-
1
-
-
0027172683
-
Relaxation of imprinted genes in human cancer
-
Rainier, S., Johnson, L. A., Dobry, C. J., Ping, A. J., Grundy, P. E. and Feinberg, A. P. (1993) Relaxation of imprinted genes in human cancer. Nature, 362, 747-751.
-
(1993)
Nature
, vol.362
, pp. 747-751
-
-
Rainier, S.1
Johnson, L.A.2
Dobry, C.J.3
Ping, A.J.4
Grundy, P.E.5
Feinberg, A.P.6
-
2
-
-
0026653420
-
The essentials of DNA methylation
-
Bird, A. (1992) The essentials of DNA methylation. Cell, 70, 5-8.
-
(1992)
Cell
, vol.70
, pp. 5-8
-
-
Bird, A.1
-
3
-
-
0030014783
-
DNA topoisomerases
-
Wang, J. C. (1996) DNA topoisomerases. Annu. Rev. Biochem., 65, 635-692.
-
(1996)
Annu. Rev. Biochem
, vol.65
, pp. 635-692
-
-
Wang, J.C.1
-
4
-
-
34248374799
-
Topoisom-erase inhibitors as therapeutic weapons
-
Cortés, F., Pastor, N., Mateos, S. and Dominguez, I. (2007) Topoisom-erase inhibitors as therapeutic weapons. Expert Opin. Ther. Pat., 17, 521-532.
-
(2007)
Expert Opin. Ther. Pat
, vol.17
, pp. 521-532
-
-
Cortés, F.1
Pastor, N.2
Mateos, S.3
Dominguez, I.4
-
5
-
-
0006832263
-
Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin
-
Thomsen, B., Mollerup, S., Bonven, B. J., Frank, R., Blöcker, H., Nielsen, O. F. and Westergaard, O. (1987) Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin. EMBO J., 6, 1817-1823.
-
(1987)
EMBO J
, vol.6
, pp. 1817-1823
-
-
Thomsen, B.1
Mollerup, S.2
Bonven, B.J.3
Frank, R.4
Blöcker, H.5
Nielsen, O.F.6
Westergaard, O.7
-
6
-
-
0024592815
-
Biochemical basis for the interactions of type I and type II topoisomerases with DNA
-
Osheroff, N. (1989) Biochemical basis for the interactions of type I and type II topoisomerases with DNA. Pharmacol. Ther., 41, 223-241.
-
(1989)
Pharmacol. Ther
, vol.41
, pp. 223-241
-
-
Osheroff, N.1
-
7
-
-
0032189945
-
DNA sequence selectivity of topoisomerases and topoisomerase poisons
-
Capranico, G. and Binaschi, M. (1998) DNA sequence selectivity of topoisomerases and topoisomerase poisons. Biochim. Biophys. Acta, 1400, 185-194.
-
(1998)
Biochim. Biophys. Acta
, vol.1400
, pp. 185-194
-
-
Capranico, G.1
Binaschi, M.2
-
8
-
-
0021955171
-
Quantitation of eukaryotic topoisomerase I reactivity with DNA. Preferential cleavage of supercoiled DNA
-
Muller, M. T. (1985) Quantitation of eukaryotic topoisomerase I reactivity with DNA. Preferential cleavage of supercoiled DNA. Biochim. Biophys. Acta, 20, 263-267.
-
(1985)
Biochim. Biophys. Acta
, vol.20
, pp. 263-267
-
-
Muller, M.T.1
-
9
-
-
0031003701
-
Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I
-
Pourquier, P., Ueng, L.-M., Kohlhagen, G., Mazumder, A., Gupta, M., Kohn, K. W. and Pommier, Y. (1997) Effects of uracil incorporation, DNA mismatches, and abasic sites on cleavage and religation activities of mammalian topoisomerase I. J. Biol. Chem., 272, 7792-7796.
-
(1997)
J. Biol. Chem
, vol.272
, pp. 7792-7796
-
-
Pourquier, P.1
Ueng, L.-M.2
Kohlhagen, G.3
Mazumder, A.4
Gupta, M.5
Kohn, K.W.6
Pommier, Y.7
-
10
-
-
0032571493
-
Substitution of 5-methylcytosines for cytosines enhances the stability of topoisomerase I-DNA complexes and modulates the sequence selectivity of camptothecin-induced DNA cleavage
-
Carrasco, C., Waring, M. J. and Bailly, C. (1998) Substitution of 5-methylcytosines for cytosines enhances the stability of topoisomerase I-DNA complexes and modulates the sequence selectivity of camptothecin-induced DNA cleavage. FEBS Lett., 425, 337-340.
-
(1998)
FEBS Lett
, vol.425
, pp. 337-340
-
-
Carrasco, C.1
Waring, M.J.2
Bailly, C.3
-
11
-
-
37149000618
-
Protection of halogenated DNA from strand breakage and sister-chromatid exchange induced by the topoisomerase I inhibitor camptothecin
-
Orta, M. L., Mateos, S., Cantero, G., Wolff, L. J. and Cortés, F. (2008) Protection of halogenated DNA from strand breakage and sister-chromatid exchange induced by the topoisomerase I inhibitor camptothecin. Mutat. Res., 637, 40-48.
-
(2008)
Mutat. Res
, vol.637
, pp. 40-48
-
-
Orta, M.L.1
Mateos, S.2
Cantero, G.3
Wolff, L.J.4
Cortés, F.5
-
12
-
-
0000163138
-
Gel electrophoresis of DNA
-
Irwin, N, Ford, N, Nolan, C. and Ferguson, M, eds, Cold Spring Harbor Laboratory, New York
-
Sambrook, J., Fritsch, E. F. and Maniatis, T. (2003) Gel electrophoresis of DNA. In: Irwin, N., Ford, N., Nolan, C. and Ferguson, M. (eds), Molecular Cloning. A Laboratory Manual. Cold Spring Harbor Laboratory, New York.
-
(2003)
Molecular Cloning. A Laboratory Manual
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
13
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
-
(1976)
Anal. Biochem
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
14
-
-
0023713928
-
DNase I hypersensitivity is independent of endogenous topoisomerase II activity during chicken erythrocyte differentiation
-
Muller, M. T. and Mehta, V. B. (1988) DNase I hypersensitivity is independent of endogenous topoisomerase II activity during chicken erythrocyte differentiation. Mol. Cell. Biol., 8, 3661-3669.
-
(1988)
Mol. Cell. Biol
, vol.8
, pp. 3661-3669
-
-
Muller, M.T.1
Mehta, V.B.2
-
15
-
-
0029041130
-
Analysis of topoisomerase I/DNA complexes in patients administered topothecan
-
Subramanian, D., Kraut, E., Staubus, A., Young, D. C. and Muller, M. T. (1995) Analysis of topoisomerase I/DNA complexes in patients administered topothecan. Cancer Res., 55, 2097-2103.
-
(1995)
Cancer Res
, vol.55
, pp. 2097-2103
-
-
Subramanian, D.1
Kraut, E.2
Staubus, A.3
Young, D.C.4
Muller, M.T.5
-
16
-
-
25844472609
-
The DNA demethylating 5-azaC induces endoreduplication in cultured Chinese hamster cells
-
Mateos, S., Domínguez, I., Pastor, N., Cantero, G. and Cortés, F. (2005) The DNA demethylating 5-azaC induces endoreduplication in cultured Chinese hamster cells. Mutat. Res., 578, 33-42.
-
(2005)
Mutat. Res
, vol.578
, pp. 33-42
-
-
Mateos, S.1
Domínguez, I.2
Pastor, N.3
Cantero, G.4
Cortés, F.5
-
17
-
-
0023919963
-
A simple technique for quantification of low levels of DNA damage in individual cells
-
Singh, N. P., McCoy, M. T., Tice, R. R. and Schneider, E. L. (1988) A simple technique for quantification of low levels of DNA damage in individual cells. Exp. Cell Res., 175, 184-191.
-
(1988)
Exp. Cell Res
, vol.175
, pp. 184-191
-
-
Singh, N.P.1
McCoy, M.T.2
Tice, R.R.3
Schneider, E.L.4
-
18
-
-
0028918375
-
The comet assay: A comprehensive review
-
Fairbairn, D. W., Olive, P. L. and O'Neill, K. L. (1995) The comet assay: a comprehensive review. Mutat. Res., 339, 37-59.
-
(1995)
Mutat. Res
, vol.339
, pp. 37-59
-
-
Fairbairn, D.W.1
Olive, P.L.2
O'Neill, K.L.3
-
19
-
-
0025305451
-
Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells
-
Olive, P. L., Banath, J. P. and Durand, R. E. (1990) Detection of etoposide resistance by measuring DNA damage in individual Chinese hamster cells. J. Natl Cancer Inst., 82, 779-783.
-
(1990)
J. Natl Cancer Inst
, vol.82
, pp. 779-783
-
-
Olive, P.L.1
Banath, J.P.2
Durand, R.E.3
-
20
-
-
0018860957
-
Cellular differentiation, cytidine analogs and DNA methylation
-
Jones, P. A. and Taylor, S. M. (1980) Cellular differentiation, cytidine analogs and DNA methylation. Cell, 20, 85-93.
-
(1980)
Cell
, vol.20
, pp. 85-93
-
-
Jones, P.A.1
Taylor, S.M.2
-
21
-
-
0021813307
-
Nuclear matrix associated DNA methylase
-
Burdon, R. H., Quershi, M. and Adams, R. L. P. (1985) Nuclear matrix associated DNA methylase. Biochim. Biophys. Acta, 825, 70-79.
-
(1985)
Biochim. Biophys. Acta
, vol.825
, pp. 70-79
-
-
Burdon, R.H.1
Quershi, M.2
Adams, R.L.P.3
-
22
-
-
0020955602
-
Induction of chromosome decondensation, sister-chromatid exchanges and endoreduplications by 5-azacytidine, an inhibitor of DNA methylation
-
Hori, T. A. (1983) Induction of chromosome decondensation, sister-chromatid exchanges and endoreduplications by 5-azacytidine, an inhibitor of DNA methylation. Mutat. Res., 121, 47-52.
-
(1983)
Mutat. Res
, vol.121
, pp. 47-52
-
-
Hori, T.A.1
-
23
-
-
0029056196
-
The influence of DNA methylation on topoisomerase II activity and its possible link with genome instability in different cell lines of the Syrian hamster
-
Kirchner, S., Schiffmann, D. and Stopper, H. (1995) The influence of DNA methylation on topoisomerase II activity and its possible link with genome instability in different cell lines of the Syrian hamster. Toxicol. In Vitro, 9, 519-525.
-
(1995)
Toxicol. In Vitro
, vol.9
, pp. 519-525
-
-
Kirchner, S.1
Schiffmann, D.2
Stopper, H.3
-
24
-
-
0035835052
-
DNA methylation influences the decatenation activity of topoisomerase II
-
Boos, G. and Stopper, H. (2001) DNA methylation influences the decatenation activity of topoisomerase II. Int. J. Biol. Macrom., 28, 103-106.
-
(2001)
Int. J. Biol. Macrom
, vol.28
, pp. 103-106
-
-
Boos, G.1
Stopper, H.2
-
25
-
-
0037219218
-
Roles of DNA topoisomerases in chromosome segregation and mitosis
-
Cortés, F., Pastor, N., Mateos, S. and Dominguez, I. (2003) Roles of DNA topoisomerases in chromosome segregation and mitosis. Rev. Mutat. Res., 543, 59-66.
-
(2003)
Rev. Mutat. Res
, vol.543
, pp. 59-66
-
-
Cortés, F.1
Pastor, N.2
Mateos, S.3
Dominguez, I.4
-
26
-
-
0028237868
-
Effects of DNA methylation on topoisomerase I and II cleavage activities
-
Leteurtre, F., Kohlhagen, G., Fesen, M. R., Tanizawa, A., Kohn, K. W. and Pommier, Y. (1994) Effects of DNA methylation on topoisomerase I and II cleavage activities. J. Biol. Chem., 269, 7893-7900.
-
(1994)
J. Biol. Chem
, vol.269
, pp. 7893-7900
-
-
Leteurtre, F.1
Kohlhagen, G.2
Fesen, M.R.3
Tanizawa, A.4
Kohn, K.W.5
Pommier, Y.6
-
27
-
-
0021760306
-
Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA
-
Been, M. D., Burgess, R. R. and Champox, J. J. (1984) Nucleotide sequence preference at rat liver and wheat germ type 1 DNA topoisomerase breakage sites in duplex SV40 DNA. Nucleic Acids Res., 12, 3097-3114.
-
(1984)
Nucleic Acids Res
, vol.12
, pp. 3097-3114
-
-
Been, M.D.1
Burgess, R.R.2
Champox, J.J.3
-
28
-
-
0024592815
-
Biochemical basis for the interactions of type I and type II topoisomerases with DNA
-
Osheroff, N. (1989) Biochemical basis for the interactions of type I and type II topoisomerases with DNA. Pharmacol. Ther., 41, 223-241.
-
(1989)
Pharmacol. Ther
, vol.41
, pp. 223-241
-
-
Osheroff, N.1
-
29
-
-
0020489806
-
Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA
-
Edwards, K. A., Halligan, B. D., Davis, J. L., Nivera, N. D. and Liu, L. F. (1982) Recognition sites of eukaryotic DNA topoisomerase I: DNA nucleotide sequencing analysis of topo I cleavage sites on SV40 DNA. Nucleic Acids Res., 10, 2565-2576.
-
(1982)
Nucleic Acids Res
, vol.10
, pp. 2565-2576
-
-
Edwards, K.A.1
Halligan, B.D.2
Davis, J.L.3
Nivera, N.D.4
Liu, L.F.5
-
30
-
-
0022369729
-
A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena r-chromatin
-
Bonven, B. J., Gocke, E. and Westergaard, O. (1985) A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in Tetrahymena r-chromatin. Cell, 41, 541-551.
-
(1985)
Cell
, vol.41
, pp. 541-551
-
-
Bonven, B.J.1
Gocke, E.2
Westergaard, O.3
-
31
-
-
0034446542
-
DNA methylation, nuclear structure, gene expression and cancer
-
Leonhardt, H. and Cardoso, M. C. (2000) DNA methylation, nuclear structure, gene expression and cancer. J. Cell Biochem., 35 (Suppl.), 78-83.
-
(2000)
J. Cell Biochem
, vol.35
, Issue.SUPPL.
, pp. 78-83
-
-
Leonhardt, H.1
Cardoso, M.C.2
-
32
-
-
0026526740
-
In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics
-
Käs, E. and Laemli, U. K. (1992) In vivo topoisomerase II cleavage of the Drosophila histone and satellite III repeats: DNA sequence and structural characteristics. EMBO J., 11, 705-716.
-
(1992)
EMBO J
, vol.11
, pp. 705-716
-
-
Käs, E.1
Laemli, U.K.2
-
33
-
-
36949016699
-
Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state
-
Kanai, Y. and Hirohashi, S. (2007) Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state. Carcinogenesis, 28, 2434-2442.
-
(2007)
Carcinogenesis
, vol.28
, pp. 2434-2442
-
-
Kanai, Y.1
Hirohashi, S.2
-
34
-
-
0037068378
-
DNA methylation and cancer
-
Jones, P. A. (2002) DNA methylation and cancer. Oncogene, 21, 5358-5360.
-
(2002)
Oncogene
, vol.21
, pp. 5358-5360
-
-
Jones, P.A.1
-
35
-
-
0036274359
-
The fundamental role of epigenetic events in cancer
-
Jones, P. A. and Baylin, S. B. (2002) The fundamental role of epigenetic events in cancer. Nat. Rev. Genet., 3, 415-428.
-
(2002)
Nat. Rev. Genet
, vol.3
, pp. 415-428
-
-
Jones, P.A.1
Baylin, S.B.2
-
36
-
-
14644396228
-
Detection and interpretation of altered methylation patterns in cancer cells
-
Ushijima, T. (2005) Detection and interpretation of altered methylation patterns in cancer cells. Nat. Rev. Cancer, 5, 223-231.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 223-231
-
-
Ushijima, T.1
-
37
-
-
33644846509
-
Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction?
-
Baylin, S. B. and Ohm, J. E. (2006) Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat. Rev. Cancer, 6, 107-116.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 107-116
-
-
Baylin, S.B.1
Ohm, J.E.2
-
38
-
-
33749070191
-
Targeting DNA methylation in cancer
-
Szyf, M. (2006) Targeting DNA methylation in cancer. Bull. Cancer, 93, 961-972.
-
(2006)
Bull. Cancer
, vol.93
, pp. 961-972
-
-
Szyf, M.1
-
39
-
-
33744918070
-
DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukaemia
-
Yang, A. S., Doshi, K. D., Choi, S. W. et al. (2006) DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukaemia. Cancer Res., 66, 5495-5503.
-
(2006)
Cancer Res
, vol.66
, pp. 5495-5503
-
-
Yang, A.S.1
Doshi, K.D.2
Choi, S.W.3
-
40
-
-
34548585368
-
The use of hypomethylating agents in the treatment of hematologic malignancies
-
Kishlinger, J. E. and Godley, L. A. (2007) The use of hypomethylating agents in the treatment of hematologic malignancies. Leuk. Lymphoma, 48, 1676-1695.
-
(2007)
Leuk. Lymphoma
, vol.48
, pp. 1676-1695
-
-
Kishlinger, J.E.1
Godley, L.A.2
-
41
-
-
34547799171
-
DNA methyltransferases as targets for cancer therapy
-
Goshal, K. and Bai, S. (2007) DNA methyltransferases as targets for cancer therapy. Drugs Today, 43, 395-422.
-
(2007)
Drugs Today
, vol.43
, pp. 395-422
-
-
Goshal, K.1
Bai, S.2
-
42
-
-
43749117734
-
A phase II study of 5-azacytidine for patients with primary and post-essential thrombocythemia/polycytemia vera myelofibrosis
-
Quintás-Cardama, A., Tong, W., Kantarjian, H. et al. (2008) A phase II study of 5-azacytidine for patients with primary and post-essential thrombocythemia/polycytemia vera myelofibrosis. Leukemia, 22, 965-970.
-
(2008)
Leukemia
, vol.22
, pp. 965-970
-
-
Quintás-Cardama, A.1
Tong, W.2
Kantarjian, H.3
-
43
-
-
38949120072
-
Treatment strategies in myelodysplastic syndromes
-
Atallah, E. and Garcia-Manero, G. (2008) Treatment strategies in myelodysplastic syndromes. Cancer Invest., 26, 208-216.
-
(2008)
Cancer Invest
, vol.26
, pp. 208-216
-
-
Atallah, E.1
Garcia-Manero, G.2
-
44
-
-
0022340594
-
Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
-
Hsiang, Y. H., Hertzberg, R., Hecht, S. and Liu, L. F. (1985) Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. J. Biol. Chem., 260, 14873-14878.
-
(1985)
J. Biol. Chem
, vol.260
, pp. 14873-14878
-
-
Hsiang, Y.H.1
Hertzberg, R.2
Hecht, S.3
Liu, L.F.4
-
45
-
-
19144361907
-
Camptothecin and its analogues: A review on their chemotherapeutic potential
-
Sriram, D., Yogeeswari, P., Thirumurugan, R. and Bal, T. R. (2005) Camptothecin and its analogues: a review on their chemotherapeutic potential. Nat. Prod. Res., 19, 393-412.
-
(2005)
Nat. Prod. Res
, vol.19
, pp. 393-412
-
-
Sriram, D.1
Yogeeswari, P.2
Thirumurugan, R.3
Bal, T.R.4
-
46
-
-
1542507062
-
Camptothecin: Current perspectives
-
Thomas, C. J., Rahier, N. J. and Hecht, S. M. (2004) Camptothecin: current perspectives. Bioorg. Med. Chem., 12, 1585-1604.
-
(2004)
Bioorg. Med. Chem
, vol.12
, pp. 1585-1604
-
-
Thomas, C.J.1
Rahier, N.J.2
Hecht, S.M.3
-
47
-
-
33749034730
-
Topoisomerase I inhibitors: Camptothecins and beyond
-
Pommier, Y. (2006) Topoisomerase I inhibitors: camptothecins and beyond. Nat. Rev. Cancer, 6, 789-802.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 789-802
-
-
Pommier, Y.1
|