-
1
-
-
0031903015
-
Downstream signalling events regulated by phosphatidylinositol 3-kinase activity
-
DOI 10.1016/S0898-6568(97)00129-0, PII S0898656897001290
-
Duronio V, Scheid MP and Ettinger S: Downstream signaling events regulated by phosphatidylinositol 3-kinase activity. Cell Signal 10: 233-239, 1998. (Pubitemid 28205901)
-
(1998)
Cellular Signalling
, vol.10
, Issue.4
, pp. 233-239
-
-
Duronio, V.1
Scheid, M.P.2
Ettinger, S.3
-
2
-
-
0032881288
-
AKT/PKB and other D3 phosphoinositide-regulated kinases: Kinase activation by phosphoinositide-dependent phosphorylation
-
DOI 10.1146/annurev.biochem.68.1.965
-
Chan TO, Rittenhouse SE and Tsichlis PN: AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 68: 965-1014, 1999. (Pubitemid 29449213)
-
(1999)
Annual Review of Biochemistry
, vol.68
, pp. 965-1014
-
-
Chan, T.O.1
Rittenhouse, S.E.2
Tsichlis, P.N.3
-
3
-
-
0034652392
-
Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells
-
DOI 10.1073/pnas.040560897
-
Jiang BH, Zheng JZ, Aoki M and Vogt PK: Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc Natl Acad Sci USA 97: 1749-1753, 2000. (Pubitemid 30118514)
-
(2000)
Proceedings of the National Academy of Sciences of the United States of America
, vol.97
, Issue.4
, pp. 1749-1753
-
-
Jiang, B.-H.1
Zheng, J.Z.2
Aoki, M.3
Vogt, P.K.4
-
4
-
-
1642471831
-
PI3K/Akt and apoptosis: Size matters
-
DOI 10.1038/sj.onc.1207115, Apoptosis - Part 2
-
Franke TF, Hornik CP, Segev L, Shostak GA and Sugimoto C: PI3K/Akt and apoptosis: size matters. Oncogene 22: 8983-8998, 2003. (Pubitemid 38121699)
-
(2003)
Oncogene
, vol.22
, Issue.56 REV. ISS. 8
, pp. 8983-8998
-
-
Franke, T.F.1
Hornik, C.P.2
Segev, L.3
Shostak, G.A.4
Sugimoto, C.5
-
6
-
-
27844432603
-
AKT signaling in normal and malignant cells
-
DOI 10.1038/sj.onc.1209100, PII 1209100
-
Testa JR and Tsichlis PN: Akt signaling in normal and malignant cells. Oncogene 24: 7391-7393, 2005. (Pubitemid 41637978)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7391-7393
-
-
Testa, J.R.1
Tsichlis, P.N.2
-
7
-
-
39049094092
-
Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery
-
DOI 10.2174/156800908783497159
-
Cheng GZ, Park S, Shu S, et al: Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery. Curr Cancer Drug Targets 8: 2-6, 2008. (Pubitemid 351237904)
-
(2008)
Current Cancer Drug Targets
, vol.8
, Issue.1
, pp. 2-6
-
-
Cheng, G.Z.1
Park, S.2
Shu, S.3
He, L.4
Kong, W.5
Zhang, W.6
Yuan, Z.7
Wang, L.-H.8
Cheng, J.Q.9
-
8
-
-
0036632368
-
The phosphatidylinositol 3-kinase-AKT pathway in human cancer
-
Vivanco I and Sawyers CL: The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat Rev Cancer 2: 489-501, 2002. (Pubitemid 37328931)
-
(2002)
Nature Reviews Cancer
, vol.2
, Issue.7
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
10
-
-
0035990924
-
Inhibition of protein kinase B/Akt: Implications for cancer therapy
-
DOI 10.1016/S0163-7258(02)00193-6, PII S0163725802001936
-
Hill MM and Hemmings B: Inhibition of protein kinase B/Akt. Implications for cancer therapy. Pharmacol Ther 93: 243-251, 2002. (Pubitemid 34615565)
-
(2002)
Pharmacology and Therapeutics
, vol.93
, Issue.2-3
, pp. 243-251
-
-
Hill, M.M.1
Hemmings, B.A.2
-
11
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
DOI 10.1016/S0898-6568(01)00271-6, PII S0898656801002716
-
Nicholson KM and Anderson NG: The protein kinase B/Akt signaling pathway in human malignancy. Cell Signal 14: 381-395, 2002. (Pubitemid 34214843)
-
(2002)
Cellular Signalling
, vol.14
, Issue.5
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
13
-
-
13844273087
-
PI3K-Akt pathway: Its functions and alterations in human cancer
-
DOI 10.1023/B:APPT.0000045801.15585.dd
-
Osaki M, Oshimura M and Ito H: PI3K-Akt pathway: Its functions and alterations in human cancer. Apoptosis 9: 667-676, 2004. (Pubitemid 40941196)
-
(2004)
Apoptosis
, vol.9
, Issue.6
, pp. 667-676
-
-
Osaki, M.1
Oshimura, M.2
Ito, H.3
-
14
-
-
32044466838
-
Exploiting the PI3K/AKT pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, Lu Y and Mills GB: Exploiting the PI3K/AKT pathway for cancer drug discovery. Nat Rev Drug Discov 4: 988-1004, 2005.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
Lu, Y.4
Mills, G.B.5
-
15
-
-
27844445642
-
Perturbations of the AKT signaling pathway in human cancer
-
DOI 10.1038/sj.onc.1209085, PII 1209085
-
Altomare DA and Testa JR: Perturbations of the AKT signaling pathway in human cancer. Oncogene 24: 7455-7464, 2005. (Pubitemid 41637985)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7455-7464
-
-
Altomare, D.A.1
Testa, J.R.2
-
16
-
-
39049151617
-
Deregulation of the akt pathway in human cancer
-
DOI 10.2174/156800908783497140
-
Tokunaga E, Oki E, Egashira A, Sadanaga N, Morita M, Kakeji Y and Maehara Y: Deregulation of the Akt pathway in human cancer. Curr Cancer Drug Targets 8: 27-36, 2008. (Pubitemid 351237907)
-
(2008)
Current Cancer Drug Targets
, vol.8
, Issue.1
, pp. 27-36
-
-
Tokunaga, E.1
Oki, E.2
Egashira, A.3
Sadanaga, N.4
Morita, M.5
Kakeji, Y.6
Maehara, Y.7
-
17
-
-
27844553839
-
AKT crystal structure and AKT-specific inhibitors
-
DOI 10.1038/sj.onc.1209087, PII 1209087
-
Kumar CC and Madison V: AKT crystal structure and AKT-specific inhibitors. Oncogene 24: 7493-7501, 2005. (Pubitemid 41637989)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7493-7501
-
-
Kumar, C.C.1
Madison, V.2
-
18
-
-
27844598284
-
The Akt/PKB pathway: Molecular target for cancer drug discovery
-
DOI 10.1038/sj.onc.1209088, PII 1209088
-
Cheng JQ, Lindsley CW, Cheng GZ, Yang H and Nicosia SV: The Akt/PKB pathway: molecular target for cancer drug discovery. Oncogene 24: 7482-7492, 2005. (Pubitemid 41637988)
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7482-7492
-
-
Cheng, J.Q.1
Lindsley, C.W.2
Cheng, G.Z.3
Yang, H.4
Nicosia, S.V.5
-
19
-
-
33645287685
-
Akt/PKB signaling in cancer: A function in cell motility and invasion
-
Yoeli-Lerner M and Toker A: Akt/PKB signaling in cancer: a function in cell motility and invasion. Cell Cycle 5: 603-605, 2006.
-
(2006)
Cell Cycle
, vol.5
, pp. 603-605
-
-
Yoeli-Lerner, M.1
Toker, A.2
-
20
-
-
27744534653
-
Inhibition of P13K/Akt signaling: An emerging paradigm for targeted cancer therapy
-
Chen YL, Law PY and Loh HH: Inhibition of PI3K/Akt signaling: an emerging paradigm for targeted cancer therapy. Curr Med Chem Anticancer Agents 5: 575-589, 2005. (Pubitemid 41601056)
-
(2005)
Current Medicinal Chemistry - Anti-Cancer Agents
, vol.5
, Issue.6
, pp. 575-589
-
-
Chen, Y.L.1
Law, P.-Y.2
Loh, H.H.3
-
22
-
-
35349005202
-
Recent progress in the discovery of Akt inhibitor as anticancer agents
-
Li, Q: Recent progress in the discovery of Akt inhibitor as anticancer agents. Expert opin ther patents 17: 1077-1130, 2007.
-
(2007)
Expert Opin Ther Patents
, vol.17
, pp. 1077-1130
-
-
Li, Q.1
-
24
-
-
44149105620
-
Antiproliferative effect of Scutellaria barbata D. Don. on cultured human uterine leiomyoma cells by down-regulation of the expression of Bcl-2 protein
-
Kim KW, Jin UH, Kim DI, et al: Antiproliferative effect of Scutellaria barbata D. Don. on cultured human uterine leiomyoma cells by down-regulation of the expression of Bcl-2 protein. Phytother Res 22: 583-590, 2008.
-
(2008)
Phytother Res
, vol.22
, pp. 583-590
-
-
Kim, K.W.1
Jin, U.H.2
Kim, D.I.3
-
25
-
-
33846998658
-
Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer
-
Suh SJ, Yoon JW, Lee TK, et al: Chemoprevention of Scutellaria bardata on human cancer cells and tumorigenesis in skin cancer. Phytother Res 21: 135-141, 2007.
-
(2007)
Phytother Res
, vol.21
, pp. 135-141
-
-
Suh, S.J.1
Yoon, J.W.2
Lee, T.K.3
-
26
-
-
27644445236
-
Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo
-
DOI 10.1021/jf051506+
-
Goh D, Lee YH and Ong ES: Inhibitory effects of a chemically standardized extract from Scutellaria barbata in human colon cancer cell lines, LoVo. J Agric Food Chem 53: 8197-8204, 2005. (Pubitemid 41564626)
-
(2005)
Journal of Agricultural and Food Chemistry
, vol.53
, Issue.21
, pp. 8197-8204
-
-
Goh, D.1
Yian, H.L.2
Eng, S.O.3
-
27
-
-
42449157296
-
Inhibition activity of Scutellariae barbata extracts against human hepatocellular carcinoma cells
-
Lin JM, Liu Y and Luo RC: Inhibition activity of Scutellariae barbata extracts against human hepatocellular carcinoma cells. Nanfang Yikedadue Xuebao 26: 591-593, 2006.
-
(2006)
Nanfang Yikedadue Xuebao
, vol.26
, pp. 591-593
-
-
Lin, J.M.1
Liu, Y.2
Luo, R.C.3
-
28
-
-
4344672755
-
Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549
-
DOI 10.1016/j.lfs.2004.05.015, PII S0024320504005752
-
Yin X, Zhou J, Jie C, Xing D and Zhang Y: Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549. Life Sci 75: 2233-2244, 2004. (Pubitemid 39120026)
-
(2004)
Life Sciences
, vol.75
, Issue.18
, pp. 2233-2244
-
-
Yin, X.1
Zhou, J.2
Jie, C.3
Xing, D.4
Zhang, Y.5
-
29
-
-
4444271271
-
Methylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway
-
Cha YY, Lee EO, Lee HJ, et al: Methylene chloride fraction of Scutellaria barbata induces apoptosis in human U937 leukemia cells via the mitochondrial signaling pathway. Clin Chim Acta 348: 41-48, 2004.
-
(2004)
Clin Chim Acta
, vol.348
, pp. 41-48
-
-
Cha, Y.Y.1
Lee, E.O.2
Lee, H.J.3
-
30
-
-
34548614165
-
Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents
-
DOI 10.1002/ptr.2062
-
Yu J, Liu H, Lei J, Tan W, Hu X and Zou G: Antitumor activity of chloroform fraction of Scutellaria barbata and its active constituents. Phytother Res 21: 817-822, 2007. (Pubitemid 47401849)
-
(2007)
Phytotherapy Research
, vol.21
, Issue.9
, pp. 817-822
-
-
Yu, J.1
Liu, H.2
Lei, J.3
Tan, W.4
Hu, X.5
Zou, G.6
-
31
-
-
1642271439
-
Inhibitory effects of Scutellaria barbata D. Don on human uterine leiomyomal smooth muscle cell proliferation through cell cycle analysis
-
Lee TK, L.D., Kim DI, Lee YC, Chang YC and Kim CH: Inhibitory effects of Scutellaria barbata D. Don on human uterine leiomyomal smooth muscle cell proliferation through cell cycle analysis. Int Immunopharmacol 4: 447-454, 2004.
-
(2004)
Int Immunopharmacol
, vol.4
, pp. 447-454
-
-
Lee, T.K.1
L, D.2
Kim, D.I.3
Lee, Y.C.4
Chang, Y.C.5
Kim, C.H.6
-
32
-
-
77955323884
-
Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231
-
Bui-Xuan NH, Tang PM, Wong CK and Fung KP: Photo-activated pheophorbide-a, an active component of Scutellaria barbata, enhances apoptosis via the suppression of ERK-mediated autophagy in the estrogen receptor-negative human breast adenocarcinoma cells MDA-MB-231. J Ethnopharmacol 131: 95-103, 2010.
-
(2010)
J Ethnopharmacol
, vol.131
, pp. 95-103
-
-
Bui-Xuan, N.H.1
Tang, P.M.2
Wong, C.K.3
Fung, K.P.4
-
33
-
-
63449141434
-
Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3
-
Dai ZJ, Wang XJ, Li ZF, et al: Scutellaria barbate extract induces apoptosis of hepatoma H22 cells via the mitochondrial pathway involving caspase-3. World J Gastroenterol 14: 7321-7328, 2008.
-
(2008)
World J Gastroenterol
, vol.14
, pp. 7321-7328
-
-
Dai, Z.J.1
Wang, X.J.2
Li, Z.F.3
-
34
-
-
68649100672
-
Chinese medicinal herb Scutellaria barbata modulates apoptosis and cell survival in murine and human prostate cancer cells and tumor development in TRAMP mice
-
Wong BY, Nguyen DL, Lin T, et al: Chinese medicinal herb Scutellaria barbata modulates apoptosis and cell survival in murine and human prostate cancer cells and tumor development in TRAMP mice. Eur J Cancer Prev 18: 331-341, 2009.
-
(2009)
Eur J Cancer Prev
, vol.18
, pp. 331-341
-
-
Wong, B.Y.1
Nguyen, D.L.2
Lin, T.3
-
35
-
-
45349105163
-
Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells
-
Fong S, Shoemaker M, Cadaoas J, et al: Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells. Cancer Biol Ther 7: 577-586, 2008. (Pubitemid 351847034)
-
(2008)
Cancer Biology and Therapy
, vol.7
, Issue.4
, pp. 577-586
-
-
Fong, S.1
Shoemaker, M.2
Cadaoas, J.3
Lo, A.4
Liao, W.5
Tagliaferri, M.6
Cohen, I.7
Shtivelman, E.8
-
36
-
-
20344384859
-
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo
-
DOI 10.1158/1535-7163.MCT-05-0005
-
Luo Y, Shoemaker AR, Liu X, et al: Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivo. Mol Cancer Ther 4: 977-986, 2005. (Pubitemid 40909080)
-
(2005)
Molecular Cancer Therapeutics
, vol.4
, Issue.6
, pp. 977-986
-
-
Luo, Y.1
Shoemaker, A.R.2
Liu, X.3
Woods, K.W.4
Thomas, S.A.5
De Jong, R.6
Han, E.K.7
Li, T.8
Stoll, V.S.9
Powlas, J.A.10
Oleksijew, A.11
Mitten, M.J.12
Shi, Y.13
Guan, R.14
McGonigal, T.P.15
Klinghofer, V.16
Johnson, E.F.17
Leverson, J.D.18
Bouska, J.J.19
Mamo, M.20
Smith, R.A.21
Gramling-Evans, E.E.22
Zinker, B.A.23
Mika, A.K.24
Nguyen, P.T.25
Oltersdorf, T.26
Rosenberg, S.H.27
Li, Q.28
Giranda, V.L.29
more..
-
37
-
-
0029656181
-
Phase I-II study: Triciribine (tricyclic nucleoside phosphate) for metastatic breast cancer
-
Hoffman K, Holmes FA, Fraschini G, et al: Phase I-II study: triciribine (tricyclic nucleoside phosphate) for metastatic breast cancer. Cancer Chemother Pharmacol 37: 254-258, 1996.
-
(1996)
Cancer Chemother Pharmacol
, vol.37
, pp. 254-258
-
-
Hoffman, K.1
Holmes, F.A.2
Fraschini, G.3
-
38
-
-
34347219022
-
Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/akt inhibitors with reduced hypotension
-
DOI 10.1021/jm0701019
-
Zhu GD, Gandhi VB, Gong J, et al: Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase B/Akt inhibitors with reduced hypotension. J Med Chem 50: 2990-3003, 2007. (Pubitemid 47001242)
-
(2007)
Journal of Medicinal Chemistry
, vol.50
, Issue.13
, pp. 2990-3003
-
-
Zhu, G.-D.1
Gandhi, V.B.2
Gong, J.3
Thomas, S.4
Woods, K.W.5
Song, X.6
Li, T.7
Diebold, R.B.8
Luo, Y.9
Liu, X.10
Guan, R.11
Klinghofer, V.12
Johnson, E.F.13
Bouska, J.14
Olson, A.15
Marsh, K.C.16
Stoll, V.S.17
Mamo, M.18
Polakowski, J.19
Campbell, T.J.20
Martin, R.L.21
Gintant, G.A.22
Penning, T.D.23
Li, Q.24
Rosenberg, S.H.25
Giranda, V.L.26
more..
-
39
-
-
33748284463
-
Regulation of aneiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression
-
DOI 10.1002/jcp.20707
-
Xia C, Meng Q, Cao Z, Shi X and Jiang BH: Regulation of angiogenesis and tumor growth by p110 alpha and AKT1 via VEGF expression. J Cell Physiol 209: 56-66, 2006. (Pubitemid 44318667)
-
(2006)
Journal of Cellular Physiology
, vol.209
, Issue.1
, pp. 56-66
-
-
Xia, C.1
Meng, Q.2
Cao, Z.3
Shi, X.4
Jiang, B.-H.5
-
40
-
-
84856248776
-
PTEN and phosphatidylinositol 3′-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: Evidence for an effect on the tumor and endothelial compartment
-
Su JD, Mayo LD, Donner DB and Durden DL: PTEN and phosphatidylinositol 3′-kinase inhibitors up-regulate p53 and block tumor-induced angiogenesis: evidence for an effect on the tumor and endothelial compartment. Cancer Res 68: 635-643, 2003.
-
(2003)
Cancer Res
, vol.68
, pp. 635-643
-
-
Su, J.D.1
Mayo, L.D.2
Donner, D.B.3
Durden, D.L.4
-
41
-
-
27344446874
-
Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71
-
Wong WR, Chen YY, Yang SM, Chen YL and Horng JT: Phosphorylation of PI3K/Akt and MAPK/ERK in an early entry step of enterovirus 71. Life Sci 78: 82-90, 2005.
-
(2005)
Life Sci
, vol.78
, pp. 82-90
-
-
Wong, W.R.1
Chen, Y.Y.2
Yang, S.M.3
Chen, Y.L.4
Horng, J.T.5
|