Cometin is a novel neurotrophic factor that promotes neurite outgrowth and neuroblast migration in vitro and supports survival of spiral ganglion neurons in vivo

Experimental Neurology

Volumn 233, Issue 1, 2012, Pages 172-181

  Jørgensen, Jesper Roland ^a   Fransson, Anette ^b   Fjord Larsen, Lone ^a   Thompson, Lachlan H ^c   Houchins, Jeffrey P ^d   Andrade, Nuno ^e   Torp, Malene ^a   Kalkkinen, Nisse ^f   Andersson, Elisabet ^b   Lindvall, Olle ^e   Ulfendahl, Mats ^b   Brunak, Søren ^g,h   Johansen, Teit E ^a   Wahlberg, Lars U ^a  

^a NsGene AS   (Denmark)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d R and D Systems Inc   (United States)

^e LUND UNIVERSITY HOSPITAL   (Sweden)

^f UNIVERSITY OF HELSINKI   (Finland)

^g TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

^h UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Floor plate; Meteorin; Migration; Neurotrophic; Novel protein; Spiral ganglion; Trophic factor

Indexed keywords

COMETIN; GROWTH FACTOR; JANUS KINASE; MESSENGER RNA; METEORIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROTROPHIC FACTOR; RECOMBINANT PROTEIN; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL FUNCTION; CELL MIGRATION; CELL SURVIVAL; COMETIN GENE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG SCREENING; ENZYME INHIBITION; EVOKED BRAIN STEM AUDITORY RESPONSE; FEMALE; GENE; GENE EXPRESSION REGULATION; GENE FUNCTION; GUINEA PIG; HEARING IMPAIRMENT; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MALE; METEORIN GENE; NERVE FIBER GROWTH; NEUROBLAST; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN SECRETION; RAT; SPINAL GANGLION;

EID: 84856214544     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2011.09.027     Document Type: Article

References (43)

1. Airaksinen M.S., Holm L., Hatinen T. Evolution of the GDNF family ligands and receptors. Brain Behav. Evol. 2006, 68:181-190.
2. Alvarez-Buylla A., Garcia-Verdugo J.M. Neurogenesis in adult subventricular zone. J. Neurosci. 2002, 22:629-634.
3. Barde Y.A., Edgar D., Thoenen H. Purification of a new neurotrophic factor from mammalian brain. EMBO J. 1982, 1:549-553.
4. Bendtsen J.D., Nielsen H., von Heijne G., Brunak S. Improved prediction of signal peptides: SignalP 3.0. J. Mol. Biol. 2004, 340:783-795.
5. Berkemeier L.R., Winslow J.W., Kaplan D.R., Nikolics K., Goeddel D.V., Rosenthal A. Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 1991, 7:857-866.
6. Briscoe J., Pierani A., Jessell T.M., Ericson J. A homeodomain protein code specifies progenitor cell identity and neuronal fate in the ventral neural tube. Cell 2000, 101:435-445.
7. Fjord-Larsen L., Johansen J.L., Kusk P., Tornoe J., Gronborg M., Rosenblad C., Wahlberg L.U. Efficient in vivo protection of nigral dopaminergic neurons by lentiviral gene transfer of a modified Neurturin construct. Exp. Neurol. 2005, 195:49-60.
8. Fransson A., Maruyama J., Miller J.M., Ulfendahl M. Post-treatment effects of local GDNF administration to the inner ears of deafened guinea pigs. J. Neurotrauma 2010, 27:1745-1751.
9. Gundersen H.J., Bagger P., Bendtsen T.F., Evans S.M., Korbo L., Marcussen N., Moller A., Nielsen K., Nyengaard J.R., Pakkenberg B. The new stereological tools: disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis. APMIS 1988, 96:857-881.
10. Hall R.D. Estimation of surviving spiral ganglion cells in the deaf rat using the electrically evoked auditory brainstem response. Hear. Res. 1990, 49:155-168.
11. Hallbook F., Ibanez C.F., Persson H. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 1991, 6:845-858.
12. Harlow E., Land D. Antibodies: A Laboratory Manual 1988, Cold Spring Harbor Laboratory Press.
13. Hohn A., Leibrock J., Bailey K., Barde Y.A. Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 1990, 344:339-341.
14. Imitola J., Raddassi K., Park K.I., Mueller F.J., Nieto M., Teng Y.D., Frenkel D., Li J., Sidman R.L., Walsh C.A., Snyder E.Y., Khoury S.J. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:18117-18122.
15. Jensen M.L., Timmermann D.B., Johansen T.H., Schousboe A., Varming T., Ahring P.K. The beta subunit determines the ion selectivity of the GABAA receptor. J. Biol. Chem. 2002, 277:41438-41447.
16. Jones D.H., Nakashima T., Sanchez O.H., Kozieradzki I., Komarova S.V., Sarosi I., Morony S., Rubin E., Sarao R., Hojilla C.V., Komnenovic V., Kong Y.Y., Schreiber M., Dixon S.J., Sims S.M., Khokha R., Wada T., Penninger J.M. Regulation of cancer cell migration and bone metastasis by RANKL. Nature 2006, 440:692-696.
17. Jorgensen J.R., Thompson L., Fjord-Larsen L., Krabbe C., Torp M., Kalkkinen N., Hansen C., Wahlberg L. Characterization of Meteorin-an evolutionary conserved neurotrophic factor. J. Mol. Neurosci. 2009, 39:104-116.
18. Jorgensen J.R., Emerich D.F., Thanos C., Thompson L.H., Torp M., Bintz B., Fjord-Larsen L., Johansen T.E., Wahlberg L.U. Lentiviral delivery of Meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model. Neurobiol. Dis. 2011, 41:160-168.
19. Lanave C., Colangelo A.M., Saccone C., Alberghina L. Molecular evolution of the neurotrophin family members and their Trk receptors. Gene 2007, 394:1-12.
20. Lawson S.N., Biscoe T.J. Development of mouse dorsal root ganglia: an autoradiographic and quantitative study. J. Neurocytol. 1979, 8:265-274.
21. Lee H.S., Han J., Lee S.H., Park J.A., Kim K.W. Meteorin promotes the formation of GFAP-positive glia via activation of the Jak-STAT3 pathway. J. Cell Sci. 2010, 123:1959-1968.
22. Leibrock J., Lottspeich F., Hohn A., Hofer M., Hengerer B., Masiakowski P., Thoenen H., Barde Y.A. Molecular cloning and expression of brain-derived neurotrophic factor. Nature 1989, 341:149-152.
23. Lein E.S., Hawrylycz M.J., Ao N., Ayres M., Bensinger A., Bernard A., Boe A.F., Boguski M.S., Brockway K.S., Byrnes E.J., Chen L., Chen L., Chen T.M., Chin M.C., Chong J., Crook B.E., Czaplinska A., Dang C.N., Datta S., Dee N.R., Desaki A.L., Desta T., Diep E., Dolbeare T.A., Donelan M.J., Dong H.W., Dougherty J.G., Duncan B.J., Ebbert A.J., Eichele G., Estin L.K., Faber C., Facer B.A., Fields R., Fischer S.R., Fliss T.P., Frensley C., Gates S.N., Glattfelder K.J., Halverson K.R., Hart M.R., Hohmann J.G., Howell M.P., Jeung D.P., Johnson R.A., Karr P.T., Kawal R., Kidney J.M., Knapik R.H., Kuan C.L., Lake J.H., Laramee A.R., Larsen K.D., Lau C., Lemon T.A., Liang A.J., Liu Y., Luong L.T., Michaels J., Morgan J.J., Morgan R.J., Mortrud M.T., Mosqueda N.F., Ng L.L., Ng R., Orta G.J., Overly C.C., Pak T.H., Parry S.E., Pathak S.D., Pearson O.C., Puchalski R.B., Riley Z.L., Rockett H.R., Rowland S.A., Royall J.J., Ruiz M.J., Sarno N.R., Schaffnit K., Shapovalova N.V., Sivisay T., Slaughterbeck C.R., Smith S.C., Smith K.A., Smith B.I., Sodt A.J., Stewart N.N., Stumpf K.R., Sunkin S.M., Sutram M., Tam A., Teemer C.D., Thaller C., Thompson C.L., Varnam L.R., Visel A., Whitlock R.M., Wohnoutka P.E., Wolkey C.K., Wong V.Y., Wood M., Yaylaoglu M.B., Young R.C., Youngstrom B.L., Yuan X.F., Zhang B., Zwingman T.A., Jones A.R. Genome-wide atlas of gene expression in the adult mouse brain. Nature 2007, 445:168-176.
24. Levi-Montalcini R. The nerve growth factor 35years later. Science 1987, 237:1154-1162.
25. Levy Y.S., Gilgun-Sherki Y., Melamed E., Offen D. Therapeutic potential of neurotrophic factors in neurodegenerative diseases. BioDrugs 2005, 19:97-127.
26. Magdaleno S., Jensen P., Brumwell C.L., Seal A., Lehman K., Asbury A., Cheung T., Cornelius T., Batten D.M., Eden C., Norland S.M., Rice D.S., Dosooye N., Shakya S., Mehta P., Curran T. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol. 2006, 4:e86.
27. Maruyama J., Miller J.M., Ulfendahl M. Glial cell line-derived neurotrophic factor and antioxidants preserve the electrical responsiveness of the spiral ganglion neurons after experimentally induced deafness. Neurobiol. Dis. 2008, 29:14-21.
28. Nishino J., Yamashita K., Hashiguchi H., Fujii H., Shimazaki T., Hamada H. Meteorin: a secreted protein that regulates glial cell differentiation and promotes axonal extension. EMBO J. 2004, 23:1998-2008.
29. Park J.A., Lee H.S., Ko K.J., Park S.Y., Kim J.H., Choe G., Kweon H.S., Song H.S., Ahn J.C., Yu Y.S., Kim K.W. Meteorin regulates angiogenesis at the gliovascular interface. Glia 2008, 56:247-258.
30. Pettingill L.N., Richardson R.T., Wise A.K., O'Leary S.J., Shepherd R.K. Neurotrophic factors and neural prostheses: potential clinical applications based upon findings in the auditory system. IEEE Trans. Biomed. Eng. 2007, 54:1138-1148.
31. Placzek M., Briscoe J. The floor plate: multiple cells, multiple signals. Nat. Rev. Neurosci. 2005, 6:230-240.
32. Ramialison M., Bajoghli B., Aghaallaei N., Ettwiller L., Gaudan S., Wittbrodt B., Czerny T., Wittbrodt J. Rapid identification of PAX2/5/8 direct downstream targets in the otic vesicle by combinatorial use of bioinformatics tools. Genome Biol. 2008, 9:R145.
33. Robin A.M., Zhang Z.G., Wang L., Zhang R.L., Katakowski M., Zhang L., Wang Y., Zhang C., Chopp M. Stromal cell-derived factor 1alpha mediates neural progenitor cell motility after focal cerebral ischemia. J. Cereb. Blood Flow Metab. 2006, 26:125-134.
34. Ruben R.J. Development of the inner ear of the mouse: a radioautographic study of terminal mitoses. Acta Otolaryngol. 1967, (Suppl. 44).
35. Shinohara T., Bredberg G., Ulfendahl M., Pyykko I., Olivius N.P., Kaksonen R., Lindstrom B., Altschuler R., Miller J.M. Neurotrophic factor intervention restores auditory function in deafened animals. Proc. Natl. Acad. Sci. U.S.A. 2002, 99:1657-1660.
36. Sims T.J., Vaughn J.E. The generation of neurons involved in an early reflex pathway of embryonic mouse spinal cord. J. Comp. Neurol. 1979, 183:707-719.
37. Su A.I., Wiltshire T., Batalov S., Lapp H., Ching K.A., Block D., Zhang J., Soden R., Hayakawa M., Kreiman G., Cooke M.P., Walker J.R., Hogenesch J.B. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:6062-6067.
38. Sun W., Kim H., Moon Y. Control of neuronal migration through rostral migration stream in mice. Anat. Cell Biol. 2010, 43:269-279.
39. Thompson J.D., Higgins D.G., Gibson T.J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 1994, 22:4673-4680.
40. Thored P., Arvidsson A., Cacci E., Ahlenius H., Kallur T., Darsalia V., Ekdahl C.T., Kokaia Z., Lindvall O. Persistent production of neurons from adult brain stem cells during recovery after stroke. Stem Cells 2006, 24:739-747.
41. Voermans C., Anthony E.C., Mul E., van der Schoot E., Hordijk P. SDF-1-induced actin polymerization and migration in human hematopoietic progenitor cells. Exp. Hematol. 2001, 29:1456-1464.
42. Walker J.R., Su A.I., Self D.W., Hogenesch J.B., Lapp H., Maier R., Hoyer D., Bilbe G. Applications of a rat multiple tissue gene expression data set. Genome Res. 2004, 14:742-749.
43. Watanabe F., Kirkegaard M., Matsumoto S., Gont C., Mannstrom P., Ulfendahl M., Fridberger A. Signaling through erbB receptors is a critical functional regulator in the mature cochlea. Eur. J. Neurosci. 2010, 32:717-724.