Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism

Journal of Dermatological Science

Volumn 65, Issue 2, 2012, Pages 86-94

  Cartee, Todd V ^a,b   White, Kellie J ^a,b   Newton West, Marvin ^a,b   Swerlick, Robert A ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell adhesion; Endothelial; Hypoxia; TNF; VCAM 1

Indexed keywords

ALPHA KETOGLUTARATE DIOXYGENASE; ASPARAGYLHYDROXYLASE; CHEMICAL COMPOUND; DIMETHYLOXALLYLGLYCINE; DIOXYGENASE; HYPOXIA INDUCIBLE FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OXYGENASE; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL CULTURE; CELL IMMORTALIZATION; CELLULAR DISTRIBUTION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE; GENE EXPRESSION; GENE SILENCING; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HIF 1ALPHA GENE; HIF 2ALPHA GENE; HUMAN; HUMAN CELL; HYPOXIA; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; IRON CHELATION; MARKER GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; QUANTITATIVE STUDY; REAL TIME POLYMERASE CHAIN REACTION; VCAM 1 GENE; WESTERN BLOTTING;

AMINO ACIDS, DICARBOXYLIC; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BINDING SITES; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICROSCOPY, FLUORESCENCE; NF-KAPPA B; PROMOTER REGIONS, GENETIC; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, MESSENGER; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84856441550     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2011.10.003     Document Type: Article

References (41)

1. Elices M.J., Osborn L., Takada Y., Crouse C., Luhowskyj S., Hemler M.E., et al. VCAM-1 on activated endothelium interacts with the leukocyte integrin VLA-4 at a site distinct from the VLA-4/fibronectin binding site. Cell 1990, 60:577-584.
2. Das P.K., De Boer O.J., Visser A., Verhagen C.E., Bos J.D., Pals S.T. Differential expression of ICAM-1, E-selectin and VCAM-1 by endothelial cells in psoriasis and contact dermatitis. Acta Derm. Venereol. Suppl. (Stockh.) 1994, 186:21-22.
3. Foster C.A. VCAM-1/alpha 4-integrin adhesion pathway: therapeutic target for allergic inflammatory disorders. J. Allergy Clin. Immunol. 1996, 98:S270-S277.
4. Barbadillo C., G-Arroyo A., Salas C., Mulero J., Sanchez-Madrid F., Andreu J.L. Anti-integrin immunotherapy in rheumatoid arthritis: protective effect of anti-alpha 4 antibody in adjuvant arthritis. Springer Semin. Immunopathol. 1995, 16:427-436.
5. Miller D.H., Khan O.A., Sheremata W.A., Blumhardt L.D., Rice G.P.A., Libonati M.A., et al. A controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 2003, 348:15-23.
6. Polman C.H., O'Connor P.W., Havrdova E., Hutchinson M., Kappos L., Miller D.H., et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis. N. Engl. J. Med. 2006, 354:899-910.
7. MacDonald J.K., McDonald J.W. Natalizumab for induction of remission in Crohn's disease. Cochrane Database Syst Rev 2006, 3:CD006097.
8. Koo S.W., Casper K.A., Otto K.B., Gira A.K., Swerlick R.A. Iron chelators inhibit VCAM-1 expression in human dermal microvascular endothelial cells. J. Invest. Dermatol. 2003, 120:871-879.
9. 2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 1999, 15:551-578.
10. Epstein A.C., Gleadle J.M., McNeill L.A., Hewitson K.S., O'Rourke J., Mole D.R., et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell 2001, 107:43-54.
11. Gira A.K., Kowalczyk A.P., Feng Y., Swerlick R.A. Iron chelators and hypoxia mimetics inhibit IFNgamma-mediated Jak-STAT signaling. J. Invest. Dermatol. 2009, 129:723-729.
12. Swerlick R.A., Lee K.H., Wick T.M., Lawley T.J. Human dermal microvascular endothelial but not human umbilical vein endothelial cells express CD36 in vivo and in vitro. J. Immunol. 1992, 148:78-83.
13. Swerlick R.A., Garcia-Gonzalez E., Kubota Y., Xu Y.L., Lawley T.J. Studies of the modulation of MHC antigen and cell adhesion molecule expression on human dermal microvascular endothelial cells. J. Invest. Dermatol. 1991, 97:190-196.
14. Moreno C.S., Beresford G.W., Louis-Plence P., Morris A.C., Boss J.M. CREB regulates MHC class II expression in a CIITA-dependent manner. Immunity 1999, 10:143-151.
15. Beresford G.W., Boss J.M. CIITA coordinates multiple histone acetylation modifications at the HLA-DRA promoter. Nat. Immunol. 2001, 2:652-657.
16. Marui N., Offermann M.K., Swerlick R., Kunsch C., Rosen C.A., Ahmad M., et al. Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells. J. Clin. Invest. 1993, 92:1866-1874.
17. Neish A.S., Read M.A., Thanos D., Pine R., Maniatis T., Collins T. Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1. Mol. Cell. Biol. 1995, 15:2558-2569.
18. Gille J., Swerlick R.A., Lawley T.J., Caughman S.W. Differential regulation of vascular cell adhesion molecule-1 gene transcription by tumor necrosis factor alpha and interleukin-1 alpha in dermal microvascular endothelial cells. Blood 1996, 87:211-217.
19. Aragones J., Fraisl P., Baes M., Carmeliet P. Oxygen sensors at the crossroad of metabolism. Cell Metab 2009, 9:11-22.
20. Johnson A.B., Denko N., Barton M.C. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat. Res. 2008, 640:174-179.
21. Hampton-Smith R.J., Peet D.J. From polyps to people: a highly familiar response to hypoxia. Ann. N. Y. Acad. Sci. 2009, 1177:19-29.
22. Walmsley S.R., Print C., Farahi N., Peyssonnaux C., Johnson R.S., Cramer T., et al. Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity. J. Exp. Med. 2005, 201:105-115.
23. Fitzpatrick S.F., Tambuwala M.M., Bruning U., Schaible B., Scholz C.C., Byrne A., et al. An intact canonical NF-kappaB pathway is required for inflammatory gene expression in response to hypoxia. J. Immunol. 2011, 186:1091-1096.
24. Oliver K.M., Taylor C.T., Cummins E.P. Hypoxia. Regulation of NFkappaB signalling during inflammation: the role of hydroxylases. Arthritis Res. Ther. 2009, 11:215.
25. Yamaji-Kegan K., Su Q., Angelini D.J., Johns R.A. IL-4 is proangiogenic in the lung under hypoxic conditions. J. Immunol. 2009, 182:5469-5476.
26. Yamashita T., Ohneda O., Sakiyama A., Iwata F., Ohneda K., Fujii-Kuriyama Y. The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Blood 2008, 112:1482-1492.
27. Cummins E.P., Berra E., Comerford K.M., Ginouves A., Fitzgerald K.T., Seeballuck F., et al. Prolyl hydroxylase-1 negatively regulates IkappaB kinase-beta, giving insight into hypoxia-induced NFkappaB activity. Proc Natl Acad Sci USA 2006, 103:18154-18159.
28. Bracken C.P., Fedele A.O., Linke S., Balrak W., Lisy K., Whitelaw M.L., et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J. Biol. Chem. 2006, 281:22575-22585.
29. Cockman M.E., Lancaster D.E., Stolze I.P., Hewitson K.S., McDonough M.A., Coleman M.L., et al. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci USA 2006, 103:14767-14772.
30. Dunwell J.M., Purvis A., Khuri S. Cupins: the most functionally diverse protein superfamily?. Phytochemistry 2004, 65:7-17.
31. Hausinger R.P. FeII/alpha-ketoglutarate-dependent hydroxylases and related enzymes. Crit. Rev. Biochem. Mol. Biol. 2004, 39:21-68.
32. Cloos P.A., Christensen J., Agger K., Helin K. Erasing the methyl mark: histone demethylases at the center of cellular differentiation and disease. Genes Dev. 2008, 22:1115-1140.
33. Cloos P.A., Christensen J., Agger K., Maiolica A., Rappsilber J., Antal T., et al. The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3. Nature 2006, 442:307-311.
34. Yamane K., Toumazou C., Tsukada Y., Erdjument-Bromage H., Tempst P., Wong J., et al. JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. Cell 2006, 125:483-495.
35. Hsieh J.C., Slater S.A., Whitfield G.K., Dawson J.L., Hsieh G., Sheedy C., et al. Analysis of hairless corepressor mutants to characterize molecular cooperation with the vitamin D receptor in promoting the mammalian hair cycle. J. Cell. Biochem. 2010, 110:671-686.
36. Wilkes D.S. Chronic lung allograft rejection and airway microvasculature: is HIF-1 the missing link?. J. Clin. Invest. 2011, 121:2155-2157.
37. Sica A., Melillo G., Varesio L. Hypoxia: a double-edged sword of immunity. J Mol Med (Berl) 2011, 89:657-665.
38. Cramer T., Yamanishi Y., Clausen B.E., Forster I., Pawlinski R., Mackman N., et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell 2003, 112:645-657. [erratum appears in Cell. 2003 May 2;113(3):419].
39. Lukashev D., Klebanov B., Kojima H., Grinberg A., Ohta A., Berenfeld L., et al. Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J. Immunol. 2006, 177:4962-4965.
40. Tsai A.G., Johnson P.C., Intaglietta M. Is the distribution of tissue pO(2) homogeneous?. Antioxid. Redox Signal. 2007, 9:979-984.
41. Hangai-Hoger N., Cabrales P., Briceno J.C., Tsai A.G., Intaglietta M. Microlymphatic and tissue oxygen tension in the rat mesentery. Am J Physiol Heart Circ Physiol 2004, 286:H878-H883.