A duplicated nitrotienyl derivative with antimycobacterial activity: synthesis, X-ray crystallography, biological and mutagenic activity tests

European Journal of Medicinal Chemistry

Volumn 41, Issue 10, 2006, Pages 1196-1200

  Rando, D G ^a   Doriguetto, A C ^b   Tomich de Paula da Silva, C H ^a   Ellena, J ^a   Sato, D N ^c   Leite, C Q F ^d   Varanda, E A ^d   Ferreira, E I ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF ALFENAS   (Brazil)

^c INSTITUTO ADOLFO LUTZ   (Brazil)

^d SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Antimycobacterial activity; Mutagenicity; Nitrotienyl derivative; Potential antimycobacterial agent; X ray structure determination

Indexed keywords

5,5' DINITRO 2 [2,3 DIAZA 4 (2' TIENYL)BUTA 1,3 DIENYL]TIOPHENE; ANTIMYCOBACTERIAL AGENT; ISONIAZID; NITRO DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; MINIMUM INHIBITORY CONCENTRATION; MUTAGENIC ACTIVITY; MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; NONHUMAN; X RAY CRYSTALLOGRAPHY;

ANTITUBERCULAR AGENTS; CRYSTALLOGRAPHY, X-RAY; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM AVIUM; MYCOBACTERIUM KANSASII; NITRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; THIOPHENES;

EID: 33749681683     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2006.04.009     Document Type: Article

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