Active specific immunotherapy with autologous tumor cell vaccines for stage II colon cancer: Logistics, efficacy, safety and immunological pharmacodynamics

Human Vaccines

Volumn 2, Issue 4, 2006, Pages 185-191

  Hanna Jr , Michael G ^a,d   Hoover Jr , Herbert C ^b   Pinedo, H M ^c   Finer, Mitchell ^a  

^a Intracel   (United States)

^b St joseph'S candler   (United States)

^c VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^d Intracel   (United States)

Author keywords

Autologous tumor cells; BCG; OncoVAX; Prevention of recurrence; Stage II colon cancer; Tumor cell vaccine

Indexed keywords

BCG VACCINE; ONCOVAX; TUMOR ANTIGEN; TUMOR CELL VACCINE;

BLADDER CANCER; CANCER IMMUNOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURVIVAL; CLINICAL TRIAL; COLON CANCER; DELAYED HYPERSENSITIVITY; DRUG EFFICACY; DRUG FORMULATION; DRUG MECHANISM; DRUG RESEARCH; DRUG SAFETY; HUMAN; IMMUNE RESPONSE; IMMUNOREACTIVITY; INJECTION SITE ULCER; IRRADIATION; PATIENT COMPLIANCE; REVIEW; TUBERCULOSIS; UNSPECIFIED SIDE EFFECT;

EID: 33748858272     PISSN: 15548600     EISSN: 15548619     Source Type: Journal    
DOI: 10.4161/hv.2.4.3196     Document Type: Review

References (23)

1. Ries LAG, Harkins D, Krapcho M, Mariotto A, Miller BA, Feuer EJ, Clegg L, Eisner MP, Horner MJ, Howlader N, Hayat M, Hankey BF, Edwards BK (ed). SEER Cancer Statistics Review, 1975-2003, National Cancer Institute, Bethesda, MD (retrieved: July 28, 2006 from http://seer.cancer.gov/csr/1975_2003/, based on November 2005 SEER data submission, posted to the SEER web site, 2006.
2. American Cancer Society, Cancer Facts and Figures; 2006.
3. Colorectal Cancer: Facts & Figures. Colon Cancer Alliance; 2001.
4. Moertel CG, Fleming TR, Macdonald JS, Haller DG, Laurie JA, Tangen CM, Ungerleider JS, Emerson WA, Tormey DC, Glick JH, et al. Intergroup study of fluorouracil plus levamisole as adjuvant therapy for stage II/Dukes' B2 colon cancer. J Clin Oncol. 1995; 13:2936-43.
5. NIH Consensus Conference: Adjuvant therapy for patients with colon and rectal cancer. JAMA. 1990; 264:1444-50.
6. Laurie JA, Moertel CG, Fleming TR, Wieand HS, Leigh JE, Rubin J, McCormack GW, Gerstner JB, Krook JE, Malliard J, Twito DI, Morton RF, Tschette LK, Barlow JF. Surgical adjuvant therapy of large-bowel carcinoma: an evaluation of levamisole and the combination of levamisole and fluorouracil. J Clin Oncol. 1989; 7:1447-56.
7. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. International multicentre pooled analysis of colon cancer trials (IMPACT). Lancet 1995; 345:939-44.
8. Cohen AM, Minsky BD, Schilsky RL. Cancer of the Colon. In DeVita VT, Hellman S, Rosenberg SA, eds. Cancer: principles and practice of oncology. 5th ed. Philadelphia: Lippincott-Raven 1997; 1144-97.
9. Tumor Node Metastases, American Joint Committee on Cancer System, Source.
10. The international multicenter pooled analysis of B2 colon cancer trials (IMPACT B2) investigators. Efficacy of adjuvant fluorouracil and folinic acid in B2 colon cancer. J Clin Oncol 1999; 17:1356-63.
11. Benson AB, Schrag, D, Somerfield MR, Cohen AM, Figueredo AT, Flynn PJ, Krzyzanowska MK, Maroun J, McAllister P, Van Cutsem E, Brouwers M, Charette M, and Haller DG. American Society of Clinical Oncology Recommendations on Adjuvant Chemotherapy for Stage II Colon Cancer. J Clin Oncol 2004; 22:3408-19.
12. Liefers G-J, Cleton-Jansen A-M, van de Velde CJH., Hermans J, van Krieken JHJM, Cornelisse CJ, Tollenaar RAEM. Micrometastases and survival in stage II colorectal cancer. New England Journal of Medicine. 2004; 339:223-8.
13. Hoover Jr HC, Brandhorst JS, Peters LC, Surdyke MG, Takeshita Y, Madariaga, J, Muenz LR, Hanna Jr MG. Adjuvant active specific immunotherapy for human colorectal cancer: 6.5-year median follow-up of a phase III prospectively randomized trial. J Clin Oncol 1993; 11:390-9.
14. Hoover Jr HC, Surdyke M, Dangel RB, Peters LC, Hanna Jr MG. Delayed cutaneous hypersensitivity to autologous tumor cells in colon cancer patients immunized with an autologous tumor cell: Bacillus Calmette-Guérin vaccine. Cancer Res 1984, 44:1671-1676.
15. Harris J, Ryan L, Adams G, Benson A, Haller D. Survival and relapse in adjuvant autologous tumor vaccine therapy for Dukes' B and C colon cancer - EST 5283. ASCO abstract, 1994.
16. Eastern Cooperative Oncology Group. Final report on EST 5283, October 1995.
17. Harris JE, Ryan L, Hoover HC Jr, Stuart RK, Oken MM, Benson AB 3rd, Mansour E, Haller DG, Manola J, Hanna MG Jr. Adjuvant active specific immunotherapy of stage II and III colon cancer with an autologous tumor cell vaccine: ECOG study E 5283. J Clin Oncol 2000; 18:148-57.
18. Vermorken JB, Claessen AME, Van Tinteren H, Gall HE, Ezinga R, Meijer S, Scheper RJ, Meijer CJLM, Bloemena E, Ransom JH, Hanna Jr MG, Pinedo HM. Active specific immunotherapy for stage II and stage III human colon cancer: a randomized trial. Lancet 1999; 353:345-50.
19. Hsueh EC, Gupta RK, Qi K, Morton DL. Correlation of specific immune responses with survival in melanoma patients with distant metastases receiving polyvalent melanoma cell vaccine. J Clin Oncol 1998; 16:2913-20.
20. Berd D, Maguire Jr. HC, Mastrangelo MJ. Induction of cell-mediated immunity to autologous melanoma cells and regression of metastases after treatment with a melanoma cell vaccine preceded by cyclophosphamide. Cancer Research 1986; 46:2572-7.
21. McCune CS, O'Donnell RW, Marquis DM, Sahasrabudhe M. Renal cell carcinoma treated by vaccines for active specific immunotherapy: correlation of survival with skin testing by autologous tumor cells. Cancer Immunolog Immunother 1990; 32:62-6.
22. Morton DL, Leland MD, Foshag J, Hoon DSB, Nizze JA, Wanek LA, Chang C, Davtyan DG, Gupta RK, Elashoff R, Irie RF. Prolongation of Survival in Metastatic Melanoma after active specific immunotherapy with a new polyvalent melanoma vaccine. Annals of Surgey 1992; 216:463-82.
23. Pages F, Berger A, Camus M, Sanchez-Cabo F, Costes A, Molidor R, Mlecnik B, Kirilovsky A, Nilsson M, Damotte D, Meatchi T, Bruneval P, Cugnenc PH, Trajanoski Z, Fridman WH, Galon J. Effector Memory T Cells, Early Metastasis, and Survival in Colorectal Cancer. N Engl J Med 2005; 353:2654-66.