Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: The importance of potassium and chloride ions for its structure and function

Biochemistry

Volumn 46, Issue 14, 2007, Pages 4305-4321

  Haapalainen, Antti M ^a   Meriläinen, Gitte ^a   Pirilä, Päivi L ^a   Kondo, Naomi ^b   Fukao, Toshiyuki ^b   Wierenga, Rik K ^a  

^a UNIVERSITY OF OULU   (Finland)

^b GIFU UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; CATALYSIS; CHEMICAL BONDS; COMPLEXATION; CRYSTALLOGRAPHY; POTASSIUM COMPOUNDS;

CARBON CARBON BOND; CHLORIDE IONS; POTASSIUM IONS; THIOLYTIC DEGRADATION MECHANISM;

ENZYME KINETICS;

ACETYL COENZYME A ACETYLTRANSFERASE; CHLORIDE ION; POTASSIUM CHLORIDE; POTASSIUM ION;

ARTICLE; BINDING SITE; CATALYSIS; CHEMICAL BINDING; CLAISEN CONDENSATION; CRYSTALLOGRAPHY; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; MITOCHONDRION; PRIORITY JOURNAL;

ACETYL-COA C-ACETYLTRANSFERASE; ACYL COENZYME A; AMINO ACID SEQUENCE; APOENZYMES; BINDING SITES; CATALYSIS; CHLORIDES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DIPEPTIDES; ESCHERICHIA COLI; HUMANS; HYDROGEN BONDING; IONS; KINETICS; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHENYLALANINE; POTASSIUM; PROLINE; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 34147103372     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi6026192     Document Type: Article

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