Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: A structure-activity relationship study based on inhibitors for the Wnt response

Journal of Medicinal Chemistry

Volumn 55, Issue 2, 2012, Pages 697-708

  Lanier, Marion ^a,c   Schade, Dennis ^a,b,c   Willems, Erik ^b,c   Tsuda, Masanao ^b   Spiering, Sean ^b   Kalisiak, Jaroslaw ^a   Mercola, Mark ^b,c   Cashman, John R ^a,c  

^a HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c ChemRegen Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(2 METHOXYPHENYL)BENZAMIDE; 2 CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(4 ACETYLPHENYL)BENZAMIDE; 2 CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(4 CYANOPHENYL)BENZAMIDE; 2 CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N[4 (DIMETHYLAMINO)PHENYL]BENZAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDO 2 YL)N(PARA TOLYL)BENZAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(2 ACETYLPHENYL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(2 ETHOXYPHENYL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(2 HYDROXYPHENYL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(4 METHOXYPHENYL)BENZAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(ISOQUINOLIN 1 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(ISOQUINOLIN 4 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(ISOQUINOLIN 5 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(ISOQUINOLIN 8 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(NAPHTHALEN 1 YL)BENZAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(QUINOLIN 4 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(QUINOLIN 5 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(QUINOLIN 8 YL) TRANS CYCLOHEXYLCARBOXAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(QUINOLIN 8 YL)BENZAMIDE; 4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)N(QUINOLIN 8 YL)CIS CYCLOHEXYLCARBOXAMIDE; 4 [CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)]N(2 ACETYLPYRIDIN 3 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 [CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)]N(6 ACETYLPYRIDIN 3 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 [CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)]N(8 OXO 5,6,7,8 TETRAHYDRONAPHTHALEN 1 YL)TRANS CYCLOHEXYL CARBOXAMIDEE; 4 [CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)]N(9H FLUOREN 9 ON 1 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 [CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)]N(PYRIDIN 2 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 [CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)]N(PYRIDIN 3 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 [CIS ENDO(1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)]N(PYRIDIN 4 YL)TRANS CYCLOHEXYLCARBOXAMIDE; 4 CIS ENDO[3A,4,7,7A TETRAHYDRO 1H 4,7 ETHANOISOINDOLE 1,3(2H) DION 2 YL]N QUINOLIN 8 YLBENZAMIDE; METHYL 2 [4 (CIS ENDO 1,3 DIOXOOCTAHYDRO 2H 4,7 METHANOISOINDOL 2 YL)]N TRANS CYCLOHEXANECARBOXAMIDO)BENZOATE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG; WNT PROTEIN INHIBITOR;

CARDIOMYOGENESIS; CELL DIFFERENTIATION; CELL STIMULATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SYNTHESIS; EMBRYO; EMBRYONIC STEM CELL; HEART DEVELOPMENT; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IC 50; INTRACELLULAR SIGNALING; MUSCLE DEVELOPMENT; REVIEW; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

CELL DIFFERENTIATION; CELL LINE; EMBRYONIC STEM CELLS; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MYOCYTES, CARDIAC; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDRONAPHTHALENES; WNT PROTEINS;

EID: 84856371983     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm2010223     Document Type: Review

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