Lentiviral delivery of Meteorin protects striatal neurons against excitotoxicity and reverses motor deficits in the quinolinic acid rat model

Neurobiology of Disease

Volumn 41, Issue 1, 2011, Pages 160-168

  Jørgensen, Jesper Roland ^a   Emerich, Dwaine F ^b   Thanos, Chris ^c   Thompson, Lachlan H ^d,e   Torp, Malene ^a   Bintz, Briannan ^c   Fjord Larsen, Lone ^a   Johansen, Teit E ^a   Wahlberg, Lars U ^a  

^a NsGene AS   (Denmark)

^b InCytu Inc   (United States)

^c CytoSolv Inc   (United States)

^d FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Excitotoxicity; Gene therapy; Huntington's Disease; Neuroprotection; Neurotrophic factor

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; GROWTH FACTOR; LENTIVIRUS VECTOR; METEORIN; QUINOLINIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFECT; DRUG POTENCY; EMBRYO; EXCITOTOXICITY; GENE EXPRESSION; GLIA CELL; GLIOSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MOTOR DYSFUNCTION; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; VIRAL GENE DELIVERY SYSTEM; VIRAL GENE THERAPY; WEIGHT REDUCTION;

ANIMALS; BEHAVIOR, ANIMAL; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; GENE THERAPY; GENETIC VECTORS; HEK293 CELLS; HUMANS; HUNTINGTON DISEASE; LENTIVIRUS; MALE; MICE; MOVEMENT DISORDERS; NERVE TISSUE PROTEINS; NEURONS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78349312097     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2010.09.003     Document Type: Article

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