Synthesis and antimicrobial evaluation of new isoxazole and pyrazole derivatives

Saudi Pharmaceutical Journal

Volumn 11, Issue 3, 2003, Pages 111-117

  Goda, F E ^a   Maarouf, A R ^a   EL Bendary, E R ^a  

^a MANSOURA UNIVERSITY   (Egypt)

Author keywords

Antimicrobial activity; Isoxazolin 5 ones; Pyrazolidin 3,5 diones; Pyrazolin 5 ones

Indexed keywords

AMPICILLIN; ISOXAZOLE; ISOXAZOLINE DERIVATIVE; KETONE DERIVATIVE; PYRAZOLE DERIVATIVE; PYRAZOLINE DERIVATIVE; STREPTOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DRUG SCREENING; DRUG SYNTHESIS; INFRARED SPECTROSCOPY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; ROOM TEMPERATURE; TANDEM MASS SPECTROMETRY;

EID: 0043131865     PISSN: 13190164     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Sugiura, S.; Ohno, S.; Ohtani, O.; Izumi, K; Kitamilado, T.; Asa; H; Kato, K; Hori, M.; Fujimura, H. Synthesis and Antinflammatory and Hypnotic Activity of 5-Alkoxy-3-(N-Substituted Carbamoyl)-1-phenylpyrazoles. J. Med. Chem. 1977, 20: 80.
2. ManFrendini S., Bazzanini, R., Baraldi, P., Bonora, M., Marangoni, M., Simoni D., Pani, A., Scintu, F., Pinna E., Pisana L., La Colla, P. Pyrazole related nucleosides 4-Synthesis and antitumor activity of some 1-tetrahydropyranyl-4-substituted pyrazoles. Anticancer Drug Res., 1996, 11(3): 193-204.
3. Farghaly, A., Bekhit, A., Patk, J., Design and synthesis of some oxadiazolyl, thiadiazolyl, thiazolidinyl, and thiazolyl derivatives of 1H pyrazoles as antiinflammatory antimicrobial agents. Arch. Pharm (Weinheim)., 2000, 333, (2-3): 53-7.
4. Farghaly, A., Soliman, F., ElSemary, M., Rostom, A., Synthesis, antimicrobial and antiinflammatory activity of some pyrazoles. Pharmazie 2001, 56, (1): 18-32.
5. Katritzky, A. R. Advances in Heterocyclic Chemistry, Vol 6; Academic press; New York, 1966: P 347
6. Hawking, F.; Schnitzer, R.J., Eds. Experimental Chemotherapy 1; Academic press New York, 1963: p197
7. Shinkai, H., Onogi, S., Tanaka, M., Shibata, T., Iwao, M., Wakitani, K., Uchida, I., Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents. J. Med. Chem., 1998, 41, (11): 1927-33.
8. Fevig, J., Buriak, J., Stouten, P., knabb, R., Lam, G., Wong, P., Wexler, R; Preparation of pyrrolidine and isoxazolidine benzamidines as potential inhibitor or of coagulation factor Xa. Bioorg Med. Chem. Lett., 1999, 9, (8):1195-200.
9. Merino, P. Franco, S., Merchan, F., Tejero, T., Stereodivergent approches to the synthesis of isoxazolidine analogues of alpha-amino acid nucleosides. Total synthesis of isoxazolidinyl deoxypolyxin C and uracil polyoxin C. J. Org. Chem., 2000, 65, (18): 5575-89.
10. 4 T-cell leukemia. Anticancer Res., 2001, 21, (3B): 1857-68.
11. Hall IH; Barnes BJ; Ward ES; Wheaton JP; Warren AE; Izydore RA. Tmolt4 leukemic type II isoform of IMP dehyrogenase as a target for 1,2,4-triazolidine-3,5-dione, 1-(1-(3-methylphenyl)ethylidineamino)-4,4-diethyl-3,5-azetidinediones, 3,5-isoxazolidinediones, and 4,4-disubstituted-3,5-pyrazolidinediones. Arch Pharm. (Weinheim). 2001, 334(4): 109-16
12. Munmckhof, W., Giles, C., Turnidge, J., Post-antibiotic growth supression of Linezolid against Gram-postive Bacteria. J. Antimicrob. Chemotherapy 2001, 47, (6): 879-83.
13. Tantawy, A.; Goda, F.E. Development of some new alicyclic amine derivatives of chemotherapeutic interest. Chin. Pharm. J. 1992, 44, 295.
14. Tantawy, A.; Eisa, H.; Ismail, A.; El-Kerdawy, M. Synthesis of 1- substituted -4- arylhydrazono-3-methyl-2-pyrazolin-5-ones as potential antinfalommatory agents. Alex. J. Pharm. Sci, 1988, 11 (21): 113
15. Tantawy, A.; Goda, F.; Abdelal, A. M. Synthesis and characterization of certain new 3-methyl-4-(substituted phenylazo) isoxazol-5-ones and 3-methyl-4- (substituted phenylazo)-pyrazol-5-ones potential antibacterial agents. Chim. Pharm. J. 1995, 47 (1): 37-45
16. 3](HL-pyrazole and imidazole). J. Inorg. Biochem., 2000, 78, (4):363-70.
17. Aeillo, E., Aeillo, S., Mingoia, F., Bacchi, A., Pelizzi, G., Musiu, C., Setzu, M., Pani, A., La Colla P., Marongiu M., synthesis and antimicrobial activity of new 3-(1-R-3(5)-methyl-4-nitroso-1H-5(3)-pyrazolyl)-5-methylisoxazoles. Bioorg. Med. Chem., 2000, 8, (12): 2719-28.
18. Soliman, R., Habib, N., Ashour, F., El-Taiebi, M., synthesis and antimicrobial activity of novel pyrazole, pyrazoline, pyrazolidinone and pyrazolidinedione derivatives of benzimidazole. Boll. Chim. Farm., 2001, 140, (3): 140-8.
19. Nigram, S. C.; Saharia, G. S.; Sharma, H. R. Studies in Heterocyclic compounds part XXXVIII: synthesis and in vitro screening of 4, 6 - dimethyl -5- (arylazo-N-substituted p-sulphamylbenzenazo) pyrimidine -2- thiols. J. Indian Chem. Soc. 1983, 60, 583
20. Kreutzberger, A.; Tantawy, A. Antiviral Agents XXIII: Addition on 2- Aminoadamantane. Chem. Zeitg. 1983, 107: 205.
21. El-Kerdawy, M.; Tantawy, A.; Gad, L.M.; Rady, E. Synthesis and Characterization of 1,2,4-triazolo[4,3-b]quinoxalines and 1,2,4-triazolo-s-triazines as potential antibacterial agents Chin. Pharm. J. 1991, 43: 5.
22. Hugo, W. B.; Russelle, AD, Pharmacenutical Microbiology; Blackwell Scientific publications, 1977; p 185.
23. Jones, R.N., Barry, A.L., Gavan, T.L., Washington J.A., II. Susceptibility tests: micridilution and macrodilution broth procedures. In: Lennette, E.H., Balows, A., Hausler, Jr. W.J., Shadomy, H.J., (Eds). Manual of clinical Microbiology4th ed. Washington DC: American Society for Microbiology, , (1985), 972-7.