메뉴 건너뛰기




Volumn 4, Issue 3, 2011, Pages 377-392

Immune cells in colorectal cancer: Prognostic relevance and role of MSI

Author keywords

Colorectal cancer; Immune response T lymphocytes; Microsatellite instability

Indexed keywords

CD3 ANTIGEN; CD45RO ANTIGEN; CD8 ANTIGEN; FAS LIGAND; GAMMA INTERFERON; GRANZYME B; HLA DR ANTIGEN; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2 RECEPTOR ALPHA; INTERLEUKIN 8; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; PROTEIN KINASE B; TRANSCRIPTION FACTOR FOXP3; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; VASCULOTROPIN;

EID: 84856474856     PISSN: 18752292     EISSN: 18752284     Source Type: Journal    
DOI: 10.1007/s12307-011-0068-5     Document Type: Review
Times cited : (83)

References (110)
  • 1
    • 77956103532 scopus 로고    scopus 로고
    • A review of the most promising biomarkers in colorectal cancer: One step closer to targeted therapy
    • Deschoolmeester V, BaayM, Specenier P, Lardon F, Vermorken JB (2010) A review of the most promising biomarkers in colorectal cancer: one step closer to targeted therapy. Oncologist 7:699-731
    • (2010) Oncologist , vol.7 , pp. 699-731
    • Deschoolmeester, V.1    Baaym Specenier, P.2    Lardon, F.3    Vermorken, J.B.4
  • 2
    • 77951627056 scopus 로고    scopus 로고
    • The chromosomal instability pathway in colon cancer
    • Pino MS, Chung DC (2010) The chromosomal instability pathway in colon cancer. Gastroenterology 6:2059-2072
    • (2010) Gastroenterology , vol.6 , pp. 2059-2072
    • Pino, M.S.1    Chung, D.C.2
  • 3
    • 77949270273 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer-The stable evidence
    • Vilar E, Gruber SB (2010) Microsatellite instability in colorectal cancer-the stable evidence. Nat Rev Clin Oncol 3:153-162
    • (2010) Nat Rev Clin Oncol , vol.3 , pp. 153-162
    • Vilar, E.1    Gruber, S.B.2
  • 4
    • 73449091519 scopus 로고    scopus 로고
    • DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome
    • Poulogiannis G, Frayling IM, Arends MJ (2010) DNA mismatch repair deficiency in sporadic colorectal cancer and Lynch syndrome. Histopathology 2:167-179
    • (2010) Histopathology , vol.2 , pp. 167-179
    • Poulogiannis, G.1    Frayling, I.M.2    Arends, M.J.3
  • 5
    • 0035117962 scopus 로고    scopus 로고
    • Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer
    • GradyW, Rajput A, Lutterbaugh J, Markowitz S (2001) Detection of aberrantly methylated hMLH1 promoter DNA in the serum of patients with microsatellite unstable colon cancer. Cancer Res 3:900-902 (Pubitemid 32174399)
    • (2001) Cancer Research , vol.61 , Issue.3 , pp. 900-902
    • Grady, W.M.1    Rajput, A.2    Lutterbaugh, J.D.3    Markowitz, S.D.4
  • 6
    • 0034521521 scopus 로고    scopus 로고
    • Colorectal carcinomas with high microsatellite instability: Defining a distinct immunologic and molecular entity with respect to prognostic markers
    • DOI 10.1053/hupa.2000.20383
    • Edmonston T, Cuesta K, Burkholder S, Barusevicius A, Rose D, Kovatich A, Boman B, Fry R, Fishel R, Palazzo J (2000) Colorectal carcinomas with high microsatellite instability: defining a distinct immunologic and molecular entity with respect to prognostic markers. Hum Pathol 12:1506-1514 (Pubitemid 32047002)
    • (2000) Human Pathology , vol.31 , Issue.12 , pp. 1506-1514
    • Edmonston, T.B.1    Cuesta, K.H.2    Burkholder, S.3    Barusevicius, A.4    Rose, D.5    Kovatich, A.J.6    Boman, B.7    Fry, R.8    Fishel, R.9    Palazzo, J.P.10
  • 7
    • 0033563165 scopus 로고    scopus 로고
    • Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification
    • Toyota M, Ho C, Ahuja N, Jair KW, Li Q, Ohe Toyota M, Baylin SB, Issa JP (1999) Identification of differentially methylated sequences in colorectal cancer by methylated CpG island amplification. Cancer Res 10:2307-2312 (Pubitemid 29242273)
    • (1999) Cancer Research , vol.59 , Issue.10 , pp. 2307-2312
    • Toyota, M.1    Ho, C.2    Ahuja, N.3    Jair, K.-W.4    Li, Q.5    Ohe-Toyota, M.6    Baylin, S.B.7    Issa, J.-P.J.8
  • 8
    • 33947216118 scopus 로고    scopus 로고
    • The adaptive immunologic microenvironment in colorectal cancer: A novel perspective
    • DOI 10.1158/0008-5472.CAN-06-4806
    • Galon J, Fridman WH, Pages F (2007) The adaptive immunologic microenvironment in colorectal cancer: a novel perspective. Cancer Res 5:1883-1886 (Pubitemid 46424201)
    • (2007) Cancer Research , vol.67 , Issue.5 , pp. 1883-1886
    • Galon, J.1    Fridman, W.-H.2    Pages, F.3
  • 11
    • 54249127469 scopus 로고    scopus 로고
    • The essential role of the in situ immune reaction in human colorectal cancer
    • Pages F, Galon J, Fridman WH (2008) The essential role of the in situ immune reaction in human colorectal cancer. J Leukoc Biol 4:981-987
    • (2008) J Leukoc Biol , vol.4 , pp. 981-987
    • Pages, F.1    Galon, J.2    Fridman, W.H.3
  • 15
    • 27944441722 scopus 로고    scopus 로고
    • Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis
    • DOI 10.1002/ijc.21303
    • Watson NF, Ramage JM, Madjd Z, Spendlove I, Ellis IO, Scholefield JH, Durrant LG (2006) Immunosurveillance is active in colorectal cancer as downregulation but not complete loss of MHC class I expression correlates with a poor prognosis. Int.J. Cancer 1:6-10 (Pubitemid 41681574)
    • (2006) International Journal of Cancer , vol.118 , Issue.1 , pp. 6-10
    • Watson, N.F.S.1    Ramage, J.M.2    Madjd, Z.3    Spendlove, I.4    Ellis, I.O.5    Scholefield, J.H.6    Durrant, L.G.7
  • 16
    • 0036322003 scopus 로고    scopus 로고
    • + T cells in immune responses to colorectal cancer
    • DOI 10.1007/s00262-002-0276-4
    • Titu LV, Monson JR, Greenman J (2002) The role of CD8(+) T cells in immune responses to colorectal cancer. Cancer Immunol Immunother 5:235-247 (Pubitemid 34810704)
    • (2002) Cancer Immunology, Immunotherapy , vol.51 , Issue.5 , pp. 235-247
    • Titu, L.V.1    Monson, J.R.2    Greenman, J.3
  • 18
    • 43049181690 scopus 로고    scopus 로고
    • Immune cells in colorectal cancer: Prognostic relevance and therapeutic strategies
    • DOI 10.1586/14737140.8.4.561
    • Atreya I, Neurath MF (2008) Immune cells in colorectal cancer: prognostic relevance and therapeutic strategies. Expert Rev Anticancer Ther 4:561-572 (Pubitemid 351818351)
    • (2008) Expert Review of Anticancer Therapy , vol.8 , Issue.4 , pp. 561-572
    • Atreya, I.1    Neurath, M.F.2
  • 19
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: Implications for new anticancer therapies
    • DOI 10.1002/path.1027
    • Bingle L, Brown NJ, Lewis CE (2002) The role of tumourassociated macrophages in tumour progression: implications for new anticancer therapies. J Pathol 3:254-265 (Pubitemid 34189413)
    • (2002) Journal of Pathology , vol.196 , Issue.3 , pp. 254-265
    • Bingle, L.1    Brown, N.J.2    Lewis, C.E.3
  • 20
    • 0037441914 scopus 로고    scopus 로고
    • Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with stage II and stage III colon carcinoma: A role for the host response in prognosis
    • DOI 10.1002/cncr.11152
    • Khorana AA, Ryan CK, Cox C, Eberly S, Sahasrabudhe DM (2003) Vascular endothelial growth factor, CD68, and epidermal growth factor receptor expression and survival in patients with Stage II and Stage III colon carcinoma: a role for the host response in prognosis. Cancer 4:960-968 (Pubitemid 36173146)
    • (2003) Cancer , vol.97 , Issue.4 , pp. 960-968
    • Khorana, A.A.1    Ryan, C.K.2    Cox, C.3    Eberly, S.4    Sahasrabudhe, D.M.5
  • 21
    • 0036355045 scopus 로고    scopus 로고
    • + immune cells in regional lymph node metastases from colorectal cancer as potential prognostic predictors
    • DOI 10.1007/s003840100337
    • Oberg A, Samii S, Stenling R, Lindmark G (2002) Different occurrence of CD8+, CD45R0+, and CD68+ immune cells in regional lymph node metastases from colorectal cancer as potential prognostic predictors. Int J Colorectal Dis 1:25-29 (Pubitemid 41398987)
    • (2002) International Journal of Colorectal Disease , vol.17 , Issue.1 , pp. 25-29
    • Oberg, A.1    Samii, S.2    Stenling, R.3    Lindmark, G.4
  • 22
    • 0038148426 scopus 로고    scopus 로고
    • Prognostic significance of CD8+ T cell and macrophage peritumoral infiltration in colorectal cancer
    • Funada Y, Noguchi T, Kikuchi R, Takeno S, Uchida Y, Gabbert HE (2003) Prognostic significance of CD8+ T cell and macrophage peritumoral infiltration in colorectal cancer. Oncol Rep 2:309-313
    • (2003) Oncol Rep , vol.2 , pp. 309-313
    • Funada, Y.1    Noguchi, T.2    Kikuchi, R.3    Takeno, S.4    Uchida, Y.5    Gabbert, H.E.6
  • 24
    • 77956362433 scopus 로고    scopus 로고
    • Intratumoral macrophage counts correlate with tumor progression in colorectal cancer
    • Kang JC, Chen JS, Lee CH, Chang JJ, Shieh YS (2010) Intratumoral macrophage counts correlate with tumor progression in colorectal cancer. J Surg Oncol 3:242-248
    • (2010) J Surg Oncol , vol.3 , pp. 242-248
    • Kang, J.C.1    Chen, J.S.2    Lee, C.H.3    Chang, J.J.4    Shieh, Y.S.5
  • 25
    • 64049092259 scopus 로고    scopus 로고
    • Reduced beta-catenin and peroxisome proliferator-activated receptor-gamma expression levels are associated with colorectal cancer metastatic progression: Correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome
    • PancioneM, Forte N, Sabatino L, Tomaselli E, Parente D, Febbraro A, Colantuoni V (2009) Reduced beta-catenin and peroxisome proliferator-activated receptor-gamma expression levels are associated with colorectal cancer metastatic progression: correlation with tumor-associated macrophages, cyclooxygenase 2, and patient outcome. Hum Pathol 5:714-725
    • (2009) Hum Pathol , vol.5 , pp. 714-725
    • Pancionem Forte, N.1    Sabatino, L.2    Tomaselli, E.3    Parente, D.4    Febbraro, A.5    Colantuoni, V.6
  • 26
    • 77955410185 scopus 로고    scopus 로고
    • Tumor associated macrophages protect colon cancer cells from TRAILinduced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells
    • Kaler P, Galea V, Augenlicht L, Klampfer L (2010) Tumor associated macrophages protect colon cancer cells from TRAILinduced apoptosis through IL-1beta-dependent stabilization of Snail in tumor cells. PLoS One 7:e11700
    • (2010) PLoS One , vol.7
    • Kaler, P.1    Galea, V.2    Augenlicht, L.3    Klampfer, L.4
  • 27
    • 73449139396 scopus 로고    scopus 로고
    • The NF-kappaB/AKT-dependent induction of wnt signaling in colon cancer cells by macrophages and IL-1beta
    • Kaler P, Godasi BN, Augenlicht L, Klampfer L (2009) The NF-kappaB/AKT-dependent Induction of Wnt Signaling in Colon Cancer Cells by Macrophages and IL-1beta. Cancer Microenviron 1:69-80
    • (2009) Cancer Microenviron , vol.1 , pp. 69-80
    • Kaler, P.1    Godasi, B.N.2    Augenlicht, L.3    Klampfer, L.4
  • 29
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxia-inducible factors HIF-1α and HIF-2α in normal human tissues, cancers, and tumor-associated macrophages
    • Talks KL, Turley H, Gatter KC, Maxwell PH, Pugh CW, Ratcliffe PJ, Harris AL (2000) The expression and distribution of the hypoxia-inducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am J Pathol 2:411-421 (Pubitemid 30626905)
    • (2000) American Journal of Pathology , vol.157 , Issue.2 , pp. 411-421
    • Talks, K.L.1    Turley, H.2    Gatter, K.C.3    Maxwell, P.H.4    Pugh, C.W.5    Ratcliffe, P.J.6    Harris, A.L.7
  • 30
    • 69249219322 scopus 로고    scopus 로고
    • Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization
    • Green CE, Liu T, Montel V, Hsiao G, Lester RD, Subramaniam S, Gonias SL, Klemke RL (2009) Chemoattractant signaling between tumor cells and macrophages regulates cancer cell migration, metastasis and neovascularization. PLoS One 8:e6713
    • (2009) PLoS One , vol.8
    • Green, C.E.1    Liu, T.2    Montel, V.3    Hsiao, G.4    Lester, R.D.5    Subramaniam, S.6    Gonias, S.L.7    Klemke, R.L.8
  • 31
    • 77949262399 scopus 로고    scopus 로고
    • Activated macrophages induce metastatic behavior of colon cancer cells
    • Jedinak A, Dudhgaonkar S, Sliva D (2010) Activated macrophages induce metastatic behavior of colon cancer cells. Immunobiology 3:242-249
    • (2010) Immunobiology , vol.3 , pp. 242-249
    • Jedinak, A.1    Dudhgaonkar, S.2    Sliva, D.3
  • 34
    • 43349104148 scopus 로고    scopus 로고
    • Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner
    • DOI 10.1007/s00262-007-0417-x
    • Yaqub S, Henjum K, Mahic M, Jahnsen FL, Aandahl EM, Bjornbeth BA, Tasken K (2008) Regulatory T cells in colorectal cancer patients suppress anti-tumor immune activity in a COX-2 dependent manner. Cancer Immunol Immunother 6:813-821 (Pubitemid 351660125)
    • (2008) Cancer Immunology, Immunotherapy , vol.57 , Issue.6 , pp. 813-821
    • Yaqub, S.1    Henjum, K.2    Mahic, M.3    Jahnsen, F.L.4    Aandahl, E.M.5    Bjornbeth, B.A.6    Tasken, K.7
  • 39
    • 0022515473 scopus 로고
    • Lymphocytic infiltration and survival in rectal cancer
    • Jass JR (1986) Lymphocytic infiltration and survival in rectal cancer. J Clin Pathol 6:585-589 (Pubitemid 16069660)
    • (1986) Journal of Clinical Pathology , vol.39 , Issue.6 , pp. 585-589
    • Jass, J.R.1
  • 40
    • 0030787373 scopus 로고    scopus 로고
    • Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer
    • DOI 10.1002/(SICI)1096-9896(199707)182:3<318::AID-PATH862>3.0.CO;2- 6
    • Ropponen KM, Eskelinen MJ, Lipponen PK, Alhava E, Kosma VM (1997) Prognostic value of tumour-infiltrating lymphocytes (TILs) in colorectal cancer. J Pathol 3:318-324 (Pubitemid 27285785)
    • (1997) Journal of Pathology , vol.182 , Issue.3 , pp. 318-324
    • Ropponen, K.M.1    Eskelinen, M.J.2    Lipponen, P.K.3    Alhava, E.4    Kosma, V.-M.5
  • 41
    • 33847621560 scopus 로고    scopus 로고
    • Focus on TILs: Prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer
    • Ohtani H (2007) Focus on TILs: prognostic significance of tumor infiltrating lymphocytes in human colorectal cancer. Cancer Immun 4
    • (2007) Cancer Immun , vol.4
    • Ohtani, H.1
  • 42
    • 24944447713 scopus 로고    scopus 로고
    • Lymphocyte subsets in peripheral blood as prognostic factors in colorectal cancer
    • Milasiene V, Stratilatovas E, Norkiene V, Jonusauskaite R (2005) Lymphocyte subsets in peripheral blood as prognostic factors in colorectal cancer. J BUON 2:261-264 (Pubitemid 41320571)
    • (2005) Journal of B.U.ON. , vol.10 , Issue.2 , pp. 261-264
    • Milasiene, V.1    Stratilatovas, E.2    Norkiene, V.3    Jonusauskaite, R.4
  • 46
    • 35648987934 scopus 로고    scopus 로고
    • The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer
    • DOI 10.1136/gut.2006.117812
    • Atreya I, Schimanski CC, Becker C, Wirtz S, Dornhoff H, Schnurer E, Berger MR, Galle PR, Herr W, Neurath MF (2007) The T-box transcription factor eomesodermin controls CD8 T cell activity and lymph node metastasis in human colorectal cancer. Gut 11:1572-1578 (Pubitemid 350033196)
    • (2007) Gut , vol.56 , Issue.11 , pp. 1572-1578
    • Atreya, I.1    Schimanski, C.C.2    Becker, C.3    Wirtz, S.4    Dornhoff, H.5    Schnurer, E.6    Berger, M.R.7    Galle, P.R.8    Herr, W.9    Neurath, M.F.10
  • 48
    • 0032529466 scopus 로고    scopus 로고
    • + T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer
    • Naito Y, Saito K, Shiiba K, Ohuchi A, Saigenji K, Nagura H, Ohtani H (1998) CD8+ T cells infiltrated within cancer cell nests as a prognostic factor in human colorectal cancer. Cancer Res 16:3491-3494 (Pubitemid 28376536)
    • (1998) Cancer Research , vol.58 , Issue.16 , pp. 3491-3494
    • Naito, Y.1    Saito, K.2    Shiiba, K.3    Ohuchi, A.4    Saigenji, K.5    Nagura, H.6    Ohtani, H.7
  • 50
    • 0038236541 scopus 로고    scopus 로고
    • + ratio of tumour infiltrating lymphocytes in colorectal cancer and HLA-DR expression on tumour cells
    • DOI 10.1007/s00262-003-0388-5
    • Diederichsen AC, Hjelmborg JB, Christensen PB, Zeuthen J, Fenger C (2003) Prognostic value of the CD4+/CD8+ ratio of tumour infiltrating lymphocytes in colorectal cancer and HLADR expression on tumour cells. Cancer Immunol Immunother 7:423-428 (Pubitemid 36831363)
    • (2003) Cancer Immunology, Immunotherapy , vol.52 , Issue.7 , pp. 423-428
    • Diederichsen, A.C.P.1    Hjelmborg, J.V.B.2    Christensen, P.B.3    Zeuthen, J.4    Fenge, C.5
  • 52
    • 9144273838 scopus 로고    scopus 로고
    • + T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: Possible association with suppression of micrometastasis
    • DOI 10.1038/sj.bjc.6602201
    • Chiba T, Ohtani H, Mizoi T, Naito Y, Sato E, Nagura H, Ohuchi A, Ohuchi K, Shiiba K, Kurokawa Y, Satomi S (2004) Intraepithelial CD8+ T-cell-count becomes a prognostic factor after a longer follow-up period in human colorectal carcinoma: possible association with suppression of micrometastasis. Br J Cancer 9:1711-1717 (Pubitemid 39546145)
    • (2004) British Journal of Cancer , vol.91 , Issue.9 , pp. 1711-1717
    • Chiba, T.1    Ohtani, H.2    Mizoi, T.3    Naito, Y.4    Sato, E.5    Nagura, H.6    Ohuchi, A.7    Ohuchi, K.8    Shiiba, K.9    Kurokawa, Y.10    Satomi, S.11
  • 53
    • 33748754842 scopus 로고    scopus 로고
    • Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes
    • DOI 10.1111/j.1365-2559.2006.02520.x
    • Baker K, Chong G, Foulkes WD, Jass JR (2006) Transforming growth factor-beta pathway disruption and infiltration of colorectal cancers by intraepithelial lymphocytes. Histopathology 4:371-380 (Pubitemid 44401544)
    • (2006) Histopathology , vol.49 , Issue.4 , pp. 371-380
    • Baker, K.1    Chong, G.2    Foulkes, W.D.3    Jass, J.R.4
  • 55
    • 40949089575 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes and perforation in colon cancer predict positive response to 5-fluorouracil chemotherapy
    • DOI 10.1158/1078-0432.CCR-07-1994
    • Morris M, Platell C, Iacopetta B (2008) Tumor-infiltrating lymphocytes and perforation in colon cancer predict positive response to 5-fluorouracil chemotherapy. Clin Cancer Res 5:1413-1417 (Pubitemid 351413923)
    • (2008) Clinical Cancer Research , vol.14 , Issue.5 , pp. 1413-1417
    • Morris, M.1    Platell, C.2    Iacopetta, B.3
  • 59
    • 67649497425 scopus 로고    scopus 로고
    • Comparison of the prognostic value of inflammationbased pathologic and biochemical criteria in patients undergoing potentially curative resection for colorectal cancer
    • Roxburgh CS, Salmond JM, Horgan PG, Oien KA, McMillan DC (2009) Comparison of the prognostic value of inflammationbased pathologic and biochemical criteria in patients undergoing potentially curative resection for colorectal cancer. Ann Surg 5:788-793
    • (2009) Ann Surg , vol.5 , pp. 788-793
    • Roxburgh, C.S.1    Salmond, J.M.2    Horgan, P.G.3    Oien, K.A.4    McMillan, D.C.5
  • 60
    • 67651089733 scopus 로고    scopus 로고
    • Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer
    • Roxburgh CS, Salmond JM, Horgan PG, Oien KA, McMillan DC (2009) Tumour inflammatory infiltrate predicts survival following curative resection for node-negative colorectal cancer. Eur J Cancer 12:2138-2145
    • (2009) Eur J Cancer , vol.12 , pp. 2138-2145
    • Roxburgh, C.S.1    Salmond, J.M.2    Horgan, P.G.3    Oien, K.A.4    McMillan, D.C.5
  • 63
    • 62449228000 scopus 로고    scopus 로고
    • T cell-mediated immunoregulation in the gastrointestinal tract
    • Saurer L, Mueller C (2009) T cell-mediated immunoregulation in the gastrointestinal tract. Allergy 4:505-519
    • (2009) Allergy , vol.4 , pp. 505-519
    • Saurer, L.1    Mueller, C.2
  • 64
    • 70349451599 scopus 로고    scopus 로고
    • Combination of microsatellite instability and lymphocytic infiltrate as a prognostic indicator for adjuvant therapy in colon cancer
    • Kumar S, Chang EY, Frankhouse J, Dorsey PB, Lee RG, Johnson N (2009) Combination of microsatellite instability and lymphocytic infiltrate as a prognostic indicator for adjuvant therapy in colon cancer. Arch Surg 9:835-840
    • (2009) Arch Surg , vol.9 , pp. 835-840
    • Kumar, S.1    Chang, E.Y.2    Frankhouse, J.3    Dorsey, P.B.4    Lee, R.G.5    Johnson, N.6
  • 65
    • 1842867040 scopus 로고    scopus 로고
    • Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic
    • DOI 10.1002/bjs.4472
    • Phillips SM, Banerjea A, Feakins R, Li SR, Bustin SA, Dorudi S (2004) Tumour-infiltrating lymphocytes in colorectal cancer with microsatellite instability are activated and cytotoxic. Br J Surg 4:469-475 (Pubitemid 38491119)
    • (2004) British Journal of Surgery , vol.91 , Issue.4 , pp. 469-475
    • Phillips, S.M.1    Banerjea, A.2    Feakins, R.3    Li, S.R.4    Bustin, S.A.5    Dorudi, S.6
  • 67
    • 27444445519 scopus 로고    scopus 로고
    • The immunogenicity of colorectal cancers with high-degree microsatellite instability
    • Banerjea A, Bustin S, Dorudi S (2005) The immunogenicity of colorectal cancers with high-degree microsatellite instability. World J Surg Oncol 1:26
    • (2005) World J Surg Oncol , vol.1 , pp. 26
    • Banerjea, A.1    Bustin, S.2    Dorudi, S.3
  • 68
    • 0141815907 scopus 로고    scopus 로고
    • Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability
    • Ishikawa T, Fujita T, Suzuki Y, Okabe S, Yuasa Y, Iwai T, Kawakami Y (2003) Tumor-specific immunological recognition of frameshift-mutated peptides in colon cancer with microsatellite instability. Cancer Res 17:5564-5572 (Pubitemid 37139879)
    • (2003) Cancer Research , vol.63 , Issue.17 , pp. 5564-5572
    • Ishikawa, T.1    Fujita, T.2    Suzuki, Y.3    Okabe, S.4    Yuasa, Y.5    Iwai, T.6    Kawakami, Y.7
  • 74
    • 19944365184 scopus 로고    scopus 로고
    • Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases
    • DOI 10.1038/sj.bjc.6602534
    • Buckowitz A, Knaebel H, Benner A, Blaker H, Gebert J, Kienle P, von Knebel Doeberitz M, Kloor M (2005) Microsatellite instability in colorectal cancer is associated with local lymphocyte infiltration and low frequency of distant metastases. Br J Cancer 9:1746-1753 (Pubitemid 40756487)
    • (2005) British Journal of Cancer , vol.92 , Issue.9 , pp. 1746-1753
    • Buckowitz, A.1    Knaebel, H.-P.2    Benner, A.3    Blaker, H.4    Gebert, J.5    Kienle, P.6    Von Knebel Doeberitz, M.7    Kloor, M.8
  • 76
    • 33845599552 scopus 로고    scopus 로고
    • Tumour budding in colorectal carcinoma
    • DOI 10.1111/j.1365-2559.2006.02551.x
    • Prall F (2007) Tumour budding in colorectal carcinoma. Histopathology 1:151-162 (Pubitemid 44953405)
    • (2007) Histopathology , vol.50 , Issue.1 , pp. 151-162
    • Prall, F.1
  • 78
    • 33846577890 scopus 로고    scopus 로고
    • Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: A potential role for dysregulation of the transforming growth factor-β pathway
    • DOI 10.1016/j.ejca.2006.11.012, PII S0959804906010264
    • Baker K, Zlobec I, Tornillo L, Terracciano L, Jass JR, Lugli A (2007) Differential significance of tumour infiltrating lymphocytes in sporadic mismatch repair deficient versus proficient colorectal cancers: a potential role for dysregulation of the transforming growth factor-beta pathway. Eur J Cancer 3:624-631 (Pubitemid 46178541)
    • (2007) European Journal of Cancer , vol.43 , Issue.3 , pp. 624-631
    • Baker, K.1    Zlobec, I.2    Tornillo, L.3    Terracciano, L.4    Jass, J.R.5    Lugli, A.6
  • 80
    • 3142604756 scopus 로고    scopus 로고
    • Prognostic role of CD8+ tumor-infiltrating lymphocytes in stage III colorectal cancer with and without microsatellite instability
    • DOI 10.1016/j.humpath.2004.01.022, PII S0046817704000760
    • Prall F, Duhrkop T, Weirich V, Ostwald C, Lenz P, Nizze H, Barten M (2004) Prognostic role of CD8+ tumor-infiltrating lymphocytes in stage III colorectal cancer with and without microsatellite instability. Human Pathol 7:808-816 (Pubitemid 38903073)
    • (2004) Human Pathology , vol.35 , Issue.7 , pp. 808-816
    • Prall, F.1    Duhrkop, T.2    Weirich, V.3    Ostwald, C.4    Lenz, P.5    Nizze, H.6    Barten, M.7
  • 81
    • 77950673784 scopus 로고    scopus 로고
    • Targeted immunotherapy for colorectal cancer: Monoclonal antibodies and immunotoxins
    • Shapira S, Lisiansky V, Arber N, Kraus S (2010) Targeted immunotherapy for colorectal cancer: monoclonal antibodies and immunotoxins. Expert Opin Investig Drugs S67-S77
    • (2010) Expert Opin Investig Drugs
    • Shapira, S.1    Lisiansky, V.2    Arber, N.3    Kraus, S.4
  • 82
    • 54849420913 scopus 로고    scopus 로고
    • Efficiency of adjuvant active specific immunization with Newcastle disease virus modified tumor cells in colorectal cancer patients following resection of liver metastases: Results of a prospective randomized trial
    • Schulze T, Kemmner W, Weitz J, Wernecke KD, Schirrmacher V, Schlag PM (2009) Efficiency of adjuvant active specific immunization with Newcastle disease virus modified tumor cells in colorectal cancer patients following resection of liver metastases: results of a prospective randomized trial. Cancer Immunol Immunother 1:61-69
    • (2009) Cancer Immunol Immunother , vol.1 , pp. 61-69
    • Schulze, T.1    Kemmner, W.2    Weitz, J.3    Wernecke, K.D.4    Schirrmacher, V.5    Schlag, P.M.6
  • 83
    • 33748858272 scopus 로고    scopus 로고
    • Active specific immunotherapy with autologous tumor cell vaccines for stage II colon cancer: Logistics, efficacy, safety and immunological pharmacodynamics
    • Hanna MG Jr, Hoover HC Jr, Pinedo HM, Finer M (2006) Active specific immunotherapy with autologous tumor cell vaccines for stage II colon cancer: logistics, efficacy, safety and immunological Pharmacodynamics. Hum Vaccin 4:185-191 (Pubitemid 44422486)
    • (2006) Human Vaccines , vol.2 , Issue.4 , pp. 185-191
    • Hanna Jr., M.G.1    Hoover Jr., H.C.2    Pinedo, H.M.3    Finer, M.4
  • 84
    • 78049442950 scopus 로고    scopus 로고
    • Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model
    • Wen Y, Wang CT, Ma TT, Li ZY, Zhou LN, Mu B, Leng F, Shi HS, Li YO, Wei YQ (2010) Immunotherapy targeting fibroblast activation protein inhibits tumor growth and increases survival in a murine colon cancer model. Cancer Sci
    • (2010) Cancer Sci
    • Wen, Y.1    Wang, C.T.2    Ma, T.T.3    Li, Z.Y.4    Zhou, L.N.5    Mu, B.6    Leng, F.7    Shi, H.S.8    Li, Y.O.9    Wei, Y.Q.10
  • 85
    • 77649312369 scopus 로고    scopus 로고
    • Neoadjuvant immunotherapy enhances radiosensitivity through natural killer cell activation
    • Chi CH, Wang YS, Yang CH, Chi KH (2010) Neoadjuvant immunotherapy enhances radiosensitivity through natural killer cell activation. Cancer Biother Radiopharm 1:39-45
    • (2010) Cancer Biother Radiopharm , vol.1 , pp. 39-45
    • Chi, C.H.1    Wang, Y.S.2    Yang, C.H.3    Chi, K.H.4
  • 86
    • 75149139044 scopus 로고    scopus 로고
    • Combination of CTL-associated antigen-4 blockade and depletion of CD25 regulatory T cells enhance tumour immunity of dendritic cell-based vaccine in a mouse model of colon cancer
    • Saha A, Chatterjee SK (2010) Combination of CTL-associated antigen-4 blockade and depletion of CD25 regulatory T cells enhance tumour immunity of dendritic cell-based vaccine in a mouse model of colon cancer. Scand J Immunol 2:70-82
    • (2010) Scand J Immunol , vol.2 , pp. 70-82
    • Saha, A.1    Chatterjee, S.K.2
  • 88
    • 0242708508 scopus 로고    scopus 로고
    • Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis
    • DOI 10.1038/sj.bjc.6600507
    • Lovig T, Andersen SN, Thorstensen L, Diep CB, Meling GI, Lothe RA, Rognum TO (2002) Strong HLA-DR expression in microsatellite stable carcinomas of the large bowel is associated with good prognosis. Br J Cancer 7:756-762 (Pubitemid 35178753)
    • (2002) British Journal of Cancer , vol.87 , Issue.7 , pp. 756-762
    • Lovig, T.1    Andersen, S.N.2    Thorstensen, L.3    Diep, C.B.4    Meling, G.I.5    Lothe, R.A.6    Rognum, T.O.7
  • 89
    • 2342649568 scopus 로고    scopus 로고
    • The correlation of microsatellite instability and tumor-infiltrating lymphocytes in hereditary non-polyposis colorectal cancer (HNPCC) and sporadic colorectal cancers: The significance of different types of lymphocyte infiltration
    • DOI 10.1093/jjco/hyh018
    • Takemoto N, Konishi F, Yamashita K, Kojima M, Furukawa T, Miyakura Y, Shitoh K, Nagai H (2004) The correlation of microsatellite instability and tumor-infiltrating lymphocytes in hereditary non-polyposis colorectal cancer (HNPCC) and sporadic colorectal cancers: the significance of different types of lymphocyte infiltration. Jpn J Clin Oncol 2:90-98 (Pubitemid 43118051)
    • (2004) Japanese Journal of Clinical Oncology , vol.34 , Issue.2 , pp. 90-98
    • Takemoto, N.1    Konishi, F.2    Yamashita, K.3    Kojima, M.4    Furukawa, T.5    Miyakura, Y.6    Shitoh, K.7    Nagai, H.8
  • 90
    • 22244434945 scopus 로고    scopus 로고
    • Immunoselective pressure and human leukocyte antigen class I antigen machinery defects in microsatellite unstable colorectal cancers
    • DOI 10.1158/0008-5472.CAN-05-0044
    • Kloor M, Becker C, Benner A, Woerner SM, Gebert J, Ferrone S, von Knebel Doeberitz M (2005) Immunoselective pressure and human leukocyte antigen class I antigen machinery defects in microsatellite unstable colorectal cancers. Cancer Res 14:6418-6424 (Pubitemid 40994430)
    • (2005) Cancer Research , vol.65 , Issue.14 , pp. 6418-6424
    • Kloor, M.1    Becker, C.2    Benner, A.3    Woerner, S.M.4    Gebert, J.5    Ferrone, S.6    Von Knebel Doeberitz, M.7
  • 93
    • 67749089307 scopus 로고    scopus 로고
    • Microsatellite and chromosomal stable colorectal cancers demonstrate poor immunogenicity and early disease recurrence
    • Banerjea A, Hands RE, Powar MP, Bustin SA, Dorudi S (2009) Microsatellite and chromosomal stable colorectal cancers demonstrate poor immunogenicity and early disease recurrence. Colorectal Dis 6:601-608
    • (2009) Colorectal Dis , vol.6 , pp. 601-608
    • Banerjea, A.1    Hands, R.E.2    Powar, M.P.3    Bustin, S.A.4    Dorudi, S.5
  • 96
    • 67650284737 scopus 로고    scopus 로고
    • Clinical implications of microsatellite instability in sporadic colon cancers
    • Sinicrope FA, Sargent DJ (2009) Clinical implications of microsatellite instability in sporadic colon cancers. Curr Opin Oncol 4:369-373
    • (2009) Curr Opin Oncol , vol.4 , pp. 369-373
    • Sinicrope, F.A.1    Sargent, D.J.2
  • 100
    • 77953171013 scopus 로고    scopus 로고
    • Risk factors CD8+:FOXP3+ cell ratio is a novel survival marker for colorectal cancer
    • Kirk R (2010) Risk factors. CD8+:FOXP3+ cell ratio is a novel survival marker for colorectal cancer. Nat Rev Clin Oncol 6:299
    • (2010) Nat Rev Clin Oncol , vol.6 , pp. 299
    • Kirk, R.1
  • 102
    • 44149104641 scopus 로고    scopus 로고
    • Foxp3 and microsatellite stability phenotype in colorectal cancer
    • DOI 10.1136/gut.2007.139568
    • Loddenkemper C, Nagorsen D, Zeitz M (2008) Foxp3 and microsatellite stability phenotype in colorectal cancer. Gut 6:725-726 (Pubitemid 351716960)
    • (2008) Gut , vol.57 , Issue.6 , pp. 725-726
    • Loddenkemper, C.1    Nagorsen, D.2    Zeitz, M.3
  • 108
    • 78349267001 scopus 로고    scopus 로고
    • Clinical impact of tumor-infiltrating lymphocytes for survival in stage II colon cancer
    • Lee WS, Park S, Lee WY, Yun SH, Chun HK (2010) Clinical impact of tumor-infiltrating lymphocytes for survival in stage II colon cancer. Cancer
    • (2010) Cancer
    • Lee, W.S.1    Park, S.2    Lee, W.Y.3    Yun, S.H.4    Chun, H.K.5
  • 110
    • 77955725489 scopus 로고    scopus 로고
    • Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients
    • Deng L, Zhang H, Luan Y, Zhang J, Xing Q, Dong S, Wu X, Liu M, Wang S (2010) Accumulation of foxp3+ T regulatory cells in draining lymph nodes correlates with disease progression and immune suppression in colorectal cancer patients. Clin Cancer Res 16:4105-4112
    • (2010) Clin Cancer Res , vol.16 , pp. 4105-4112
    • Deng, L.1    Zhang, H.2    Luan, Y.3    Zhang, J.4    Xing, Q.5    Dong, S.6    Wu, X.7    Liu, M.8    Wang, S.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.