Maternal and neonatal effects of bolus administration of ephedrine and phenylephrine during spinal anaesthesia for caesarean delivery: a randomised study

International Journal of Obstetric Anesthesia

Volumn 19, Issue 1, 2010, Pages 24-30

  Prakash, S ^a   Pramanik, V ^a   Chellani, H ^a   Salhan, S ^a   Gogia, A R ^a  

^a SAFDARJUNG HOSPITAL   (India)

Author keywords

Anaesthetic technique; Complication; Drugs; ephedrine, phenylephrine; hypotension; spinal

Indexed keywords

EPHEDRINE; PHENYLEPHRINE;

ACID BASE BALANCE; ADULT; APGAR SCORE; ARTICLE; BOLUS INJECTION; BRADYCARDIA; CESAREAN SECTION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; HYPOTENSION; MAJOR CLINICAL STUDY; NAUSEA; NEUROLOGIC EXAMINATION; NEWBORN; PH; RANDOMIZED CONTROLLED TRIAL; SPINAL ANESTHESIA; SPINAL HYPOTENSION; SYSTOLIC BLOOD PRESSURE; UMBILICAL ARTERY; VOMITING;

ACID-BASE EQUILIBRIUM; ADULT; ANESTHESIA, OBSTETRICAL; ANESTHESIA, SPINAL; ANTI-ULCER AGENTS; ANTIEMETICS; APGAR SCORE; CESAREAN SECTION; DOUBLE-BLIND METHOD; EPHEDRINE; FEMALE; HEMODYNAMICS; HUMANS; HYPOTENSION; INFANT, NEWBORN; METOCLOPRAMIDE; PAIN MEASUREMENT; PHENYLEPHRINE; POSTOPERATIVE NAUSEA AND VOMITING; PREGNANCY; RANITIDINE; SAMPLE SIZE; VASOCONSTRICTOR AGENTS;

EID: 71849099674     PISSN: 0959289X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijoa.2009.02.007     Document Type: Article

References (26)

1. Rout C.C., and Rocke D.A. Prevention of hypotension following spinal anesthesia for Cesarean section. Int Anesthesiol Clin 32 (1994) 117-135
2. Ngan Kee W.D., and Khaw K.S. Vasopressors in obstetrics: what should we be using?. Curr Opin Anaesthesiol 19 (2006) 238-243
3. Riley E.T. Spinal anaesthesia for Caesarean delivery: keep the pressure up and don't spare the vasoconstrictors. Br J Anaesth 92 (2004) 459-461
4. Ngan Kee W.D., Khaw K.S., Lee B.B., Lau T.K., and Gin T. A dose response study of prophylactic intravenous ephedrine for the prevention of hypotension during spinal anesthesia for cesarean delivery. Anesth Analg 90 (2000) 1390-1395
5. Ngan Kee W.D., Lau T.K., Khaw K.S., and Lee B.B. Comparison of metaraminol and ephedrine infusions for maintaining arterial pressure during spinal anesthesia for elective cesarean section. Anesthesiology 95 (2001) 307-313
6. Ngan Kee W.D., Khaw K.S., and Ng F.F. Comparison of phenylephrine infusion regimens for maintaining maternal blood pressure during spinal anaesthesia for Caesarean section. Br J Anaesth 92 (2004) 469-474
7. Mercier F.J., Riley E.T., Frederickson W.L., Roger-Christoph S., Benhamou D., and Cohen S.E. Phenylephrine infusion during spinal anesthesia for elective Cesarean section. Anesthesiology 95 (2001) 668-674
8. Cooper D.W., Carpenter M., Mowbray P., Desira W.R., Ryall D.M., and Kokri M.S. Fetal and maternal effects of phenylephrine and ephedrine during spinal anesthesia for Cesarean delivery. Anesthesiology 97 (2002) 1582-1590
9. Pierce E.T., Carr D.B., and Datta S. Effects of ephedrine and phenylephrine on maternal and fetal atrial natriuretic peptide levels during elective Cesarean section. Acta Anesthesiol Scand 38 (1994) 48-51
10. LaPorta R.F., Arthur G.R., and Datta S. Phenylephrine in treating maternal hypotension due to spinal anesthesia for Cesarean delivery: effects on neonatal catecholamine concentrations, acid base status and Apgar scores. Acta Anesthesiol Scand 39 (1995) 901-905
11. Thomas D.G., Robson S.C., Redfern N., Hughes D., and Boys R.J. Randomized trial of bolus phenylephrine or ephedrine for maintenance of arterial pressure during spinal anesthesia for Caesarean section. Br J Anaesth 76 (1996) 61-65
12. Scanlon J.W., Brown Jr. W.U., and Alper M.H. Neurobehavioral responses of newborn infants after maternal epidural anesthesia. Anesthesiology 40 (1974) 121-128
13. Lee A., Ngan Kee W.D., and Gin T. A quantitative, systematic review of randomized controlled trials of ephedrine versus phenylephrine for the management of hypotension during spinal anesthesia for cesarean delivery. Anesth Analg 94 (2002) 920-926
14. Cooper D.W. Ephedrine, phenylephrine and fetal acidosis. Anaesthesia 60 (2005) 237-238
15. Datta S., Alper M.H., Ostheimer G.W., and Weiss J.B. Method of ephedrine administration and nausea and hypotension during spinal anesthesia for cesarean section. Anesthesiology 56 (1982) 68-70
16. Lee A., Ngan Kee W.D., and Gin T. A dose-response meta-analysis of prophylactic intravenous ephedrine for the prevention of hypotension during spinal anesthesia for elective Cesarean delivery. Anesth Analg 98 (2004) 483-490
17. Cooper D.W., Gibb S.C., Meek T., et al. Effect of intravenous vasopressor on spread of spinal anaesthesia and fetal acid-base equilibrium. Br J Anaesth 98 (2007) 649-656
18. Cooper D.W., and Gowni R.R. Impact of changing from ephedrine to phenylephrine as the first-line vasopressor during urgent caesarean section. Int J Obstet Anesth 15 (2006) 339-340
19. Ngan Kee W.D., Khaw K.S., Lau T.K., Ng F.F., Chui K., and Ng K.L. Randomized double-blinded comparison of phenylephrine vs ephedrine for maintaining blood pressure during spinal anaesthesia for non-elective Caesarean section. Anaesthesia 63 (2008) 1319-1326
20. Amiel-Tison C., Barrier G., Shnider S.M., Levinson G., and Hughes S.C. Stefani SJ: A new neurologic and adaptive capacity scoring system for evaluating obstetric medications in full-term newborns. Anesthesiology 56 (1982) 340-350
21. Brockhurst N.J., and Littleford J.A. Halpern SH The Neurologic and Adaptive Capacity Score: A systematic review of its use in obstetric anesthesia research. Anesthesiology 92 (2000) 237-246
22. Als H., Tronick E., and Lester B.M. Brazelton TB: The Brazelton Neonatal Behavioral Assessment Scale (BNBAS). J Abnorm Child Psychol 5 (1977) 215-231
23. Hughes S.C., Ward M.G., Levison G., et al. Placental transfer of ephedrine does not affect neonatal outcome. Anesthesiology 63 (1985) 217-219
24. Corke B.C., Datta S., Ostheimer G.W., Weiss J.B., and Alper M.H. Spinal anaesthesia for Caesarean section: The influence of hypotension on neonatal outcome. Anaesthesia 17 (1982) 658-662
25. Erkinaro T., Kavasmaa T., Päkkilä M., et al. Ephedrine and phenylephrine for the treatment of maternal hypotension in a chronic sheep model of increased placental vascular resistance. Br J Anaesth 96 (2006) 231-237
26. Saravanan S., Kocarev M., Wilson R.C., et al. Equivalent dose of ephedrine and phenylephrine in the prevention of post-spinal hypotension in Caesarean section. Br J Anaesth 96 (2006) 95-99