A pilot study of the phase angle between cortisol and melatonin in major depression - A potential biomarker?

Journal of Psychiatric Research

Volumn 44, Issue 2, 2010, Pages 69-74

  Buckley, Theresa M ^a,b   Schatzberg, Alan F ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b High Desert Sleep Center   (United States)

Author keywords

Biomarker; Cortisol; Depression; Melatonin; Phase angle

Indexed keywords

BIOLOGICAL MARKER; HYDROCORTISONE; MELATONIN;

ADULT; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; DEMOGRAPHY; FEMALE; HORMONE DETERMINATION; HOSPITAL ADMISSION; HUMAN; HYDROCORTISONE BLOOD LEVEL; MAJOR DEPRESSION; MALE; PATHOPHYSIOLOGY; PILOT STUDY; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY;

ADULT; CIRCADIAN RHYTHM; CROSS-SECTIONAL STUDIES; DEPRESSIVE DISORDER, MAJOR; FEMALE; HUMANS; HYDROCORTISONE; MALE; MELATONIN; MIDDLE AGED; PILOT PROJECTS; ROC CURVE; TIME FACTORS; YOUNG ADULT;

EID: 73749086978     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2009.06.012     Document Type: Article

References (35)

1. Barden N., Shink E., Labbe M., Vacher R., Rochford J., and Mocaer E. Antidepressant action of agomelatine (S 20098) in a transgenic mouse model. Progress in Neuropsychopharmacology and Biologial Psychiatry 29 (2005) 908-916
2. Barth J., Schumacher M., and Herrmann-Lingen C. Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosomatic Medicine 66 (2004) 802-813
3. Beck-Friis J., Kjellman B.F., Aperia B., Unden F., von Rosen D., Ljunggren J.G., and Wetterberg L. Serum melatonin in relation to clinical variables in patients with major depressive disorder and a hypothesis of a low melatonin syndrome. Acta Psychiatrica Scandinavica 71 (1985) 319-330
4. Beck-Friis J., Ljunggren J.G., Thoren M., von Rosen D., Kjellman B.F., and Wetterberg L. Melatonin, cortisol and ACTH in patients with major depressive disorder and healthy humans with special reference to the outcome of the dexamethasone suppression test. Psychoneuroendocrinology 10 (1985) 173-186
5. Brown R.P., Kocsis J.H., Caroff S., Amsterdam J., Winokur A., Stokes P., et al. Depressed mood and reality disturbance correlate with decreased nocturnal melatonin in depressed patients. Acta Psychiatrica Scandinavica 76 (1987) 272-275
6. Buckley T.M., and Schatzberg A.F. On the interactions of the hypothalamic-pituitary-adrenal (HPA) axis and sleep: normal HPA axis activity and circadian rhythm, exemplary sleep disorders. Journal of Clinical Endocrinology and Metabolism 90 (2005) 3106-3114
7. Buckley T.M., Mullen B.C., and Schatzberg A.F. The acute effects of a mineralocorticoid receptor (MR) agonist on nocturnal hypothalamic-adrenal-pituitary (HPA) axis activity in healthy controls. Psychoneuroendocrinology 32 (2007) 859-864
8. Buijs R.M., Wortel J., Van Heerikhuize J.J., Feenstra M.G., Ter Horst G.J., Romijn H.J., et al. Anatomical and functional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway. European Journal of Neuroscience 11 (1999) 1535-1544
9. Caufriez A., Moreno-Reyes R., Leproult R., Vertongen F., Van Cauter E., and Copinschi G. Immediate effects of an 8-h advance shift of the rest-activity cycle on 24-h profiles of cortisol. American Journal of Physiology - Endocrinology and Metabolism 282 (2002) E1147-E1153
10. Claustrat B., Brun J., and Chazot G. The basic physiology and pathophysiology of melatonin. Sleep Medicine Reviews 9 (2005) 11-24
11. den Boer J.A., Bosker F.J., and Meesters Y. Clinical efficacy of agomelatine in depression: the evidence. International Clinical Psychopharmacology 21 Suppl. 1 (2006) S21-S24
12. Farmer A., Korszun A., Owen M.J., Craddock N., Jones L., Jones I., et al. Medical disorders in people with recurrent depression. British Journal of Psychiatry 192 (2008) 351-355
13. Jarrett D.B., Coble P.A., and Kupfer D.J. Reduced cortisol latency in depressive illness. Archives of General Psychiatry 40 (1983) 506-511
14. Kalsbeek A., Buijs R.M., van Heerikhuize J.J., Arts M., and van der Woude T.P. Vasopressin-containing neurons of the suprachiasmatic nuclei inhibit corticosterone release. Brain Research 580 (1992) 62-67
15. Lewy A.J., Cutler N.L., and Sack R.L. The endogenous melatonin profile as a marker for circadian phase position. Journal of Biological Rhythms 14 (1999) 227-236
16. Lewy A.J., Lefler B.J., Emens J.S., and Bauer V.K. The circadian basis of winter depression. The Proceedings of the National Academy of Sciences USA 103 (2006) 7414-7419
17. Lewy A.J., Rough J.N., Songer J.B., Mishra N., Yuhas K., and Emens J.S. The phase shift hypothesis for the circadian component of winter depression. Dialogues of Clinical Neuroscience 9 (2007) 291-300
18. Modai I., Malmgren R., Wetterberg L., Eneroth P., Valevski A., and Asberg M. Blood levels of melatonin, serotonin, cortisol, and prolactin in relation to the circadian rhythm of platelet serotonin uptake. Psychiatry Research 43 (1992) 161-166
19. Musselman D.L., Betan E., Larsen H., and Phillips L.S. Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment. Biological Psychiatry 54 (2003) 317-329
20. Presman D.M., Hoijman E., Ceballos N.R., Galigniana M.D., and Pecci A. Melatonin inhibits glucocorticoid receptor nuclear translocation in mouse thymocytes. Endocrinology 147 (2006) 5452-5459
21. Reghunandanan V., Reghunandanan R., and Marya R.K. Vasopressin: its possible role in circadian time keeping. Chronobiologia 18 (1991) 39-47
22. Rouillon F. Efficacy and tolerance profile of agomelatine and practical use in depressed patients. International Clinical Psychopharmacology 21 Suppl. 1 (2006) S31-S35
23. Rubin R.T., Heist E.K., McGeoy S.S., Hanada K., and Lesser I.M. Neuroendocrine aspects of primary endogenous depression. XI. Serum melatonin measures in patients and matched control subjects. Archives of General Psychiatry 49 (1992) 558-567
24. Schatzberg A.F., and Rothschild A.J. Psychotic (delusional) major depression: should it be included as a distinct syndrome in DSM-IV?. American Journal of Psychiatry 149 (1992) 733-745
25. Schatzberg A.F., Rothschild A.J., Stahl J.B., Bond T.C., Rosenbaum A.H., Lofgren S.B., et al. The dexamethasone suppression test: identification of subtypes of depression. American Journal of Psychiatry 140 (1983) 88-91
26. Spencer R.L., Kim P.J., Kalman B.A., and Cole M.A. Evidence for mineralocorticoid receptor facilitation of glucocorticoid receptor-dependent regulation of hypothalamic-pituitary-adrenal axis activity. Endocrinology 139 (1998) 2718-2726
27. van Coevorden A., Mockel J., Laurent E., Kerkhofs M., L'Hermite-Baleriaux M., Decoster C., et al. Neuroendocrine rhythms and sleep in aging men. American Journal of Physiology 260 (1991) E651-E661
28. Voderholzer U., Laakmann G., Becker U., Haag C., Baghai T., Riemann D., et al. Circadian profiles of melatonin in melancholic depressed patients and healthy subjects in relation to cortisol secretion and sleep. Psychiatry Research 71 (1997) 151-161
29. Wehr T.A., Aeschbach D., and Duncan Jr. W.C. Evidence for a biological dawn and dusk in the human circadian timing system. Journal of Physiology 535 (2001) 937-951
30. Wetterberg L. Melatonin and affective disorders. Ciba Foundation Symposium 117 (1985) 253-265
31. Wetterberg, L., Aperia, B., Beck-Friis, J., Kjellman, B. F., Ljunggren, J. G., Nilsonne, A., Petterson, U., Tham, A., & Unden, F. (1982). Melatonin and cortisol levels in psychiatric illness. Lancet 2, 100.
32. Wetterberg L., Beck-Friis J., Kjellman B.F., and Ljunggren J.G. Circadian rhythms in melatonin and cortisol secretion in depression. Advances in Biochemical Psychopharmacology 39 (1984) 197-205
33. Wiedemann K., Lauer C., Loycke A., Pollmacher T., Durst P., Macher J.P., et al. Antiglucocorticoid treatment disrupts endocrine cycle and nocturnal sleep pattern. European Archives of Psychiatry and Clinical Neuroscience 241 (1992) 372-375
34. Wright Jr. K.P., Hughes R.J., Kronauer R.E., Dijk D.J., and Czeisler C.A. Intrinsic near-24-h pacemaker period determines limits of circadian entrainment to a weak synchronizer in humans. Proceedings of the National Academy of Sciences USA 98 (2001) 14027-14032
35. Wurtman R.J., Altschule M.D., and Holmgren U. Effects of pinealectomy and of a bovine pineal extract in rats. American Journal of Physiology 197 (1959) 108-110