In vitro intestinal absorption and first-pass intestinal and hepatic metabolism of cycloastragenol, a potent small molecule telomerase activator

Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 5, 2010, Pages 477-486

  Zhu, Jing ^a   Lee, Stephanie ^a   Ho, Maurice K C ^a   Hu, Yueqing ^a   Pang, Haihong ^a   Ip, Fanny C F ^a   Chin, Allison C ^a   Harley, Calvin B ^a   Ip, Nancy Y ^a   Wong, Yung H ^a  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

Author keywords

Absorption; Caco 2 cells; Cycloastragenol; Liver microsomes; Metabolism; TAT2

Indexed keywords

ASTRAGALOSIDE IV; CYCLOASTRAGENOL; CYCLOSPORIN A; QUINIDINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG METABOLISM; DRUG PENETRATION; DRUG TRANSFORMATION; FIRST PASS EFFECT; HUMAN; HUMAN CELL; HYDROXYLATION; INTESTINE ABSORPTION; INTESTINE EPITHELIUM; LIVER METABOLISM; LIVER MICROSOME; NONHUMAN; OXIDATION; RAT;

EID: 78449260398     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.DMPK-10-RG-037     Document Type: Article

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