Gene-by-environment effect of house dust mite on purinergic receptor P2Y12 (P2RY12) and lung function in children with asthma

Clinical and Experimental Allergy

Volumn 42, Issue 2, 2012, Pages 229-237

  Bunyavanich, S ^a,b   Boyce, J A ^a,b   Raby, B A ^a,b   Weiss, S T ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Asthma; House dust mite; Leukotriene; Lung function; Purinergic receptor

Indexed keywords

PURINERGIC P2Y12 RECEPTOR;

ARTICLE; ASTHMA; CHILD; DERMATOPHAGOIDES; DERMATOPHAGOIDES FARINAE; DERMATOPHAGOIDES PTERONYSSINUS; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HAPLOTYPE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; NONHUMAN; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; ASTHMA; CHILD; COHORT STUDIES; FEMALE; GENE-ENVIRONMENT INTERACTION; HUMANS; LEUKOTRIENE E4; LUNG; MALE; MICE; POLYMORPHISM, SINGLE NUCLEOTIDE; PULMONARY EOSINOPHILIA; PYROGLYPHIDAE; RECEPTORS, PURINERGIC P2Y12; RESPIRATORY FUNCTION TESTS;

EID: 84856456900     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/j.1365-2222.2011.03874.x     Document Type: Article

References (40)

1. Lee TH, Woszczek G, Farooque SP. Leukotriene E4: perspective on the forgotten mediator. J Allergy Clin Immunol 2009; 124:417-21.
2. Austen KF, Maekawa A, Kanaoka Y, Boyce JA. The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiological implications. J Allergy Clin Immunol 2009; 124:406-14; quiz 15-6.
3. Paruchuri S, Tashimo H, Feng C et al. Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med 2009; 206:2543-55.
4. Rabinovitch N, Graber NJ, Chinchilli VM et al. Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma. J Allergy Clin Immunol 2010; 126:545-51 e1-4.
5. 4, as compared with normal airways, but not to LTC4, LTD4, methacholine, and histamine. Am Rev Respir Dis 1990; 142:1112-8.
6. Scadding GW, Scadding GK. Recent advances in antileukotriene therapy. Curr Opin Allergy Clin Immunol 2010; 10:370-6.
7. Fontana P, Dupont A, Gandrille S et al. Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. Circulation 2003; 108:989-95.
8. Fontana P, Gaussem P, Aiach M et al. P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study. Circulation 2003; 108:2971-3.
9. Zee RY, Michaud SE, Diehl KA et al. Purinergic receptor P2Y, G-protein coupled, 12 gene variants and risk of incident ischemic stroke, myocardial infarction, and venous thromboembolism. Atherosclerosis 2008; 197:694-9.
10. Rudez G, Pons D, Leebeek F et al. Platelet receptor P2RY12 haplotypes predict restenosis after percutaneous coronary interventions. Hum Mutat 2008; 29:375-80.
11. Simon T, Verstuyft C, Mary-Krause M et al. Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 2009; 360:363-75.
12. Nonaka Y, Hiramoto T, Fujita N. Identification of endogenous surrogate ligands for human P2Y12 receptors by in silico and in vitro methods. Biochem Biophys Res Commun 2005; 337:281-8.
13. Barrett NA, Maekawa A, Rahman OM et al. Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol 2009; 182:1119-28.
14. Childhood Asthma Management Program Research Group. The Childhood Asthma Management Program (CAMP): design, rationale, and methods. Control Clin Trials 1999; 20:91-120.
15. Himes BE, Hunninghake GM, Baurley JW et al. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet 2009; 84:581-93.
16. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-5.
17. R Development Core Team R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2010.
18. Lange C, DeMeo D, Silverman EK et al. PBAT: tools for family-based association studies. Am J Hum Genet 2004; 74:367-9.
19. Laird NM, Lange C. Family-based designs in the age of large-scale gene-association studies. Nat Rev Genet 2006; 7:385-94.
20. Benjamini Y, Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Ann Stat 2001; 29:1165-88.
21. Rice TK, Schork NJ, Rao DC. Methods for handling multiple testing. Adv Genet 2008; 60:293-308.
22. Gabriel SB, Schaffner SF, Nguyen H et al. The structure of haplotype blocks in the human genome. Science 2002; 296:2225-9.
23. Vansteelandt S, Demeo DL, Lasky-Su J et al. Testing and estimating gene-environment interactions in family-based association studies. Biometrics 2008; 64:458-67.
24. Platts-Mills TA, Hayden ML, Chapman MD, Wilkins SR. Seasonal variation in dust mite and grass-pollen allergens in dust from the houses of patients with asthma. J Allergy Clin Immunol 1987; 79:781-91.
25. Sporik R, Platts-Mills TA, Cogswell JJ. Exposure to house dust mite allergen of children admitted to hospital with asthma. Clin Exp Allergy 1993; 23:740-6.
26. Sharma S, Raby BA, Hunninghake GM et al. Variants in TGFB1, dust mite exposure, and disease severity in children with asthma. Am J Respir Crit Care Med 2009; 179:356-62.
27. Hunninghake GM, Soto-Quiros ME, Lasky-Su J et al. Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations. J Allergy Clin Immunol 2008; 122:93-8, 8 e1-5.
28. Maekawa A, Kanaoka Y, Xing W, Austen KF. Functional recognition of a distinct receptor preferential for leukotriene E4 in mice lacking the cysteinyl leukotriene 1 and 2 receptors. Proc Natl Acad Sci USA 2008; 105:16695-700.
29. Lynch KR, O'Neill GP, Liu Q et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature 1999; 399:789-93.
30. Heise CE, O'Dowd BF, Figueroa DJ et al. Characterization of the human cysteinyl leukotriene 2 receptor. J Biol Chem 2000; 275:30531-6.
31. National Center for Biotechnology Information (NCBI). Entrez SNP. Available at (accessed on 8 February 2011).
32. Conde L, Vaquerizas JM, Dopazo H et al. PupaSuite: finding functional single nucleotide polymorphisms for large-scale genotyping purposes. Nucleic Acids Res 2006; 34:W621-5.
33. Repapi E, Sayers I, Wain LV et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet 2010; 42:36-44.
34. Hancock DB, Eijgelsheim M, Wilk JB et al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet 2010; 42:45-52.
35. Li X, Howard TD, Moore WC et al. Importance of hedgehog interacting protein and other lung function genes in asthma. J Allergy Clin Immunol 2011; 127:1457-65.
36. Moffatt M, Gut IG, the GABRIEL consortium et al. A GABRIEL consortium large-scale genome-wide association study of asthma. N Engl J Med 2010; 363:1211-21.
37. Boyce JA. The role of mast cells in asthma. Prostaglandins Leukot Essent Fatty Acids 2003; 69:195-205.
38. Weiss ST, Tosteson TD, Segal MR et al. Effects of asthma on pulmonary function in children. A longitudinal population-based study. Am Rev Respir Dis 1992; 145:58-64.
39. Gold DR, Wypij D, Wang X et al. Gender- and race-specific effects of asthma and wheeze on level and growth of lung function in children in six U.S. cities. Am J Respir Crit Care Med 1994; 149:1198-208.
40. London SJ, Romieu I. Gene by environment interaction in asthma. Annu Rev Public Health 2009; 30:55-80.