A limited role for regulatory T cells in post-ischemic neovascularization

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 2, 2012, Pages 328-336

  Hellingman, A A ^a   van der Vlugt, L E P M ^a   Lijkwan, M A ^a   Bastiaansen, A J N M ^a   Sparwasser, T ^b   Smits, H H ^a   Hamming, J F ^a   Quax, P H A ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b INSTITUTE OF INFECTION IMMUNOLOGY   (Germany)

Author keywords

Arteriogenesis; Hind limb ischemia; Neovascularization; Regulatory T cells

Indexed keywords

DIPHTHERIA TOXIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MONOCLONAL ANTIBODY;

ANIMAL; ARTICLE; BLOOD; C57BL MOUSE; FEMORAL ARTERY; HINDLIMB; IMMUNOLOGY; ISCHEMIA; LYMPH NODE; METABOLISM; MOUSE; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY; PATHOPHYSIOLOGY; REGULATORY T LYMPHOCYTE; SKELETAL MUSCLE; TRANSGENIC MOUSE; VASCULARIZATION;

ANIMALS; ANTIBODIES, MONOCLONAL; DIPHTHERIA TOXIN; FEMORAL ARTERY; HINDLIMB; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; ISCHEMIA; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MUSCLE, SKELETAL; NEOVASCULARIZATION, PATHOLOGIC; T-LYMPHOCYTES, REGULATORY;

MUS;

EID: 84856352383     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2011.01300.x     Document Type: Article

References (33)

1. van Weel V, van Tongeren RB, van Hinsbergh VW, et al Vascular growth in ischemic limbs: a review of mechanisms and possible therapeutic stimulation. Ann Vasc Surg. 2008; 22: 582-97.
2. van Oostrom MC, van Oostrom O, Quax PH, et al Insights into mechanisms behind arteriogenesis: what does the future hold? J Leukoc Biol. 2008; 84: 1379-91.
3. Sakaguchi S. Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self. Nat Immunol. 2005; 6: 345-52.
4. von Boehmer H. Mechanisms of suppression by suppressor T cells. Nat Immunol. 2005; 6: 338-44.
5. Sakaguchi S. Naturally arising CD4+ regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu Rev Immunol. 2004; 22: 531-62.
6. Belkaid Y, Rouse BT. Natural regulatory T cells in infectious disease. Nat Immunol. 2005; 6: 353-60.
7. van Es T, van Puijvelde GH, Foks AC, et al Vaccination against Foxp3(+) regulatory T cells aggravates atherosclerosis. Atherosclerosis. 2010; 209: 74-80.
8. Ait-Oufella H, Salomon BL, Potteaux S, et al Natural regulatory T cells control the development of atherosclerosis in mice. Nat Med. 2006; 12: 178-80.
9. Mallat Z, Ait-Oufella H, Tedgui A. Regulatory T-cell immunity in atherosclerosis. Trends Cardiovasc Med. 2007; 17: 113-8.
10. Zouggari Y, Ait-Oufella H, Waeckel L, et al Regulatory T cells modulate postischemic neovascularization. Circulation. 2009; 120: 1415-25.
11. Tang Q, Henriksen KJ, Boden EK, et al Cutting edge: CD28 controls peripheral homeostasis of CD4+CD25+ regulatory T cells. J Immunol. 2003; 171: 3348-52.
12. Tang Q, Smith JA, Szot GL, et al CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo. J Immunol. 2003; 170: 1510-6.
13. Salomon B, Lenschow DJ, Rhee L, et al B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 2000; 12: 431-40.
14. Mak T.W. CD28. In: Tak W. Mak, editor. The gene knockout factsbook: A-H. London : Academic Press; 1998. p. 161-4.
15. Webster KE, Walters S, Kohler RE, et al In vivo expansion of T reg cells with IL-2-mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression. J Exp Med. 2009; 206: 751-60.
16. Kohm AP, McMahon JS, Podojil JR, et al Cutting edge: anti-CD25 monoclonal antibody injection results in the functional inactivation, not depletion, of CD4+CD25+ T regulatory cells. J Immunol. 2006; 176: 3301-5.
17. Shibata K, Yamada H, Nakamura R, et al Identification of CD25+ gamma delta T cells as foetal thymus-derived naturally occurring IL-17 producers. J Immunol. 2008; 181: 5940-7.
18. Driesen J, Popov A, Schultze JL. CD25 as an immune regulatory molecule expressed on myeloid dendritic cells. Immunobiology. 2008; 213: 849-58.
19. Becknell B, Caligiuri MA. Interleukin-2, interleukin-15, and their roles in human natural killer cells. Adv Immunol. 2005; 86: 209-39.
20. Lahl K, Loddenkemper C, Drouin C, et al Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med. 2007; 204: 57-63.
21. Morgan ME, Sutmuller RP, Witteveen HJ, et al CD25+ cell depletion hastens the onset of severe disease in collagen-induced arthritis. Arthritis Rheum. 2003; 48: 1452-60.
22. Lahl K, Loddenkemper C, Drouin C, et al Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med. 2007; 204: 57-63.
23. Hellingman AA, Bastiaansen AJ, de Vries MR, et al Variations in surgical procedures for hind limb ischaemia mouse models result in differences in collateral formation. Eur J Vasc Endovasc Surg. 2010.
24. Rausch S, Huehn J, Loddenkemper C, et al Establishment of nematode infection despite increased Th2 responses and immunopathology after selective depletion of Foxp3+ cells. Eur J Immunol. 2009; 39: 3066-77.
25. Taguchi O, Takahashi T. Mouse models of autoimmune disease suggest that self-tolerance is maintained by unresponsive autoreactive T cells. Immunology. 1996; 89: 13-9.
26. McHugh RS, Shevach EM. Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol. 2002; 168: 5979-83.
27. van Weel V, Toes RE, Seghers L, et al Natural killer cells and CD4+ T-cells modulate collateral artery development. Arterioscler Thromb Vasc Biol. 2007; 27: 2310-8.
28. Stabile E, Burnett MS, Watkins C, et al Impaired arteriogenic response to acute hindlimb ischemia in CD4-knockout mice. Circulation. 2003; 108: 205-10.
29. Stabile E, Kinnaird T, la SA, et al CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16. Circulation. 2006; 113: 118-24.
30. Stephens LA, Mason D. CD25 is a marker for CD4+ thymocytes that prevent autoimmune diabetes in rats, but peripheral T cells with this function are found in both CD25+ and. J Immunol. 2000; 165: 3105-10.
31. Lehmann J, Huehn J, de la Rosa M, et al Expression of the integrin alpha Ebeta 7 identifies unique subsets of CD25+ as well as. Proc Natl Acad Sci USA. 2002; 99: 13031-6.
32. Saito M, Iwawaki T, Taya C, et al Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol. 2001; 19: 746-50.
33. Brunkow ME, Jeffery EW, Hjerrild KA, et al Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat Genet. 2001; 27: 68-73.