Towards a neuroimaging biomarker of depression vulnerability

Translational Neuroscience

Volumn 2, Issue 4, 2011, Pages 281-292

  Farb, Norman A S ^a   Segal, Zindel V ^b,c   Anderson, Adam K ^a,b  

^a ROTMAN RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Biomarker; Depression; Emotion; Functional Magnetic Resonance Imaging; Imaging; Major Depressive Disorder; Reactivity; Relapse

Indexed keywords

BIOLOGICAL MARKER;

AMYGDALOID NUCLEUS; BRAIN RADIOGRAPHY; CINGULATE GYRUS; COGNITIVE THERAPY; DEPRESSION; DISEASE PREDISPOSITION; DYSPHORIA; ELECTROENCEPHALOGRAM; EMOTIONALITY; EVIDENCE BASED MEDICINE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HIPPOCAMPUS; HUMAN; MAJOR DEPRESSION; MENTAL PERFORMANCE; NEGATIVE FEEDBACK; NEUROIMAGING; PRIORITY JOURNAL; RECURRENCE RISK; REMISSION; REVIEW; RISK ASSESSMENT; SENSORY FEEDBACK; VENTROMEDIAL PREFRONTAL CORTEX; WORKING MEMORY;

EID: 84856294810     PISSN: 20813856     EISSN: 20816936     Source Type: Journal    
DOI: 10.2478/s13380-011-0033-2     Document Type: Review

References (169)

1. A. J. Gelenberg 2010 The prevalence and impact of depression J. Clin. Psychiatry 71 e06 20331925 10.4088/JCP.8001tx17c
2. D. Richards 2011 Prevalence and clinical course of depression: A review Clin. Psychol. Rev. 31 1117 1125 21820991 10.1016/j.cpr.2011.07.004
3. H. U. Wittchen B. Knauper R. C. Kessler 1994 Lifetime risk of depression Br. J. Psychiatry Suppl. 26 16 22 7873133 (Pubitemid 24358524)
4. P. E. Greenberg R. C. Kessler H. G. Birnbaum S. A. Leong S. W. Lowe P. A. Berglund, et al. 2003 The economic burden of depression in the United States: how did it change between 1990 and 2000? J. Clin. Psychiatry 64 1465 75 14728109 10.4088/JCP.v64n1211 (Pubitemid 41270106)
5. L. L. Judd 1997 The clinical course of unipolar major depressive disorders Arch. Gen. Psychiatry 54 989 991 9366654 1:STN:280: DyaK1c%2FjtlCnuw%3D%3D 10.1001/archpsyc.1997.01830230015002
6. C. J. Murray A. D. Lopez 1997 Mortality by cause for eight regions of the world: Global Burden of Disease Study Lancet 349 1269 1276 9142060 1:STN:280:DyaK2s3os12lug%3D%3D 10.1016/S0140-6736(96)07493-4 (Pubitemid 27192468)
7. A. D. Lopez C. D. Mathers M. Ezzati D. T. Jamison C. J. Murray 2006 Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data Lancet 367 1747 1757 16731270 10.1016/S0140-6736(06)68770-9 (Pubitemid 43767064)
8. F. Angst H. H. Stassen P. J. Clayton J. Angst 2002 Mortality of patients with mood disorders: follow-up over 34-38 years J. Affect. Disord. 68 167 181 12063145 1:STN:280:DC%2BD38zitVWitg%3D%3D 10.1016/S0165-0327(01)00377-9 (Pubitemid 34628324)
9. Bromet E., Andrade L. H., Hwang I., Sampson N. A., Alonso J., de Girolamo G. et al., Cross-national epidemiology of DSM-IV major depressive episode, BMC Med., 2011, 9
10. R. C. Kessler P. Berglund O. Demler R. Jin D. Koretz K. R. Merikangas, et al. 2003 The epidemiology of major depressive disorder: results from the National Comorbidity Survey Replication (NCS-R) JAMA 289 3095 3105 12813115 10.1001/jama.289.23.3095 (Pubitemid 37432885)
11. G. A. Fava E. Tomba 2010 New modalities of assessment and treatment planning in depression: the sequential approach CNS Drugs 24 453 465 20443645 10.2165/11531580-000000000-00000
12. G. A. Fava S. K. Park N. Sonino 2006 Treatment of recurrent depression Expert Rev. Neurother. 6 1735 1740 17144786 1:CAS:528:DC%2BD2sXmsVSitQ%3D%3D 10.1586/14737175.6.11.1735 (Pubitemid 44904017)
13. I. Andersen K. Thielen P. Bech E. Nygaard F. Diderichsen 2011 Increasing prevalence of depression from 2000 to 2006 Scand. J. Public Health 39 857 863 21965477 10.1177/1403494811424611
14. M. M. Weissman P. Wickeramaratne Y. Nomura V. Warner H. Verdeli D. J. Pilowsky, et al. 2005 Families at high and low risk for depression: a 3-generation study Arch. Gen. Psychiatry 62 29 36 15630070 10.1001/archpsyc.62. 1.29 (Pubitemid 40096068)
15. S. Horstmann E. B. Binder 2011 Glucocorticoids as predictors of treatment response in depression Harv. Rev. Psychiatry 19 125 143 21631159 10.3109/10673229.2011.586550
16. B. M. Iacoviello L. B. Alloy L. Y. Abramson W. G. Whitehouse M. E. Hogan 2006 The course of depression in individuals at high and low cognitive risk for depression: a prospective study J. Affect. Disord. 93 61 69 16545464 10.1016/j.jad.2006.02.012 (Pubitemid 43816051)
17. L. B. Alloy L. Y. Abramson W. G. Whitehouse M. E. Hogan C. Panzarella D. T. Rose 2006 Prospective incidence of first onsets and recurrences of depression in individuals at high and low cognitive risk for depression J. Abnorm. Psychol. 115 145 156 16492105 10.1037/0021-843X.115.1.145
18. J. Spasojevic L. B. Alloy 2001 Rumination as a common mechanism relating depressive risk factors to depression Emotion 1 25 37 12894809 1:STN:280:DC%2BD3szmtF2hsA%3D%3D 10.1037/1528-3542.1.1.25
19. G. M. Slavich S. M. Monroe I. H. Gotlib 2011 Early parental loss and depression history: associations with recent life stress in major depressive disorder J. Psychiatr. Res. 45 1146 1152 21470621 10.1016/j.jpsychires.2011.03. 004
20. E. J. Robison S. A. Shankman B. R. McFarland 2009 Independent associations between personality traits and clinical characteristics of depression J. Nerv. Ment. Dis. 197 476 483 19597354 10.1097/NMD.0b013e3181aad5fc
21. V. Lorant C. Croux S. Weich D. Deliège J. Mackenbach M. Ansseau 2007 Depression and socio-economic risk factors: 7-year longitudinal population study Br. J. Psychiatry 190 293 298 17401034 10.1192/bjp.bp.105.020040 (Pubitemid 46580677)
22. V. Lorant D. Deliège W. Eaton A. Robert P. Philippot M. Ansseau 2003 Socioeconomic inequalities in depression: a meta-analysis Am. J. Epidemiol. 157 98 112 12522017 1:STN:280:DC%2BD3s%2FhsFemuw%3D%3D 10.1093/aje/kwf182 (Pubitemid 36077441)
23. P. F. Sullivan M. C. Neale K. S. Kendler 2000 Genetic epidemiology of major depression: review and meta-analysis Am. J. Psychiatry 157 1552 1562 11007705 1:STN:280:DC%2BD3M%2FgvVOitQ%3D%3D 10.1176/appi.ajp.157.10.1552
24. G. Hasler 2010 Pathophysiology of depression: do we have any solid evidence of interest to clinicians? World Psychiatry 9 155 161 20975857
25. R. J. Davidson D. A. Lewis L. B. Alloy D. G. Amaral G. Bush J. D. Cohen, et al. 2002 Neural and behavioral substrates of mood and mood regulation Biol. Psychiatry 52 478 502 12361665 10.1016/S0006-3223(02)01458-0 (Pubitemid 35284019)
26. W. C. Drevets 2001 Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders Curr. Opin. Neurobiol. 11 240 249 11301246 1:CAS:528:DC%2BD3MXksFektrw%3D 10.1016/S0959-4388(00)00203-8 (Pubitemid 32289413)
27. W. C. Drevets M. E. Raichle 1992 Neuroanatomical circuits in depression: implications for treatment mechanisms Psychopharmacol. Bull. 28 261 274 1480730 1:STN:280:DyaK3s7is1GhsA%3D%3D
28. R. J. DeRubeis G. J. Siegle S. D. Hollon 2008 Cognitive therapy versus medication for depression: treatment outcomes and neural mechanisms Nat. Rev. Neurosci. 9 788 796 18784657 1:CAS:528:DC%2BD1cXhtFeit7bE 10.1038/nrn2345
29. H. S. Mayberg 2003 Modulating dysfunctional limbic-cortical circuits in depression: towards development of brain-based algorithms for diagnosis and optimised treatment Br. Med. Bull. 65 193 207 12697626 10.1093/bmb/65.1.193 (Pubitemid 36406467)
30. R. J. Davidson D. Pizzagalli J. B. Nitschke K. Putnam 2002 Depression: perspectives from affective neuroscience Annu. Rev. Psychol. 53 545 574 11752496 10.1146/annurev.psych.53.100901.135148
31. W. C. Drevets J. L. Price M. L. Furey 2008 Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression Brain Struct. Funct. 213 93 118 18704495 10.1007/s00429-008-0189-x
32. H. S. Mayberg M. Liotti S. K. Brannan S. McGinnis R. K. Mahurin P. A. Jerabek, et al. 1999 Reciprocal limbic-cortical function and negative mood: converging PET findings in depression and normal sadness Am. J. Psychiatry 156 675 682 10327898 1:STN:280:DyaK1M3lvFyrsA%3D%3D (Pubitemid 29220063)
33. H. S. Mayberg 1997 Limbic-cortical dysregulation: a proposed model of depression J. Neuropsychiatry Clin Neurosci 9 471 481 9276848 1:STN:280:DyaK2svit1Omuw%3D%3D (Pubitemid 27363950)
34. D. G. Amaral 2003 The amygdala, social behavior, and danger detection Ann. N Y Acad. Sci. 1000 337 347 14766647 10.1196/annals.1280.015 (Pubitemid 38264850)
35. A. Ohman 2005 The role of the amygdala in human fear: automatic detection of threat Psychoneuroendocrinology 30 953 958 15963650 10.1016/j.psyneuen.2005. 03.019 (Pubitemid 40982478)
36. M. Zhong X. Wang J. Xiao J. Yi X. Zhu J. Liao, et al. 2011 Amygdala hyperactivation and prefrontal hypoactivation in subjects with cognitive vulnerability to depression Biol. Psychol. 88 233 242 21878364 10.1016/j.biopsycho.2011.08.007
37. G. J. Siegle W. Thompson C. S. Carter S. R. Steinhauer M. E. Thase 2007 Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: related and independent features Biol. Psychiatry 61 198 209 17027931 10.1016/j.biopsych.2006.05.048 (Pubitemid 46072788)
38. B. Abler S. Erk U. Herwig H. Walter 2007 Anticipation of aversive stimuli activates extended amygdala in unipolar depression J. Psychiatr. Res. 41 511 522 17010993 10.1016/j.jpsychires.2006.07.020 (Pubitemid 46242139)
39. P. J. Whalen L. M. Shin L. H. Somerville A. A. McLean H. Kim 2002 Functional neuroimaging studies of the amygdala in depression Semin. Clin. Neuropsychiatry 7 234 242 12382206 10.1053/scnp.2002.35219
40. A. K. Anderson K. Christoff I. Stappen D. Panitz D. G. Ghahremani G. Glover, et al. 2003 Dissociated neural representations of intensity and valence in human olfaction Nat. Neurosci. 6 196 202 12536208 1:CAS:528: DC%2BD3sXmsFGgtQ%3D%3D 10.1038/nn1001 (Pubitemid 36182790)
41. D. M. Small M. D. Gregory Y. E. Mak D. Gitelman M. M. Mesulam T. Parrish 2003 Dissociation of neural representation of intensity and affective valuation in human gustation Neuron 39 701 711 12925283 1:CAS:528:DC%2BD3sXmslOmu7g%3D 10.1016/S0896-6273(03)00467-7 (Pubitemid 36993586)
42. A. K. Anderson E. A. Phelps 2001 Lesions of the human amygdala impair enhanced perception of emotionally salient events Nature 411 305 309 11357132 1:STN:280:DC%2BD3M3msVyguw%3D%3D 10.1038/35077083 (Pubitemid 32467035)
43. A. Santos D. Mier P. Kirsch A. Meyer-Lindenberg 2011 Evidence for a general face salience signal in human amygdala Neuroimage 54 3111 3116 21081170 10.1016/j.neuroimage.2010.11.024
44. S. V. Mahler K. C. Berridge 2009 Which cue to "want?" Central amygdala opioid activation enhances and focuses incentive salience on a prepotent reward cue J. Neurosci. 29 6500 6513 19458221 1:CAS:528: DC%2BD1MXmsFentrg%3D 10.1523/JNEUROSCI.3875-08.2009
45. I. Liberzon K. L. Phan L. R. Decker S. F. Taylor 2003 Extended amygdala and emotional salience: a PET activation study of positive and negative affect Neuropsychopharmacology 28 726 733 12655318 10.1038/sj.npp.1300113
46. W. A. Cunningham J. J. Van Bavel I. R. Johnsen 2008 Affective flexibility: evaluative processing goals shape amygdala activity Psychol. Sci. 19 152 160 18271863 10.1111/j.1467-9280.2008.02061.x
47. O. T. Ousdal J. Jensen A. Server A. R. Hariri P. H. Nakstad O. A. Andreassen 2008 The human amygdala is involved in general behavioral relevance detection: evidence from an event-related functional magnetic resonance imaging Go-NoGo task Neuroscience 156 450 455 18775476 1:CAS:528:DC%2BD1cXht1egu77N 10.1016/j.neuroscience.2008.07.066
48. W. A. Cunningham N. L. Arbuckle A. Jahn S. M. Mowrer A. M. Abduljalil 2011 Reprint of: Aspects of neuroticism and the amygdala: chronic tuning from motivational styles Neuropsychologia 49 657 662 21414464 10.1016/j. neuropsychologia.2011.02.027
49. N. L. Balderston D. H. Schultz F. J. Helmstetter 2011 The human amygdala plays a stimulus specific role in the detection of novelty Neuroimage 55 1889 1898 21256226 10.1016/j.neuroimage.2011.01.034
50. J. U. Blackford J. W. Buckholtz S. N. Avery D. H. Zald 2010 A unique role for the human amygdala in novelty detection Neuroimage 50 1188 1193 20045069 10.1016/j.neuroimage.2009.12.083
51. D. R. Bach D. Talmi R. Hurlemann A. Patin R. J. Dolan 2011 Automatic relevance detection in the absence of a functional amygdala Neuropsychologia 49 1302 1305 21345345 10.1016/j.neuropsychologia.2011.02.032
52. A. Versace W. K. Thompson D. Zhou J. R. Almeida S. Hassel C. R. Klein, et al. 2010 Abnormal left and right amygdala-orbitofrontal cortical functional connectivity to emotional faces: state versus trait vulnerability markers of depression in bipolar disorder Biol. Psychiatry 67 422 431 20159144 10.1016/j.biopsych.2009.11.025
53. J. R. Almeida A. Versace A. Mechelli S. Hassel K. Quevedo D. J. Kupfer, et al. 2009 Abnormal amygdala-prefrontal effective connectivity to happy faces differentiates bipolar from major depression Biol. Psychiatry 66 451 459 19450794 10.1016/j.biopsych.2009.03.024
54. C. S. Monk R. G. Klein E. H. Telzer E. A. Schroth S. Mannuzza J. L. Moulton 3rd, et al. 2008 Amygdala and nucleus accumbens activation to emotional facial expressions in children and adolescents at risk for major depression Am. J. Psychiatry 165 90 98 17986682 10.1176/appi.ajp.2007.06111917 (Pubitemid 351704557)
55. G. Wagner E. Sinsel T. Sobanski S. Köhler V. Marinou H. J. Mentzel, et al. 2006 Cortical inefficiency in patients with unipolar depression: an event-related FMRI study with the Stroop task Biol. Psychiatry 59 958 965 16458263 10.1016/j.biopsych.2005.10.025
56. H. Walter R. C. Wolf M. Spitzer N. Vasic 2007 Increased left prefrontal activation in patients with unipolar depression: an event-related, parametric, performance-controlled fMRI study J. Affect. Disord. 101 175 185 17197035 10.1016/j.jad.2006.11.017 (Pubitemid 46879932)
57. N. A. Farb A. K. Anderson R. T. Bloch Z. V. Segal 2011 Mood-linked responses in medial prefrontal cortex predict relapse in patients with recurrent unipolar depression Biol. Psychiatry 70 366 372 21531382 10.1016/j.biopsych. 2011.03.009
58. N. A. Farb A. K. Anderson H. Mayberg J. Bean D. McKeon Z. V. Segal 2010 Minding one's emotions: mindfulness training alters the neural expression of sadness Emotion 10 25 33 20141299 10.1037/a0017151
59. Y. I. Sheline D. M. Barch J. L. Price M. M. Rundle S. N. Vaishnavi A. Z. Snyder, et al. 2009 The default mode network and self-referential processes in depression Proc. Natl. Acad. Sci. U S A 106 1942 1947 19171889 1:CAS:528:DC%2BD1MXitVKitr0%3D 10.1073/pnas.0812686106
60. Y. I. Sheline J. L. Price Z. Yan M. A. Mintun 2010 Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus Proc. Natl. Acad. Sci. U S A 107 11020 11025 20534464 1:CAS:528:DC%2BC3cXmvVaiurY%3D 10.1073/pnas.1000446107
61. J. M. Hooley S. A. Gruber H. A. Parker J. Guillamot J. Rogowska D. A. Yurgelun-Todd 2009 Cortico-limbic response to personally challenging emotional stimuli after complete recovery from depression Psychiatry Res. 172 83 91 19452633 10.1016/j.pscychresns.2009.02.001
62. T. Baumgartner D. Knoch P. Hotz C. Eisenegger E. Fehr 2011 Dorsolateral and ventromedial prefrontal cortex orchestrate normative choice Nat. Neurosci. 14 1468 1474 21964488 1:CAS:528:DC%2BC3MXht1GqsLzK 10.1038/nn.2933
63. S. Qin E. J. Hermans H. J. van Marle J. Luo G. Fernández 2009 Acute psychological stress reduces working memory-related activity in the dorsolateral prefrontal cortex Biol. Psychiatry 66 25 32 19403118 10.1016/j.biopsych.2009.03.006
64. M. Koenigs E. D. Huey M. Calamia V. Raymont D. Tranel J. Grafman 2008 Distinct regions of prefrontal cortex mediate resistance and vulnerability to depression J. Neurosci. 28 12341 12348 19020027 1:CAS:528:DC%2BD1cXhsVGmtLjL 10.1523/JNEUROSCI.2324-08.2008
65. P. R. Goldin K. McRae W. Ramel J. J. Gross 2008 The neural bases of emotion regulation: reappraisal and suppression of negative emotion Biol. Psychiatry 63 577 586 17888411 10.1016/j.biopsych.2007.05.031 (Pubitemid 351273191)
66. I. C. Ballard V. P. Murty R. M. Carter J. J. MacInnes S. A. Huettel R. A. Adcock 2011 Dorsolateral prefrontal cortex drives mesolimbic dopaminergic regions to initiate motivated behavior J. Neurosci. 31 10340 10346 21753011 1:CAS:528:DC%2BC3MXptlSjtb4%3D 10.1523/JNEUROSCI.0895-11.2011
67. S. Nolen-Hoeksema 2000 The role of rumination in depressive disorders and mixed anxiety/depressive symptoms J. Abnorm. Psychol. 109 504 511 11016119 1:STN:280:DC%2BD3cvmsVamsQ%3D%3D 10.1037/0021-843X.109.3.504
68. R. E. Cooney J. Joormann F. Eugène E. L. Dennis I. H. Gotlib 2010 Neural correlates of rumination in depression Cogn. Affect. Behav. Neurosci. 10 470 478 21098808 10.3758/CABN.10.4.470
69. E. H. Koster E. De Lissnyder N. Derakshan R. De Raedt 2011 Understanding depressive rumination from a cognitive science perspective: the impaired disengagement hypothesis Clin. Psychol. Rev. 31 138 145 20817334 10.1016/j.cpr.2010.08.005
70. L. R. Baxter Jr. J. M. Schwartz M. E. Phelps J. C. Mazziota B. H. Guze C. E. Selin, et al. 1989 Reduction of prefrontal cortex glucose metabolism common to three types of depression Arch. Gen. Psychiatry 46 243 250 2784046 1:CAS:528:DyaK3MXksVOitbg%3D 10.1001/archpsyc.1989.01810030049007 (Pubitemid 19078261)
71. S. Grimm J. Beck D. Schuepbach D. Hell P. Boesiger F. Bermpohl, et al. 2008 Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder Biol. Psychiatry 63 369 376 17888408 10.1016/j.biopsych.2007.05.033
72. H. Barbas 2000 Connections underlying the synthesis of cognition, memory, and emotion in primate prefrontal cortices Brain Res. Bull. 52 319 330 10922509 1:STN:280:DC%2BD3cvisFGhtg%3D%3D 10.1016/S0361-9230(99)00245-2 (Pubitemid 30462201)
73. S. T. Carmichael J. L. Price 1995 Limbic connections of the orbital and medial prefrontal cortex in macaque monkeys J. Comp. Neurol. 363 615 641 8847421 1:STN:280:DyaK28vgt1GmtA%3D%3D 10.1002/cne.903630408 (Pubitemid 26028725)
74. E. T. Rolls 2004 Convergence of sensory systems in the orbitofrontal cortex in primates and brain design for emotion Anat. Rec. Part A 281 1212 1225 10.1002/ar.a.20126 (Pubitemid 39458665)
75. S. Bouret B. J. Richmond 2010 Ventromedial and orbital prefrontal neurons differentially encode internally and externally driven motivational values in monkeys J. Neurosci. 30 8591 8601 20573905 1:CAS:528:DC%2BC3cXos1Knurs%3D 10.1523/JNEUROSCI.0049-10.2010
76. T. Johnstone C. M. van Reekum H. L. Urry N. H. Kalin R. J. Davidson 2007 Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression J. Neurosci. 27 8877 8884 17699669 1:CAS:528:DC%2BD2sXhtVegt7bP 10.1523/JNEUROSCI.2063-07.2007 (Pubitemid 47292771)
77. K. J. Ressler H. S. Mayberg 2007 Targeting abnormal neural circuits in mood and anxiety disorders: from the laboratory to the clinic Nat. Neurosci. 10 1116 1124 17726478 1:CAS:528:DC%2BD2sXps1SgtbY%3D 10.1038/nn1944 (Pubitemid 47339944)
78. H. Damasio T. Grabowski R. Frank A. M. Galaburda A. R. Damasio 1994 The return of Phineas Gage: clues about the brain from the skull of a famous patient Science 264 1102 1105 8178168 1:STN:280:DyaK2c3jtleqtg%3D%3D 10.1126/science.8178168 (Pubitemid 24210669)
79. J. S. Beer E. A. Heerey D. Keltner D. Scabini R. T. Knight 2003 The regulatory function of self-conscious emotion: insights from patients with orbitofrontal damage J. Pers. Soc. Psychol. 85 594 604 14561114 10.1037/0022-3514.85.4.594 (Pubitemid 37249670)
80. J. S. Beer O. P. John D. Scabini R. T. Knight 2006 Orbitofrontal cortex and social behavior: integrating self-monitoring and emotion-cognition interactions J. Cogn. Neurosci. 18 871 879 16839295 10.1162/jocn.2006.18.6.871 (Pubitemid 44066125)
81. C. Hercher G. Turecki N. Mechawar 2009 Through the looking glass: examining neuroanatomical evidence for cellular alterations in major depression J. Psychiatr. Res. 43 947 961 19233384 10.1016/j.jpsychires.2009.01.006
82. G. Rajkowska J. J. Miguel-Hidalgo J. Wei G. Dilley S. D. Pittman H. Y. Meltzer, et al. 1999 Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression Biol. Psychiatry 45 1085 1098 10331101 1:STN:280:DyaK1M3mtFCrtA%3D%3D 10.1016/S0006-3223(99)00041-4 (Pubitemid 29236550)
83. G. Rajkowska 2003 Depression: what we can learn from postmortem studies Neuroscientist 9 273 284 12934710 10.1177/1073858403252773 (Pubitemid 36899115)
84. J. L. Price W. C. Drevets 2010 Neurocircuitry of mood disorders Neuropsychopharmacology 35 192 216 19693001 10.1038/npp.2009.104
85. Hamani C., Machado D. C., Hipólide D. C., Dubiela F. P., Suchecki D., Macedo C. E. et al., Deep Brain Stimulation Reverses Anhedonic-Like Behavior in a Chronic Model of Depression: Role of Serotonin and Brain Derived Neurotrophic Factor, Biol. Psychiatry, 2011, Epub ahead of print
86. H. S. Mayberg A. M. Lozano V. Voon H. E. McNeely D. Seminowicz C. Hamani, et al. 2005 Deep brain stimulation for treatment-resistant depression Neuron 45 651 660 15748841 1:CAS:528:DC%2BD2MXis1yrs7w%3D 10.1016/j.neuron.2005.02.014 (Pubitemid 40320700)
87. D. A. Gusnard E. Akbudak G. L. Shulman M. E. Raichle 2001 Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function Proc. Natl. Acad. Sci. U S A 98 4259 4264 11259662 1:CAS:528:DC%2BD3MXis1Khur0%3D 10.1073/pnas.071043098 (Pubitemid 32249932)
88. W. M. Kelley C. N. Macrae C. L. Wyland S. Caglar S. Inati T. F. Heatherton 2002 Finding the self? An event-related fMRI study J. Cogn. Neurosci. 14 785 794 12167262 1:STN:280:DC%2BD38vhtFymtg%3D%3D 10.1162/08989290260138672 (Pubitemid 34761799)
89. M. Beauregard J. M. Leroux S. Bergman Y. Arzoumanian G. Beaudoin P. Bourgouin, et al. 1998 The functional neuroanatomy of major depression: an fMRI study using an emotional activation paradigm Neuroreport 9 3253 3258 9831460 1:STN:280:DyaK1M%2Fkslemtw%3D%3D 10.1097/00001756-199810050-00022 (Pubitemid 28522345)
90. I. H. Gotlib J. P. Hamilton R. E. Cooney M. K. Singh M. L. Henry J. Joormann 2010 Neural processing of reward and loss in girls at risk for major depression Arch. Gen. Psychiatry 67 380 387 20368513 10.1001/archgenpsychiatry. 2010.13
91. C. H. Fu S. C. Williams A. J. Cleare M. J. Brammer N. D. Walsch J. Kim, et al. 2004 Attenuation of the neural response to sad faces in major depression by antidepressant treatment: a prospective, eventrelated functional magnetic resonance imaging study Arch. Gen. Psychiatry 61 877 889 15351766 10.1001/archpsyc.61.9.877 (Pubitemid 39181077)
92. C. H. Chen K. Ridler J. Suckling S. Williams C. H. Fu E. Merlo-Pich, et al. 2007 Brain imaging correlates of depressive symptom severity and predictors of symptom improvement after antidepressant treatment Biol. Psychiatry 62 407 414 17217921 1:CAS:528:DC%2BD2sXpsFGlsrk%3D 10.1016/j.biopsych.2006.09.018 (Pubitemid 47284016)
93. J. C. Wu J. C. Gillin M. S. Buchsbaum T. Hershey J. C. Johnson W. E. Bunney Jr. 1992 Effect of sleep deprivation on brain metabolism of depressed patients Am. J. Psychiatry 149 538 543 1554042 1:STN:280:DyaK383gs1GgsQ%3D%3D
94. D. Ebert H. Feistel A. Barocka W. Kaschka 1994 Increased limbic blood flow and total sleep deprivation in major depression with melancholia Psychiatry Res. 55 101 109 10711798 1:STN:280:DC%2BD3c7nsV2nsg%3D%3D 10.1016/0925-4927(94) 90004-3 (Pubitemid 24197577)
95. A. L. Brody S. Saxena D. H. Silverman S. Alborzian L. A. Fairbanks M. E. Phelps, et al. 1999 Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine Psychiatry Res. 91 127 139 10641577 1:CAS:528:DyaK1MXnvFylsbs%3D 10.1016/S0925-4927(99)00034-7 (Pubitemid 29474048)
96. J. Wu M. S. Buchsbaum J. C. Gillin C. Tang S. Cadwell M. Wiegand, et al. 1999 Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex Am. J. Psychiatry 156 1149 1158 10450253 1:STN:280:DyaK1MznvVOntQ%3D%3D (Pubitemid 29374872)
97. D. Pizzagalli R. D. Pascual-Marqui J. B. Nitschke T. R. Oakes C. L. Larson H. C. Abercrombie, et al. 2001 Anterior cingulate activity as a predictor of degree of treatment response in major depression: evidence from brain electrical tomography analysis Am. J. Psychiatry 158 405 415 11229981 1:STN:280:DC%2BD3M7pslSksw%3D%3D 10.1176/appi.ajp.158.3.405 (Pubitemid 32205197)
98. R. J. Davidson W. Irwin M. J. Anderle N. H. Kalin 2003 The neural substrates of affective processing in depressed patients treated with venlafaxine Am. J. Psychiatry 160 64 75 12505803 10.1176/appi.ajp.160.1.64 (Pubitemid 36042428)
99. H. S. Mayberg S. K. Brannan R. K. Mahurin P. A. Jerabek J. S. Brickman J. L. Tekell, et al. 1997 Cingulate function in depression: a potential predictor of treatment response Neuroreport 8 1057 1061 9141092 1:STN:280: DyaK2s3osFyktw%3D%3D 10.1097/00001756-199703030-00048 (Pubitemid 27152174)
100. C. Lemogne P. Delaveau M. Freton S. Guionnet P. Fossati 2012 Medial prefrontal cortex and the self in major depression J. Affect. Disord. 136 e1 e11 21185083 10.1016/j.jad.2010.11.034
101. C. Lemogne G. le Bastard H. Mayberg E. Volle L. Bergouignan S. Lehéricy, et al. 2009 In search of the depressive self: extended medial prefrontal network during self-referential processing in major depression Soc. Cogn. Affect. Neurosci. 4 305 312 19307251 10.1093/scan/nsp008
102. F. Raes D. Hermans J. M. Williams K. Demyttenaere B. Sabbe G. Pieters, et al. 2006 Is overgeneral autobiographical memory an isolated memory phenomenon in major depression? Memory 14 584 594 16754243 10.1080/09658210600624614 (Pubitemid 43878734)
103. S. Reppermund H. Brodaty J. D. Crawford N. A. Kochan M. J. Slavin J. N. Trollor, et al. 2011 The relationship of current depressive symptoms and past depression with cognitive impairment and instrumental activities of daily living in an elderly population: The Sydney Memory and Ageing Study J. Psychiatr. Res. 45 1600 1607 21871636 1:STN:280:DC%2BC3Mbms1emsA%3D%3D 10.1016/j.jpsychires. 2011.08.001
104. M. Bellani M. Baiano P. Brambilla 2010 Brain anatomy of major depression - I. Focus on hippocampus Epidemiol. Psichiatr. Soc. 19 298 301 21322503
105. S. Campbell G. Macqueen 2004 The role of the hippocampus in the pathophysiology of major depression J. Psychiatry Neurosci. 29 417 426 15644983 (Pubitemid 40075713)
106. J. Xia J. Chen Y. Zhou J. Zhang B. Yang L. Xia, et al. 2004 Volumetric MRI analysis of the amygdala and hippocampus in subjects with major depression J Huazhong Univ Sci Technolog Med Sci 24 500 502 15641704 10.1007/BF02831120
107. Y. I. Sheline B. L. Mittler M. A. Mintun 2002 The hippocampus and depression Eur. Psychiatry 17 Suppl.3 300 305 15177085 10.1016/S0924-9338(02) 00655-7 (Pubitemid 34839392)
108. Young K. D., Erickson K., Nugent A. C., Fromm S. J., Mallinger A. G., Furey M. L. et al., Functional anatomy of autobiographical memory recall deficits in depression, Psychol. Med., 2011, 1-13
109. D. Hermans H. Vandromme E. Debeer F. Raes K. Demyttenaere E. Brunfaut, et al. 2008 Overgeneral autobiographical memory predicts diagnostic status in depression Behav. Res. Ther. 46 668 677 18342835 10.1016/j.brat.2008.01.018
110. T. Dalgleish J. M. Williams A. M. Golden N. Perkins L. F. Barrett P. J. Barnard, et al. 2007 Reduced specificity of autobiographical memory and depression: the role of executive control J. Exp. Psychol. Gen. 136 23 42 17324083 10.1037/0096-3445.136.1.23
111. J. L. Nandrino L. Pezard A. Posté C. Réveillère D. Beaune 2002 Autobiographical memory in major depression: a comparison between first-episode and recurrent patients Psychopathology 35 335 340 12590191 10.1159/000068591 (Pubitemid 36216632)
112. E. Watkins J. D. Teasdale 2001 Rumination and overgeneral memory in depression: effects of self-focus and analytic thinking J. Abnorm. Psychol. 110 353 357 11358029 1:STN:280:DC%2BD3M3mslegtA%3D%3D 10.1037/0021-843X.110.2.333 (Pubitemid 32423040)
113. J. A. Sumner J. W. Griffith S. Mineka 2010 Overgeneral autobiographical memory as a predictor of the course of depression: a meta-analysis Behav. Res. Ther. 48 614 625 20399418 10.1016/j.brat.2010.03.013
114. Y. I. Sheline 2011 Depression and the hippocampus: cause or effect? Biol. Psychiatry 70 308 309 21791257 10.1016/j.biopsych.2011.06.006
115. M. Desseilles E. Balteau V. Sterpenich T. T. Dang-Vu A. Darsaud G. Vandewalle, et al. 2009 Abnormal neural filtering of irrelevant visual information in depression J. Neurosci. 29 1395 1403 19193886 1:CAS:528:DC%2BD1MXhvFCrurw%3D 10.1523/JNEUROSCI.3341-08.2009
116. C. Mulert G. Juckel M. Brunnmeier S. Karch G. Leicht R. Mergl, et al. 2007 Prediction of treatment response in major depression: integration of concepts J. Affect. Disord. 98 215 225 16996140 1:CAS:528:DC%2BD2sXhtVKhtbk%3D 10.1016/j.jad.2006.07.021 (Pubitemid 46149060)
117. T. W. Schmitz E. De Rosa A. K. Anderson 2009 Opposing influences of affective state valence on visual cortical encoding J. Neurosci. 29 7199 7207 19494142 1:CAS:528:DC%2BD1MXntFGktbw%3D 10.1523/JNEUROSCI.5387-08.2009
118. K. Keenan A. Hipwell X. Feng M. Rischall A. Henneberger S. Klosterman 2010 Lack of assertion, peer victimization, and risk for depression in girls: testing a diathesis-stress model J. Adolesc. Health 47 526 528 20970089 10.1016/j.jadohealth.2010.03.016
119. A. Kercher R. M. Rapee 2009 A test of a cognitive diathesis-stress generation pathway in early adolescent depression J. Abnorm. Child Psychol. 37 845 855 19291388 10.1007/s10802-009-9315-3
120. J. R. Abela D. U. D'Alessandro 2002 Beck's cognitive theory of depression: a test of the diathesis-stress and causal mediation components Br. J. Clin. Psychol. 41 111 128 12034000 10.1348/014466502163912 (Pubitemid 34678693)
121. D. L. Spangler A. D. Simons S. M. Monroe M. E. Thase 1993 Evaluating the hopelessness model of depression: diathesis-stress and symptom components J. Abnorm. Psychol. 102 592 600 8282929 1:STN:280:DyaK2c7htVCktQ%3D%3D 10.1037/0021-843X.102.4.592 (Pubitemid 23333501)
122. I. H. Gotlib J. Joormann K. L. Minor J. Hallmayer 2008 HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression Biol. Psychiatry 63 847 851 18005940 1:CAS:528:DC%2BD1cXksVKrtbc%3D 10.1016/j.biopsych.2007.10.008 (Pubitemid 351458452)
123. J. Miranda J. J. Gross J. B. Persons J. Hahn 1998 Mood matters: negative mood induction activates dysfunctional attitudes in women vulnerable to depression Cognitive Ther. Res. 22 363 376 10.1023/A:1018709212986 (Pubitemid 28425760)
124. J. Miranda J. B. Persons 1988 Dysfunctional attitudes are mood-state dependent J. Abnorm. Psychol. 97 76 79 3351115 1:STN:280:DyaL1c7ntVegug%3D%3D 10.1037/0021-843X.97.1.76
125. S. Hedlund S. S. Rude 1995 Evidence of latent depressive schemas in formerly depressed individuals J. Abnorm. Psychol. 104 517 525 7673575 1:STN:280:DyaK2MvgtlygsA%3D%3D 10.1037/0021-843X.104.3.517
126. L. M. Bylsma B. H. Morris J. Rottenberg 2008 A meta-analysis of emotional reactivity in major depressive disorder Clin. Psychol. Rev. 28 676 691 18006196 10.1016/j.cpr.2007.10.001 (Pubitemid 351374605)
127. F. Peeters J. Berkhof J. Rottenberg N. A. Nicolson 2010 Ambulatory emotional reactivity to negative daily life events predicts remission from major depressive disorder Behav. Res. Ther. 48 754 760 20537317 10.1016/j.brat.2010. 04.008
128. L. M. Bylsma A. Taylor-Clift J. Rottenberg 2011 Emotional reactivity to daily events in major and minor depression J. Abnorm. Psychol. 120 155 167 21319928 10.1037/a0021662
129. R. J. Thompson H. Berenbaum K. Bredemeier 2011 Cross-sectional and longitudinal relations between affective instability and depression J. Affect. Disord. 130 53 59 20951438 10.1016/j.jad.2010.09.021
130. C. Kuehner K. Liebsch S. Huffziger 2009 Research letter: emotional reactivity to induced rumination predicts 1-year levels of depressive symptoms Psychol. Med. 39 1226 1228 19368746 10.1017/S0033291709005704
131. A. M. Charbonneau A. H. Mezulis J. S. Hyde 2009 Stress and emotional reactivity as explanations for gender differences in adolescents' depressive symptoms J. Youth Adolesc. 38 1050 1058 19636770 10.1007/s10964-009-9398-8
132. C. D. Scher R. E. Ingram Z. V. Segal 2005 Cognitive reactivity and vulnerability: empirical evaluation of construct activation and cognitive diatheses in unipolar depression Clin. Psychol. Rev. 25 487 510 15914266 10.1016/j.cpr.2005.01.005 (Pubitemid 40725816)
133. R. Lethbridge N. B. Allen 2008 Mood induced cognitive and emotional reactivity, life stress, and the prediction of depressive relapse Behav. Res. Ther. 46 1142 1150 18707676 10.1016/j.brat.2008.06.011
134. I. H. Gotlib J. Joormann 2010 Cognition and depression: current status and future directions Annu. Rev. Clin. Psychol. 6 285 312 20192795 10.1146/annurev.clinpsy.121208.131305
135. W. Ramel P. R. Goldin L. T. Eyler G. G. Brown I. H. Gotlib J. R. McQuaid 2007 Amygdala reactivity and mood-congruent memory in individuals at risk for depressive relapse Biol. Psychiatry 61 231 239 16950223 10.1016/j.biopsych.2006. 05.004 (Pubitemid 46072786)
136. B. L. Fredrickson R. W. Levenson 1998 Positive emotions speed recovery from the cardiovascular sequelae of negative emotions Cogn. Emot. 12 191 220 21852890 10.1080/026999398379718 (Pubitemid 128467184)
137. B. R. McFarland D. N. Klein 2009 Emotional reactivity in depression: diminished responsiveness to anticipated reward but not to anticipated punishment or to nonreward or avoidance Depress. Anxiety 26 117 122 18972567 10.1002/da.20513
138. J. D. Teasdale Z. Segal J. M. Williams 1995 How does cognitive therapy prevent depressive relapse and why should attentional control (mindfulness) training help? Behav. Res. Ther. 33 25 39 7872934 1:STN:280:DyaK2M7nslyjug%3D%3D 10.1016/0005-7967(94)E0011-7
139. J. D. Teasdale R. G. Moore H. Hayhurst M. Pope S. Williams Z. V. Segal 2002 Metacognitive awareness and prevention of relapse in depression: empirical evidence J. Consult. Clin. Psychol. 70 275 287 11952186 10.1037/0022-006X.70.2. 275 (Pubitemid 34274872)
140. I. M. Anderson C. Shippen G. Juhasz D. Chase E. Thomas D. Downey, et al. 2011 State-dependent alteration in face emotion recognition in depression Br. J. Psychiatry 198 302 308 21263011 10.1192/bjp.bp.110.078139
141. D. L. Santesso K. T. Steele R. Bogdan A. J. Holmes C. M. Deveney T. M. Meites, et al. 2008 Enhanced negative feedback responses in remitted depression Neuroreport 19 1045 1048 18580576 1:CAS:528:DC%2BD1cXns1Olt7o%3D 10.1097/WNR.0b013e3283036e73
142. J. M. Williams D. Healy J. D. Teasdale W. White E. S. Paykel 1990 Dysfunctional attitudes and vulnerability to persistent depression Psychol. Med. 20 375 381 2356263 1:STN:280:DyaK3c3ovVShsQ%3D%3D 10.1017/S0033291700017694 (Pubitemid 20169848)
143. J. D. Teasdale J. Dent 1987 Cognitive vulnerability to depression: an investigation of two hypotheses Br. J. Clin. Psychol. 26 113 126 3580646 10.1111/j.2044-8260.1987.tb00737.x
144. M. L. Moulds E. Kandris A. D. Williams T. Lang C. Yap K. Hoffmeister 2008 An investigation of the relationship between cognitive reactivity and rumination Behav. Ther. 39 65 71 18328871 10.1016/j.beth.2007.05.001 (Pubitemid 351323796)
145. Z. V. Segal S. Kennedy M. Gemar K. Hood R. Pedersen T. Buis 2006 Cognitive reactivity to sad mood provocation and the prediction of depressive relapse Arch. Gen. Psychiatry 63 749 755 16818864 10.1001/archpsyc.63.7.749
146. T. Barnhofer T. Chittka 2010 Cognitive reactivity mediates the relationship between neuroticism and depression Behav. Res. Ther. 48 275 281 20070952 10.1016/j.brat.2009.12.005
147. C. Firk C. R. Markus 2009 Mood and cortisol responses following tryptophan-rich hydrolyzed protein and acute stress in healthy subjects with high and low cognitive reactivity to depression Clin. Nutr. 28 266 271 19345451 1:CAS:528:DC%2BD1MXntVKgtLg%3D 10.1016/j.clnu.2009.03.002
148. Z. V. Segal L. Bizzini G. Bondolfi 2005 Cognitive behaviour therapy reduces long term risk of relapse in recurrent major depressive disorder Evid. Based Ment. Health 8 38 15851801 10.1136/ebmh.8.2.38
149. Z. V. Segal P. Bieling T. Young G. MacQueen R. Cooke L. Martin, et al. 2010 Antidepressant monotherapy vs sequential pharmacotherapy and mindfulness-based cognitive therapy, or placebo, for relapse prophylaxis in recurrent depression Arch. Gen. Psychiatry 67 1256 1264 21135325 10.1001/archgenpsychiatry.2010.168
150. G. Bondolfi F. Jermann M. V. der Linden M. Gex-Fabry L. Bizzini B. W. Rouget, et al. 2010 Depression relapse prophylaxis with Mindfulness-Based Cognitive Therapy: replication and extension in the Swiss health care system J. Affect. Disord. 122 224 231 19666195 10.1016/j.jad.2009.07.007
151. J. D. Teasdale Z. V. Segal J. M. Williams V. A. Rigdeway J. M. Soulsby M. A. Lau 2000 Prevention of relapse/recurrence in major depression by mindfulness-based cognitive therapy J. Consult. Clin. Psychol. 68 615 623 10965637 1:STN:280:DC%2BD3cvlvVOksA%3D%3D 10.1037/0022-006X.68.4.615
152. F. Raes D. Dewulf C. Van Heeringen J. M. Williams 2009 Mindfulness and reduced cognitive reactivity to sad mood: evidence from a correlational study and a non-randomized waiting list controlled study Behav. Res. Ther. 47 623 627 19362705 10.1016/j.brat.2009.03.007
153. D. M. Fresco Z. V. Segal T. Buis S. Kennedy 2007 Relationship of posttreatment decentering and cognitive reactivity to relapse in major depression J. Consult. Clin. Psychol. 75 447 55 17563161 10.1037/0022-006X.75.3. 447 (Pubitemid 47444748)
154. M. Koenigs J. Grafman 2009 The functional neuroanatomy of depression: distinct roles for ventromedial and dorsolateral prefrontal cortex Behav. Brain Res. 201 239 243 19428640 10.1016/j.bbr.2009.03.004
155. I. H. Gotlib P. J. Hamilton 2008 Neuroimaging and Depression: Current Status and Unresolved Issues Curr. Dir. Psychol. Sci. 17 159 163 10.1111/j.1467-8721.2008.00567.x
156. C. Lemogne H. Mayberg L. Bergouignan E. Volle P. Delaveau S. Lehéricy, et al. 2010 Self-referential processing and the prefrontal cortex over the course of depression: a pilot study J. Affect. Disord. 124 196 201 19945172 10.1016/j.jad.2009.11.003
157. M. Ritchey F. Dolcos K. M. Eddington T. J. Strauman R. Cabeza 2011 Neural correlates of emotional processing in depression: changes with cognitive behavioral therapy and predictors of treatment response J. Psychiatr. Res. 45 577 587 20934190 10.1016/j.jpsychires.2010.09.007
158. T. F. Denson W. C. Pedersen J. Ronquillo A. S. Nandy 2009 The angry brain: neural correlates of anger, angry rumination, and aggressive personality J. Cogn. Neurosci. 21 734 744 18578600 10.1162/jocn.2009.21051
159. J. D. Coie N. F. Watt S. G. West J. D. Hawkins J. R. Asarnow H. J. Markman, et al. 1993 The science of prevention. A conceptual framework and some directions for a national research program Am. Psychol. 48 1013 1022 8256874 1:STN:280:DyaK2c%2FnvFSltQ%3D%3D 10.1037/0003-066X.48.10.1013
160. A. F. Marquand J. Mourão-Miranda M. J. Brammer A. J. Cleare C. H. Fu 2008 Neuroanatomy of verbal working memory as a diagnostic biomarker for depression Neuroreport 19 1507 1511 18797307 10.1097/WNR.0b013e328310425e
161. C. H. Fu J. Mourão-Miranda S. G. Costafreda A. Khanna A. F. Marquand S. C. Williams, et al. 2008 Pattern classification of sad facial processing: toward the development of neurobiological markers in depression Biol. Psychiatry 63 656 662 17949689 10.1016/j.biopsych.2007.08.020 (Pubitemid 351329278)
162. I. A. Cook A. M. Hunter M. Abrams B. Siegman A. F. Leuchter 2009 Midline and right frontal brain function as a physiologic biomarker of remission in major depression Psychiatry Res. 174 152 157 19853417 10.1016/j.pscychresns. 2009.04.011
163. M. Ising S. Horstmann S. Kloiber S. Lucae E. B. Binder N. Kern, et al. 2007 Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker? Biol. Psychiatry 62 47 54 17123470 1:CAS:528:DC%2BD2sXmsFKrurw%3D 10.1016/j.biopsych.2006.07.039 (Pubitemid 46898222)
164. T. M. Buckley A. F. Schatzberg 2010 A pilot study of the phase angle between cortisol and melatonin in major depression - a potential biomarker? J. Psychiatr. Res. 44 69 74 20004915 10.1016/j.jpsychires.2009.06.012
165. M. Fuchikami S. Morinobu M. Segawa Y. Okamoto S. Yamawaki N. Ozaki, et al. 2011 DNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression PLoS One 6 e23881 21912609 1:CAS:528:DC%2BC3MXht1WrtrfJ 10.1371/journal.pone.0023881
166. V. Peralta M. J. Cuesta 1998 Lack of insight in mood disorders J. Affect. Disord. 49 55 58 9574860 1:STN:280:DyaK1c3jsVWmug%3D%3D 10.1016/S0165-0327(97) 00198-5 (Pubitemid 28139097)
167. K. N. Ochsner B. Hughes E. R. Robertson J. C. Cooper J. D. Gabrieli 2009 Neural systems supporting the control of affective and cognitive conflicts J. Cogn. Neurosci. 21 1842 1855 18823233 10.1162/jocn.2009.21129
168. R. M. Piech J. Lewis C. H. Parkinson A. M. Owen A. C. Roberts P. E. Downing, et al. 2010 Neural correlates of affective influence on choice Brain Cogn. 72 282 288 19857920 10.1016/j.bandc.2009.09.012
169. D. A. Pizzagalli 2011 Frontocingulate dysfunction in depression: toward biomarkers of treatment response Neuropsychopharmacology 36 183 206 20861828 10.1038/npp.2010.166