Stereospecificity of the dehydratase domain of the erythromycin polyketide synthase

Journal of the American Chemical Society

Volumn 132, Issue 42, 2010, Pages 14697-14699

  Valenzano, Chiara R ^a   You, Young Ok ^a   Garg, Ashish ^a   Keatinge Clay, Adrian ^c   Khosla, Chaitan ^b   Cane, David E ^a  

^a BROWN UNIVERSITY   (United States)

^b STANFORD UNIVERSITY   (United States)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6-DEOXYERYTHRONOLIDE B SYNTHASE; HYDRATION REACTION; IN-SITU; METHYL ESTERS; POLYKETIDE SYNTHASES; RIFAMYCINS; STEREOSPECIFICITY; SYNTHASES; THIOESTERS;

CATALYSIS; DEHYDRATION; ESTERS; MIXTURES; STEREOCHEMISTRY;

DEWATERING;

2 METHYL 3 HYDROXYPENTANOYL DERIVATIVE; 2 METHYL 3 HYDROXYPENTANOYL N ACETYLCYSTEAMINE THIOESTER; 6 DEOXYERYTHRONOLIDE B SYNTHASE; ACYLTRANSFERASE; ERYTHROMYCIN; HYDROLYASE; METHYLMALONYL COENZYME A CARBOXYLTRANSFERASE; POLYKETIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SYNTHETASE; THIOESTER; TYLACTONE SYNTHASE; UNCLASSIFIED DRUG; VALERIC ACID DERIVATIVE;

ARTICLE; CATALYSIS; CHEMICAL STRUCTURE; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; REACTION ANALYSIS; STEREOCHEMISTRY; STEREOSPECIFICITY;

ACYL CARRIER PROTEIN; AMINO ACID SEQUENCE; BIOCATALYSIS; CHROMATOGRAPHY, GAS; CHROMATOGRAPHY, LIQUID; MASS SPECTROMETRY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; NADP; POLYKETIDE SYNTHASES; RECOMBINANT PROTEINS; STEREOISOMERISM;

EID: 77958502924     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja107344h     Document Type: Article

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