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Volumn 33, Issue 2, 2011, Pages 106-114

Alzheimer′s disease - Not an exaggeration of healthy aging

Author keywords

Alzheimer s disease; cerebrospinal fluid; functional magnetic resonance imaging; positron emission tomography scan; prefontral corex; subjective cognitive complains; whole brain volume

Indexed keywords


EID: 84856432909     PISSN: 02537176     EISSN: 09751564     Source Type: Journal    
DOI: 10.4103/0253-7176.92047     Document Type: Review
Times cited : (15)

References (83)
  • 4
    • 0344287524 scopus 로고    scopus 로고
    • Executive functioningas a potential mediator of age-related cognitive decline in normal adults
    • Salthouse TA, Atkinson TM, Berish DE. Executive functioningas a potential mediator of age-related cognitive decline in normal adults. J Exp Psychol Gen 2003;132:566.
    • (2003) J Exp Psychol Gen , vol.132 , pp. 566
    • Salthouse, T.A.1    Atkinson, T.M.2    Berish, D.E.3
  • 5
    • 3042703222 scopus 로고    scopus 로고
    • Comparability of functional MRI response in young and old during inhibition
    • DOI 10.1097/00001756-200401190-00025
    • Nielson KA, Langenecker SA, Ross TJ, Garavan H, Rao SM, Stein EA. Comparability of functional MRI response in young and old during inhibition. Neuroreport 2004;15:129-33. (Pubitemid 41614985)
    • (2004) NeuroReport , vol.15 , Issue.1 , pp. 129-133
    • Nielson, K.A.1    Langenecker, S.A.2    Ross, T.J.3    Garavan, H.4    Rao, S.M.5    Stein, E.A.6
  • 6
    • 1642415073 scopus 로고    scopus 로고
    • An Age-Related Deficit in Prefrontal Cortical Function Associated With Refreshing Information
    • Johnson MK, Mitchell KJ, Raye CL, Greene EJ. An age-related deficit in prefrontal cortical function associated with refreshing information. Psychol Sci 2004;15:127-32. (Pubitemid 38361305)
    • (2004) Psychological Science , vol.15 , Issue.2 , pp. 127-132
    • Johnson, M.K.1    Mitchell, K.J.2    Raye, C.L.3    Greene, E.J.4
  • 8
    • 0942301375 scopus 로고    scopus 로고
    • Age-related Changes in Neural Activity during Visual Target Detection Measured by fMRI
    • DOI 10.1093/cercor/bhg113
    • Madden DJ, Whiting WL, Provenzale JM, Huettel SA. Age-related changes in neural activity during visual target detection measured by fMRI. Cereb Cortex 2004;14:143-55. (Pubitemid 38141529)
    • (2004) Cerebral Cortex , vol.14 , Issue.2 , pp. 143-155
    • Madden, D.J.1    Whiting, W.L.2    Provenzale, J.M.3    Huettel, S.A.4
  • 9
    • 21644467859 scopus 로고    scopus 로고
    • Dissociating age-related changes in cognitive strategy and neural efficiency using event-related fMRI
    • Rypma B, Berger JS, Genova HM, Rebbechi D, D'Esposito M. Dissociating age-related changes in cognitive strategy and neural efficiency using event-related fMRI. Cortex 2005;41:582-94. (Pubitemid 40932321)
    • (2005) Cortex , vol.41 , Issue.4 , pp. 582-594
    • Rypma, B.1    Berger, J.S.2    Genova, H.M.3    Rebbechi, D.4    D'Esposito, M.5
  • 11
    • 20544474329 scopus 로고    scopus 로고
    • Brain aging: Reorganizing discoveries about the aging mind
    • Reuter-Lorenz PA, Lustig C. Brain aging: Reorganizing discoveries about the aging mind. Curr Opin Neurobiol 2005;15:245.
    • (2005) Curr Opin Neurobiol , vol.15 , pp. 245
    • Reuter-Lorenz, P.A.1    Lustig, C.2
  • 12
    • 0032919077 scopus 로고    scopus 로고
    • Context-dependent, neural system-specific neurophysiological concomitants of ageing: Mapping PET correlates during cognitive activation
    • DOI 10.1093/brain/122.5.963
    • Esposito G, Kirkby BS, Van Horn JD, Ellmore TM, Berman KF. Context-dependent, neural system-specific neurophysiological concomitants of ageing: Mapping PET correlates during cognitive activation. Brain 1999;122:963-79. (Pubitemid 29219268)
    • (1999) Brain , vol.122 , Issue.5 , pp. 963-979
    • Esposito, G.1    Kirkby, B.S.2    Van Horn, J.D.3    Ellmore, T.M.4    Berman, K.F.5
  • 13
    • 0028612042 scopus 로고
    • Neuropsychological perspectives on memory and cognitive decline in normal human aging
    • Shimamura AP. Neuropsychological perspectives on memory and cognitive decline in normal human aging. Seminar in Neurosci 1994;6:387-94.
    • (1994) Seminar in Neurosci , vol.6 , pp. 387-94
    • Shimamura, A.P.1
  • 14
    • 16544382241 scopus 로고    scopus 로고
    • Normal cognitive Changes with aging
    • Anstey KJ, Low LF. Normal cognitive Changes With aging. Aust Fam Physician 2004;33:783-7.
    • (2004) Aust Fam Physician , vol.33 , pp. 783-7
    • Anstey, K.J.1    Low, L.F.2
  • 15
    • 61649112904 scopus 로고    scopus 로고
    • When does age-related cognitive decline begin?
    • Salthouse TA. When does age-related cognitive decline begin? Neurobiol Aging 2009;30:507-14.
    • (2009) Neurobiol Aging , vol.30 , pp. 507-14
    • Salthouse, T.A.1
  • 16
    • 0035679504 scopus 로고    scopus 로고
    • What cognitive changes can be expected with normal ageing?
    • DOI 10.1046/j.1440-1614.2001.00966.x
    • Christensen H. What cognitive changes can be expected with normal ageing? Aust NZ J Psychiat 2001;35:768-75. (Pubitemid 34048448)
    • (2001) Australian and New Zealand Journal of Psychiatry , vol.35 , Issue.6 , pp. 768-775
    • Christensen, H.1
  • 17
    • 0031472365 scopus 로고    scopus 로고
    • Brain oscillations and human memory: EEG correlates in the upper alpha and theta band
    • DOI 10.1016/S0304-3940(97)00771-4, PII S0304394097007714
    • Klimesch W Doppelmayr M, Pachinger T, Ripper B, Barain Oscillation and Human Memory: EEG correlates in the upper Alpha and theta Band. NeurosienceLett 1997;238:9-12. (Pubitemid 28015771)
    • (1997) Neuroscience Letters , vol.238 , Issue.1-2 , pp. 9-12
    • Klimesch, W.1    Doppelmayr, M.2    Pachinger, T.3    Ripper, B.4
  • 18
    • 0032907015 scopus 로고    scopus 로고
    • EEG alpha and theta oscillations reflect cognitive and memory performance: A review and analysis
    • DOI 10.1016/S0165-0173(98)00056-3, PII S0165017398000563
    • Klimesch W. EEG alpha and theta oscillations reflect cognitive and memory performance: A review and analysis. Brain Res Brain Res Rev 1999;29:169-95. (Pubitemid 29191338)
    • (1999) Brain Research Reviews , vol.29 , Issue.2-3 , pp. 169-195
    • Klimesch, W.1
  • 20
    • 0033786531 scopus 로고    scopus 로고
    • Jelic v Discrimination of Alzheimer's disease and mild cognitive impairment by equivalent EEG sources: A cross-sectional and longitudinal study
    • Huang C, Wahlund L, Dierks T, Julin P, Winblad B, Jelic V Discrimination of Alzheimer's disease and mild cognitive impairment by equivalent EEG sources: A cross-sectional and longitudinal study. Clin Neurophysiol 2000;111:1961-7.
    • (2000) Clin Neurophysiol , vol.111 , pp. 1961-1967
    • Huang, C.1    Wahlund, L.2    Dierks, T.3    Julin, P.4    Winblad, B.5
  • 21
    • 0025881803 scopus 로고
    • From early to late adulthood changes in EEG sleep of depressed patients and healthy volunteers
    • Lauer CJ, Riemann D, Wiegand M, Berger M. From early to late adulthood changes in EEG sleep of depressed patients and healthy volunteers. Biological Psychiatry 1991;29:979-93.
    • (1991) Biological Psychiatry , vol.29 , pp. 979-93
    • Lauer, C.J.1    Riemann, D.2    Wiegand, M.3    Berger, M.4
  • 23
    • 0036790026 scopus 로고    scopus 로고
    • Focal temporoparietal slow activity in Alzheimer's disease revealed by magnetoencephalography
    • Fernández A, Maestú F Amo C, Gil P, Fehr T, Wienbruch C, et al . Focal temporoparietal slow activity in Alzheimer's disease revealed by magnetoencephalography. Biol Psychiatry 2002;52:764-70.
    • (2002) Biol Psychiatry , vol.52 , pp. 764-70
    • Fernández, A.1    Maestú, F.2    Amo, C.3    Gil, P.4    Fehr, T.5    Wienbruch, C.6
  • 24
    • 0026585127 scopus 로고
    • Dementia of the aged: Disease or atypical-accelerated aging? Biopathological and psychological perspectives
    • Von Dras DD, Blumenthal HT. Dementia of the aged: Disease or atypical-accelerated aging? Biopathological and psychological perspectives. J Am Geriatr Soc 1992;40:285-94.
    • (1992) J Am Geriatr Soc , vol.40 , pp. 285-94
    • Von Dras, D.D.1    Blumenthal, H.T.2
  • 26
    • 0023276014 scopus 로고
    • Neocortical cell counts in normal human adult aging
    • DOI 10.1002/ana.410210603
    • Terry RD, DeTeresa R, Hansen LA. Neocortical cell counts in normal human adult aging. Ann Neurol 1987;21:530-9. (Pubitemid 17081187)
    • (1987) Annals of Neurology , vol.21 , Issue.6 , pp. 530-539
    • Terry, R.D.1    DeTeresa, R.2    Hansen, L.A.3
  • 30
    • 0026508904 scopus 로고
    • Decreased gray matter in normal aging: An in vivo magnetic resonance study
    • Lim KO, Zipursky RB, Watts MC, Pfefferbaum A. Decreased gray matter in normal aging: An in vivo magnetic resonance study. J Gerontol 1992;47:b26-30.
    • (1992) J Gerontol , vol.47 , pp. 26-30
    • Lim, K.O.1    Zipursky, R.B.2    Watts, M.C.3    Pfefferbaum, A.4
  • 32
    • 38349081521 scopus 로고    scopus 로고
    • Brain volume decline in aging: Evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve
    • Fotenos AF, Mintun MA, Snyder AZ, Morris JC, Buckner RL. Brain volume decline in aging: Evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve. Arch Neurol 2008;65:113-120.
    • (2008) Arch Neurol , vol.65 , pp. 113-120
    • Fotenos, A.F.1    Mintun, M.A.2    Snyder, A.Z.3    Morris, J.C.4    Buckner, R.L.5
  • 33
    • 0034783432 scopus 로고    scopus 로고
    • Changes in brain morphology in Alzheimer disease and normal aging: Is Alzheimer disease an exaggerated aging process?
    • Ohnishi T, Matsuda H, Tabira T, Asada T, Uno M. Changes in brain morphology in Alzheimer disease and normal aging: Is Alzheimer disease an exaggerated aging process? AJNR Am J Neuroradiol 2001;22:1680-5. (Pubitemid 32999576)
    • (2001) American Journal of Neuroradiology , vol.22 , Issue.9 , pp. 1680-1685
    • Ohnishi, T.1    Matsuda, H.2    Asada, T.3    Tabira, T.4    Uno, M.5
  • 35
    • 1042305449 scopus 로고    scopus 로고
    • Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: Replicability of regional differences in volume
    • DOI 10.1016/S0197-4580(03)00118-0
    • Raz N, Gunning-Dixon F Head D, Rodrigue KM, Williamson A, Acker JD. Aging, sexual dimorphism, and hemispheric asymmetry of the cerebral cortex: Replicability of regional differences in volume. Neurobiol Aging 2004;25:377-96. (Pubitemid 38220973)
    • (2004) Neurobiology of Aging , vol.25 , Issue.3 , pp. 377-396
    • Raz, N.1    Gunning-Dixon, F.2    Head, D.3    Rodrigue, K.M.4    Williamson, A.5    Acker, J.D.6
  • 36
    • 0031919190 scopus 로고    scopus 로고
    • Neuroanatomical correlates of cognitive aging: Evidence from structural magnetic resonance imaging
    • DOI 10.1037/0894-4105.12.1.95
    • Raz N, Gunning-Dixon FM, Head D, Dupuis JH, Acker JD. Neuro anatomical correlates of cognitive aging: Evidence from structural magnetic resonance imaging. Neuropsychology 1998;12:95-114. (Pubitemid 28070401)
    • (1998) Neuropsychology , vol.12 , Issue.1 , pp. 95-114
    • Raz, N.1    Gunning-Dixon, F.M.2    Head, D.3    Dupuis, J.H.4    Acker, J.D.5
  • 37
    • 0034848980 scopus 로고    scopus 로고
    • Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer disease
    • Salat DH, Kaye JA, Janowsky JS. Selective preservation and degeneration within the prefrontal cortex in aging and Alzheimer disease. Arch Neurol 2001;58:140.
    • (2001) Arch Neurol , vol.58 , pp. 140
    • Salat, D.H.1    Kaye, J.A.2    Janowsky, J.S.3
  • 39
    • 0742270004 scopus 로고    scopus 로고
    • Differential aging of the medial temporal lobe: A study of a five-year change
    • Raz N,Rodrigue KM, Head D, Kennedy KM, Acker JD. Differential aging of the medial temporal lobe: A study of a five-year change. Neurology 2004;62:433-8. (Pubitemid 38200856)
    • (2004) Neurology , vol.62 , Issue.3 , pp. 433-438
    • Raz, N.1    Rodrigue, K.M.2    Head, D.3    Kennedy, K.M.4    Acker, J.D.5
  • 42
    • 0036734230 scopus 로고    scopus 로고
    • Age-related total gray matter and white matter changes in normal adult brain. Part I: Volumetric MR imaging analysis
    • Ge Y, Grossman RI, Babb JS, Rabin ML, Mannon LJ, Kolson DL. Age-related total gray matter and white matter changes in normal adult brain. Part I: Volumetric MR Imaging Analysis. AJNR Am J Neuroradiol 2002;23:1327-33. (Pubitemid 35033881)
    • (2002) American Journal of Neuroradiology , vol.23 , Issue.8 , pp. 1327-1333
    • Ge, Y.1    Grossman, R.I.2    Babb, J.S.3    Rabin, M.L.4    Mannon, L.J.5    Kolson, D.L.6
  • 43
    • 0025930525 scopus 로고
    • Studies of central nervous system disorders with single photon emission computed tomography and positron emission tomography: Evolution over the past 2 decades
    • Alavi A, Hirsch LJ. Studies of central nervous system disorders with single photon emission computed tomography and positron emission tomography: Evolution over the past 2 decades. Semin Nucl Med 1991;21:58-81.
    • (1991) Semin Nucl Med , vol.21 , pp. 58-81
    • Alavi, A.1    Hirsch, L.J.2
  • 44
    • 0029067185 scopus 로고
    • Regional cerebral function determined by FDG -PET in healthy volunteers: Normal patterns and changes with age
    • Loessner A, Alavi A, Lewandrowski KU, Mozley D, Souder E, Gur RE. Regional cerebral function determined by FDG -PET in healthy volunteers: Normal patterns and changes with age. J Nucl Med 1995;36:1141-9.
    • (1995) J Nucl Med , vol.36 , pp. 1141-9
    • Loessner, A.1    Alavi, A.2    Lewandrowski, K.U.3    Mozley, D.4    Souder, E.5    Gur, R.E.6
  • 46
    • 0023712050 scopus 로고
    • Sensitivity of cerebral glucose metabolism to age, gender, brain volume, brain atrophy and cerebrovascular risk factors
    • Yoshii F, Barbar WW, Aracy JY, Loewenstein D, Apicella A, Smith D, et al. Sensitivity of cerebral glucose metabolism to age, gender, brain volume, brain atrophy and cerebrovascular risk factors. J Cereb Blood Flow Metab 1988;8:654-61.
    • (1988) J Cereb Blood Flow Metab , vol.8 , pp. 654-61
    • Yoshii, F.1    Barbar, W.W.2    Aracy, J.Y.3    Loewenstein, D.4    Apicella, A.5    Smith, D.6
  • 49
    • 0030060954 scopus 로고    scopus 로고
    • Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol
    • Volkow ND, Wang GJ, Fowler JS, Logan J, Gatley SJ, MacGregor RR, et al . Measuring age-related changes in dopamine D2 receptors with 11C-raclopride and 18F-N-methylspiroperidol. Psychiatry Res 1996;67:11-6.
    • (1996) Psychiatry Res , vol.67 , pp. 11-6
    • Volkow, N.D.1    Wang, G.J.2    Fowler, J.S.3    Logan, J.4    Gatley, S.J.5    MacGregor, R.R.6
  • 51
    • 77649314191 scopus 로고    scopus 로고
    • APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    • Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, et al . APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Ann Neurol 2010;67:122-31.
    • (2010) Ann Neurol , vol.67 , pp. 122-31
    • Morris, J.C.1    Roe, C.M.2    Xiong, C.3    Fagan, A.M.4    Goate, A.M.5    Holtzman, D.M.6
  • 52
    • 78650668064 scopus 로고    scopus 로고
    • Correlation between cognitive impairment and CSF biomarkers in amnesic MCI, non-amnesic MCI, and Alzheimer's disease
    • Haldenwanger A, Eling P, Kastrup A, Hildebrandt H. Correlation between cognitive impairment and CSF biomarkers in amnesic MCI, non-amnesic MCI, and Alzheimer's disease. J Alzheimers Dis 2010;22:971-80.
    • (2010) J Alzheimers Dis , vol.22 , pp. 971-80
    • Haldenwanger, A.1    Eling, P.2    Kastrup, A.3    Hildebrandt, H.4
  • 53
    • 0021256895 scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
    • Glenner GG, Wong CW. Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem Biophys Res Commun 1984;120:885-90. (Pubitemid 14104991)
    • (1984) Biochemical and Biophysical Research Communications , vol.120 , Issue.3 , pp. 885-890
    • Glenner, G.G.1    Wong, C.W.2
  • 55
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer's related changes
    • Braak H, Braak E. Neuropathological staging of Alzheimer's related changes. Acta Neuropathol 1991;82:239-59.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-59
    • Braak, H.1    Braak, E.2
  • 56
    • 0030805991 scopus 로고    scopus 로고
    • Frequency of stages of Alzheimer-related lesions in different age categories
    • DOI 10.1016/S0197-4580(97)00056-0, PII S0197458097000560
    • Braak H, Braak E. Frequency of stages of Alzheimer-related lesions in different age categories, neurobiology of aging. 1997;18:351-7. (Pubitemid 27435070)
    • (1997) Neurobiology of Aging , vol.18 , Issue.4 , pp. 351-357
    • Braak, H.1    Braak, E.2
  • 57
    • 0030698871 scopus 로고    scopus 로고
    • Life and death of neurons in the aging brain
    • 17 October Available from: [Last cited on 2011 Jun 08]
    • Morrison JH, Hof PR. Life and death of neurons in the aging brain. Science, Vol. 278, 17 October 1997. Available from: http://www.sciencemag.org. [Last cited on 2011 Jun 08]
    • (1997) Science , vol.278
    • Morrison, J.H.1    Hof, P.R.2
  • 58
    • 74949133311 scopus 로고    scopus 로고
    • Hippocampal mean diffusivity and memory in healthy elderly individuals: A cross-sectional study
    • Carlesimo GA, Cherubini A, Caltagirone C, Spalletta G. Hippocampal mean diffusivity and memory in healthy elderly individuals: A cross-sectional study. Neurology 2010;74:194-200.
    • (2010) Neurology , vol.74 , pp. 194-200
    • Carlesimo, G.A.1    Cherubini, A.2    Caltagirone, C.3    Spalletta, G.4
  • 59
    • 0037337293 scopus 로고    scopus 로고
    • White matter structural integrity in healthy aging adults and patients with Alzheimer disease: A magnetic resonance imaging study
    • DOI 10.1001/archneur.60.3.393
    • Bartzokis G, Cummings JL, Sultzer D, Henderson VW, Nuechterlein KH, Mintz J. White matter structural integrity in healthy aging adults and patients with Alzheimer disease: A magnetic resonance imaging study. Arch Neurol 2003;60:393-8. (Pubitemid 36314365)
    • (2003) Archives of Neurology , vol.60 , Issue.3 , pp. 393-398
    • Bartzokis, G.1    Cummings, J.L.2    Sultzer, D.3    Henderson, V.W.4    Nuechterlein, K.H.5    Mintz, J.6
  • 60
    • 0346770038 scopus 로고    scopus 로고
    • Age-related myelin breakdown: A developmental model of cognitive decline and Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2003.03.001
    • Bartzokis G. Age-related myelin breakdown: A developmental model of cognitive decline and Alzheimer's disease. Neurobiol Aging 2004;25:5-18; author reply 49-62. (Pubitemid 37522186)
    • (2004) Neurobiology of Aging , vol.25 , Issue.1 , pp. 5-18
    • Bartzokis, G.1
  • 61
    • 3042662696 scopus 로고    scopus 로고
    • Heterogeneous age-related breakdown of white matter structural integrity: Implications for cortical "disconnection" in aging and Alzheimer's disease
    • DOI 10.1016/j.neurobiolaging.2003.09.005, PII S019745800300232X
    • Bartzokis G, Sultzer D, Lu PH, Nuechterlein KH, Mintz J,Cummings JL. Heterogeneous age-related breakdown of white matter structural integrity: Implications for cortical disconnection in aging and Alzheimer's disease. Neurobiol Aging 2004;25:843-51. (Pubitemid 38813164)
    • (2004) Neurobiology of Aging , vol.25 , Issue.7 , pp. 843-851
    • Bartzokis, G.1    Sultzer, D.2    Lu, P.H.3    Nuechterlein, K.H.4    Mintz, J.5    Cummings, J.L.6
  • 62
    • 70349970009 scopus 로고    scopus 로고
    • Callosal atrophy in mild cognitive impairment and Alzheimer's disease: Different effects in differentstages
    • Di Paola M, Luders E, Di Iulio F, Varsi AE, Sancesario G, Passafiume D, et al . Callosal atrophy in mild cognitive impairment and Alzheimer's disease: Different effects in differentstages. Neuroimage 2010;49:141-9.
    • (2010) Neuroimage , vol.49 , pp. 141-9
    • Di Paola, M.1    Luders, E.2    Di Iulio, F.3    Varsi, A.E.4    Sancesario, G.5    Passafiume, D.6
  • 66
    • 0020410117 scopus 로고
    • Age-correlated loss of dopaminergic binding sites in human basal ganglia
    • DOI 10.1111/j.1471-4159.1982.tb07996.x
    • Severson JA, Marcusson J, Winblad B, Finch CE. Age-correlated loss of dopamin ergic binding sites in human basal ganglia. J Neurochem 1982;39:1623-31. (Pubitemid 13184139)
    • (1982) Journal of Neurochemistry , vol.39 , Issue.6 , pp. 1623-1631
    • Severson, J.A.1    Marcusson, J.2    Winblad, B.3    Finch, C.E.4
  • 68
    • 0023180069 scopus 로고
    • The dopamine and serotonin systems during aging in human and rodent brain. A brief review
    • Morgan DG. The dopamine and serotonin systems during aging in human and rodent brain. A brief review. Prog Neuropsychopharmacol Biol Psychiatry 1987;11:153-7. (Pubitemid 17120285)
    • (1987) Progress in Neuro-Psychopharmacology and Biological Psychiatry , vol.11 , Issue.2-3 , pp. 153-157
    • Morgan, D.G.1
  • 71
    • 62149141359 scopus 로고    scopus 로고
    • Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease
    • Reeves S, Brown R, Howard R, Grasby P.Increased striatal dopamine (D2/D3) receptor availability and delusions in Alzheimer disease. AJNR Am J Neurol 2009;72:528-34.
    • (2009) AJNR Am J Neurol , vol.72 , pp. 528-34
    • Reeves, S.1    Brown, R.2    Howard, R.3    Grasby, P.4
  • 72
    • 0020072221 scopus 로고
    • Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain
    • Whitehouse PJ, Price DL, Struble RG, Clark AW, Coyle JT, Delon MR. Alzheimer's disease and senile dementia: Loss of neurons in the basal forebrain. Science 1982;215: 1237-9. (Pubitemid 12106486)
    • (1982) Science , vol.215 , Issue.4537 , pp. 1237-1239
    • Whitehouse, P.J.1    Price, D.L.2    Struble, R.G.3
  • 73
    • 0020657372 scopus 로고
    • Presynaptic cholinergic dysfunction in patients with dementia
    • DOI 10.1111/j.1471-4159.1983.tb11311.x
    • Sims NR, Bowen DM, Allen SJ, Smith CC, Neary D, Thomas DJ, et al . Presynaptic cholinergic dysfunction in patients with dementia. J Neurochem 1983;40:503-9. (Pubitemid 13195690)
    • (1983) Journal of Neurochemistry , vol.40 , Issue.2 , pp. 503-509
    • Sims, N.R.1    Bowen, D.M.2    Allen, S.J.3
  • 74
    • 0021797563 scopus 로고
    • Neurochemical studies of early-onset Alzheimer's disease. Possible influence on treatment
    • Francis PT, Palmer AM, Sims NR, Bowen DM, Davison AN, Esiri MM, et al . Neurochemical studies of early-onset Alzheimer's disease. Possible influence on treatment. N Engl J Med 1985;313:7-11. (Pubitemid 15068737)
    • (1985) New England Journal of Medicine , vol.313 , Issue.1 , pp. 7-11
    • Francis, P.T.1    Palmer, A.M.2    Sims, N.R.3
  • 75
    • 0027269660 scopus 로고
    • Cortical pyramidal neurone loss may cause glutamatergic hypoactivity and cognitive impairment in Alzheimer's disease: Investigative and therapeutic perspectives
    • Francis PT, Sims NR, Procter AW, Bowen DM. Cortical pyramidal neurone loss may cause glutamatergichypo-activity and cognitive impairment in Alzheimer's disease: Investigative and therapeutic perspectives. J Neurochem 1993;60:1589-604. (Pubitemid 23127561)
    • (1993) Journal of Neurochemistry , vol.60 , Issue.5 , pp. 1589-1604
    • Francis, P.T.1    Sims, N.R.2    Procter, A.W.3    Bowen, D.M.4
  • 76
    • 0029657946 scopus 로고    scopus 로고
    • The neurochemistry of Alzheimer type, vascular type and mixed type dementias compared
    • Gsell W, Strein I, Riederer P. The neurochemistry of Alzheimer type, vascular type and mixed type dementias compared. J Neural Transm Suppl 1996;47:73-101. (Pubitemid 26275591)
    • (1996) Journal of Neural Transmission, Supplement , Issue.47 , pp. 73-101
    • Gsell, W.1    Strein, I.2    Riederer, P.3
  • 77
    • 0032502612 scopus 로고    scopus 로고
    • Age-related changes in nicotinic acetylcholine receptor subunits α4 and β2 messenger RNA expression in postmortem human frontal cortex and hippocampus
    • DOI 10.1016/S0304-3940(98)00205-5, PII S0304394098002055
    • Tohgi H, Utsugisawa K, Yoshimura M, Nagane Y Mihara M. Age-related changes in nicotinic acetylcholine receptor subunits α4 and ß2 messenger RNA expression in postmortem human frontal cortex and hippocampus. Neurosci Lett 1998;245:139-42. (Pubitemid 28287342)
    • (1998) Neuroscience Letters , vol.245 , Issue.3 , pp. 139-142
    • Tohgi, H.1    Utsugisawa, K.2    Yoshimura, M.3    Nagane, Y.4    Mihara, M.5
  • 78
    • 0033529754 scopus 로고    scopus 로고
    • Changes with aging and ischemia in nicotinic acetylcholine receptor subunit α7 mRNA expression in postmortem human frontal cortex and putamen
    • DOI 10.1016/S0304-3940(99)00473-5, PII S0304394099004735
    • Utsugisawa K, Nagane Y Tohgi H, Yoshimura M, Ohba H, Genda Y Changes with aging and ischemia in nicotinic acetylcholine receptor subunit α7 mRNA expression in postmortem human frontal cortex and putamen. Neurosci Lett 1999;270:145-8. (Pubitemid 29343575)
    • (1999) Neuroscience Letters , vol.270 , Issue.3 , pp. 145-148
    • Utsugisawa, K.1    Nagane, Y.2    Tohgi, H.3    Yoshimura, M.4    Ohba, H.5    Genda, Y.6
  • 79
    • 0025994795 scopus 로고
    • The medial temporal lobe memory system
    • Squire LR, Zola-Morgan S. The medial temporal lobe memory system. Science 1991;253:1380-6. (Pubitemid 21917285)
    • (1991) Science , vol.253 , Issue.5026 , pp. 1380-1386
    • Squire, L.R.1    Zola-Morgan, S.2
  • 80
    • 0034788544 scopus 로고    scopus 로고
    • Age-related changes in the n-methyl-d-aspartate receptor binding sites within the human basal ganglia
    • DOI 10.1006/exnr.2001.7737
    • Villares JC, Stavale JN. Age-Related Changes in the N-Methyl-aspartate receptor binding sites within the human basal ganglia. Exp Neurol 2001;171:391-404. (Pubitemid 32955300)
    • (2001) Experimental Neurology , vol.171 , Issue.2 , pp. 391-404
    • Villares, J.C.1    Stavale, J.N.2
  • 81
    • 0001788650 scopus 로고    scopus 로고
    • Neuroprotective and symptomalogical action of memantine relevant for Alzheimer's disease: A unified glutamatergic hypothesis on the mechanism of action
    • Danysz W, Parsons CG, Möbius HJ, Stöffler A, Quack G. Neuroprotective and symptomalogical action of memantine relevant for Alzheimer's disease: A unified glutamatergic hypothesis on the mechanism of action. Neurotox Res 2000;2:85-97.
    • (2000) Neurotox Res , vol.2 , pp. 85-97
    • Danysz, W.1    Parsons, C.G.2    Möbius, H.J.3    Stöffler, A.4    Quack, G.5
  • 83
    • 0034925118 scopus 로고    scopus 로고
    • The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: The role of Aβ1-42
    • DOI 10.1046/j.1471-4159.2001.00451.x
    • Lauderback CM, Hackett JM, Huang FF, Keller JN, Szweda LI, Markesbery WR, et al . The glial glutamate transporter, GLT-1, is oxidatively modified by 4-hydroxy-2-nonenal in the Alzheimer's disease brain: The role of Abeta1-42. J Neurochem 2001;78:413-6. (Pubitemid 32664423)
    • (2001) Journal of Neurochemistry , vol.78 , Issue.2 , pp. 413-416
    • Lauderback, C.M.1    Hackett, J.M.2    Huang, F.F.3    Keller, J.N.4    Szweda, L.I.5    Markesbery, W.R.6    Allan Butterfield, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.