Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b] thiophenes

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 10, 2005, Pages 2617-2620

  Ryu, Chung Kyu ^a   Lee, Su Kyung ^a   Han, Ja Young ^a   Jung, Ok Jai ^a   Lee, Jung Yoon ^a   Jeong, Seong Hee ^a  

^a Ewha Womans University   (South Korea)

Author keywords

4,7 Dioxobenzo b thiophene; Antifungal; Antimicrobial compounds; Fungi; Substitution effects

Indexed keywords

ANTIFUNGAL AGENT; FLUCYTOSINE; THIOPHENE DERIVATIVE;

ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS; CANDIDA; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG SYNTHESIS; IN VITRO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE;

ASPERGILLUS; CANDIDA; FUNGI;

EID: 18144371186     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.03.042     Document Type: Article

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10. 3 with TMS. High-resolution mass spectra (HRMS EI) were taken with Jeol JMS AX505 WA. 2,5-Dimethoxybenzaldehyde and other reagents were purchased from Aldrich Chemical Co
11. 3S: 224.0507. Found: 224.0508
12. 3S: 194.0038. Found: 194.00377
13. 3S: 261.9258. Found: 261.9259
14. 3/EtOAc or crystallized from EtOH afforded 5-arylamino-4,7-dioxobenzo[b]thiophenes 3-5 or 6, respectively
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