Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 4, 2012, Pages 1251-1256

  Cummings, Hannah E ^a,b,i   Barbi, Joseph ^a,c   Reville, Patrick ^a,b   Oghumu, Steve ^a,b   Zorko, Nicholas ^a   Sarkar, Anasuya ^d   Keiser, Tracy L ^a   Lu, Bao ^e   Rückle, Thomas ^f   Varikuti, Sanjay ^a,b   Lezama Davila, Claudio ^a,b   Wewers, Mark D ^d   Whitacre, Caroline ^a   Radzioch, Danuta ^g   Rommel, Christian ^h   Seveau, Stéphanie ^a   Satoskar, Abhay R ^a,b  

^a OHIO STATE UNIVERSITY   (United States)

^b THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d OHIO STATE UNIVERSITY   (United States)

^e BOSTON CHILDREN S HOSPITAL   (United States)

^f MERCK SERONO S A   (Switzerland)

^g MCGILL UNIVERSITY   (Canada)

^h Intellikine Inc   (United States)

ⁱ BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; STIBOGLUCONATE SODIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENZYME DEFICIENCY; ENZYME INHIBITION; HOST PARASITE INTERACTION; LEISHMANIA MEXICANA; MACROPHAGE; MOUSE; NEUTROPHIL; NONHUMAN; PARASITE LOAD; PATHOGENESIS; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SKIN LEISHMANIASIS; SPECIES INVASION;

ANIMALS; ANTIMONY SODIUM GLUCONATE; DISEASE RESISTANCE; FLOW CYTOMETRY; HOST-PARASITE INTERACTIONS; HUMANS; LEISHMANIA MEXICANA; LEISHMANIASIS, CUTANEOUS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; NEUTROPHILS; PHAGOCYTES; PHOSPHATIDYLINOSITOL 3-KINASES; QUINOXALINES; THIAZOLIDINEDIONES;

LEISHMANIA MEXICANA; MUS;

EID: 84856404461     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1110339109     Document Type: Article

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