Synthesis and evaluation of the antifungal activity of 2-(substituted-amino)-4,5-dialkyl-thiophene-3-carbonitrile derivatives

Latin American Journal of Pharmacy

Volumn 30, Issue 8, 2011, Pages 1492-1499

  Mendonça, Francisco J B ^a   Lima Neto, Reginaldo G ^b   de Oliveira, Tiago B ^b   de Lima, Mariado C A ^b   Pitta, Ivan R ^b   Galdino, Suely L ^b   da Cruz, Rayssa M D ^a   de Araújo, Rodrigo S A ^a   Neves, Rejane P ^b  

^a STATE UNIVERSITY OF PARAÍBA   (Brazil)

^b FEDERAL UNIVERSITY OF PERNAMBUCO   (Brazil)

Author keywords

Antifungal activity; Candida; Criptococcus neoformans; Gewald reaction; Minimal fungicidal concentration; Thiophene derivatives

Indexed keywords

2 [(1H INDOL 2 YLMETHYLIDENE)AMINO] 5 METHYL THIOPHENE 3 CARBONITRILE; 2 [(2 NITROBENZYLIDENE)AMINO] 5 METHYL THIOPHENE 3 CARBONITRILE; 2 [(4 BENZYLOXIBENZYLIDENE)AMINO] 5 METHYL THIOPHENE 3 CARBONITRILE; 2 [(4 BROMOBENZYLIDENE)AMINO] 4,5,6,7 TETRAHYDRO 4H BENZO[B]THIOPHENE 3 CARBONITRILE; 2 [(4 BROMOBENZYLIDENE)AMINO] 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHENE 3 CARBONITRILE; 2 [(4 CHLOROBENZYLIDENE)AMINO] 4,5,6,7 TETRAHYDRO 4H BENZO[B]THIOPHENE 3 CARBONITRILE; 2 [(4 CHLOROBENZYLIDENE)AMINO] 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHENE 3 CARBONITRILE; 2 [(4 CHLOROBENZYLIDENE)AMINO] 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBONITRILE; 2 [(4 DIMETHYLAMINOBENZYLIDENE)AMINO] 5 METHYL THIOPHENE 3 CARBONITRILE; 2 [(4 FLUOROBENZYLIDENE)AMINO] 5 METHYL THIOPHENE 3 CARBONITRILE; 2 [(4 METHOXYBENZYLIDENE)AMINO] 5 METHYL THIOPHENE 3 CARBONITRILE; 2 [(4 NITROBENZYLIDENE)AMINO] 4,5,6,7 TETRAHYDRO 4H BENZO[B]THIOPHENE 3 CARBONITRILE; 2 [(4 NITROBENZYLIDENE)AMINO] 5 METHYL THIOPHENE 3 CARBONITRILE; 2 [(BENZYLIDENE)AMINO] 5,6 DIHYDRO 4H CYCLOPENTA[B]THIOPHENE 3 CARBONITRILE; 2 [(BENZYLIDENE)AMINO] 5,6,7,8 TETRAHYDRO 4H CYCLOHEPTA[B]THIOPHENE 3 CARBONITRILE; AMPHOTERICIN B; ANTIFUNGAL AGENT; FLUCONAZOLE; THIOPHENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; CANDIDA ALBICANS; CANDIDA KRUSEI; CANDIDA PARAPSILOSIS; CANDIDA TROPICALIS; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; DRUG SCREENING; DRUG SYNTHESIS; FUNGAL STRAIN; FUNGICIDAL ACTIVITY; FUNGUS ISOLATION; IN VITRO STUDY; MINIMAL FUNGICIDAL CONCENTRATION; NONHUMAN; PHARMACOLOGICAL PARAMETERS; STRUCTURE ACTIVITY RELATION;

EID: 84856259133     PISSN: 03262383     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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