CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16

Circulation

Volumn 113, Issue 1, 2006, Pages 118-124

  Stabile, Eugenio ^a,e   Kinnaird, Timothy ^a   La Sala, Andrea ^b   Hanson, Sue Kim ^d   Watkins, Craig ^a   Campia, Umberto ^a   Shou, Matie ^a   Zbinden, Stephan ^a   Fuchs, Shmuel ^a   Kornfeld, Hardy ^c   Epstein, Stephen E ^a   Burnett, Mary Susan ^a  

^a WASHINGTON HOSPITAL CENTER   (United States)

^b IRCCS SAN RAFFAELE PISANA   (Italy)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Angiogenesis; Inflammation; Interleukins; Lymphocytes

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; INTERLEUKIN 16;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY LIGATION; ARTICLE; BLOOD FLOW; BRAIN ISCHEMIA; CD8+ T LYMPHOCYTE; CELL INFILTRATION; COLLATERAL CIRCULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMORAL ARTERY; LASER DOPPLER FLOWMETRY; LIMB ISCHEMIA; MONONUCLEAR CELL; MOUSE; MUSCLE ATROPHY; MYOFIBROSIS; NONHUMAN; PERIPHERAL ISCHEMIA; PRIORITY JOURNAL; ANIMAL; ARTERIOLOSCLEROSIS; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CYTOLOGY; DISEASE MODEL; GENETICS; IMMUNE SYSTEM; IMMUNOLOGY; ISCHEMIA; MOUSE MUTANT; NEUTROPHIL CHEMOTAXIS; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD8; ARTERIOLOSCLEROSIS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CHEMOTAXIS, LEUKOCYTE; COLLATERAL CIRCULATION; DISEASE MODELS, ANIMAL; FEMORAL ARTERY; IMMUNE SYSTEM; INTERLEUKIN-16; ISCHEMIA; MICE; MICE, KNOCKOUT;

EID: 33644859752     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.105.576702     Document Type: Article

References (22)

1. Baroldi G, Mantero O, Scomazzoni G. The collaterals of the coronary arteries in normal and pathologic hearts. Circ Res. 1956;4:223-229.
2. Heil M, Schaper W. Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis). Circ Res. 2004;3:95:449-458.
3. Arras M, Ito WD, Scholz D, Winkler B, Schaper J, Schaper W. Monocyte activation in angiogenesis and collateral growth in the rabbit hindlimb. J Clin Invest. 1998;101:40-50.
4. Heil M, Ziegelhoeffer T, Pipp F, Kostin S, Martin S, Clauss M, Schaper W. Blood monocyte concentration is critical for enhancement of collateral artery growth. Am J Physiol Heart Circ Physiol. 2002;283:H2411-H2419.
5. -/- mice. Circulation. 1999;99:3188-98.
6. Stabile E, Burnett MS, Watkins C, Kinnaird T, Bachis A, la Sala A, Miller JM, Shou M, Epstein SE, Fuchs S. Impaired arteriogenic response to acute hindlimb ischemia in CD4-knockout mice. Circulation. 2003 15:108:205-210.
7. + T-lymphocytes and activated microglia/macrophages. J Neuroimmunol. 2001;114:232-241.
8. Cruikshank WW, Kornfeld H, Center DM. Interleukin-16. J Leukoc Biol. 2000;67:757-766.
9. Couffinhal T, Silver M, Zheng LP, Kearney M, Witzenbichler B, Isner JM. Mouse model of angiogenesis. Am J Pathol. 1998;152:1667-1679.
10. Lee CW, Stabile E, Kinnaird T, Shou M, Devaney JM, Epstein SE, Burnett MS. Temporal patterns of gene expression after acute hindlimb ischemia in mice: insights into the genomic program for collateral vessel development. J Am Coll Cardiol. 2004;43:474-82.
11. Kinnaird T, Stabile E, Burnett MS, Shou M, Lee CW, Barr S, Fuchs S, Epstein SE. Local delivery of marrow-derived stromal cells augments collateral perfusion through paracrine mechanisms. Circulation. 2004;109:1543-1549.
12. Esposito G, Prasad SV, Rapacciuolo A, Mao L, Koch WJ, Rockman HA. Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. Circulation. 2001;103:1453-1458.
13. Scholz D, Ziegelhoeffer T, Helisch A, Wagner S, Friedrich C, Podzuweit T, Schaper W. Contribution of arteriogenesis and angiogenesis to postocclusive hindlimb perfusion in mice. J Mol Cell Cardiol. 2002;34:775-787.
14. Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, Nagy JA, Hooper A, Priller J, De Klerck B, Compernolle V, Daci E, Bohlen P, Dewerchin M, Herbert JM, Fava R, Matthys P, Carmeliet G, Collen D, Dvorak HF, Hicklin DJ, Carmeliet P. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med. 2002;8:831-840.
15. Yu HC, Burrell LM, Black MJ, Wu LL, Dilley RJ, Cooper ME, Johnston CI. Salt induces myocardial and renal fibrosis in normotensive and hypertensive rats. Circulation. 1998;98:2621-2628.
16. + lymphocytes. J Immunol. 2005;174:2738-2745.
17. Girgis L, Davis MM, Fazakas de St Groth B. The avidity spectrum of T cell receptor interactions accounts for T cell anergy in a double transgenic model. J Exp Med. 1999;189:265-278.
18. Wilson KC, Center DM, Cruikshank WW. The effect of interleukin-16 and its precursor on T lymphocyte activation and growth. Growth Factors. 2004;22:97-104.
19. Rand TH, Cruikshank WW, Center DM, Weller PF. CD4-mediated stimulation of human eosinophils: lymphocyte chemoattractant factor and other CD4-binding ligands elicit eosinophil migration. J Exp Med. 1991;173:1521-1528.
20. Kaser A, Dunzendorfer S, Offner FA, Ryan T, Schwabegger A, Cruikshank WW, Wiedermann CJ, Tilg H. A role for IL-16 in the cross-talk between dendritic cells and T cells. J Immunol. 1999;163: 3232-3238.
21. Schaper W, Buschmann I. Arteriogenesis, the good and bad of it. Cardiovasc Res. 1999;43:835-837.
22. Heil M, Schaper W. Influence of mechanical, cellular, and molecular factors on collateral artery growth (arteriogenesis). Circ Res. 2004;95:449-458.