Essential role of the donor acyl carrier protein in stereoselective chain translocation to a fully reducing module of the nanchangmycin polyketide synthase

Biochemistry

Volumn 51, Issue 4, 2012, Pages 879-887

  Guo, Xun ^a   Liu, Tiangang ^b   Deng, Zixin ^b,c   Cane, David E ^a  

^a BROWN UNIVERSITY   (United States)

^b WUHAN UNIVERSITY   (China)

^c Shanghai Jiao Tong University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACYL CARRIER PROTEINS; DIASTEREOMERS; KETOSYNTHASE; POLYKETIDE SYNTHASES; POLYKETIDES; STEREO-SELECTIVE; STEREOSPECIFICITY; SYNTHASES; THIOESTERASES; THIOESTERS;

CONDENSATION REACTIONS; ETHERS; KETONES;

SUBSTRATES;

ACYL CARRIER PROTEIN; HEXANOIC ACID DERIVATIVE; NANCHANGMYCIN SYNTHASE; POLYKETIDE SYNTHASE; PYRONE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOESTER; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; DIASTEREOISOMER; ENANTIOMER; ENZYME KINETICS; ENZYME SPECIFICITY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; STEREOCHEMISTRY; STEREOSPECIFICITY;

ACYL CARRIER PROTEIN; ACYLATION; AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOCATALYSIS; CATALYTIC DOMAIN; ETHERS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; KINETICS; MOLECULAR STRUCTURE; OXIDATION-REDUCTION; POLYKETIDE SYNTHASES; POLYKETIDES; PROTEIN SUBUNITS; RECOMBINANT FUSION PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPIRO COMPOUNDS; STEREOISOMERISM; STREPTOMYCES; SUBSTRATE SPECIFICITY;

EID: 84856484329     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201768v     Document Type: Article

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