-
2
-
-
6944230093
-
Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging
-
O'Connell JB, Maggard MA, Ko CY. Colon cancer survival rates with the new American Joint Committee on Cancer sixth edition staging. J Natl Cancer Inst 2004;96:1420-1425.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 1420-1425
-
-
O'Connell, J.B.1
Maggard, M.A.2
Ko, C.Y.3
-
3
-
-
2542563257
-
Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: Who benefits and by how much?
-
Gill S, Loprinzi CL, Sargent DJ et al. Pooled analysis of fluorouracil-based adjuvant therapy for stage II and III colon cancer: Who benefits and by how much? J Clin Oncol 2004;22:1797-1806.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1797-1806
-
-
Gill, S.1
Loprinzi, C.L.2
Sargent, D.J.3
-
4
-
-
34548488936
-
Phase III study comparing a semimonthly with a monthly regimen of fluorouracil and leucovorin as adjuvant treatment for stage II and III colon cancer patients: Final results of GERCOR C96.1
-
André T, Quinaux E, Louvet C et al. Phase III study comparing a semimonthly with a monthly regimen of fluorouracil and leucovorin as adjuvant treatment for stage II and III colon cancer patients: Final results of GERCOR C96.1. J Clin Oncol 2007;25:3732-3738.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3732-3738
-
-
André, T.1
Quinaux, E.2
Louvet, C.3
-
5
-
-
0032949446
-
Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04)
-
Mamounas E, Wieand S, Wolmark N et al. Comparative efficacy of adjuvant chemotherapy in patients with Dukes' B versus Dukes' C colon cancer: Results from four National Surgical Adjuvant Breast and Bowel Project adjuvant studies (C-01, C-02, C-03, and C-04). J Clin Oncol 1999;17:1349-1355.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1349-1355
-
-
Mamounas, E.1
Wieand, S.2
Wolmark, N.3
-
6
-
-
67650315187
-
Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial
-
André T, Boni C, Navarro M et al. Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol 2009;27:3109-3116.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3109-3116
-
-
André, T.1
Boni, C.2
Navarro, M.3
-
7
-
-
67650290547
-
Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3
-
Van Cutsem E, Labianca R, Bodoky G et al. Randomized phase III trial comparing biweekly infusional fluorouracil/leucovorin alone or with irinotecan in the adjuvant treatment of stage III colon cancer: PETACC-3. J Clin Oncol 2009;27:3117-3125.
-
(2009)
J Clin Oncol
, vol.27
, pp. 3117-3125
-
-
van Cutsem, E.1
Labianca, R.2
Bodoky, G.3
-
8
-
-
34548160680
-
Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: Results of CALGB 89803
-
Saltz LB, Niedzwiecki D, Hollis D et al. Irinotecan fluorouracil plus leucovorin is not superior to fluorouracil plus leucovorin alone as adjuvant treatment for stage III colon cancer: Results of CALGB 89803. J Clin Oncol 2007;25:3456-3461.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3456-3461
-
-
Saltz, L.B.1
Niedzwiecki, D.2
Hollis, D.3
-
9
-
-
0041885405
-
Colon cancer survival is associated with increasing number of lymph nodes analyzed: A secondary survey of intergroup trial INT-0089
-
Le Voyer TE, Sigurdson ER, Hanlon AL et al. Colon cancer survival is associated with increasing number of lymph nodes analyzed: A secondary survey of intergroup trial INT-0089. J Clin Oncol 2003;21:2912-2919.
-
(2003)
J Clin Oncol
, vol.21
, pp. 2912-2919
-
-
Le Voyer, T.E.1
Sigurdson, E.R.2
Hanlon, A.L.3
-
10
-
-
69949094407
-
Tissue biomarker development in a multicentre trial context: A feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial
-
Bosman FT, Yan P, Tejpar S et al. Tissue biomarker development in a multicentre trial context: A feasibility study on the PETACC3 stage II and III colon cancer adjuvant treatment trial. Clin Cancer Res 2009;15:5528-5533.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5528-5533
-
-
Bosman, F.T.1
Yan, P.2
Tejpar, S.3
-
11
-
-
33845373278
-
Colorectal cancer and genetic alterations in the Wnt pathway
-
Segditsas S, Tomlinson I. Colorectal cancer and genetic alterations in the Wnt pathway. Oncogene 2006;25:7531-7537.
-
(2006)
Oncogene
, vol.25
, pp. 7531-7537
-
-
Segditsas, S.1
Tomlinson, I.2
-
12
-
-
0023748414
-
Genetic alterations during colorectal-tumor development
-
Vogelstein B, Fearon ER, Hamilton SR et al. Genetic alterations during colorectal-tumor development. N Engl J Med 1988;319:525-532.
-
(1988)
N Engl J Med
, vol.319
, pp. 525-532
-
-
Vogelstein, B.1
Fearon, E.R.2
Hamilton, S.R.3
-
13
-
-
0024514647
-
Allelotype of colorectal carcinomas
-
Vogelstein B, Fearon ER, Kern SE et al. Allelotype of colorectal carcinomas. Science 1989;244:207-211.
-
(1989)
Science
, vol.244
, pp. 207-211
-
-
Vogelstein, B.1
Fearon, E.R.2
Kern, S.E.3
-
14
-
-
0024536654
-
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas
-
Baker SJ, Fearon ER, Nigro JM et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science 1989;244:217-221.
-
(1989)
Science
, vol.244
, pp. 217-221
-
-
Baker, S.J.1
Fearon, E.R.2
Nigro, J.M.3
-
15
-
-
72449176846
-
Molecular origins of cancer: Molecular basis of colorectal cancer
-
Markowitz SD, Bertagnolli MM. Molecular origins of cancer: Molecular basis of colorectal cancer. N Engl J Med 2009;361:2449-2460.
-
(2009)
N Engl J Med
, vol.361
, pp. 2449-2460
-
-
Markowitz, S.D.1
Bertagnolli, M.M.2
-
17
-
-
0027136828
-
Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history
-
Lothe RA, Peltomaki P, Meling GI et al. Genomic instability in colorectal cancer: Relationship to clinicopathological variables and family history. Cancer Res 1993;53:5849-5852.
-
(1993)
Cancer Res
, vol.53
, pp. 5849-5852
-
-
Lothe, R.A.1
Peltomaki, P.2
Meling, G.I.3
-
18
-
-
1242292420
-
Genomic instability and colon cancer
-
Grady WM. Genomic instability and colon cancer. Cancer Metastasis Rev 2004;23:11-27.
-
(2004)
Cancer Metastasis Rev
, vol.23
, pp. 11-27
-
-
Grady, W.M.1
-
19
-
-
0027158031
-
Clues to the pathogenesis of familial colorectal cancer
-
Aaltonen LA, Peltomäki P, Leach FS et al. Clues to the pathogenesis of familial colorectal cancer. Science 1993;260:812-816.
-
(1993)
Science
, vol.260
, pp. 812-816
-
-
Aaltonen, L.A.1
Peltomäki, P.2
Leach, F.S.3
-
20
-
-
0027285475
-
Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis
-
Ionov Y, Peinado MA, Malkhosyan S et al. Ubiquitous somatic mutations in simple repeated sequences reveal a new mechanism for colonic carcinogenesis. Nature 1993;363:558-561.
-
(1993)
Nature
, vol.363
, pp. 558-561
-
-
Ionov, Y.1
Peinado, M.A.2
Malkhosyan, S.3
-
21
-
-
0030592517
-
Lessons from hereditary colorectal cancer
-
Kinzler KW, Vogelstein B. Lessons from hereditary colorectal cancer. Cell 1996;87:159-170.
-
(1996)
Cell
, vol.87
, pp. 159-170
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
22
-
-
0031017268
-
Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
-
Kane MF, Loda M, Gaida GM et al. Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 1997;57:808-811.
-
(1997)
Cancer Res
, vol.57
, pp. 808-811
-
-
Kane, M.F.1
Loda, M.2
Gaida, G.M.3
-
23
-
-
0032146118
-
Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability
-
Cunningham JM, Christensen ER, Tester DJ et al. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability. Cancer Res 1998;58:3455-3460.
-
(1998)
Cancer Res
, vol.58
, pp. 3455-3460
-
-
Cunningham, J.M.1
Christensen, E.R.2
Tester, D.J.3
-
24
-
-
33746794561
-
Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): A guide for clinicians
-
Hendriks YM, de Jong AE, Morreau H et al. Diagnostic approach and management of Lynch syndrome (hereditary nonpolyposis colorectal carcinoma): A guide for clinicians. CA Cancer J Clin 2006;56:213-225.
-
(2006)
CA Cancer J Clin
, vol.56
, pp. 213-225
-
-
Hendriks, Y.M.1
de Jong, A.E.2
Morreau, H.3
-
25
-
-
0036569940
-
Mutations at coding repeat sequences in mismatch repair-deficient human cancers: Toward a new concept of target genes for instability
-
Duval A, Hamelin R. Mutations at coding repeat sequences in mismatch repair-deficient human cancers: Toward a new concept of target genes for instability. Cancer Res 2002;62:2447-2454.
-
(2002)
Cancer Res
, vol.62
, pp. 2447-2454
-
-
Duval, A.1
Hamelin, R.2
-
26
-
-
35148887112
-
Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability
-
Miquel C, Jacob S, Grandjouan S et al. Frequent alteration of DNA damage signalling and repair pathways in human colorectal cancers with microsatellite instability. Oncogene 2007;26:5919-5926.
-
(2007)
Oncogene
, vol.26
, pp. 5919-5926
-
-
Miquel, C.1
Jacob, S.2
Grandjouan, S.3
-
27
-
-
0346057796
-
BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency
-
Oliveira C, Pinto M, Duval A et al. BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency. Oncogene 2003;22:9192-9196.
-
(2003)
Oncogene
, vol.22
, pp. 9192-9196
-
-
Oliveira, C.1
Pinto, M.2
Duval, A.3
-
29
-
-
36749025213
-
Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
-
Shen L, Toyota M, Kondo Y et al. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A 2007;104:18654-18659.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 18654-18659
-
-
Shen, L.1
Toyota, M.2
Kondo, Y.3
-
30
-
-
10744233937
-
Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
-
Umar A, Boland CR, Terdiman JP et al. Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 2004;96:261-268.
-
(2004)
J Natl Cancer Inst
, vol.96
, pp. 261-268
-
-
Umar, A.1
Boland, C.R.2
Terdiman, J.P.3
-
31
-
-
58749102767
-
Deficient mismatch repair system in patients with sporadic advanced colorectal cancer
-
Koopman M, Kortman GA, Mekenkamp L et al. Deficient mismatch repair system in patients with sporadic advanced colorectal cancer. Br J Cancer 2009;100:266-273.
-
(2009)
Br J Cancer
, vol.100
, pp. 266-273
-
-
Koopman, M.1
Kortman, G.A.2
Mekenkamp, L.3
-
32
-
-
0034642605
-
Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer
-
Gryfe R, Kim H, Hsieh ET et al. Tumor microsatellite instability and clinical outcome in young patients with colorectal cancer. N Engl J Med 2000;342:69-77.
-
(2000)
N Engl J Med
, vol.342
, pp. 69-77
-
-
Gryfe, R.1
Kim, H.2
Hsieh, E.T.3
-
33
-
-
0038002279
-
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer
-
Ribic CM, Sargent DJ, Moore MJ et al. Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer. N Engl J Med 2003;349:247-257.
-
(2003)
N Engl J Med
, vol.349
, pp. 247-257
-
-
Ribic, C.M.1
Sargent, D.J.2
Moore, M.J.3
-
34
-
-
0033523204
-
Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers
-
Halling KC, French AJ, McDonnell SK et al. Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers. J Natl Cancer Inst 1999;91:1295-1303.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 1295-1303
-
-
Halling, K.C.1
French, A.J.2
McDonnell, S.K.3
-
35
-
-
14544300998
-
Systematic review of microsatellite instability and colorectal cancer prognosis
-
Popat S, Hubner R, Houlston RS. Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 2005;23:609-618.
-
(2005)
J Clin Oncol
, vol.23
, pp. 609-618
-
-
Popat, S.1
Hubner, R.2
Houlston, R.S.3
-
36
-
-
77949274921
-
Stage-specific prognostic value of molecular markers in colon cancer: Results of the translational study on the PETACC 3-EORTC 40993-SAKK 60-00 trial [abstract 4002]
-
Roth AD, Tejpar S, Yan P et al. Stage-specific prognostic value of molecular markers in colon cancer: Results of the translational study on the PETACC 3-EORTC 40993-SAKK 60-00 trial [abstract 4002]. J Clin Oncol 2009;27(15 suppl):169s.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Roth, A.D.1
Tejpar, S.2
Yan, P.3
-
37
-
-
77749251731
-
A quantitative multigene RT-PCR assay for prediction of recurrence in stage II colon cancer: Selection of the genes in four large studies and results of the independent, prospectively designed QUASAR validation study [abstract 4000]
-
Kerr D, Gray R, Quirke P et al. A quantitative multigene RT-PCR assay for prediction of recurrence in stage II colon cancer: Selection of the genes in four large studies and results of the independent, prospectively designed QUASAR validation study [abstract 4000]. J Clin Oncol 2009;25(15 suppl):169s.
-
(2009)
J Clin Oncol
, vol.25
, Issue.15 SUPPL.
-
-
Kerr, D.1
Gray, R.2
Quirke, P.3
-
38
-
-
0035428087
-
Microsatellite instability is a predictive marker for survival benefit from adjuvant chemotherapy in a population-based series of stage III colorectal carcinoma
-
Elsaleh H, Iacopetta B. Microsatellite instability is a predictive marker for survival benefit from adjuvant chemotherapy in a population-based series of stage III colorectal carcinoma. Clin Colorectal Cancer 2001;1:104-109.
-
(2001)
Clin Colorectal Cancer
, vol.1
, pp. 104-109
-
-
Elsaleh, H.1
Iacopetta, B.2
-
39
-
-
53749096264
-
Confirmation of deficient mismatch repair (dMMR) as a predictive marker for lack of benefit from 5-FU based chemotherapy in stage II and III colon cancer (CC): A pooled molecular reanalysis of randomized chemotherapy trials [abstract 4008]
-
Sargent DJ, Marsoni S, Thibodeau SN et al. Confirmation of deficient mismatch repair (dMMR) as a predictive marker for lack of benefit from 5-FU based chemotherapy in stage II and III colon cancer (CC): A pooled molecular reanalysis of randomized chemotherapy trials [abstract 4008]. J Clin Oncol 2008;26:180s.
-
(2008)
J Clin Oncol
, vol.180 s
, pp. 26
-
-
Sargent, D.J.1
Marsoni, S.2
Thibodeau, S.N.3
-
40
-
-
59249097606
-
The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status
-
Jover R, Zapater P, Castells A et al. The efficacy of adjuvant chemotherapy with 5-fluorouracil in colorectal cancer depends on the mismatch repair status. Eur J Cancer 2009;45:365-373.
-
(2009)
Eur J Cancer
, vol.45
, pp. 365-373
-
-
Jover, R.1
Zapater, P.2
Castells, A.3
-
41
-
-
64649096900
-
Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803
-
Bertagnolli MM, Niedzwiecki D, Compton CC et al. Microsatellite instability predicts improved response to adjuvant therapy with irinotecan, fluorouracil, and leucovorin in stage III colon cancer: Cancer and Leukemia Group B Protocol 89803. J Clin Oncol 2009;27:1814-1821.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1814-1821
-
-
Bertagnolli, M.M.1
Niedzwiecki, D.2
Compton, C.C.3
-
42
-
-
77949274921
-
Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETACC 3-EORTC 40993-SAKK 60/00 trial) [abstract 4001]
-
Tejpar S, Bosman F, Delorenzi M et al. Microsatellite instability (MSI) in stage II and III colon cancer treated with 5FU-LV or 5FU-LV and irinotecan (PETACC 3-EORTC 40993-SAKK 60/00 trial) [abstract 4001]. J Clin Oncol 2009;27(15 suppl):169s.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Tejpar, S.1
Bosman, F.2
Delorenzi, M.3
-
43
-
-
67650284737
-
Clinical implications of microsatellite instability in sporadic colon cancers
-
Sinicrope FA, Sargent DJ. Clinical implications of microsatellite instability in sporadic colon cancers. Curr Opin Oncol 2009;21:369-373.
-
(2009)
Curr Opin Oncol
, vol.21
, pp. 369-373
-
-
Sinicrope, F.A.1
Sargent, D.J.2
-
44
-
-
50349091081
-
Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer
-
French AJ, Sargent DJ, Burgart LJ et al. Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer. Clin Cancer Res 2008;14:3408-3415.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3408-3415
-
-
French, A.J.1
Sargent, D.J.2
Burgart, L.J.3
-
45
-
-
0028321495
-
Allelic loss of chromosome 18q and prognosis in colorectal cancer
-
Jen J, Kim H, Piantadosi S et al. Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med 1994;331:213-221.
-
(1994)
N Engl J Med
, vol.331
, pp. 213-221
-
-
Jen, J.1
Kim, H.2
Piantadosi, S.3
-
46
-
-
0003119527
-
Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator
-
Ogunbiyi OA, Goodfellow PJ, Herfarth K et al. Confirmation that chromosome 18q allelic loss in colon cancer is a prognostic indicator. J Clin Oncol 1998;16:427-433.
-
(1998)
J Clin Oncol
, vol.16
, pp. 427-433
-
-
Ogunbiyi, O.A.1
Goodfellow, P.J.2
Herfarth, K.3
-
47
-
-
25144456860
-
A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis
-
Popat S, Houlston RS. A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis. Eur J Cancer 2005;41:2060-2070.
-
(2005)
Eur J Cancer
, vol.41
, pp. 2060-2070
-
-
Popat, S.1
Houlston, R.S.2
-
48
-
-
0031780224
-
Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer
-
Martínez-López E, Abad A, Font A et al. Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer. Gastroenterology 1998;114:1180-1187.
-
(1998)
Gastroenterology
, vol.114
, pp. 1180-1187
-
-
Martínez-López, E.1
Abad, A.2
Font, A.3
-
49
-
-
33847739833
-
Relationship between chromosome 18q status and colorectal cancer prognosis: A prospective, blinded analysis of 280 patients
-
Popat S, Zhao D, Chen Z et al. Relationship between chromosome 18q status and colorectal cancer prognosis: A prospective, blinded analysis of 280 patients. Anticancer Res 2007;27:627-633.
-
(2007)
Anticancer Res
, vol.27
, pp. 627-633
-
-
Popat, S.1
Zhao, D.2
Chen, Z.3
-
50
-
-
0035912144
-
Molecular predictors of survival after adjuvant chemotherapy for colon cancer
-
Watanabe T, Wu TT, Catalano PJ et al. Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med 2001;344:1196-1206.
-
(2001)
N Engl J Med
, vol.344
, pp. 1196-1206
-
-
Watanabe, T.1
Wu, T.T.2
Catalano, P.J.3
-
51
-
-
77951746831
-
Presence of 18q loss of heterozygosity (LOH) and disease-free and overall survival in stage II colon cancer: CALGB Protocol 9581 [abstract 4012]
-
Bertagnolli MM, Niedzwiecki D, Hall M et al. Presence of 18q loss of heterozygosity (LOH) and disease-free and overall survival in stage II colon cancer: CALGB Protocol 9581 [abstract 4012]. J Clin Oncol 2009;27(15 suppl):171s.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Bertagnolli, M.M.1
Niedzwiecki, D.2
Hall, M.3
-
52
-
-
36749081020
-
New approaches to assessing and treating early-stage colon and rectal cancers: Cooperative group strategies for assessing optimal approaches in early-stage disease
-
Benson AB 3rd. New approaches to assessing and treating early-stage colon and rectal cancers: Cooperative group strategies for assessing optimal approaches in early-stage disease. Clin Cancer Res 2007;13:6913s-6920s.
-
(2007)
Clin Cancer Res
, vol.13
-
-
Benson III, A.B.1
-
53
-
-
33845269589
-
Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification
-
Tanaka T, Watanabe T, Kazama Y et al. Chromosome 18q deletion and Smad4 protein inactivation correlate with liver metastasis: A study matched for T- and N- classification. Br J Cancer 2006;95:1562-1567.
-
(2006)
Br J Cancer
, vol.95
, pp. 1562-1567
-
-
Tanaka, T.1
Watanabe, T.2
Kazama, Y.3
-
54
-
-
20244365185
-
SMAD4 as a prognostic marker in colorectal cancer
-
Alazzouzi H, Alhopuro P, Salovaara R et al. SMAD4 as a prognostic marker in colorectal cancer. Clin Cancer Res 2005;11:2606-2611.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2606-2611
-
-
Alazzouzi, H.1
Alhopuro, P.2
Salovaara, R.3
-
55
-
-
24344444413
-
SMAD4 levels and response to 5-fluorouracil in colorectal cancer
-
Alhopuro P, Alazzouzi H, Sammalkorpi H et al. SMAD4 levels and response to 5-fluorouracil in colorectal cancer. Clin Cancer Res 2005;11:6311-6316.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 6311-6316
-
-
Alhopuro, P.1
Alazzouzi, H.2
Sammalkorpi, H.3
-
57
-
-
33645736791
-
Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers
-
Gaasenbeek M, Howarth K, Rowan AJ et al. Combined array-comparative genomic hybridization and single-nucleotide polymorphism-loss of heterozygosity analysis reveals complex changes and multiple forms of chromosomal instability in colorectal cancers. Cancer Res 2006;66:3471-3479.
-
(2006)
Cancer Res
, vol.66
, pp. 3471-3479
-
-
Gaasenbeek, M.1
Howarth, K.2
Rowan, A.J.3
-
58
-
-
33751302361
-
Chromosomal instability in microsatellite-unstable and stable colon cancer
-
Trautmann K, Terdiman JP, French AJ et al. Chromosomal instability in microsatellite-unstable and stable colon cancer. Clin Cancer Res 2006;12:6379-6385.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 6379-6385
-
-
Trautmann, K.1
Terdiman, J.P.2
French, A.J.3
-
59
-
-
46349086833
-
Association between chromosomal instability and prognosis in colorectal cancer: A meta-analysis
-
Walther A, Houlston R, Tomlinson I. Association between chromosomal instability and prognosis in colorectal cancer: A meta-analysis. Gut 2008;57:941-950.
-
(2008)
Gut
, vol.57
, pp. 941-950
-
-
Walther, A.1
Houlston, R.2
Tomlinson, I.3
-
61
-
-
0034895979
-
P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma
-
Elsaleh H, Powell B, McCaul K et al. P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma. Clin Cancer Res 2001;7:1343-1349.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1343-1349
-
-
Elsaleh, H.1
Powell, B.2
McCaul, K.3
-
62
-
-
24944525406
-
Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients
-
Westra JL, Schaapveld M, Hollema H et al. Determination of TP53 mutation is more relevant than microsatellite instability status for the prediction of disease-free survival in adjuvant-treated stage III colon cancer patients. J Clin Oncol 2005;23:5635-5643.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5635-5643
-
-
Westra, J.L.1
Schaapveld, M.2
Hollema, H.3
-
63
-
-
0035105560
-
The results of colorectal cancer treatment by p53 status: Treatment-specific overview
-
discussion 333-334
-
Petersen S, Thames HD, Nieder C et al. The results of colorectal cancer treatment by p53 status: Treatment-specific overview. Dis Colon Rectum 2001;44:322-333; discussion 333-334.
-
(2001)
Dis Colon Rectum
, vol.44
, pp. 322-333
-
-
Petersen, S.1
Thames, H.D.2
Nieder, C.3
-
64
-
-
15244362062
-
P53 abnormalities and outcomes in colorectal cancer: A systematic review
-
Munro AJ, Lain S, Lane DP. P53 abnormalities and outcomes in colorectal cancer: A systematic review. Br J Cancer 2005;92:434-444.
-
(2005)
Br J Cancer
, vol.92
, pp. 434-444
-
-
Munro, A.J.1
Lain, S.2
Lane, D.P.3
-
65
-
-
15444349773
-
p53 and thymidylate synthase expression in untreated stage II colon cancer: Associations with recurrence, survival, and site
-
Lenz HJ, Danenberg KD, Leichman CG et al. p53 and thymidylate synthase expression in untreated stage II colon cancer: Associations with recurrence, survival, and site. Clin Cancer Res 1998;4:1227-1234.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 1227-1234
-
-
Lenz, H.J.1
Danenberg, K.D.2
Leichman, C.G.3
-
66
-
-
0037440051
-
Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study
-
Allegra CJ, Paik S, Colangelo LH et al. Prognostic value of thymidylate synthase, Ki-67, and p53 in patients with Dukes' B and C colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study. J Clin Oncol 2003;21:241-250.
-
(2003)
J Clin Oncol
, vol.21
, pp. 241-250
-
-
Allegra, C.J.1
Paik, S.2
Colangelo, L.H.3
-
67
-
-
32544444419
-
The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: Influence of tumor site, type of mutation, and adjuvant treatment
-
Russo A, Bazan V, Iacopetta B et al. The TP53 colorectal cancer international collaborative study on the prognostic and predictive significance of p53 mutation: Influence of tumor site, type of mutation, and adjuvant treatment. J Clin Oncol 2005;23:7518-7528.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7518-7528
-
-
Russo, A.1
Bazan, V.2
Iacopetta, B.3
-
68
-
-
33845355719
-
A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer
-
Popat S, Chen Z, Zhao D et al. A prospective, blinded analysis of thymidylate synthase and p53 expression as prognostic markers in the adjuvant treatment of colorectal cancer. Ann Oncol 2006;17:1810-1817.
-
(2006)
Ann Oncol
, vol.17
, pp. 1810-1817
-
-
Popat, S.1
Chen, Z.2
Zhao, D.3
-
69
-
-
0032521205
-
Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A Southwest Oncology Group study
-
Ahnen DJ, Feigl P, Quan G et al. Ki-ras mutation and p53 overexpression predict the clinical behavior of colorectal cancer: A Southwest Oncology Group study. Cancer Res 1998;58:1149-1158.
-
(1998)
Cancer Res
, vol.58
, pp. 1149-1158
-
-
Ahnen, D.J.1
Feigl, P.2
Quan, G.3
-
70
-
-
0033986545
-
p53 gene mutation, microsatellite instability and adjuvant chemotherapy: Impact on survival of 388 patients with Dukes' C colon carcinoma
-
Elsaleh H, Powell B, Soontrapornchai P et al. p53 gene mutation, microsatellite instability and adjuvant chemotherapy: Impact on survival of 388 patients with Dukes' C colon carcinoma. Oncology 2000;58:52-59.
-
(2000)
Oncology
, vol.58
, pp. 52-59
-
-
Elsaleh, H.1
Powell, B.2
Soontrapornchai, P.3
-
71
-
-
33646757232
-
The complexity of p53 stabilization and activation
-
Lavin MF, Gueven N. The complexity of p53 stabilization and activation. Cell Death Differ 2006;13:941-950.
-
(2006)
Cell Death Differ
, vol.13
, pp. 941-950
-
-
Lavin, M.F.1
Gueven, N.2
-
72
-
-
0028879677
-
p53 point mutation and survival in colorectal cancer patients
-
Goh HS, Yao J, Smith DR. p53 point mutation and survival in colorectal cancer patients. Cancer Res 1995;55:5217-5221.
-
(1995)
Cancer Res
, vol.55
, pp. 5217-5221
-
-
Goh, H.S.1
Yao, J.2
Smith, D.R.3
-
74
-
-
0032490124
-
Kirsten ras mutations in patients with colorectal cancer: The multicenter RASCAL study
-
Andreyev HJ, Norman AR, Cunningham D et al. Kirsten ras mutations in patients with colorectal cancer: The multicenter RASCAL study. J Natl Cancer Inst 1998;90:675-684.
-
(1998)
J Natl Cancer Inst
, vol.90
, pp. 675-684
-
-
Andreyev, H.J.1
Norman, A.R.2
Cunningham, D.3
-
75
-
-
0035444798
-
Kirsten ras mutations in patients with colorectal cancer: The 'RASCAL II' study
-
Andreyev HJ, Norman AR, Cunningham D et al. Kirsten ras mutations in patients with colorectal cancer: The 'RASCAL II' study. Br J Cancer 2001;85:692-696.
-
(2001)
Br J Cancer
, vol.85
, pp. 692-696
-
-
Andreyev, H.J.1
Norman, A.R.2
Cunningham, D.3
-
76
-
-
18344398895
-
Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer
-
Belly RT, Rosenblatt JD, Steinmann M et al. Detection of mutated K12-ras in histologically negative lymph nodes as an indicator of poor prognosis in stage II colorectal cancer. Clin Colorectal Cancer 2001;1:110-116.
-
(2001)
Clin Colorectal Cancer
, vol.1
, pp. 110-116
-
-
Belly, R.T.1
Rosenblatt, J.D.2
Steinmann, M.3
-
77
-
-
75749102647
-
Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
-
Roth AD, Tejpar S, Delorenzi M et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol 2010;28:466-474.
-
(2010)
J Clin Oncol
, vol.28
, pp. 466-474
-
-
Roth, A.D.1
Tejpar, S.2
Delorenzi, M.3
-
78
-
-
73149107502
-
KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803
-
Ogino S, Meyerhardt JA, Irahara N et al. KRAS mutation in stage III colon cancer and clinical outcome following intergroup trial CALGB 89803. Clin Cancer Res 2009;15:7322-7329.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 7322-7329
-
-
Ogino, S.1
Meyerhardt, J.A.2
Irahara, N.3
-
79
-
-
54949085398
-
K-ras mutations and benefit from cetuximab in advanced colorectal cancer
-
Karapetis CS, Khambata-Ford S, Jonker DJ et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359:1757-1765.
-
(2008)
N Engl J Med
, vol.359
, pp. 1757-1765
-
-
Karapetis, C.S.1
Khambata-Ford, S.2
Jonker, D.J.3
-
80
-
-
0034026701
-
p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer
-
Bouzourene H, Gervaz P, Cerottini JP et al. p53 and Ki-ras as prognostic factors for Dukes' stage B colorectal cancer. Eur J Cancer 2000;36:1008-1015.
-
(2000)
Eur J Cancer
, vol.36
, pp. 1008-1015
-
-
Bouzourene, H.1
Gervaz, P.2
Cerottini, J.P.3
-
81
-
-
4444343743
-
Ki-ras gene mutations, LOH of the APC and DCC genes, and microsatellite instability in primary colorectal carcinoma are not associated with micrometastases in pericolonic lymph nodes or with patients' survival
-
Zauber NP, Wang C, Lee PS et al. Ki-ras gene mutations, LOH of the APC and DCC genes, and microsatellite instability in primary colorectal carcinoma are not associated with micrometastases in pericolonic lymph nodes or with patients' survival. J Clin Pathol 2004;57:938-942.
-
(2004)
J Clin Pathol
, vol.57
, pp. 938-942
-
-
Zauber, N.P.1
Wang, C.2
Lee, P.S.3
-
82
-
-
0032948553
-
p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer
-
Tortola S, Marcuello E, González I et al. p53 and K-ras gene mutations correlate with tumor aggressiveness but are not of routine prognostic value in colorectal cancer. J Clin Oncol 1999;17:1375-1381.
-
(1999)
J Clin Oncol
, vol.17
, pp. 1375-1381
-
-
Tortola, S.1
Marcuello, E.2
González, I.3
-
83
-
-
0035863495
-
K-ras and p16 aberrations confer poor prognosis in human colorectal cancer
-
Esteller M, González S, Risques RA et al. K-ras and p16 aberrations confer poor prognosis in human colorectal cancer. J Clin Oncol 2001;19:299-304.
-
(2001)
J Clin Oncol
, vol.19
, pp. 299-304
-
-
Esteller, M.1
González, S.2
Risques, R.A.3
-
84
-
-
77149143393
-
KRAS mutation, cancer recurrence, and patient survival in stage III colon cancer: Findings from CALGB 89803 [abstract 4037]
-
Fuchs C, Ogino S, Meyerhardt JA et al. KRAS mutation, cancer recurrence, and patient survival in stage III colon cancer: Findings from CALGB 89803 [abstract 4037]. J Clin Oncol 2009;27(15 suppl):177s.
-
(2009)
J Clin Oncol
, vol.27
, Issue.15 SUPPL.
-
-
Fuchs, C.1
Ogino, S.2
Meyerhardt, J.A.3
-
85
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
Lièvre A, Bachet JB, Boige V et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J Clin Oncol 2008;26:374-379.
-
(2008)
J Clin Oncol
, vol.26
, pp. 374-379
-
-
Lièvre, A.1
Bachet, J.B.2
Boige, V.3
-
86
-
-
34548238762
-
Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
-
Khambata-Ford S, Garrett CR, Meropol NJ et al. Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 2007;25:3230-3237.
-
(2007)
J Clin Oncol
, vol.25
, pp. 3230-3237
-
-
Khambata-Ford, S.1
Garrett, C.R.2
Meropol, N.J.3
-
87
-
-
40149088765
-
KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
-
De Roock W, Piessevaux H, De Schutter J et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol 2008;19:508-515.
-
(2008)
Ann Oncol
, vol.19
, pp. 508-515
-
-
de Roock, W.1
Piessevaux, H.2
de Schutter, J.3
-
88
-
-
63849088630
-
Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
-
Van Cutsem E, Köhne CH, Hitre E et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 2009;360:1408-1417.
-
(2009)
N Engl J Med
, vol.360
, pp. 1408-1417
-
-
van Cutsem, E.1
Köhne, C.H.2
Hitre, E.3
-
89
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A et al. Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 2009;27:663-671.
-
(2009)
J Clin Oncol
, vol.27
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
-
90
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado RG, Wolf M, Peeters M et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008;26:1626-1634.
-
(2008)
J Clin Oncol
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
Wolf, M.2
Peeters, M.3
-
91
-
-
0037194728
-
Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status
-
Rajagopalan H, Bardelli A, Lengauer C et al. Tumorigenesis: RAF/RAS oncogenes and mismatch-repair status. Nature 2002;418:934.
-
(2002)
Nature
, vol.418
, pp. 934
-
-
Rajagopalan, H.1
Bardelli, A.2
Lengauer, C.3
-
92
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C et al. Mutations of the BRAF gene in human cancer. Nature 2002;417:949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
93
-
-
10744232660
-
Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors
-
Ikenoue T, Hikiba Y, Kanai F et al. Functional analysis of mutations within the kinase activation segment of B-Raf in human colorectal tumors. Cancer Res 2003;63:8132-8137.
-
(2003)
Cancer Res
, vol.63
, pp. 8132-8137
-
-
Ikenoue, T.1
Hikiba, Y.2
Kanai, F.3
-
94
-
-
1342299898
-
Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas
-
Fransén K, Klintenäs M, Osterström A et al. Mutation analysis of the BRAF, ARAF and RAF-1 genes in human colorectal adenocarcinomas. Carcinogenesis 2004;25:527-533.
-
(2004)
Carcinogenesis
, vol.25
, pp. 527-533
-
-
Fransén, K.1
Klintenäs, M.2
Osterström, A.3
-
95
-
-
22244472992
-
Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
-
Samowitz WS, Sweeney C, Herrick J et al. Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res 2005;65:6063-6069.
-
(2005)
Cancer Res
, vol.65
, pp. 6063-6069
-
-
Samowitz, W.S.1
Sweeney, C.2
Herrick, J.3
-
96
-
-
67649652208
-
BRAF mutation in metastatic colorectal cancer
-
Tol J, Nagtegaal ID, Punt CJ. BRAF mutation in metastatic colorectal cancer. N Engl J Med 2009;361:98-99.
-
(2009)
N Engl J Med
, vol.361
, pp. 98-99
-
-
Tol, J.1
Nagtegaal, I.D.2
Punt, C.J.3
-
97
-
-
58249089525
-
CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
-
Ogino S, Nosho K, Kirkner GJ et al. CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 2009;58:90-96.
-
(2009)
Gut
, vol.58
, pp. 90-96
-
-
Ogino, S.1
Nosho, K.2
Kirkner, G.J.3
-
98
-
-
0024164649
-
Fluorouracil: Biochemistry and pharmacology
-
Pinedo HM, Peters GF. Fluorouracil: Biochemistry and pharmacology. J Clin Oncol 1988;6:1653-1664.
-
(1988)
J Clin Oncol
, vol.6
, pp. 1653-1664
-
-
Pinedo, H.M.1
Peters, G.F.2
-
99
-
-
0015962412
-
Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate
-
Santi DV, McHenry CS, Sommer H. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. Biochemistry 1974;13:471-481.
-
(1974)
Biochemistry
, vol.13
, pp. 471-481
-
-
Santi, D.V.1
McHenry, C.S.2
Sommer, H.3
-
100
-
-
0022344622
-
Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells
-
Berger SH, Jenh CH, Johnson LF et al. Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells. Mol Pharmacol 1985;28:461-467.
-
(1985)
Mol Pharmacol
, vol.28
, pp. 461-467
-
-
Berger, S.H.1
Jenh, C.H.2
Johnson, L.F.3
-
101
-
-
0036534108
-
Thymidylate synthase expression in colorectal cancer: A prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy
-
Edler D, Glimelius B, Hallström M et al. Thymidylate synthase expression in colorectal cancer: A prognostic and predictive marker of benefit from adjuvant fluorouracil-based chemotherapy. J Clin Oncol 2002;20:1721-1728.
-
(2002)
J Clin Oncol
, vol.20
, pp. 1721-1728
-
-
Edler, D.1
Glimelius, B.2
Hallström, M.3
-
102
-
-
0028151449
-
The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
-
Johnston PG, Fisher ER, Rockette HE et al. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J Clin Oncol 1994;12:2640-2647.
-
(1994)
J Clin Oncol
, vol.12
, pp. 2640-2647
-
-
Johnston, P.G.1
Fisher, E.R.2
Rockette, H.E.3
-
103
-
-
1442290323
-
Thymidylate synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis
-
Popat S, Matakidou A, Houlston RS. Thymidylate synthase expression and prognosis in colorectal cancer: A systematic review and meta-analysis. J Clin Oncol 2004;22:529-536.
-
(2004)
J Clin Oncol
, vol.22
, pp. 529-536
-
-
Popat, S.1
Matakidou, A.2
Houlston, R.S.3
-
104
-
-
1642472091
-
Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial
-
Sakamoto J, Hamashima H, Suzuki H et al. Thymidylate synthase expression as a predictor of the prognosis of curatively resected colon carcinoma in patients registered in an adjuvant immunochemotherapy clinical trial. Oncol Rep 2003;10:1081-1090.
-
(2003)
Oncol Rep
, vol.10
, pp. 1081-1090
-
-
Sakamoto, J.1
Hamashima, H.2
Suzuki, H.3
-
105
-
-
43049134491
-
Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
-
Soong R, Shah N, Salto-Tellez M et al. Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy. Ann Oncol 2008;19:915-919.
-
(2008)
Ann Oncol
, vol.19
, pp. 915-919
-
-
Soong, R.1
Shah, N.2
Salto-Tellez, M.3
-
106
-
-
0141455146
-
Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: Predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil
-
Kornmann M, Schwabe W, Sander S et al. Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA expression levels: Predictors for survival in colorectal cancer patients receiving adjuvant 5-fluorouracil. Clin Cancer Res 2003;9:4116-4124.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 4116-4124
-
-
Kornmann, M.1
Schwabe, W.2
Sander, S.3
-
107
-
-
33646717954
-
Thymidylate synthase expression in colon carcinomas with microsatellite instability
-
Sinicrope FA, Rego RL, Halling KC et al. Thymidylate synthase expression in colon carcinomas with microsatellite instability. Clin Cancer Res 2006;12:2738-2744.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 2738-2744
-
-
Sinicrope, F.A.1
Rego, R.L.2
Halling, K.C.3
-
108
-
-
27144456276
-
Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients
-
Westra JL, Hollema H, Schaapveld M et al. Predictive value of thymidylate synthase and dihydropyrimidine dehydrogenase protein expression on survival in adjuvantly treated stage III colon cancer patients. Ann Oncol 2005;16:1646-1653.
-
(2005)
Ann Oncol
, vol.16
, pp. 1646-1653
-
-
Westra, J.L.1
Hollema, H.2
Schaapveld, M.3
-
109
-
-
0034048729
-
Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase
-
Salonga D, Danenberg KD, Johnson M et al. Colorectal tumors responding to 5-fluorouracil have low gene expression levels of dihydropyrimidine dehydrogenase, thymidylate synthase, and thymidine phosphorylase. Clin Cancer Res 2000;6:1322-1327.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1322-1327
-
-
Salonga, D.1
Danenberg, K.D.2
Johnson, M.3
-
110
-
-
0030883708
-
Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin
-
Leichman CG, Lenz HJ, Leichman L et al. Quantitation of intratumoral thymidylate synthase expression predicts for disseminated colorectal cancer response and resistance to protracted-infusion fluorouracil and weekly leucovorin. J Clin Oncol 1997;15:3223-3229.
-
(1997)
J Clin Oncol
, vol.15
, pp. 3223-3229
-
-
Leichman, C.G.1
Lenz, H.J.2
Leichman, L.3
-
111
-
-
25144517063
-
Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers
-
Morganti M, Ciantelli M, Giglioni B et al. Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers. Eur J Cancer 2005;41:2176-2183.
-
(2005)
Eur J Cancer
, vol.41
, pp. 2176-2183
-
-
Morganti, M.1
Ciantelli, M.2
Giglioni, B.3
-
112
-
-
2442480694
-
A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels
-
Mandola MV, Stoehlmacher J, Zhang W et al. A 6 bp polymorphism in the thymidylate synthase gene causes message instability and is associated with decreased intratumoral TS mRNA levels. Pharmacogenetics 2004;14:319-327.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 319-327
-
-
Mandola, M.V.1
Stoehlmacher, J.2
Zhang, W.3
-
113
-
-
38149024196
-
Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer
-
Lurje G, Zhang W, Yang D et al. Thymidylate synthase haplotype is associated with tumor recurrence in stage II and stage III colon cancer. Pharmacogenet Genomics 2008;18:161-168.
-
(2008)
Pharmacogenet Genomics
, vol.18
, pp. 161-168
-
-
Lurje, G.1
Zhang, W.2
Yang, D.3
-
114
-
-
0035860142
-
A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil
-
Iacopetta B, Grieu F, Joseph D et al. A polymorphism in the enhancer region of the thymidylate synthase promoter influences the survival of colorectal cancer patients treated with 5-fluorouracil. Br J Cancer 2001;85:827-830.
-
(2001)
Br J Cancer
, vol.85
, pp. 827-830
-
-
Iacopetta, B.1
Grieu, F.2
Joseph, D.3
-
115
-
-
25144481273
-
Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil
-
Hitre E, Budai B, Adleff V et al. Influence of thymidylate synthase gene polymorphisms on the survival of colorectal cancer patients receiving adjuvant 5-fluorouracil. Pharmacogenet Genomics 2005;15:723-730.
-
(2005)
Pharmacogenet Genomics
, vol.15
, pp. 723-730
-
-
Hitre, E.1
Budai, B.2
Adleff, V.3
-
116
-
-
77951705106
-
Tissue biomarkers (BIOM) in colon cancer (COC): The translational study on the randomized phase III trial comparing infused irinotecan/5-fluorouracil (5-FU)/folinic acid (FA) to 5-FU/FA in stage II-III COC patients (pts) [abstract 4022]
-
updated information presented at the meeting
-
Roth AD, Tejpar S, Yan P et al. Tissue biomarkers (BIOM) in colon cancer (COC): The translational study on the randomized phase III trial comparing infused irinotecan/5-fluorouracil (5-FU)/folinic acid (FA) to 5-FU/FA in stage II-III COC patients (pts) [abstract 4022]. J Clin Oncol 2007;25:169s; updated information presented at the meeting.
-
(2007)
J Clin Oncol
, vol.25
-
-
Roth, A.D.1
Tejpar, S.2
Yan, P.3
-
117
-
-
0036632368
-
The phosphatidylinositol 3-kinase AKT pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2002;2:489-501.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
118
-
-
10244261646
-
Tumor marker utility grading system: A framework to evaluate clinical utility of tumor markers
-
Hayes DF, Bast RC, Desch CE et al. Tumor marker utility grading system: A framework to evaluate clinical utility of tumor markers. J Natl Cancer Inst 1996;88:1456-1466.
-
(1996)
J Natl Cancer Inst
, vol.88
, pp. 1456-1466
-
-
Hayes, D.F.1
Bast, R.C.2
Desch, C.E.3
-
119
-
-
23844534811
-
Reporting recommendations for tumor marker prognostic studies (REMARK)
-
McShane LM, Altman DG, Sauerbrei W et al. Reporting recommendations for tumor marker prognostic studies (REMARK). J Natl Cancer Inst 2005;97:1180-1184.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 1180-1184
-
-
McShane, L.M.1
Altman, D.G.2
Sauerbrei, W.3
-
120
-
-
40449117669
-
Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE)
-
Deutsch EW, Ball CA, Berman JJ et al. Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE). Nat Biotechnol 2008;26:305-312.
-
(2008)
Nat Biotechnol
, vol.26
, pp. 305-312
-
-
Deutsch, E.W.1
Ball, C.A.2
Berman, J.J.3
-
121
-
-
1842475973
-
High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization
-
Nakao K, Mehta KR, Fridlyand J et al. High-resolution analysis of DNA copy number alterations in colorectal cancer by array-based comparative genomic hybridization. Carcinogenesis 2004;25:1345-1357.
-
(2004)
Carcinogenesis
, vol.25
, pp. 1345-1357
-
-
Nakao, K.1
Mehta, K.R.2
Fridlyand, J.3
-
122
-
-
38949128410
-
Progression and tumor heterogeneity analysis in early rectal cancer
-
Lips EH, van Eijk R, de Graaf EJ et al. Progression and tumor heterogeneity analysis in early rectal cancer. Clin Cancer Res 2008;14:772-781.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 772-781
-
-
Lips, E.H.1
van Eijk, R.2
de Graaf, E.J.3
-
123
-
-
33847751110
-
High-resolution copy number analysis of paraffin-embedded archival tissue using SNP BeadArrays
-
Oosting J, Lips EH, van Eijk R et al. High-resolution copy number analysis of paraffin-embedded archival tissue using SNP BeadArrays. Genome Res 2007;17:368-376.
-
(2007)
Genome Res
, vol.17
, pp. 368-376
-
-
Oosting, J.1
Lips, E.H.2
van Eijk, R.3
-
124
-
-
33847293670
-
High-throughput oncogene mutation profiling in human cancer
-
Thomas RK, Baker AC, Debiasi RM et al. High-throughput oncogene mutation profiling in human cancer. Nat Genet 2007;39:347-351.
-
(2007)
Nat Genet
, vol.39
, pp. 347-351
-
-
Thomas, R.K.1
Baker, A.C.2
Debiasi, R.M.3
-
125
-
-
50249102857
-
RNA expression analysis from formalin fixed paraffin embedded tissues
-
Farragher SM, Tanney A, Kennedy RD et al. RNA expression analysis from formalin fixed paraffin embedded tissues. Histochem Cell Biol 2008;130:435-445.
-
(2008)
Histochem Cell Biol
, vol.130
, pp. 435-445
-
-
Farragher, S.M.1
Tanney, A.2
Kennedy, R.D.3
-
126
-
-
20044382043
-
Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors
-
Devries S, Nyante S, Korkola J et al. Array-based comparative genomic hybridization from formalin-fixed, paraffin-embedded breast tumors. J Mol Diagn 2005;7:65-71.
-
(2005)
J Mol Diagn
, vol.7
, pp. 65-71
-
-
Devries, S.1
Nyante, S.2
Korkola, J.3
-
127
-
-
57349090407
-
Gene expression in fixed tissues and outcome in hepatocellular carcinoma
-
Hoshida Y, Villanueva A, Kobayashi M et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med 2008;359:1995-2004.
-
(2008)
N Engl J Med
, vol.359
, pp. 1995-2004
-
-
Hoshida, Y.1
Villanueva, A.2
Kobayashi, M.3
-
128
-
-
34848902665
-
Biomarker discovery for colon cancer using a 761 gene RT-PCR assay
-
Clark-Langone KM, Wu JY, Sangli C et al. Biomarker discovery for colon cancer using a 761 gene RT-PCR assay. BMC Genomics 2007;8:279.
-
(2007)
BMC Genomics
, vol.8
, pp. 279
-
-
Clark-Langone, K.M.1
Wu, J.Y.2
Sangli, C.3
-
129
-
-
45749127481
-
Predictive biomarkers of chemotherapy efficacy in colorectal cancer: Results from the UK MRC FOCUS trial
-
Braun MS, Richman SD, Quirke P et al. Predictive biomarkers of chemotherapy efficacy in colorectal cancer: Results from the UK MRC FOCUS trial. J Clin Oncol 2008;26:2690-2698.
-
(2008)
J Clin Oncol
, vol.26
, pp. 2690-2698
-
-
Braun, M.S.1
Richman, S.D.2
Quirke, P.3
-
130
-
-
16344366323
-
Gene expression profiling of the irinotecan pathway in colorectal cancer
-
Yu J, Shannon WD, Watson MA et al. Gene expression profiling of the irinotecan pathway in colorectal cancer. Clin Cancer Res 2005;11:2053-2062.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 2053-2062
-
-
Yu, J.1
Shannon, W.D.2
Watson, M.A.3
-
131
-
-
34249828179
-
Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs
-
Swanton C, Marani M, Pardo O et al. Regulators of mitotic arrest and ceramide metabolism are determinants of sensitivity to paclitaxel and other chemotherapeutic drugs. Cancer Cell 2007;11:498-512.
-
(2007)
Cancer Cell
, vol.11
, pp. 498-512
-
-
Swanton, C.1
Marani, M.2
Pardo, O.3
-
132
-
-
34548279988
-
Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs
-
Swanton C, Nicke B, Marani M et al. Initiation of high frequency multi-drug resistance following kinase targeting by siRNAs. Cell Cycle 2007;6:2001-2004.
-
(2007)
Cell Cycle
, vol.6
, pp. 2001-2004
-
-
Swanton, C.1
Nicke, B.2
Marani, M.3
-
133
-
-
33746609814
-
Chromosomal instability, colorectal cancer and taxane resistance
-
Swanton C, Tomlinson I, Downward J. Chromosomal instability, colorectal cancer and taxane resistance. Cell Cycle 2006;5:818-823.
-
(2006)
Cell Cycle
, vol.5
, pp. 818-823
-
-
Swanton, C.1
Tomlinson, I.2
Downward, J.3
-
134
-
-
31144459985
-
Oncogenic pathway signatures in human cancers as a guide to targeted therapies
-
Bild AH, Yao G, Chang JT et al. Oncogenic pathway signatures in human cancers as a guide to targeted therapies. Nature 2006;439:353-357.
-
(2006)
Nature
, vol.439
, pp. 353-357
-
-
Bild, A.H.1
Yao, G.2
Chang, J.T.3
-
135
-
-
33750727368
-
Genomic signatures to guide the use of chemotherapeutics
-
Potti A, Dressman HK, Bild A et al. Genomic signatures to guide the use of chemotherapeutics. Nat Med 2006;12:1294-1300.
-
(2006)
Nat Med
, vol.12
, pp. 1294-1300
-
-
Potti, A.1
Dressman, H.K.2
Bild, A.3
-
136
-
-
33947512381
-
An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer
-
Dressman HK, Berchuck A, Chan G et al. An integrated genomic-based approach to individualized treatment of patients with advanced-stage ovarian cancer. J Clin Oncol 2007;25:517-525.
-
(2007)
J Clin Oncol
, vol.25
, pp. 517-525
-
-
Dressman, H.K.1
Berchuck, A.2
Chan, G.3
-
137
-
-
44849135294
-
An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer
-
Salter KH, Acharya CR, Walters KS et al. An integrated approach to the prediction of chemotherapeutic response in patients with breast cancer. PLoS ONE 2008;3:e1908.
-
(2008)
PLoS ONE
, vol.e1908
, pp. 3
-
-
Salter, K.H.1
Acharya, C.R.2
Walters, K.S.3
-
138
-
-
0034680102
-
Molecular portraits of human breast tumours
-
Perou CM, Sørlie T, Eisen MB et al. Molecular portraits of human breast tumours. Nature 2000;406:747-752.
-
(2000)
Nature
, vol.406
, pp. 747-752
-
-
Perou, C.M.1
Sørlie, T.2
Eisen, M.B.3
-
139
-
-
0035845511
-
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications
-
Sørlie T, Perou CM, Tibshirani R et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci U S A 2001;98:10869-10874.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 10869-10874
-
-
Sørlie, T.1
Perou, C.M.2
Tibshirani, R.3
-
140
-
-
0037137519
-
A gene-expression signature as a predictor of survival in breast cancer
-
van de Vijver MJ, He YD, van't Veer LJ et al. A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med 2002;347:1999-2009.
-
(2002)
N Engl J Med
, vol.347
, pp. 1999-2009
-
-
van de Vijver, M.J.1
He, Y.D.2
van't Veer, L.J.3
-
141
-
-
33748693297
-
Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer
-
Buyse M, Loi S, van't Veer L et al. Validation and clinical utility of a 70-gene prognostic signature for women with node-negative breast cancer. J Natl Cancer Inst 2006;98:1183-1192.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 1183-1192
-
-
Buyse, M.1
Loi, S.2
van't Veer, L.3
-
142
-
-
33645825388
-
Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer
-
Foekens JA, Atkins D, Zhang Y et al. Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer. J Clin Oncol 2006;24:1665-1671.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1665-1671
-
-
Foekens, J.A.1
Atkins, D.2
Zhang, Y.3
-
143
-
-
19944422061
-
A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer
-
Paik S, Shak S, Tang G et al. A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer. N Engl J Med 2004;351:2817-2826.
-
(2004)
N Engl J Med
, vol.351
, pp. 2817-2826
-
-
Paik, S.1
Shak, S.2
Tang, G.3
-
144
-
-
33750598939
-
The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer
-
Ma X, Hilsenbeck S, Wang W et al. The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer. J Clin Oncol 2006;24:4611-4619.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4611-4619
-
-
Ma, X.1
Hilsenbeck, S.2
Wang, W.3
-
145
-
-
20144386127
-
Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival
-
Chang HY, Nuyten DS, Sneddon JB et al. Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci U S A 2005;102:3738-3743.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 3738-3743
-
-
Chang, H.Y.1
Nuyten, D.S.2
Sneddon, J.B.3
-
146
-
-
33746910265
-
Concordance among gene-expression-based predictors for breast cancer
-
Fan C, Oh DS, Wessels L et al. Concordance among gene-expression-based predictors for breast cancer. N Engl J Med 2006;355:560-569.
-
(2006)
N Engl J Med
, vol.355
, pp. 560-569
-
-
Fan, C.1
Oh, D.S.2
Wessels, L.3
-
147
-
-
58149330982
-
Meta-analysis of gene expression profiles in breast cancer: Toward a unified understanding of breast cancer subtyping and prognosis signatures
-
Wirapati P, Sotiriou C, Kunkel S et al. Meta-analysis of gene expression profiles in breast cancer: Toward a unified understanding of breast cancer subtyping and prognosis signatures. Breast Cancer Res 2008;10:R65.
-
(2008)
Breast Cancer Res
, vol.10
-
-
Wirapati, P.1
Sotiriou, C.2
Kunkel, S.3
-
148
-
-
33144462268
-
Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis
-
Sotiriou C, Wirapati P, Loi S et al. Gene expression profiling in breast cancer: Understanding the molecular basis of histologic grade to improve prognosis. J Natl Cancer Inst 2006;98:262-272.
-
(2006)
J Natl Cancer Inst
, vol.98
, pp. 262-272
-
-
Sotiriou, C.1
Wirapati, P.2
Loi, S.3
-
149
-
-
2442684455
-
Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer
-
Wang Y, Jatkoe T, Zhang Y et al. Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol 2004;22:1564-1571.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1564-1571
-
-
Wang, Y.1
Jatkoe, T.2
Zhang, Y.3
-
150
-
-
33750593381
-
Stage II colon cancer prognosis prediction by tumor gene expression profiling
-
Barrier A, Boelle PY, Roser F et al. Stage II colon cancer prognosis prediction by tumor gene expression profiling. J Clin Oncol 2006;24:4685-4691.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4685-4691
-
-
Barrier, A.1
Boelle, P.Y.2
Roser, F.3
-
151
-
-
34247184203
-
Interpretation of microarray data in cancer
-
Michiels S, Koscielny S, Hill C. Interpretation of microarray data in cancer. Br J Cancer 2007;96:1155-1158.
-
(2007)
Br J Cancer
, vol.96
, pp. 1155-1158
-
-
Michiels, S.1
Koscielny, S.2
Hill, C.3
-
152
-
-
33947546541
-
Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study
-
Kim GP, Colangelo LH, Wieand HS et al. Prognostic and predictive roles of high-degree microsatellite instability in colon cancer: A National Cancer Institute-National Surgical Adjuvant Breast and Bowel Project collaborative study. J Clin Oncol 2007;25:767-772.
-
(2007)
J Clin Oncol
, vol.25
, pp. 767-772
-
-
Kim, G.P.1
Colangelo, L.H.2
Wieand, H.S.3
-
153
-
-
53049109620
-
Microsatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study population
-
Deschoolmeester V, Van Damme N, Baay M et al. Microsatellite instability in sporadic colon carcinomas has no independent prognostic value in a Belgian study population. Eur J Cancer 2008;44:2288-2295.
-
(2008)
Eur J Cancer
, vol.44
, pp. 2288-2295
-
-
Deschoolmeester, V.1
van Damme, N.2
Baay, M.3
-
154
-
-
0031827793
-
Chromosome 18q allelic loss and prognosis in stage II and III colon cancer
-
Lanza G, Matteuzzi M, Gafa R et al. Chromosome 18q allelic loss and prognosis in stage II and III colon cancer. Int J Cancer 1998;79:390-395.
-
(1998)
Int J Cancer
, vol.79
, pp. 390-395
-
-
Lanza, G.1
Matteuzzi, M.2
Gafa, R.3
|