Lead generation of heat shock protein 90 inhibitors by a combination of fragment-based approach, virtual screening, and structure-based drug design

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 19, 2011, Pages 5778-5783

  Miura, Takaaki ^a   Fukami, Takaaki A ^a   Hasegawa, Kiyoshi ^a   Ono, Naomi ^a   Suda, Atsushi ^a   Shindo, Hidetoshi ^a   Yoon, Dong Oh ^b   Kim, Sung Jin ^b   Na, Young Jun ^b   Aoki, Yuko ^a   Shimma, Nobuo ^a   Tsukuda, Takuo ^a   Shiratori, Yasuhiko ^a  

^a CHUGAI PHARMACEUTICAL CO LTD   (Japan)

^b C and C Research Laboratories   (South Korea)

Author keywords

Fragment based approach; Hsp90 inhibitor; Virtual screening

Indexed keywords

CH 5015765; HEAT SHOCK PROTEIN 90; HEAT SHOCK PROTEIN 90 INHIBITOR; TRIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG DESIGN; DRUG EFFICACY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; STOMACH CANCER; STRUCTURE ANALYSIS; TUMOR XENOGRAFT; VIRTUAL REALITY;

ADENOSINE TRIPHOSPHATASES; ADMINISTRATION, ORAL; ANIMALS; ANTINEOPLASTIC AGENTS; BENZOPYRANS; COMPUTER SIMULATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DRUG DISCOVERY; ESCHERICHIA COLI; HSP90 HEAT-SHOCK PROTEINS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; NEOPLASMS; REPRODUCIBILITY OF RESULTS; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE; TRIAZINES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 80052573916     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.08.001     Document Type: Article

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