Platelet receptor P2RY12 haplotypes predict restenosis after percutaneous coronary interventions

Human Mutation

Volumn 29, Issue 3, 2008, Pages 375-380

  Rudež, Goran ^a   Pons, Douwe ^b,c   Leebeek, Frank ^a   Monraats, Pascalle ^b,c   Schrevel, Marlies ^a   Zwinderman, Aeilko ^d   De Winter, Robbert ^d   Tio, René ^e   Doevendans, Pieter ^f   Jukema, Wouter ^b,c   De Maat, Moniek ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ROYAL NETHERLANDS ACADEMY OF ARTS AND SCIENCES   (Netherlands)

^d ACADEMIC MEDICAL CENTER   (Netherlands)

^e UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

^f UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Haplotypes; P2RY12; P2Y12; Platelets; Restenosis

Indexed keywords

THROMBOCYTE RECEPTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC MARKER; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; P2RY12 GENE; PERCUTANEOUS CORONARY INTERVENTION; PRIORITY JOURNAL; RECEPTOR GENE; RESTENOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STENT;

AGED; ALLELES; ANGIOPLASTY, TRANSLUMINAL, PERCUTANEOUS CORONARY; BLOOD PLATELETS; CORONARY DISEASE; CORONARY RESTENOSIS; FEMALE; FOLLOW-UP STUDIES; GENE FREQUENCY; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, PURINERGIC P2; RISK FACTORS; STENTS;

EID: 40549106434     PISSN: 10597794     EISSN: None     Source Type: Journal    
DOI: 10.1002/humu.20641     Document Type: Article

References (17)

1. Agema WR, Monraats PS, Zwinderman AH, De Winter RJ, Tio RA, Doevendans PA, Waltenberger J, De Maat MP, Frants RR, Atsma DE, van der Laarse A, van der Wall EE, Jukema JW. 2004. Current PTCA practice and clinical outcomes in The Netherlands: the real world in the pre-drug-eluting stent era. Eur Heart J 25:1163-1170.
2. Chandrasekar B, Tanguay JF. 2000. Platelets and restenosis. J Am Coll Cardiol 35:555-562.
3. den Dunnen JT, Antonarakis SE. 2000. Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum Mutat 15:7-12.
4. Ellis SG, Vandormael MG, Cowley MJ, DiSciascio G, Deligonul U, Topol EJ, Bulle TM. 1990. Coronary morphologic and clinical determinants of procedural outcome with angioplasty for multivessel coronary disease. Implications for patient selection. Multivessel Angioplasty Prognosis Study Group. Circulation 82:1193-1202.
5. Fontana P, Dupont A, Gandrille S, Bachelot-Loza C, Reny JL, Aiach M, Gaussem P, 2003a. Adenosine diphosphate-induced platelet aggregation is associated with P2Y12 gene sequence variations in healthy subjects. Circulation 108:989-995.
6. Fontana P, Gaussem P, Aiach M, Fiessinger JN, Emmerich J, Reny JL. 2003b. P2Y12 H2 haplotype is associated with peripheral arterial disease: a case-control study. Circulation 108:2971-2973.
7. Goel PK, Shahi M, Agarwal AK, Srivastava S, Seth PK. 1997. Platelet aggregability and occurrence of restenosis following coronary angioplasty. Int J Cardiol 60:227-231.
8. Gresele P, Page C, Fuster V, Vermylen J. 2002. Platelets in thrombotic and non-thrombotic disorders. Cambridge: Cambridge University Press, p 107.
9. Hetherington SL, Singh RK, Lodwick D, Thompson JR, Goodall AH, Samani NJ. 2005. Dimorphism in the P2Y1 ADP receptor gene is associated with increased platelet activation response to ADP Arterioscler Thromb Vasc Biol 25:252-257.
10. Hollopeter G, Jantzen HM, Vincent D, Li G, England L, Ramakrishnan V, Yang RB, Nurden P, Nurden A, Julius D, Conley PB. 2001. Identification of the platelet ADP receptor targeted by antithrombotic drugs. Nature 409:202-207.
11. Livak KJ. 1999. Allelic discrimination using fluorogenic probes and the 5′ nuclease assay. Genet Anal 14:143-149.
12. Pache J, Kastrati A, Mehilli J, Schuhlen H, Dotzer F, Hausleiter J, Fleckenstein M, Neumann FJ, Sattelberger U, Schmitt C, and others. 2003. Intracoronary stenting and angiographic results: strut thickness effect on restenosis outcome (ISAR-STEREO-2) trial. J Am Coll Cardiol 41:1283-1288.
13. Rudez G, de Bruijne ELE, Bongers TN, Dippel DWJ, Deckers P, Poldermans D, de Maat MPM, Leebeek FWG. 2006. Genetic variation in ADP-receptor P2Y12 and the risk of arterial thrombosis. Br J Haematol 133(Suppl 1):Abstract 64.
14. Schettert IT, Pereira AC, Lopes NH, Hueb WA, Krieger JE. 2006. Association between platelet P2Y12 haplotype and risk of cardiovascular events in chronic coronary disease. Thromb Res 118:679-683.
15. Tanck MW, Klerkx AH, Jukema JW, De Knijff P, Kastelein JJ, Zwinderman AH. 2003. Estimation of multilocus haplotype effects using weighted penalised log-likelihood: analysis of five sequence variations at the cholesteryl ester transfer protein gene locus. Ann Hum Genet 67 (Pt 2):175-184.
16. Wihlborg AK, Wang L, Braun OO, Eyjolfsson A, Gustafsson R, Gudbjartsson T, Erlinge D. 2004. ADP receptor P2Y12 is expressed in vascular smooth muscle cells and stimulates contraction in human blood vessels. Arterioscler Thromb Vasc Biol 24:1810-1815.
17. Ziegler S, Schillinger M, Funk M, Felber K, Exner M, Mlekusch W, Sabeti S, Amighi J, Minar E, Brunner M, Muller M, Mannhalter C. 2005. Association of a functional polymorphism in the clopidogrel target receptor gene, P2Y12, and the risk for ischemic cerebrovascular events in patients with peripheral artery disease. Stroke 36:1394-1399.