Age-related changes in nicotinic acetylcholine receptor subunits α4 and β2 messenger RNA expression in postmortem human frontal cortex and hippocampus

Neuroscience Letters

Volumn 245, Issue 3, 1998, Pages 139-142

  Tohgi, Hideo ^a   Utsugisawa, Kimiaki ^a   Yoshimura, Masahiro ^b   Nagane, Yuriko ^a   Mihara, Masatoshi ^a  

^a IWATE MEDICAL UNIVERSITY   (Japan)

^b TOKYO MEDICAL EXAMINER S OFFICE   (Japan)

Author keywords

Aging; Cerebral cortex; Hippocampus; Nicotinic acetylcholine receptor subunits 4 and 2; Reverse transcription polymerase chain reaction

Indexed keywords

NICOTINIC RECEPTOR;

AGE; AGING; ARTICLE; CADAVER; FRONTAL CORTEX; HIPPOCAMPUS; HUMAN; HUMAN TISSUE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AGED; AGED, 80 AND OVER; AGING; BRAIN CHEMISTRY; FEMALE; FRONTAL LOBE; GENE EXPRESSION REGULATION; HIPPOCAMPUS; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RECEPTORS, NICOTINIC; RNA, MESSENGER;

EID: 0032502612     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3940(98)00205-5     Document Type: Article

References (26)

1. Anand R., Lindstrom J. Nucleotide sequence of the human nicotinic acetylcholine receptor β2 subunit gene. Nucleic Acids Res. 18:1990;4272.
2. Armitage A.K., Hall G.H., Sellers C.M. Effects of nicotine on electrocortical activity and acetylcholine release from the cat cerebral cortex. Br. J. Pharmacol. 35:1969;152-160.
3. Bartus R.T., Dean III R.L., Beer B., Lippa A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science. 217:1982;408-417.
4. 125I]-α-bungarotoxin. J. Neurosci. 5:1985;1307-1315.
5. Decker M.W. The effects of aging on hippocampal and cortical projections of the forebrain cholinergic system. Brain Res. Rev. 12:1987;423-438.
6. Deneris E.S., Connolly J., Rogers S.W., Duvoisin R. Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors. Trends Pharmacol. Sci. 12:1991;34-40.
7. Du Breuil R.M., Patel J.M., Mendelow B.V. Quantitation of β-actin-specific mRNA transcripts using xeno-competitive PCR. PCR Methods and Applications. 3:1993;57-59.
8. Flores C.M., Rogers S.W., Pabreza L.A., Wolfe B., Kellar K.J. A subtype of nicotinic cholinergic receptor is composed of α4 and β2 subunits and is upregulated by chronic nicotine treatment. Mol. Pharmacol. 41:1992;31-37.
9. Giacobini E. Cholinergic receptors in human brain: Effects of aging and Alzheimer's disease. J. Neurosci. Res. 27:1990;548-560.
10. Goldman D., Deneris E., Luyten W., Kochhar A., Patrick J., Heinemann S. Members of a nicotinic acetylcholine receptor gene family are expressed in different regions of the mammalian central nervous system. Cell. 48:1987;965-973.
11. Heinemann S., Boulter J., Connolly J., Deneris E., Duvoisin R., Hartley M., Hermans-Borgmeyer I., Hollmann M., O'Shea-Greenfield A., Papke R., Rogers S., Patrick J. The nicotinic receptor genes. Clin. Neuropharmacol. 14(Suppl. 1):1991;S45-S61.
12. Lavine N., Reuben M., Clarke P.B.S. A population of nicotinic receptors is associated with thalamocortical afferents in the adult rat: laminal and areal analysis. J. Comp. Neurol. 380:1997;175-190.
13. McNamara D., Larson D.M., Rapoport S.I., Soncrant T.T. Preferential metabolic activation of subcortical brain areas by acute administration of nicotine to rats. J. Cerebral Blood Flow Metab. 10:1990;48-56.
14. Mesulam M.-M., Mufson E.J., Levey A.I., Wainer B.H. Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry. Neuroscience. 12:1984;669-686.
15. Monteggia L.M., Gopalakrishnan M., Touma E., Idler K.B., Nash N., Arneric S.P., Sullivan J.P., Giordano T. Cloning and transient expression of genes encoding the human α4 and β2 neuronal nicotinic acetylcholine receptor (nAChR) subunits. Gene. 155:1995;189-193.
16. Nordberg A., Alafuzoff I., Winblad B. Nicotinic and muscarinic subtypes in the human brain: changes with aging and dementia. J. Neurosci. Res. 31:1992;103-111.
17. Nordberg, A. and Winblad, B., Brain nicotinic and muscarinic receptors in normal aging and dementia. In A. Fisher, I. Hanin and C. Lachman (Eds.), Alzheimer's and Parkinson's Diseases, Strategies for Research and Development, Advances in Behavioral Biology, Vol. 29, Plenum Press, 1986, pp. 95-108.
18. Parks R.W., Becker R.E., Rippey R.F., Gilbert D.G., Matthews J.R., Kabatay E., Young C.S., Vohs C., Danz V., Keim P., Collins G.T., Zigler S.S., Urycki P.G. Increased regional cerebral glucose metabolism and semantic memory performance in Alzheimer's disease: a pilot double blind transdermal nicotine positron emission tomography study. Neuropsychol. Rev. 6:1996;61-79.
19. Peng X., Gerzanich V., Anand R., Whiting P.J., Lindstrom J. Nicotine-induced increase in neuronal nicotinic receptors results from a decrease in the rate of receptor turnover. Mol. Pharmacol. 46:1994;523-530.
20. Sargent P.B. The diversity of neuronal nicotinic acetylcholine receptors. Ann. Rev. Neurosci. 16:1993;403-443.
21. Schrder H., Giacobini E., Struble R.G., Zilles K., Maelicke A., Luiten P.G.M., Strosberg A.D. Cellular distribution and expression of cortical acetylcholine receptors in aging and Alzheimer's disease. Ann. N. Y. Acad. Sci. 640:1991;189-192.
22. Tohgi, H., Utsugisawa, K., Yoshimura, M., Nagane, Y. and Mihara, M., Age-related changes in nicotinic acetylcholine receptor subunits α4 and β2 messenger RNA expression in postmortem human putamen. Implications for susceptibility to parkinsonism, Brain Res., (1998) in press.
23. Uchida S., Kagitani F., Nakayama H., Sato A. Effect of stimulation of nicotinic cholinergic receptors on cortical cerebral blood flow and changes in the effect during aging in anesthetized rats. Neurosci. Lett. 228:1997;203-206.
24. Vige X., Briley M. Scopolamine induces up-regulation of nicotinic receptors in intact brain but not in nucleus basalis lesioned rats. Neurosci. Lett. 88:1988;319-324.
25. Wada E., Wada K., Boulter J., Deneris E., Heinemann S., Patrick J., Swanson L. The distribution of α2, α3, α4 and β2 neuronal nicotinic receptor subunit mRNAs in the central nervous system: a hybridization histochemical study in rat. J. Comp. Neurol. 284:1989;314-335.
26. 3H]nicotinic acetylcholine binding in Alzheimer's disease and Parkinson's disease: an autoradiographic study. Neurology. 38:1988;720-723.