Iron chelators and hypoxia mimetics inhibit IFNγ-mediated Jak-STAT signaling

Journal of Investigative Dermatology

Volumn 129, Issue 3, 2009, Pages 723-729

  Gira, Amy K ^a,b   Kowalczyk, Andrew P ^a   Feng, Yue ^a   Swerlick, Robert A ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,2' BIPYRIDINE; DEFEROXAMINE; DIMETHYLOXALLYLGLYCINE; DIOXYGENASE; GAMMA INTERFERON; GAMMA INTERFERON RECEPTOR 1; GLUTARIC ACID DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; JANUS KINASE; JANUS KINASE 1; JANUS KINASE 2; MESSENGER RNA; STAT PROTEIN; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIODEGRADATION; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOSOME; ENDOTHELIUM CELL; ENZYME INHIBITION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; INHIBITION KINETICS; INTERFERON INDUCTION; MICROVASCULATURE; MOLECULAR MIMICRY; OXYGEN TENSION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; RNA STABILITY; RNA TRANSLATION; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; ANOXIA; CHELATING AGENTS; ENDOCYTOSIS; ENDOSOMES; HUMANS; INTERFERON-GAMMA; IRON; JANUS KINASES; MICROCIRCULATION; OXYGEN; PHOSPHORYLATION; RNA, MESSENGER; STAT TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 59949084958     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2008.269     Document Type: Article

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