12
    • 9144233004 scopus 로고    scopus 로고
    • Human but not murine toll-like receptor 2 discriminates between tri-palmitoylated and tri-lauroylated peptides
    • Grabiec A., Meng G., Fichte S., Bessler W., Wagner H., Kirschning C.J. Human but not murine toll-like receptor 2 discriminates between tri-palmitoylated and tri-lauroylated peptides. J. Biol. Chem. 2004, 279:48004-48012.
    • (2004) J. Biol. Chem. , vol.279 , pp. 48004-48012
    • Grabiec, A.1    Meng, G.2    Fichte, S.3    Bessler, W.4    Wagner, H.5    Kirschning, C.J.6
  • 13
    • 0018678716 scopus 로고
    • A new chromogenic substrate method for assay of bacterial endotoxins using Limulus hemocyte lysate
    • Harada T., Morita T., Iwanaga S., Nakamura S., Niwa M. A new chromogenic substrate method for assay of bacterial endotoxins using Limulus hemocyte lysate. Prog. Clin. Biol. Res. 1979, 29:209-220.
    • (1979) Prog. Clin. Biol. Res. , vol.29 , pp. 209-220
    • Harada, T.1    Morita, T.2    Iwanaga, S.3    Nakamura, S.4    Niwa, M.5
  • 14
    • 33747806614 scopus 로고    scopus 로고
    • Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus
    • Hashimoto M., Tawaratsumida K., Kariya H., Kiyohara A., Suda Y., Krikae F., Kirikae T., Götz F. Not lipoteichoic acid but lipoproteins appear to be the dominant immunobiologically active compounds in Staphylococcus aureus. J. Immunol. 2006, 177:3162-3169.
    • (2006) J. Immunol. , vol.177 , pp. 3162-3169
    • Hashimoto, M.1    Tawaratsumida, K.2    Kariya, H.3    Kiyohara, A.4    Suda, Y.5    Krikae, F.6    Kirikae, T.7    Götz, F.8
  • 16
    • 0033198204 scopus 로고    scopus 로고
    • Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2
    • Hirschfeld M., Kirschning C.J., Schwandner R., Wesche H., Weis J.H., Wooten R.M., Weis J.J. Cutting edge: inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by toll-like receptor 2. J. Immunol. 1999, 163:2382-2386.
    • (1999) J. Immunol. , vol.163 , pp. 2382-2386
    • Hirschfeld, M.1    Kirschning, C.J.2    Schwandner, R.3    Wesche, H.4    Weis, J.H.5    Wooten, R.M.6    Weis, J.J.7
  • 17
    • 0034662239 scopus 로고    scopus 로고
    • Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2
    • Hirschfeld M., Ma Y., Weis J.H., Vogel S.N., Weis J.J. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine toll-like receptor 2. J. Immunol. 2000, 165:618-622.
    • (2000) J. Immunol. , vol.165 , pp. 618-622
    • Hirschfeld, M.1    Ma, Y.2    Weis, J.H.3    Vogel, S.N.4    Weis, J.J.5
  • 21
    • 34548608447 scopus 로고    scopus 로고
    • Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
    • Jin M.S., Kim S.E., Heo J.Y., Lee M.E., Kim H.M., Paik S.G., Lee H., Lee J.O. Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 2007, 130:1071-1082.
    • (2007) Cell , vol.130 , pp. 1071-1082
    • Jin, M.S.1    Kim, S.E.2    Heo, J.Y.3    Lee, M.E.4    Kim, H.M.5    Paik, S.G.6    Lee, H.7    Lee, J.O.8
  • 22
    • 33646147362 scopus 로고    scopus 로고
    • Toll-like receptor function and signaling
    • Kaisho T., Akira S. Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 2006, 117:979-987.
    • (2006) J. Allergy Clin. Immunol. , vol.117 , pp. 979-987
    • Kaisho, T.1    Akira, S.2
  • 24
    • 51349158231 scopus 로고    scopus 로고
    • Signalling adaptors used by Toll-like receptors: an update
    • Kenny E.F., O'Neill L.A. Signalling adaptors used by Toll-like receptors: an update. Cytokine 2009, 43:342-349.
    • (2009) Cytokine , vol.43 , pp. 342-349
    • Kenny, E.F.1    O'Neill, L.A.2
  • 25
    • 0031774181 scopus 로고    scopus 로고
    • Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
    • Kirschning C.J., Wesche H., Merrill A.T., Rothe M. Human toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide. J. Exp. Med. 1998, 188:2091-2097.
    • (1998) J. Exp. Med. , vol.188 , pp. 2091-2097
    • Kirschning, C.J.1    Wesche, H.2    Merrill, A.T.3    Rothe, M.4
  • 26
    • 0000461773 scopus 로고
    • A description of cellular coagulation in the limulus
    • Levin J., Bang F. A description of cellular coagulation in the limulus. Bull. Johns Hopkins Hosp. 1964, 15:337-345.
    • (1964) Bull. Johns Hopkins Hosp. , vol.15 , pp. 337-345
    • Levin, J.1    Bang, F.2
  • 27
    • 0000631035 scopus 로고
    • The role of endotoxin in the extracellular coagulation of limulus blood
    • Levin J., Bang F. The role of endotoxin in the extracellular coagulation of limulus blood. Bull. Johns Hopkins Hosp. 1964, 115:265-274.
    • (1964) Bull. Johns Hopkins Hosp. , vol.115 , pp. 265-274
    • Levin, J.1    Bang, F.2
  • 28
    • 0032716031 scopus 로고    scopus 로고
    • The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors
    • Means T.K., Lien E., Yoshimura A., Wang S., Golenbock D.T., Fenton M.J. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J. Immunol. 2007, 163:6748-6755.
    • (2007) J. Immunol. , vol.163 , pp. 6748-6755
    • Means, T.K.1    Lien, E.2    Yoshimura, A.3    Wang, S.4    Golenbock, D.T.5    Fenton, M.J.6
  • 29
    • 0034210449 scopus 로고    scopus 로고
    • How does the immune system distinguish self from nonself?
    • Medzhitov R., Janeway C.A.J. How does the immune system distinguish self from nonself?. Semin. Immunol. 2000, 12:185-188.
    • (2000) Semin. Immunol. , vol.12 , pp. 185-188
    • Medzhitov, R.1    Janeway, C.A.J.2
  • 30
    • 0345671672 scopus 로고    scopus 로고
    • Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration
    • Mühlradt P.F., Kiess M., Meyer H., Süssmuth R., Jung G. Isolation, structure elucidation, and synthesis of a macrophage stimulatory lipopeptide from Mycoplasma fermentans acting at picomolar concentration. J. Exp. Med. 1997, 185:1951-1958.
    • (1997) J. Exp. Med. , vol.185 , pp. 1951-1958
    • Mühlradt, P.F.1    Kiess, M.2    Meyer, H.3    Süssmuth, R.4    Jung, G.5
  • 31
    • 0036214502 scopus 로고    scopus 로고
    • Signaling pathways induced by lipoproteins derived from Mycoplasma salivarium and a synthetic lipopeptide (FSL-1) in normal human gingival fibroblasts
    • Nakamura J., Shibata K., Hasebe A., Into T., Watanabe T., Ohata N. Signaling pathways induced by lipoproteins derived from Mycoplasma salivarium and a synthetic lipopeptide (FSL-1) in normal human gingival fibroblasts. Microbiol. Immunol. 2002, 46:151-158.
    • (2002) Microbiol. Immunol. , vol.46 , pp. 151-158
    • Nakamura, J.1    Shibata, K.2    Hasebe, A.3    Into, T.4    Watanabe, T.5    Ohata, N.6
  • 32
    • 0021811032 scopus 로고
    • A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical applications
    • Obayashi T., Tamura H., Tanaka S., Ohki M., Takahashi S., Arai M., Masuda M., Kawai T. A new chromogenic endotoxin-specific assay using recombined limulus coagulation enzymes and its clinical applications. Clin. Chim. Acta 1985, 149:55-65.
    • (1985) Clin. Chim. Acta , vol.149 , pp. 55-65
    • Obayashi, T.1    Tamura, H.2    Tanaka, S.3    Ohki, M.4    Takahashi, S.5    Arai, M.6    Masuda, M.7    Kawai, T.8
  • 33
    • 27744456905 scopus 로고    scopus 로고
    • Domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination
    • Omueti K.O., Beyer J.M., Johnson C.M., Lyle E.A., Tapping R.I. Domain exchange between human toll-like receptors 1 and 6 reveals a region required for lipopeptide discrimination. J. Biol. Chem. 2005, 280:36616-36625.
    • (2005) J. Biol. Chem. , vol.280 , pp. 36616-36625
    • Omueti, K.O.1    Beyer, J.M.2    Johnson, C.M.3    Lyle, E.A.4    Tapping, R.I.5
  • 34
    • 0033955086 scopus 로고    scopus 로고
    • Interferon-gamma-primed monocytoid cell lines: optimizing their use for in vitro detection of bacterial pyrogens
    • Peterbauer A., Eperon S., Jungi T.W., Werner E.R., Werner-Felmayer G. Interferon-gamma-primed monocytoid cell lines: optimizing their use for in vitro detection of bacterial pyrogens. J. Immunol. Methods 2000, 233:67-76.
    • (2000) J. Immunol. Methods , vol.233 , pp. 67-76
    • Peterbauer, A.1    Eperon, S.2    Jungi, T.W.3    Werner, E.R.4    Werner-Felmayer, G.5
  • 36
    • 0023808685 scopus 로고
    • Assay of pyrogenic contamination in pharmaceuticals by cytokine release from monocytes
    • Poole S., Thorpe R., Meager A., Gearing A.J. Assay of pyrogenic contamination in pharmaceuticals by cytokine release from monocytes. Dev. Biol. Stand. 1988, 69:121-123.
    • (1988) Dev. Biol. Stand. , vol.69 , pp. 121-123
    • Poole, S.1    Thorpe, R.2    Meager, A.3    Gearing, A.J.4
  • 37
    • 0007803949 scopus 로고
    • The pyrogenicity of bacterial contaminants found in biological products
    • Probey T.F., Pittman M. The pyrogenicity of bacterial contaminants found in biological products. J. Bateriol. 1945, 50:397-411.
    • (1945) J. Bateriol. , vol.50 , pp. 397-411
    • Probey, T.F.1    Pittman, M.2
  • 38
    • 0025997606 scopus 로고
    • Measurement of cytokine production by the monocytic cell line Mono Mac 6 using novel immunoradiometric assays for interleukin-1 beta and interleukin-6
    • Rafferty B., Mower J.A., Taktak Y.S., Poole S. Measurement of cytokine production by the monocytic cell line Mono Mac 6 using novel immunoradiometric assays for interleukin-1 beta and interleukin-6. J. Immunol. Methods 1991, 144:69-76.
    • (1991) J. Immunol. Methods , vol.144 , pp. 69-76
    • Rafferty, B.1    Mower, J.A.2    Taktak, Y.S.3    Poole, S.4
  • 40
    • 34250726974 scopus 로고    scopus 로고
    • Stable transduction of bovine TLR4 and bovine MD-2 into LPS-nonresponsive cells and soluble CD14 promote the ability to respond to LPS
    • Sauter K.S., Brcic M., Franchini M., Jungi T.W. Stable transduction of bovine TLR4 and bovine MD-2 into LPS-nonresponsive cells and soluble CD14 promote the ability to respond to LPS. Vet. Immunol. Immunopathol. 2007, 118:92-104.
    • (2007) Vet. Immunol. Immunopathol. , vol.118 , pp. 92-104
    • Sauter, K.S.1    Brcic, M.2    Franchini, M.3    Jungi, T.W.4
  • 41
    • 0034283666 scopus 로고    scopus 로고
    • Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids
    • Schröder N.W., Opitz B., Lamping N., Michelsen K.S., Zähringer U., Göbel U.B., Schumann R.R. Involvement of lipopolysaccharide binding protein, CD14, and Toll-like receptors in the initiation of innate immune responses by Treponema glycolipids. J. Immunol. 2000, 165:2683-2693.
    • (2000) J. Immunol. , vol.165 , pp. 2683-2693
    • Schröder, N.W.1    Opitz, B.2    Lamping, N.3    Michelsen, K.S.4    Zähringer, U.5    Göbel, U.B.6    Schumann, R.R.7
  • 42
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
    • Schwandner R., Dziarski R., Wesche H., Rothe M., Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 1999, 274:17406-17409.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17406-17409
    • Schwandner, R.1    Dziarski, R.2    Wesche, H.3    Rothe, M.4    Kirschning, C.J.5
  • 44
    • 0034669910 scopus 로고    scopus 로고
    • Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection
    • Takeuchi O., Hoshino K., Akira S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to Staphylococcus aureus infection. J. Immunol. 2000, 165:5392-5396.
    • (2000) J. Immunol. , vol.165 , pp. 5392-5396
    • Takeuchi, O.1    Hoshino, K.2    Akira, S.3
  • 46
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi O., Sato S., Horiuchi T., Hoshino K., Dong Z., Modlin R.L., Akira S. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J. Immunol. 2002, 169:10-14.
    • (2002) J. Immunol. , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3    Hoshino, K.4    Dong, Z.5    Modlin, R.L.6    Akira, S.7
  • 48
    • 0018699563 scopus 로고
    • A turbidimetric Limulus amoebocyte assay for the quantitative determination of Gram negative bacterial endotoxin
    • Teller J.D., Kelly K.M. A turbidimetric Limulus amoebocyte assay for the quantitative determination of Gram negative bacterial endotoxin. Prog. Clin. Biol. Res. 1979, 29:423-433.
    • (1979) Prog. Clin. Biol. Res. , vol.29 , pp. 423-433
    • Teller, J.D.1    Kelly, K.M.2
  • 50
    • 29344474286 scopus 로고    scopus 로고
    • Utilization of the human cell line HL-60 for chemiluminescence based detection of microorganisms and related substances
    • Timm M., Hansen E.W., Moesby L., Christensen J.D. Utilization of the human cell line HL-60 for chemiluminescence based detection of microorganisms and related substances. Eur. J. Pharmaceut. Sci. 2009, 27:252-258.
    • (2009) Eur. J. Pharmaceut. Sci. , vol.27 , pp. 252-258
    • Timm, M.1    Hansen, E.W.2    Moesby, L.3    Christensen, J.D.4
  • 52
    • 0347126491 scopus 로고    scopus 로고
    • Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists
    • Werling D., Hope J.C., Howard C.J., Jungi T.W. Differential production of cytokines, reactive oxygen and nitrogen by bovine macrophages and dendritic cells stimulated with Toll-like receptor agonists. Immunology 2004, 111:41-52.
    • (2004) Immunology , vol.111 , pp. 41-52
    • Werling, D.1    Hope, J.C.2    Howard, C.J.3    Jungi, T.W.4
  • 53
    • 33744505197 scopus 로고    scopus 로고
    • Expression of Toll-like receptors (TLR) by bovine antigen-presenting cells - potential role in pathogen discrimination?
    • Werling D., Piercy J., Coffey T.J. Expression of Toll-like receptors (TLR) by bovine antigen-presenting cells - potential role in pathogen discrimination?. Vet. Immunol. Immunopathol. 2006, 112:2-11.
    • (2006) Vet. Immunol. Immunopathol. , vol.112 , pp. 2-11
    • Werling, D.1    Piercy, J.2    Coffey, T.J.3
  • 54
    • 0029013240 scopus 로고
    • Detection of bacterial pyrogens on the basis of their effects on gamma interferon-mediated formation of neopterin or nitrite in cultured monocyte cell lines
    • Werner-Felmayer G., Baier Bitterlich G., Fuchs D., Hausen A., Murr C., Reibnegger G., Werner E.R., Wachter H. Detection of bacterial pyrogens on the basis of their effects on gamma interferon-mediated formation of neopterin or nitrite in cultured monocyte cell lines. Clin. Diagn. Lab. Immunol. 1995, 2:307-313.
    • (1995) Clin. Diagn. Lab. Immunol. , vol.2 , pp. 307-313
    • Werner-Felmayer, G.1    Baier Bitterlich, G.2    Fuchs, D.3    Hausen, A.4    Murr, C.5    Reibnegger, G.6    Werner, E.R.7    Wachter, H.8
  • 56
    • 0020987823 scopus 로고
    • Posttranslational modification and processing of membrane lipoproteins in bacteria
    • Wu H.C., Tokunaga M., Tokunaga H., Hayashi S., Giam C.Z. Posttranslational modification and processing of membrane lipoproteins in bacteria. J. Cell Biochem. 1983, 22:161-171.
    • (1983) J. Cell Biochem. , vol.22 , pp. 161-171
    • Wu, H.C.1    Tokunaga, M.2    Tokunaga, H.3    Hayashi, S.4    Giam, C.Z.5
  • 57
    • 41649115159 scopus 로고    scopus 로고
    • TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity
    • Zähringer U., Lindner B., Inamura S., Heine H., Alexander C. TLR2 - promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity. Immunobiology 2008, 213:205-224.
    • (2008) Immunobiology , vol.213 , pp. 205-224
    • Zähringer, U.1    Lindner, B.2    Inamura, S.3    Heine, H.4    Alexander, C.5


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