Multi-parametric profiling network based on gene expression and phenotype data: A novel approach to developmental neurotoxicity testing

International Journal of Molecular Sciences

Volumn 13, Issue 1, 2012, Pages 187-207

  Nagano, Reiko ^a   Akanuma, Hiromi ^a   Qin, Xian Yang ^a,b   Imanishi, Satoshi ^b   Toyoshiba, Hiroyoshi ^a   Yoshinaga, Jun ^b   Ohsako, Seiichiroh ^b   Sone, Hideko ^a  

^a NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bayesian network modeling; Developmental neurotoxicity; Embryonic stem cells; Gene expression; High content screening; Multi parametric analysis

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 4,4' ISOPROPYLIDENEDIPHENOL; ANDROSTANOLONE; CYCLOPAMINE; DEXAMETHASONE; ESTRADIOL; METHOPRENE; NEUROTOXIN; PERMETHRIN; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; THALIDMIDE; TRIIODOTYRONINE; UNCLASSIFIED DRUG; ORGANIC COMPOUND;

ANIMAL CELL; ARTICLE; BAYES THEOREM; BRAIN DISEASE; CELL TYPE; CONTROLLED STUDY; DEVELOPMENTAL NEUROTOXICITY TESTING; DEVELOPMENTAL STAGE; DNA MICROARRAY; EMBRYO DEVELOPMENT; EMBRYOID BODY; EMBRYONIC STEM CELL; GENE EXPRESSION PROFILING; GENE FUNCTION; MOUSE; NERVE CELL DIFFERENTIATION; NEUROTOXICITY; NONHUMAN; TOXICITY TESTING; ANIMAL; AUTISM; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE CELL; NERVOUS SYSTEM DEVELOPMENT; PARKINSON DISEASE; PATHOLOGY; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; TOXICITY;

ANIMALS; AUTISTIC DISORDER; BAYES THEOREM; CELLS, CULTURED; EMBRYOID BODIES; EMBRYONIC STEM CELLS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MICE; NEUROGENESIS; NEURONS; ORGANIC CHEMICALS; PARKINSON DISEASE; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS;

EID: 84856252405     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13010187     Document Type: Article

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