IL-27 inhibits pathophysiological intraocular neovascularization due to laser burn

Journal of Leukocyte Biology

Volumn 91, Issue 2, 2012, Pages 267-273

  Hasegawa, Eiichi ^a   Oshima, Yuji ^a   Takeda, Atsunobu ^a   Saeki, Kazuko ^b   Yoshida, Hiroki ^c   Sonoda, Koh Hei ^d   Ishibashi, Tatsuro ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

^c SAGA UNIVERSITY   (Japan)

^d YAMAGUCHI UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Angiogenesis; Cytokine; Inflammation; Macrophage

Indexed keywords

INTERLEUKIN 27; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; BURN; CELL MIGRATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; EYE DISEASE; IN VITRO STUDY; INTRAOCULAR NEOVASCULARIZATION; LASER; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; CHOROID; CHOROIDAL NEOVASCULARIZATION; EYE BURNS; INTERLEUKIN-10; INTERLEUKINS; LASER COAGULATION; LASERS; MACROPHAGE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, CYTOKINE; RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; SPECIFIC PATHOGEN-FREE ORGANISMS; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

MUS;

EID: 84856434214     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1110603     Document Type: Article

References (37)

1. Campochiaro, P. A. (2000) Retinal and choroidal neovascularization. J. Cell. Physiol. 184, 301-310.
2. Menchini, U., Virgili, G., Introini, U., Bandello, F., Ambesi-Impiombato, M., Pece, A., Parodi, M. B., Giacomelli, G., Capobianco, B., Varano, M., Brancato, R. (2004) Outcome of choroidal neovascularization in angioid streaks after photodynamic therapy. Retina 24, 763-771.
3. Yoshida, T., Ohno-Matsui, K., Yasuzumi, K., Kojima, A., Shimada, N., Fu-tagami, S., Tokoro, T., Mochizuki, M. (2003) Myopic choroidal neovascu-larization: a 10-year follow-up. Ophthalmology 110, 1297-1305.
4. Shah, G. K., Blinder, K. J., Hariprasad, S. M., Thomas, M. A., Ryan Jr., E. H., Bakal, J., Sharma, S. (2005) Photodynamic therapy for juxtafoveal choroidal neovascularization due to ocular histoplasmosis syndrome. Retina 25, 26-32.
5. Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gal-lins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., Sch-netz-Boutaud, N., Agarwal, A., Postel, E. A., Pericak-Vance, M. A. (2005) Complement factor H variant increases the risk of age-related macular degeneration. Science 308, 419-421.
6. Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., Farrer, L. A. (2005) Complement factor H polymorphism and age-related macular degeneration. Science 308, 421-424.
7. Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J. Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., Bracken, M. B., Ferris, F. L., Ott, J., Barnstable, C., Hoh, J. (2005) Complement factor H polymorphism in age-related macular degeneration. Science 308, 385-389.
8. Tsutsumi, C., Sonoda, K. H., Egashira, K., Qiao, H., Hisatomi, T., Nakao, S., Ishibashi, M., Charo, I. F., Sakamoto, T., Murata, T., Ishibashi, T. (2003) The critical role of ocular-infiltrating macrophages in the development of choroidal neovascularization. J. Leukoc. Biol. 74, 25-32.
9. Hijioka, K., Sonoda, K. H., Tsutsumi-Miyahara, C., Fujimoto, T., Oshima, Y., Taniguchi, M., Ishibashi, T. (2008) Investigation of the role of CD1d-restricted invariant NKT cells in experimental choroidal neovasculariza-tion. Biochem. Biophys. Res. Commun. 374, 38-43.
10. Krzystolik, M. G., Afshari, M. A., Adamis, A. P., Gaudreault, J., Gragou-das, E. S., Michaud, N. A., Li, W., Connolly, E., O'Neill, C. A., Miller, J. W. (2002) Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch. Ophthalmol. 120, 338-346.
11. Rosenfeld, P. J., Brown, D. M., Heier, J. S., Boyer, D. S., Kaiser, P. K., Chung, C. Y., Kim, R. Y. (2006) Ranibizumab for neovascular age-related macular degeneration. N. Engl. J. Med. 355, 1419-1431.
12. Angelo, L. S., Kurzrock, R. (2007) Vascular endothelial growth factor and its relationship to inflammatory mediators. Clin. Cancer Res. 13, 2825-2830.
13. Pflanz, S., Timans, J. C., Cheung, J., Rosales, R., Kanzler, H., Gilbert, J., Hibbert, L., Churakova, T., Travis, M., Vaisberg, E., Blumenschein, W. M., Mattson, J. D., Wagner, J. L., To, W., Zurawski, S., McClanahan, T. K., Gorman, D. M., Bazan, J. F., de Waal Malefyt, R., Rennick, D., Kastelein, R. A. (2002) IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity 16, 779-790.
14. Yoshida, H., Hamano, S., Senaldi, G., Covey, T., Faggioni, R., Mu, S., Xia, M., Wakeham, A. C, Nishina, H., Potter, J., Saris, C. J., Mak, T. W. (2001) WSX-1 is required for the initiation of Th1 responses and resistance to L. major infection. Immunity 15, 569-578.
15. Owaki, T., Asakawa, M., Morishima, N., Hata, K, Fukai, F., Matsui, M., Mizuguchi, J., Yoshimoto, T. (2005) A role for IL-27 in early regulation of Th1 differentiation. J. Immunol. 175, 2191-2200.
16. Amadi-Obi, A, Yu, C. R, Liu, X., Mahdi, R M., Clarke, G. L., Nussen-blatt, R B., Gery, I., Lee, Y S., Egwuagu, C. E. (2007) TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nat. Med. 13, 711-718.
17. Batten, M., Li, J., Yi, S., Kljavin, N. M., Danilenko, D. M., Lucas, S., Lee, J., de Sauvage, F. J., Ghilardi, N. (2006) Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7, 929-936.
18. Villarino, A, Hibbert, L., Lieberman, L., Wilson, E., Mak, T., Yoshida, H., Kastelein, R A, Saris, C, Hunter, C. A. (2003) The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19, 645-655.
19. Stumhofer, J. S., Laurence, A, Wilson, E. H., Huang, E., Tato, C. M., Johnson, L. M., Villarino, A. V., Huang, Q., Yoshimura, A, Sehy, D., Saris, C. J., O'Shea, J. J., Hennighausen, L., Ernst, M., Hunter, C. A. (2006) Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat. Immunol. 7, 937-945.
20. Yoshimura, T., Takeda, A, Hamano, S., Miyazaki, Y, Kinjyo, I., Ishibashi, T., Yoshimura, A, Yoshida, H. (2006) Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism. J. Immunol. 177, 5377-5385.
21. Shimizu, M., Shimamura, M., Owaki, T., Asakawa, M., Fujita, K, Kudo, M., Iwakura, Y, Takeda, Y, Luster, A. D., Mizuguchi, J., Yoshimoto, T. (2006) Antiangiogenic and antitumor activities of IL-27. J. Immunol. 176, 7317-7324.
22. Kleinman, M. E., Yamada, K., Takeda, A., Chandrasekaran, V., Nozaki, M., Baffi, J. Z., Albuquerque, R J., Yamasaki, S., Itaya, M., Pan, Y, Appu-kuttan, B., Gibbs, D., Yang, Z., Kariko, K., Ambati, B. K, Wilgus, T. A, DiPietro, L. A, Sakurai, E., Zhang, K, Smith, J. R, Taylor, E. W., Ambati, J. (2008) Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature 452, 591-597.
23. Ryan, S.J. (1979) The development of an experimental model of subreti-nal neovascularization in disciform macular degeneration. Trans. Am. Ophthalmol. Soc. 77, 707-745.
24. Igawa, T., Nakashima, H., Sadanaga, A, Masutani, K, Miyake, K, Shimizu, S., Takeda, A, Hamano, S., Yoshida, H. (2009) Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis. Mod. Rheumatol. 19, 33-41.
25. Samtani, S., Amaral, J., Campos, M. M., Fariss, R. N., Becerra, S. P. (2009) Doxycycline-mediated inhibition of choroidal neovascularization. journal>Invest. Ophthalmol. Vis. Sci. 50, 5098 -5106.
26. Campa, C., Kasman, I., Ye, W., Lee, W. P., Fuh, G., Ferrara, N. (2008) Effects of an anti-VEGF-A monoclonal antibody on laser-induced choroi-dal neovascularization in mice: optimizing methods to quantify vascular changes. Invest. Ophthalmol. Vis. Sci. 49, 1178 -1183.
27. Hou, X., Kumar, A., Lee, C., Wang, B., Arjunan, P., Dong, L., Maminish-kis, A., Tang, Z., Li, Y., Zhang, F., Zhang, S. Z., Wardega, P., Chakrabarty, S., Liu, B., Wu, Z., Colosi, P., Fariss, R. N., Lennartsson, J., Nussenblatt, R., Gutkind, J. S., Cao, Y., Li, X. (2010) PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets. Proc. Natl. Acad. Sci. USA 107, 12216-12221.
28. Stumhofer, J. S., Silver, J. S., Laurence, A., Porrett, P. M., Harris, T. H., Turka, L. A., Ernst, M., Saris, C. J., O'Shea, J. J., Hunter, C. A. (2007) Interleukins 27 and 6 induce STAT3-mediated T cell production of inter-leukin 10. Nat. Immunol. 8, 1363-1371.
29. Fitzgerald, D. C., Zhang, G. X., El-Behi, M., Fonseca-Kelly, Z., Li, H., Yu, S., Saris, C. J., Gran, B., Ciric, B., Rostami, A. (2007) Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8, 1372-1379.
30. O'Garra, A., Barrat, F. J., Castro, A. G., Vicari, A., Hawrylowicz, C. (2008) Strategies for use of IL-10 or its antagonists in human disease. Immunol. Rev. 223, 114-131.
31. Yoshida, H., Nakaya, M., Miyazaki, Y. (2009) Interleukin 27: a double-edged sword for offense and defense. J. Leukoc. Biol. 86, 1295-1303.
32. Chen, Z., Han, Z. C. (2008) STAT3: a critical transcription activator in angiogenesis. Med. Res. Rev. 28, 185-200.
33. Matsuda, S., Gomi, F., Oshima, Y., Tohyama, M., Tano, Y. (2005) Vascular endothelial growth factor reduced and connective tissue growth factor induced by triamcinolone in ARPE19 cells under oxidative stress. Invest. Ophthalmol. Vis. Sci. 46, 1062-1068.
34. Nakai, K., Fainaru, O., Bazinet, L., Pakneshan, P., Benny, O., Pravda, E., Folkman, J., D'Amato, R. J. (2008) Dendritic cells augment choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 49, 3666-3670.
35. Fitzgerald, D. C., Ciric, B., Touil, T., Harle, H., Grammatikopolou, J., Das Sarma, J., Gran, B., Zhang, G. X., Rostami, A. (2007) Suppressive effect of IL-27 on encephalitogenic Th17 cells and the effector phase of experimental autoimmune encephalomyelitis. J. Immunol. 179, 3268-3275.
36. Matsui, M., Moriya, O., Belladonna, M. L., Kamiya, S., Lemonnier, F. A., Yoshimoto, T., Akatsuka, T. (2004) Adjuvant activities of novel cytokines, interleukin-23 (IL-23) and IL-27, for induction of hepatitis C virus-specific cytotoxic T lymphocytes in HLA-A*0201 transgenic mice. J. Virol. 78, 9093-9104.
37. Apte, R. S., Richter, J., Herndon, J., Ferguson, T. A. (2006) Macrophages inhibit neovascularization in a murine model of age-related macular degeneration. PLoS Med. 3, e310.